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T11037 |
Diacylglycerol acyltransferase inhibitor-1
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Others
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Diacylglycerol Acyltransferase Inhibitor-1, a diacylglycerol acyltransferase (DGAT1) inhibitor, effectively suppresses the activity of DGAT1. |
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T13373 |
YM17E
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|
Acyltransferase
,
AChR
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T12767 |
RP 70676
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|
Acyltransferase
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T15109 |
DGAT1-IN-1
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|
Transferase
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DGAT1-IN-1 is a potent inhibitor of diacylglycerol O- acyltransferase type 1(DGAT1, IC50 of < 10 nM). |
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T9711 |
OGT-IN-2
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Others
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OGT-IN-2 is a potent O-GlcNAc transferase (OGT) inhibitor. OGT-IN-2 inhibits sOGT and ncOGT with IC50 values of 30 μM and 53 μM, respectively[1]. OGT-IN-2 can be used for the research of articular diseases[1]. |
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T10035 |
10,12-Tricosadiynoic acid
|
TDA,TCDA |
Acyltransferase
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10,12-Tricosadiynoic acid is a highly selective and orally active inhibitor of acyl-CoA oxidase-1 (ACOX1). It can treat the high-fat diet- or obesity-induced metabolic diseases by improving mitochondrial lipid and ROS me... |
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T8314 |
RP-64477
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RP64477 |
Acyltransferase
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RP-64477 is the cholesterol esterifying enzyme Acyl-coenzyme A:cholesterol O-acyltransferase (ACAT) inhibitor. |
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T6937 |
PF-04620110
|
PF04620110,PF 04620110 |
Acyltransferase
,
Transferase
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PF-04620110 is an orally active, selective and potent diglyceride acyltransferase-1 (DGAT1) inhibitor with IC50 of 19 nM. |
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T12425 |
PF-06424439 methanesulfonate
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|
Acyltransferase
,
Transferase
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PF-06424439 methanesulfonate, an orally administered, potent, and selective imidazopyridine diacylglycerol acyltransferase 2 (DGAT2) inhibitor with an IC50 of 14 nM, demonstrates slow reversibility and time-dependent inh... |
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T4681 |
T863
|
DGAT-3,DGAT-1 inhibitor |
Acyltransferase
,
Transferase
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T-863(DGAT-1 inhibitor) is an orally active, selective and potent DGAT1 (Acyl-CoA:diacylglycerol acyltransferase 1) inhibitor that interacts with the acyl-CoA binding site of DGAT1, and inhibits triacylglycerol synthesis... |
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T16409 |
OSMI-1
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Others
,
Acyltransferase
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OSMI-1 is an O-GlcNAc transferase (OGT) inhibitor (IC50=2.7 μM) that is orally active and cell-permeable. OSMI-1 inhibits protein O-GlcNA acetylation without qualitatively altering cell-surface N- or O- linked glycans. |
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T23521 |
VULM 1457
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Acyltransferase
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VULM 1457 is a potent ACAT inhibitor. VULM 1457 has remarkable hypolipidaemic activity and improves the overall myocardial ischaemia-reperfusion injury outcomes. VULM1457 significantly reduces production and secretion of... |
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T23550 |
YM-750
|
YM 750 |
Acyltransferase
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YM-750 is a potent inhibitor of acyl-CoA:cholesterol acyltransferase (ACAT), with an IC50 value of 0.18 μM. ACAT is an enzyme that catalyzes the conversion of cholesterol and long-chain fatty-acyl-coenzyme A into cholest... |
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T11733 |
K-604 dihydrochloride
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|
Acyltransferase
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K-604 dihydrochloride is a potent and selective acyl-CoA:cholesterol acyltransferase 1 inhibitor with an IC50 of 0.45±0.06 μM. |
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T8236 |
RHC 80267
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U-57908 |
Others
,
Phospholipase
,
COX
,
Acyltransferase
,
AChR
|
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RHC 80267 (U-57908) is a selective inhibitor of DAGL (IC50 : 4 μM in canine platelets) |
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T22665 |
PD 128042
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CI 976 |
Acyltransferase
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PD 128042 (CI 976) is a potent orally active and selective ACAT inhibitor(IC50: 73 nM) and a potent lysophospholipid acyltransferase(LPAT) inhibitor. CI 976 inhibits Golgi-associated LPAT activity (IC50: 15 μM) and multi... |
