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Search Results for " motility "

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阻害剤

天然化合物

リコンビナントタンパク質

ライブラリー

カタログ番号	製品名	別名	ターゲット
TP1264	Prolylleucine	((Benzyloxy)carbonyl)-L-prolyl-D-leucine	Others
	Prolylleucine (((Benzyloxy)carbonyl)-L-prolyl-D-leucine) is a dipeptide containing branched-chain amino acids.		Others
T1855	ZCL278	ZCL 278	CDK , Ras
	ZCL278 is a selective Cdc42 GTPase inhibitor.		CDK , Ras
T13385	Zamifenacin fumarate	UK-76654 fumarate	AChR
	Zamifenacin fumarate (UK-76654 fumarate) is a potent and gut-selective antagonist of muscarinic M3 receptor.		AChR
T2319	Acotiamide monohydrochloride trihydrate	Acotiamide hydrochloride,YM-443 HCl,Z-338 HCl	AChE
	Acotiamide monohydrochloride trihydrate (Z-338 HCl) is the hydrochloride salt form of acotiamide, a prokinetic agent with gastrointestinal (GI) motility-enhancing activity. Although the exact mechanism by which acotiamid...		AChE
TP1793	Nociceptin (1-13), amide		Opioid Receptor
	Nociceptin (1-13), amide is a potent ORL1 (OP4) receptor agonist with a pEC50 of 7.9 for mouse vas deferens and a Ki of 0.75 nM for binding to rat forebrain membranes.		Opioid Receptor
T7487L	Speract TFA(76901-59-2(free base))		Others
	Speract TFA is a sea urchin egg peptide that regulates sperm motility, also stimulates sperm mitochondrial metabolism.		Others
T31597	Ecabapide	DQ2511,DQ 2511,DQ-2511	Others
	Ecabapide (DQ-2511) is a novel gastrointestinal motility promoter that significantly enhances gastric emptying in SHRSP.Ecabapide activates cyclic GMP-dependent housekeeping Cl- channels in rabbit gastric wall cells.		Others
T15646	KBU2046		Others
	KBU2046 is an orally administered compound that inhibits cell motility and invasion, effectively suppressing cancer metastasis and extending lifespan. This compound uniquely targets and binds to chaperone heterocomplexes...		Others
T33868	Palmitoyl glutamic acid	N-Palmitoyl-L-glutamic acid,Palmitoylglutaminic acid
	Palmitoyl glutamic acid (N-Palmitoyl-L-glutamic acid) is an acyl amino acid that blocks aortic constriction and antagonizes haloperidol-induced oral motility disorders.
T16518	PH-002		Others
	PH-002, an inhibitor targeting the intramolecular domain interaction of apolipoprotein (apo) E4 in neuronal cells, additionally enhances mitochondrial motility and promotes neurite outgrowth, thereby countering related i...		Others
T3638	Leukadherin-1		Integrin , Complement System
	Leukadherin-1 is an allosteric activator of CD11b/CD18. Increasing CD11b/CD18-dependent cell adhesion to fibrinogen, Decreasing leukocyte motility and transendothelial migration; reduces inflammation.		Integrin , Complement System
T9239	RS-25344		PDE
	RS-25344 is a potent and selective phosphodiesterase (PDE) 4 inhibitor. It inhibits eosinophil chemotaxis and increases progressive motility of spermatozoa in vitro.		PDE
T0918	Trimebutine	Mebutin	Opioid Receptor
	Trimebutine (Mebutin) is a spasmolytic agent that regulates intestinal and colonic motility and relieves abdominal pain with antimuscarinic and weak mu-opioid agonist effects. It is marketed for the treatment of irritabl...		Opioid Receptor
T17030	Tegoprazan		ATPase , Proton pump
	Tegoprazan is a potassium-competitive acid blocker and is a potent, oral active, and highly selective inhibitor of gastric H+/K+-ATPase. That could control gastric acid secretion and motility (IC50: ranging from 0.29-0.5...		ATPase , Proton pump
T1052	Proglumide		cholecystokinin
	Proglumide (Binoside) is a cholecystokinin antagonist, which blocks both the CCKA and CCKB subtypes. Proglumide is a drug that exerts an inhibitory effect on gastric secretion and reduces gastrointestinal motility. It is...		cholecystokinin
