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T79791 |
Immunosuppressant-1
|
|
Apoptosis
|
|
Immunosuppressant-1 (Compound 31) suppresses T-cell proliferation triggered by anti-CD3/anti-CD28 co-stimulation and demonstrates immunosuppressive effects, including the induction of apoptosis in activated lymph node ce... |
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T8527 |
CPYPP
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Others
|
|
CPYPP is an inhibitor of DOCK2-Rac1 interaction. CPYPP binds to DOCK2 DHR-2 domain and inhibits the guanine nucleotide exchange factor (GEF) activity of DOCK2DHR-2 for Rac1 in a dose-dependent manner(IC50 : 22.8 µM). CPY... |
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T8546 |
BD750
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JAK
,
STAT
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BD750 is an effective immunosuppressant and a JAK3/STAT5 inhibitor, inhibits IL-2-induced JAK3/STAT5-dependent T cell proliferation(IC50 of 1.5 μM and 1.1 μM in mouse and human T cells, respectively) |
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T7527 |
Frentizole
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Beta Amyloid
|
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Frentizole, an immunosuppressive agent, is an inhibitor of the Aβ-ABAD interaction |
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T4507 |
Chlorphenesin
|
Adermykon,Chlorophenesin,Gecophen |
Antibacterial
,
Antifungal
,
Histamine Receptor
|
|
Chlorphenesin (Chlorophenesin) is an antigen-associated immunosuppressant that inhibits IgE-mediated histamine release. It is also used as an antimycotic agent. |
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T8003 |
Methotrexate disodium
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Apoptosis
,
Dehydrogenase
,
DNA/RNA Synthesis
,
Antifolate
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Methotrexate disodium is an tetrahydrofolate dehydrogenase inhibitor |
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T6033 |
Zotarolimus
|
ABT-578,A 179578 |
mTOR
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|
Zotarolimus (ABT-578), an analogue of rapamycin, inhibits FKBP-12 (IC50= 2.8 nM). |
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T1485 |
Methotrexate
|
NCI-C04671,WR19039,Amethopterin,CL14377 |
Apoptosis
,
Dehydrogenase
,
DNA/RNA Synthesis
,
Antifolate
|
|
Methotrexate (WR19039) is a folate analog, an inhibitor of the dihydrofolate reductase DHFR. Methotrexate has antimetabolic, antitumor, and immunosuppressive activities, and is commonly used in rheumatoid arthritis and v... |
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T16045 |
Methotrexate metabolite
|
DAMPA |
Antifolate
,
Drug Metabolite
|
|
Methotrexate metabolite (DAMPA) (DAMPA) is the active metabolite of Methotrexate. Methotrexate is a folic acid antagonist. Methotrexate is used as a chemotherapeutic agent and immunosuppressant. |
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T17235 |
Voclosporin
|
ISAtx-247 |
Phosphatase
|
|
Voclosporin (ISAtx-247) is a novel and orally available calcium-modulated phosphatase (CN; PP2B) inhibitor and immunosuppressant for the treatment of lupus nephritis. |
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T2648 |
Pimecrolimus
|
SDZ-ASM 981,ASM 981 |
Others
|
|
Pimecrolimus (SDZ-ASM 981), a calcineurin inhibitor immunosuppressant, binds to the receptor macrophilin-12 (FKBP-12) forming a complex that blocks the calcium-dependent signal transduction cascade mediated by calcineuri... |
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T0245 |
RS 61443
|
RS61443,Mycophenolate mofetil,TM-MMF |
Dehydrogenase
|
|
RS 61443 (Mycophenolate mofetil) is an immunosuppressant, a non-competitive, selective and reversible inhibitor of inosine monophosphate dehydrogenase (IMPDH) |
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T6459 |
Cyclosporine
|
|
Phosphatase
|
|
Cyclosporine is a calcineurin phosphatase pathway inhibitor, used as an immunosuppressant drug to prevent rejection in organ transplantation. |
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T30077 |
Anisperimus
|