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T12225L |
Nevanimibe hydrochloride
|
PD-132301 hydrochloride,ATR101 hydrochloride |
Apoptosis
,
Acyltransferase
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Nevanimibe hydrochloride (PD-132301 hydrochloride) is an orally active and selective inhibitor of acyl-coenzyme A:cholesterol O-acyltransferase 1 (ACAT1) (EC50 of 9 nM). |
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T15247 |
ESI-05
|
NSC 116966 |
cAMP
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ESI-05 (NSC-116966) is a specific EPAC2 (exchange protein directly activated by cAMP 2) antagonist (IC50: 0.4 μM). ESI-05 inhibits cAMP-mediated activation of EPAC2, as well as EAPC2, mediated Rap1 activation. |
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T6365 |
A 922500
|
A922500,DGAT-1 Inhibitor 4a |
Acyltransferase
,
Transferase
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A 922500 (DGAT-1 Inhibitor 4a) is an inhibitor for human and mouse DGAT-1 with IC50 of 7 nM and 24 nM, respectively, good selectivity over related acyltransferases, hERG, and a panel of anti-targets. |
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T2753 |
Avasimibe
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PD-148515,CI-1011 |
P450
,
Acyltransferase
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Avasimibe (PD-148515) is an orally bioavailable inhibitor of acyl-Coenzyme A: cholesterol acyltransferase (ACAT, IC50: 3.3 μM) that prevents cholesterol deposition in the arterial wall. It also inhibits human P450 isoenz... |
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T12426 |
PF-06424439
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|
Acyltransferase
,
Transferase
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T21694 |
(R)-Lisofylline
|
(R)-Lisophylline |
STAT
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(R)-Lisofylline ((R)-Lisophylline) is an inhibitor of lysophosphatidic acid acyltransferase (IC50 = 0.6 µM). (R)-Lisofylline interrupts IL-12 signaling-mediated STAT4 activation and can be used in studies about the treat... |
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T14375 |
AZD3988
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|
Transferase
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AZD3988 is an orally active and highly potent inhibitor of diacylglycerol acyltransferase-1 (DGAT-1) for the study of diabetes and obesity. |
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T11827 |
Pradigastat
|
ANJ908,LCQ908-NXA,LCQ908A,LCQ-908 |
Transferase
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Pradigastat (LCQ-908) is an orally active, potent and selective diacylglycerol acyltransferase 1 (DGAT1) inhibitor for the treatment of constipation, which may be used in the study of obesity and diabetes. |
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T30961 |
CL 277082
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CL277082,CL-277082,Ddpmhu |
Others
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CL 277082 (Ddpmhu) is an acyl coenzyme A:cholesterol O-acyltransferase inhibitor that inhibits granuloma tissue ACAT activity. |
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T14523 |
Beauvericin
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Others
,
Acyltransferase
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Beauvericin, a Fusarium mycotoxin, inhibits acyl-CoA:cholesterol acyltransferase (ACAT) in rat liver microsomal enzyme assays with an IC50 value of 3 μM. |
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T25651 |
Lecimibide
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DuP128,DuP-128,DuP 128 |
Acyltransferase
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Lecimibide (DuP 128) is a potent and selective inhibitor of acyl coenzyme A: cholesterol acyltransferase (ACAT), which can be used to study diseases due to high lipids. |
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T25635 |
Lateritin
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Bassiatin |
Acyltransferase
|
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Lateritin (Bassiatin) is An Acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor and a platelet aggregation inhibitor from the mycelial cake of Gibberella lateritium. Bassiatin is the (3S,6R) isomer. |
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T27245L |
Eflucimibe
|
L0081,F-12511 |
Acyltransferase
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Eflucimibe (L0081) is an acyl coenzyme A: cholesterol acyltransferase inhibitor for the treatment of cardiovascular disease and endocrine and metabolic disorders, and can be used to study atherosclerosis and hyperlipidem... |
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T11016 |
DGAT-1 inhibitor 2
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|
Transferase
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DGAT-1 inhibitor 2 is an effective DGAT-1 inhibitor; anti-obesity drug. Objective: DGAT-1 acyl-CoA: diacylglycerol acyltransferase 1 (DGAT1) is one of two known DGAT enzymes that catalyze the final step of triglyceride s... |
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T9186 |
Ervogastat
|
PF-06865571 |
Transferase
