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T9466 |
RTICBM-189
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|
Others
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RTICBM-189 is a potent, brain-penetrant allosteric modulator of the cannabinoid type-1 (CB1) receptor with a pIC50 of 7.54 in Ca2+ mobilization assay. RTICBM-189 has pIC50s of 5.29 and 6.25 for hCB1 and mCB1, respectivel... |
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T9452 |
PW0787
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GPR
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PW0787 is a potent, selective, orally active, and brain-penetrant GPR52 agonist (EC50=135 nM). |
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T4385 |
PF-4840154
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TRP/TRPV Channel
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PF-4840154 is a potent, selective agonist of the rat and human TrpA1 channel and elicited TrpA1-mediated nocifensive behaviour in mouse, with EC50 of 97 nM and 23 nM for rTrpA1 and hTrpA1, respectively. |
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T22976 |
MFZ 10-7
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Others
,
GluR
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MFZ 10-7 is anegative allosteric modulator of the mGluR5. |
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T16481 |
PF-04995274
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|
5-HT Receptor
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PF-04995274 is an effective, high-affinity, and partial serotonin 4 receptor (5-HT4R) agonist. PF-04995274 is brain penetrant and can be used for cognitive disorders associated with Alzheimer's disease. PF-04995274 has a... |
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T2556 |
Nandrolone decanoate
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19-Nortestosterone decanoate |
Others
,
HIV Protease
|
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Nandrolone decanoate (19-Nortestosterone decanoate) is the decanoate salt form of nandrolone, an anabolic steroid analog of testosterone with androgenic, anabolic, and erythropoietin stimulating effects. Nandrolone enter... |
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T0293 |
Metyrapone
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NSC-25265,Su-4885 |
Others
,
P450
,
Dehydrogenase
,
Autophagy
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Metyrapone (NSC-25265) is an inhibitor of the enzyme STEROID 11-BETA-MONOOXYGENASE. It is used as a test of the feedback hypothalamic-pituitary mechanism in the diagnosis of CUSHING SYNDROME. |
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T23008L |
MMPIP hydrochloride
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MMPIP hydrochloride (479077-02-6 Free base) |
GluR
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MMPIP hydrochloride is a selective antagonist of allosteric mGluR7. MMPIP hydrochloride can be used in research on the roles of mGluR7 on central nervous system functions. |
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T23444 |
TCS 1105
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N-(4-fluorobenzyl)-2-(1H-indol-3-yl)-2-oxoacetamide |
Others
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TCS 1105 is a GABAA benzodiazepine receptor (BZR) ligand. TCS 1105 blocks Sema3A induced axonal growth cones collapse. TCS 1105 reduces anxiety-like behavior and enhances offensive behavior and social dominance in mice. |
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T10038 |
11-cis-Vaccenyl acetate
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(Z)-Octadec-11-enyl acetate |
Endogenous Metabolite
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|
11-cis-Vaccenyl acetate ((Z)-Octadec-11-enyl acetate) activates olfactory neurons located in the T1 sensilla on the antenna and mediates aggregation behavior in both male and female flies. |
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T20177 |
C.I. Vat Yellow 2
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Caledon Printing Yellow 5G,Vat Yellow 2,Calcoloid Yellow GCD |
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C.I. Vat Yellow 2 (Calcoloid Yellow GCD) is a yellow dye agent that can also be used to detect adsorption behavior on natural sediments. |
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T5828 |
MS21570
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GPR
|
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MS21570 as a GPR171 antagonist based on its ability to block,with an IC50 of 220 Nm,that reduces anxiety-like behavior and fear conditioning in mice. |
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T11839L |
Lesopitron HCl
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Lesopitron HCl(132449-89-9 Free base) |
5-HT Receptor
|
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Lesopitron HCl is a 5-HT1A receptor agonist with anxiolytic effects that reverses dark avoidance behavior associated with cocaine withdrawal in mice. |
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T2571 |
Benactyzine hydrochloride
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Neuroleptone,Tranquilline,Amitakon |
AChR
,
AChE
|
|
Benactyzine hydrochloride (Neuroleptone) is a centrally acting muscarinic antagonist. Benactyzine has been used in the treatment of depression and is used in research to investigate the role of cholinergic systems on beh... |
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T60221 |
Tabernanthalog
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TBG |
5-HT Receptor
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Tabernanthalog (TBG) is a 5-HT2A agonist. In rodents,Tabernanthalog has been found to promote structural neuroplasticity, reduce alcohol-seeking and heroin-seeking behavior, and produce antidepressant effects. |
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T9325 |
2-(2-Aminothiazole-4-yl)-2-methoxyiminoa
|
|
Others
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|