LF 150195,LF-150195,LF 15-0195,LF-15-0195,LF15-0195 |
Caspase
|
|
Anisperimus (LF 15-0195) is an immunosuppressant that enhances activation-induced T-cell death by promoting caspase-8 and caspase-10 activation at the DISC level, and prevents CNS autoimmunity by promoting the developmen... |
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T6465 |
Dexamethasone Sodium Phosphate
|
Dexadreson,Dexagro,Dalalone |
IL Receptor
,
COX
|
|
Dexamethasone Sodium Phosphate (Dexadreson) , an interleukin receptor modulator, has anti-inflammatory and immunosuppressant effects. It belongs to a potent glucocorticoid class of steroid synthetic drugs. |
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T76779 |
Brodalumab
|
LP 0160,KHK-4827,AMG-827 |
IL Receptor
|
|
Brodalumab (AMG 827) is a human monoclonal antibody targeting interleukin 17 receptor (IL-17R) IgG2, often used as an immunosuppressant in the treatment of psoriasis and psoriasis. |
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T0010 |
6-Mercaptopurine
|
6-MP,Mercaptopurine |
Nucleoside Antimetabolite/Analog
,
Others
,
Dehydrogenase
,
Endogenous Metabolite
,
Autophagy
|
|
6-Mercaptopurine (6-MP) is an antimetabolite antineoplastic agent with immunosuppressant properties. It interferes with nucleic acid synthesis by inhibiting purine metabolism and is used, usually in combination with othe... |
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T36696 |
DMBA
|
|
|
|
7,12-Dimethylbenz[a]anthracene (DMBA) is a polycyclic aromatic hydrocarbon (PAH) that has been found in tobacco smoke and diesel exhaust and has carcinogenic activity.1,2It undergoes metabolic activation by numerous enzy... |
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T21493 |
Cyclosporin H
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Others
|
|
Cyclosporin H (CsH), a specific inhibitor of FPR1, inhibited lung inflammation in the ALI models. CsH significantly attenuated MTDs or NFP-induced inflammatory lung injury and activation of MAPK and AKT pathways. Cyclosp... |
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T32504 |
L-732531
|
L732531,L 732531 |
|
|
L-732531 is a tacrolimus-related immunosuppressant with lower toxicity. |
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T32462 |
L 683519
|
L683519,13-Desmethyl FK 506,L-683519 |
|
|
L 683519 is one of the Tacrolimus impurities with immunosuppressant and could restrain the activity of FK-506 binding protein. |
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T28708 |
Sch 24937
|
|
|
|
Sch 24937 is a potent immunosuppressant on B lymphocyte mediated immune responses. |
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T12535 |
Prednisolone Tebutate
|
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Others
|
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Prednisolone Tebutate is a synthetic glucocorticoid, and is an antiinflammatory and immunosuppressant. |
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T11514 |
Gusperimus trihydrochloride
|
NKT-01,BMS181173,Spanidin |
Others
|
|
Gusperimus trihydrochloride is a derivative of the antitumor antibiotic spergualin with immunosuppressant activity. |
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T24927 |
Undecylprodigiosin
|
|
|
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Undecylprodigiosin is a classical cytotoxic immunosuppressant, suppressing immune functions. It also inhibits DNA synthesis. |
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T26729 |
Azotomycin
|
Antibiotic 1719,NSC 56654,Duazomycin B |
|
|
Azotomycin is an antagonist of L-glutamine and may be used as an immunosuppressant. |
|
TP1665 |
Cyclosporin D
|
|
|
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Cyclosporin D is a metabolite of cyclosporin A, an immunosuppressant drug that binds cyclophilin D, inhibiting the phosphatase activity of calcineurin in T cells. |
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T24985 |
5-Monobutyl methotrexate
|
NSC-305986,gamma-Mbmtx,NSC 305986,NSC305986 |
|
|
5-Monobutyl methotrexate is an antineoplastic antimetabolite with immunosuppressant properties. It is a TETRAHYDROFOLATE DEHYDROGENASE inhibitor and prevents the formation of tetrahydrofolate, necessary for synthesis of ... |
