|
T9168 |
NSC 617145
|
NSC617145,NSC-617145 |
DNA/RNA Synthesis
|
|
NSC 617145 (NSC617145) is an inhibitor of WRN helicase that inhibits the ATPase, but not exonuclease, activity of WRN helicase in a concentration-dependent manner. |
|
T8492 |
BO-264
|
|
Apoptosis
,
FGFR
|
|
BO-264 is a highly potent and orally active inhibitor of transforming acidic coiled-coil 3 (TACC3, IC50 of 188 nM and a Kd of 1.5 nM). |
|
T3206 |
NKL 22
|
Histone Deacetylase Inhibitor IV,PAOA |
HDAC
|
|
NKL 22 (Histone Deacetylase Inhibitor IV) is an effective Histone Deacetylase Inhibitor. |
|
T16090 |
MK-0773
|
PF-05314882 |
Androgen Receptor
|
|
MK-0773 (PF-05314882) is a selective androgen receptor modulator that binds to AR (IC50: 6.6 nM) for the study of diseases caused by endocrine abnormalities. |
|
T13435 |
TR antagonist 1
|
|
Thyroid hormone receptor(THR)
|
|
TR antagonist 1 is a highly potent thyroid hormone receptor (TR) antagonist (IC50 of 36 and 22 nM for TRα and TRβ, respectively) that can be used to study diseases caused by endocrine abnormalities. |
|
T74643 |
RSS0680
|
|
CDK
,
AMPK
,
AAK1 (AP2 associated kinase 1)
,
PROTACs
|
|
RSS0680 is a protein kinase degrader that degrades a variety of kinases and can be used to study diseases caused by kinase abnormalities. |
|
T63305 |
Carbonic anhydrase inhibitor 6
|
|
Carbonic Anhydrase
|
|
Carbonic anhydrase inhibitor 6 is a potent human carbonic anhydrase (hCA) inhibitor that inhibits hCA IX, hCA II, hCA XII, and hCA I. It is used in the study of diseases caused by abnormalities in carbonic anhydrase. |
|
T0077 |
Dantrolene sodium
|
Lapatinib ditosylate monohydrate,Dantrolene sodium salt |
Others
,
Calcium Channel
|
|
Dantrolene sodium (Lapatinib ditosylate monohydrate) salt is a skeletal muscle relaxant and can interfere with excitation-contraction coupling in the muscle fiber. It is used for the treatment of spasticity and other neu... |
|
T38294 |
4-Deoxypyridoxine hydrochloride
|
|
S1P Receptor
|
|
4-Deoxypyridoxine (4-DPD) is a vitamin B6 antimetabolite with diverse biological activities. It inhibits transport of pyridoxine , pyridoxal, and pyridoxamine in and reduces growth of S. carlsbergensis cells. 4-DPD inhib... |
|
T39158 |
17-DMAP-GA
|
|
|
|
17-DMAP-GA, a Geldanamycin analogue, acts as an HSP90 inhibitor, leading to cell cycle abnormalities. |
|
T39718 |
Tinengotinib
|
|
|
|
Tinengotinib, a novel compound, acts as a potent modulator of protein kinases including Aurora kinase and VEGFR kinase. With its unique properties, Tinengotinib holds promise for investigating diseases marked by abnormal... |
|
T40059 |
Nicotinamide riboside tartrate
|
|
|
|
Nicotinamide riboside tartrate (NRT) is an oral NAD+ precursor that raises NAD+ levels, activates SIRT1 and SIRT3, and serves as a vitamin B3 (niacin) source. NRT also improves oxidative metabolism and protects against m... |
|
T62791 |
CDK7-IN-16
|
|
|
|
CDK7-IN-16 (Compound 9) is a potent inhibitor of CDK 7 (IC50: 1-10 nM). CDK7-IN-16 can be used in research against cancer, particularly cancers with transcriptional abnormalities. |
|
T40060 |
Nicotinamide riboside malate
|
|
|
|
Nicotinamide riboside malate is an orally active NAD+ precursor that elevates NAD+ levels and stimulates the activity of SIRT1 and SIRT3. Functioning as a vitamin B3 (niacin) source, it augments oxidative metabolism and ... |
|
T61964 |
RXFP3/4 agonist 2
|
|
RXFP receptor
|
|
RXFP3/4 agonist 2 is a potent non-peptidic bis-RXFP3/4 agonist that induces the interaction between RXFP3 and β-arrestin-2, and can be used to study diseases caused by metabolic abnormalities. |
|
T69622 |
Ritivixibat
|
|
|
|
Ritivixibat is an ileal bile acid transporter (IBAT) inhibitor and bile acid modulator. It is utilized in research related to cardiovascular diseases, fatty acid metabolism disorders, glucose utilization abnormalities, g... |
|
T22905 |
L748337
|
L-748,337 |
Adrenergic Receptor
|
|
L748337 is a competitive and potent β3-adrenoceptor antagonist that inhibits the action of β3-, β2-, and β1-adrenoceptors, activates MAPK signaling, promotes phosphorylation of Erk1/2, and inhibits the protective effects... |
|
T80446 |
ω-Conotoxin FVIA
|
|
Calcium Channel
|
|
ω-Conotoxin FVIA is an inhibitor of N-type Ca²⁺ channels (Caᵥ2.2), shown to alleviate mechanical and thermal pain abnormalities in a rat model of caudal nerve injury. This compound has potential utility in the research o... |
|
T83328 |
4A7C-301
|
|
|
|
4A7C-301, a Nurr1 agonist, exhibits potent neuroprotective effects in vitro and markedly mitigates neuropathological abnormalities while enhancing motor and olfactory functions in male mouse models with AAV2-mediated α-s... |
|
T39704 |
KSC-34
|
|
Others
|
|
KSC-34 is a covalent modifier of protein disulfide isomerase A1 (PDIA1).KSC-34 is a selective inhibitor targeting the a-site of PDIA1.It inhibits PDIA1 reductase activity in a time-dependent manner and is used to study d... |
|
T83870 |
BHD
|
|
|
|
BHD, a reversible male contraceptive agent, effectively induces spermatogenic cell apoptosis and causes abnormalities in seminiferous tubules in vivo at doses of 100 and 500 mg/kg. Additionally, it disrupts the blood-tes... |
|
T81275 |
Riboxin
|
IDP |
|
|
Riboxin (IDP), an orally administered purine derivative known as hypoxanthine riboside, exhibits antihypoxic and antihyperthermic effects. Furthermore, it demonstrates antiarrhythmic properties in cats, rabbits, and mice... |
|
T70070 |
Cisapride tartrate
|
|
|
|
Cisapride tartrate is chemically related to metoclopramide, but unlike metoclopramide, it does not cross the blood-brain barrier or have antidopaminergic effects. Cisapride is a serotonin-4 (5-HT4) receptor agonist. Cisa... |
|
T37631 |
Tetranor-12(S)-HETE
|
|
|
|
12(S)-HETE is a product of arachidonic acid metabolism through the 12-lipoxygenase pathway. It is primarily found in platelets, leukocytes, and to a lesser extent in smooth muscle cells. It enhances tumor cell adhesion t... |