2-(2-Aminothiazole-4-yl)-2-methoxyiminoa is an inhibitor of protein tyrosine phosphatases, which can lead to changes in cellular signaling pathways that affect cell behavior. |
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T0766 |
Promazine hydrochloride
|
Romtiazin hydrochloride,Sinophenin hydrochloride |
Dopamine Receptor
,
5-HT Receptor
,
Adrenergic Receptor
,
AChR
|
|
Promazine hydrochloride (Romtiazin hydrochloride) is a phenothiazine with actions similar to CHLORPROMAZINE but with less antipsychotic activity. It is primarily used in short-term treatment of disturbed behavior and as ... |
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T3275 |
Nefazodone hydrochloride
|
Dutonin,MJ-13754-1,Serzone,BMY-13754-1,BMY-13754 |
5-HT Receptor
,
Adrenergic Receptor
|
|
Nefazodone hydrochloride (Serzone) is a serotoninergic modulating antidepressant that is used in therapy of depression, aggressive behavior and panic disorder. |
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T33816 |
Ordopidine
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ACR-325,ACR 325,ACR325 |
Dopamine Receptor
|
|
Ordopidine (ACR325) is a dopaminergic stabilizer that suppresses psychostimulant-induced hyperactivity disorder and stimulates behavior during inactivity. Ordopidine acts as a dopamine D2 receptor antagonist in vitro and... |
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T40548 |
NH-3
|
|
Thyroid hormone receptor(THR)
|
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NH-3 is a potent orally active thyroid hormone receptor (THR) antagonist which exhibits reversible behavior, demonstrated by an IC 50 of 55 nM. Derived from the selective thyromi-metic GC-1, NH-3 effectively inhibits the... |
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T15781 |
LP-935509
|
|
Serine/threonin kinase
,
AAK1 (AP2 associated kinase 1)
|
|
LP-935509 is highly brain-penetrant and reverses fully established pain behavior following the SNL procedure. LP-935509 is also an effective inhibitor of BIKE (IC50=14 nM) and a modest inhibitor of GAK (IC50=320 nM). LP-... |
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T31886 |
Fulicin
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Phe-asn-glu-phe-val-NH2 |
|
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Fulicin is a D-amino acid-containing neuropeptide and can control male copulatory behavior in the land snail, Achatina fulica. |
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T33090 |
Lysyl-histidyl-phenylalanyl-arginyl-tryptophyl-glycinamide
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|
|
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Lysyl-histidyl-phenylalanyl-arginyl-tryptophyl-glycinamide is an ACTH fragment; cyclic analog evoked excessive grooming behavior in rabbits when administered intracerebroventricularly. |
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T34418 |
RS-0406
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RS0406,Phenol |
|
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RS-0406 is a new type of β-flakes blocker, which can reverse amyloid β-induced cytotoxicity and long-term enhanced damage in vitro, and inhibit amyloid-oligomer-induced behavior deterioration in vivo. |
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T81087 |
Stick Insect Hypertrehalosaemic Factor II
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|
|
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Stick Insect Hypertrehalosaemic Factor II, a synthetic peptide, exhibits identical FAB spectra, reversed-phase high-performance liquid chromatographic profiles (behavior), and biological activity (behavior) as its natura... |
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TP1982 |
Neuropeptide S(Rat)
|
Neuropeptide S (Rat) |
|
|
Potent endogenous neuropeptide S receptor (NSPR) agonist (EC50 = 3.2 nM). Increases locomotor activity and wakefulness in mice. Also reduces anxiety-like behavior in mice. |
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T38947 |
Udonitrectag
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REC 0559 |
|
|
Udonitrectag (REC 0559) is a low molecular weight compound developed to emulate the behavior of NGF, with the objective of tackling the challenge of maintaining NGF stability. |
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T10848 |
CMLD012073
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|
Others
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|
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T27550 |
HMR-1426
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HMR 1426,HMR1426 |
|
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HMR-1426 is gastric emptying inhibitor. HMR1426 shows an anorectic potential in rats and decreased body weight and fat mass. This was achieved solely by reducing food intake without influencing overall energy expenditure... |
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TP1983 |
Neuropeptide S (human)
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|
|
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Potent endogenous neuropeptide S receptor agonist (EC50 = 9.4 nM). Increases locomotor activity and wakefulness in mice. Also reduces anxiety-like behavior in mice. |
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TP1720 |
Pressinoic Acid
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|
|
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Pressinoic Acid is a peptide with potent corticotrophin-releasing activity. It is also an oxytocin inhibitor; it induces maternal behavior. |
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T75951 |
Neuropeptide S(Rat) TFA
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|
|
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Neuropeptide S(Rat) TFA, a robust endogenous agonist for the neuropeptide S receptor (NSPR) with an EC50 of 3.2 nM, enhances locomotor activity and promotes wakefulness while concurrently diminishing anxiety-like behavio... |
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T61820 |
Ar-V7-IN-1