|
TP1387 |
Cyclosporin A-Derivative 2
|
|
|
|
Derivative 2 is A novel Derivative of Cyclosporin A.Cyclosporin A is an immunosuppressant that binds to cyclophilin and inhibits calcineurin. |
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T69257 |
Methotrexate diethyl ester
|
|
|
|
Methotrexate diethyl ester is an antineoplastic antimetabolite with immunosuppressant properties. It is an inhibitor of tetrahydrofoltae dehydrogenase and prevents the formation of tetrahydrofolate, necessary for synthes... |
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T19848 |
Cyclosporin B
|
7-L-Alanine-cyclosporin A,Antibiotic S 7481F2 |
|
|
Cyclosporin B is an immunosuppressant that has revolutionized organ transplantation through its use in the prevention of graft rejection. Cyclosporin B displays antiviral properties, inhibiting the entry of hepatitis B i... |
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T82756 |
Cedelizumab
|
RWJ 49004 |
|
|
Cedelizumab (RWJ 49004), an IgG4 monoclonal antibody, selectively targets CD4 and exhibits immunosuppressant properties [1]. |
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T69177 |
Methotrexate di-n-butyl ester
|
|
|
|
Methotrexate di-n-butyl ester is an antineoplastic antimetabolite with immunosuppressant properties. It is an inhibitor of tetrahydrofoltae dehydrogenase and prevents the formation of tetrahydrofolate, necessary for synt... |
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T37822 |
AR-C 141990 hydrochloride
|
|
|
|
Monocarboxylate transporter (MCT1) inhibitor (pKi = 7.6. Exhibits approximately 10-fold selectivity for MCT1 over MCT2 and no significant activity against MCT3 or 4. Inhibits graft versus host response and prolongs card... |
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T37288 |
Remisporine B
|
|
|
|
Remisporine B is a polyketide and derivative of remisporine A that has been found inPenicilliumand has immunosuppressant activity.1,2It inhibits LPS- or concanavalin A-induced proliferation of isolated mouse splenic lymp... |
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T76836 |
Tucotuzumab
|
|
|
|
Tucotuzumab (Anti-EPCAM Recombinant Antibody) is a protein composed of an IgG1 monoclonal antibody specific for the human Epithelial Cell Adhesion Molecule (EpCAM) antigen, linked to two molecules of IL-2 . Tucotuzumab i... |
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T83217 |
Abetimus
|
LJP 394 free base |
|
|
Abetimus (LJP 394 free base), an immunosuppressant composed of four double-stranded DNA (dsDNA) oligonucleotides, can crosslink anti-dsDNA antibodies on B cell surfaces and reduce anti-dsDNA antibody levels, offering res... |
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T36986 |
Colletodiol
|
|
|
|
Colletodiol is a fungal metabolite that has been found inD. grovesiiand has immunosuppressant and antiviral activities.1,2It inhibits concanavalin A- or LPS-induced proliferation of isolated mouse splenocytes (IC50s = 12... |
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T36355 |
Sydowinin B
|
|
|
|
Sydowinin B is a xanthone polyketide that has been found inA. sydowiiand has immunosuppressant activity.1It inhibits LPS- or concanavalin A-induced proliferation of isolated mouse splenic lymphocytes (IC50s = 19.2 and 20... |
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T76719 |
Muromonab
|
|
|
|
Muromonab, a monoclonal antibody that targets the CD3 receptor, blocks cytotoxic T cell function and serves as an immunosuppressant agent. It is administered to mitigate acute rejection of solid organ transplants [1]. |
|
T83861 |
Bactobolamine
|
|
|
|
Bactobolamine, an immunosuppressant, suppresses IL-2 production in CTLL cells at a concentration of 200 µg/ml and extends heart allograft survival in both MHC-compatible and MHC-incompatible rat pairings at a dosage of 2... |
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T64032 |
CYP3A4-IN-3
|
|
|
|
CYP3A4-IN-3 is a specific, highly affinity cytochrome P450 3A4 (CYP3A4) (cytochrome P450 3A4 (CYP3A4)) inhibitor (IC50: 0.075 μM). CYP3A4-IN-3 is an analogue of ritonavir with a simpler structure and twice as much inhibi... |