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Ervogastat (PF-06865571) is a potent and well-tolerated diacylglycerol acyltransferase 2 inhibitor. Ervogastat reduces steatosis and hepatic triglyceride levels in non-alcoholic steatohepatitis (NASH). |
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T12797 |
RU-SKI 43
|
RUSKI 43 |
Hedgehog/Smoothened
,
Acyltransferase
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T77780 |
Zamaporvint
|
RXC004 |
Others
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Zamaporvint (RXC004) is a selective, orally active and potent inhibitor of the Wnt pathway that acts on the membrane-bound fatty acyltransferase porcupine to block Wnt ligand palmitoylation, secretion, and pathway activa... |
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T36126 |
TMP-153
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|
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Acyl-CoA:cholesterol acyltransferase (ACAT) catalyses the esterification of excess cellular cholesterol with fatty acids and is important for intestinal cholesterol absorption, hepatic lipoprotein secretion, and choleste... |
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T34451 |
RUSKI-201
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RU-SKI-201 |
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RUSKI-201 is the first selective Hedgehog acyltransferase (Hhat) chemical probe in cells. |
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T70575 |
AS 183
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AS 183 is an inhibitor of cholesterol acyltransferase (ACAT). |
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T16494 |
PF-06471553
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Others
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PF-06471553 is an effective and selective inhibitor of monoacylglycerol acyltransferase 3 (IC50: 92 nM). |
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T15187 |
E-5324
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Others
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T28820 |
SMP-797 HCl
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SMP-797,SMP 797,SMP797 |
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SMP-797 HCl, an ACAT (acyl-CoA-cholesterol acyltransferase) inhibitor, is used potentially for the treatment of Hyperlipidemia. |
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T24128 |
H2-005
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H2 005 |
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H2-005 is a selective inhibitor of diacylglycerol acyltransferase 2 (DGAT2). |
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T24904 |
TSI-01
|
TSI 01 |
|
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TSI-01 is a selective PAF biosynthetic enzyme lysophosphatidylcholine acyltransferase 2 inhibitor. |
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T11491 |
GSK2973980A
|
|
Transferase
|
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GSK2973980A is a selective Acyl-CoA:diacylglycerol acyltransferase 1 (DGAT1) inhibitor (IC50: 3 nM). |
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T40553 |
ACAT-IN-6
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|
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ACAT-IN-6, an acyl-Coenzyme A: cholesterol acyltransferase (ACAT) inhibitor, displays potent inhibition of NF-κB mediated transcription. |
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T70093 |
JTP 103237
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|
|
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JTP 103237 is a potent and selective monoacyglycerol acyltransferase 2 (MOGAT2) inhibitor. |
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T70160 |
PF-06427878
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|
|
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PF-06427878 is an orally active, potent and selective diacylglycerol acyltransferase 2 inhibitor. |
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T15346 |
FR-190809
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Others
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FR-190809 is a nonadrenotoxic and orally efficacious inhibitor of acyl-CoA:cholesterol O-acyltransferase (ACAT) (IC50: 45 nM). |
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T26548 |
Acaterin
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|
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Acaterin, an inhibitor of acyl-CoA: cholesterol acyltransferase (ACAT), inhibits synthesis of cholesteryl ester in macrophage J774. |
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T39415 |
ACAT-IN-9
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ACAT-IN-9, acts as an inhibitor of acyl-Coenzyme A: cholesterol acyltransferase (ACAT). By doing so, it effectively suppresses NF-κB mediated transcription. |
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T25891 |
NTE-122
|
NTE 122 |
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NTE-122 is a competitive Acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor. |
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T39414 |
ACAT-IN-7
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ACAT-IN-7 is a compound that acts as an inhibitor of acyl-Coenzyme A: cholesterol acyltransferase (ACAT) enzyme. It effectively suppresses the transcription process mediated by NF-κB. |