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|
|
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Ar-V7-IN-1 is a highly potent inhibitor specifically targeting Ar-V7, a splice variant of the androgen receptor that exhibits hormone-independent behavior. Its development shows promise for researching various indication... |
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TP2407 |
Small cardioactive peptide A
|
SCPA |
|
|
Small cardioactive peptide A, as a neuropeptide that modulates neuromuscular synapsis in Aplysia, can also function as a neural cotransmitter in molluscs and exert a role in both the central and peripheral modulation of ... |
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TP1981 |
Neuropeptide S(Mouse)
|
Neuropeptide S (Mouse) |
|
|
Potent endogenous neuropeptide S receptor (NPSR) agonist (EC50 = 3 nM). Induces mobilization of intracellular Ca2+. Increases locomotor activity and wakefulness in mice. Also reduces anxiety-like behavior in mice. |
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T80913 |
Tyr-ACTH (4-9)
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|
|
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Tyr-ACTH(4-9) is a behaviorally active peptide utilized in research on learned behavior extinction in rats [1]. |
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T68189 |
Anpirtoline free base
|
|
|
|
Anpirtoline free base is a highly potent 5-HT1B receptor agonist. Anpirtoline has been shown to decreases central serotonin synthesis and attenuate aggressive behavior in vivo. Anpirtoline also acts as an antagonist at 5... |
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T37647 |
5α-dihydro Levonorgestrel
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|
|
|
5α-dihydro Levonorgestrel is a metabolite of the synthetic progestin levonorgestrel . It lacks in vitro and in vivo estrogenic activity, but induces copulatory behavior in male rats when administered at a dose of 1 mg pe... |
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TP2067 |
Cortagine
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|
|
|
Potent and selective corticotrophin releasing factor receptor 1 (CRF1) agonist (EC50 = 0.18 nM for rat CRF1). Displays anxiolytic and antidepressant activity in vivo. Microinfusion into mouse prefrontal cortex reduces de... |
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T71262 |
AZD-8418
|
|
|
|
AZD-8418 is an mGlu2 receptor positive allosteric modulators that attenuates nicotine-taking and nicotine-seeking behavior. Acute treatment with AZD8418 (0.37, 1.12, 3.73, 7.46, and 14.92 mg/kg) and AZD8529 (1.75, 5.83, ... |
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T82425 |
Excitin 1
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|
|
|
Excitin 1, an orally active, CNS-penetrating peptide, modifies rat behavior and alters brain monoamine and amino acid levels [1]. |
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T19386 |
ITIC
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CXCR
|
|
ITIC, a non-fullerene acceptor, demonstrates exceptional thermal stability and exhibits a glass-crystal transition at a significantly lower temperature than its high glass transition temperature (Tg) of 180 °C. Furthermo... |
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TP1529 |
Galanin (1-19), human
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|
|
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Galanin (1-19), human, represents the fragment encompassing amino acids 1 to 19 of the human galanin neuropeptide. Galanin (GAL) is known for its extensive distribution and multifaceted biological roles, such as regulati... |
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TP1131 |
β-CGRP, human TFA (101462-82-2 free base)
|
CGRP-II (Human) (TFA),Human β-CGRP (TFA),β-CGRP, human TFA |
|
|
β-CGRP,human tissue is one of the calcitonin peptide, through complex behavior of calcitonin receptor like receptor (CRLR) - and receptor activity - modifying proteins (increased), and 1 and 300 - nM CRLR IC50s/RAMP1 and... |
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T75950 |
Neuropeptide S(Mouse) TFA
|
|
|
|
Neuropeptide S(Mouse) TFA, an endogenous agonist for the neuropeptide S receptor (NPSR) with an EC50 value of 3 nM, plays a significant role in physiological processes by inducing the mobilization of intracellular Ca2+. ... |
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T39936 |
HM Janelia Fluor® 526, SE
|
HM-JF526 NHS |
|
|
HM Janelia Fluor 526, SE (HM-JF526 NHS) is a derivative of hydroxymethyl JF526 (HM-JF526). SMLM (single-molecule localization microscopy) imaging in standard phosphate-buffered saline (pH 7.4) revealed that the HM-JF526 ... |
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T40528 |
Oxytocin free acid
|
9-Deamidooxytocin |
|
|
Oxytocin free acid, also known as 9-Deamidooxytocin, is an analog of oxytocin where the glycinamide residue at position 9 has been substituted with a glycine residue. Oxytocin, a pleiotropic peptide hormone, has wide-ran... |
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T69546 |
MP-135
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|
|
|
MP135 is a Novel μ−δ Opioid Receptor Heteromer-Selective Agonist. MP135 maintains untoward side effects such as respiratory depression and reward behavior; together, these results suggest that optimization of MP135 is ne... |
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T38813 |
6-Azathymine acid
|
|
|
|
6-Azathymine acid is a metabolite derived from Pymetrozine, a potent insecticide known for its effectiveness against plant-sucking insects, specifically aphids and whiteflies. Pymetrozine's neuroactivity disrupts the fee... |
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T37783 |
2,5-Anhydro-D-mannitol
|
|
|
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2,5-Anhydro-D-mannitol is an antimetabolic fructose analogue that increases food intake in rats at doses of 50-800 mg/kg by inhibiting gluconeogenesis and glycogenolysis in the liver.. It is phosphorylated in the liver, ... |