TP2137L	Pp60 c-src (521-533) (phosphorylated) acetate		Others
	pp60 c-src (521-533) (phosphorylated) acetate is a regulator of focal adhesion formation and cell spreading. pp60 c-src (521-533) (phosphorylated) acetate also regulates cell motility and is a key component in the signal...		Others
T14091	AC-73		Autophagy
	AC-73 is an orally available Cluster of Differentiation 147 (CD147) inhibitor with high bioavailability that selectively disrupts the dimerization of CD147 (the binding site is in the N-terminal IgC2 domain of CD147 incl...		Autophagy
T4341	Betrixaban	PRT054021	Factor Xa
	Betrixaban (PRT054021) is a non-vitamin K oral anticoagulant whose action is driven by the competitive and reversible inhibition of the factor Xa [1]. It was selected among all lead compounds due to its low hERG channel ...		Factor Xa
T36983	Cyclic-di-GMP disodium	Cyclic diguanylate,5GP-5GP disodium,3',5'-Cyclic diguanylic acid,Cyclic di-GMP (sodium salt),cyclic diguanylate disodium,c-di-GMP,c-di-GMP disodium	STING , Endogenous Metabolite
	Cyclic-di-GMP disodium (5GP-5GP disodium) is a bacterial second messenger and a STING agonist involved in a variety of prokaryotic processes including biofilm formation, motility, and cell cycle progression.Cyclic-di-GMP...		STING , Endogenous Metabolite
T2525	Alosetron hydrochloride	Lotronex,GR 68755C,GR 68755,GR 68755X	5-HT Receptor
	Alosetron hydrochloride (GR 68755) is the hydrochloride salt form of alosetron, a potent and selective 5-HT3 receptor antagonist. Alosetron blocks the actions of serotonin at 5-HT3 sites in the peripheral nervous system,...		5-HT Receptor
T6334	Ridaforolimus	AP23573,Deforolimus,MK-8669	mTOR , Autophagy
	Ridaforolimus (AP23573) is a small molecule and non-prodrug analogue of the lipophilic macrolide antibiotic rapamycin with potential antitumor activity. Ridaforolimus binds to and inhibits the mammalian target of rapamyc...		mTOR , Autophagy
T4230	PF-3758309 hydrochloride	PF-03758309 hydrochloride	Apoptosis , PAK
	PF-3758309 hydrochloride (PF-03758309 hydrochloride) , is a PAK4 inhibitor, is also a n orally bioavailable small-molecule inhibitor of p21-activated kinase 4 (PAK4) with potential antineoplastic activity. PF-3758309 hyd...		Apoptosis , PAK
T1242	Alvimopan		Opioid Receptor
	Alvimopan (LY 246736) is a synthetic trans-3, 4-dimethyl-4-(3-hydroxyphenyl) piperidine with peripherally selective opioid mu receptor antagonist activity. Alvimopan is a selective and competitive antagonist at mu-opioid...		Opioid Receptor
T1006	Propantheline bromide	Neopepulsan,Pro-Banthine,Neometantyl	AChR
	Propantheline bromide (Pro-Banthine) competitively antagonizes acetylcholine activity mediated by muscarinic receptors at neuroeffector sites on smooth muscle and exocrine gland cells. Propantheline Bromide is the bromid...		AChR
T4980	Betrixaban maleate		Factor Xa
	Betrixaban maleate is a non-vitamin K oral anticoagulant whose action is driven by the competitive and reversible inhibition of the factor Xa.		Factor Xa
T24848	TachypleginA	Tachyplegin A,Tachyplegin-A
	TachypleginA is a parasite motility and invasion inhibitor.
T30199	Atilmotin
	Atilmotin is a gastrointestinal agent for treating motility disorders.
T24849	TachypleginA-2	tA 2,tA-2,tA2
	TachypleginA-2 is a parasite motility and invasion inhibitor.
T32379	Kentsin
	Kentsin, as a contraceptive polypeptide, has central opiate properties on gastrointestinal motility.
T70122	Acotiamide Methyl Ether
	Acotiamide Methyl Ether is a metabolite of Acotiamide -- an acetylcholinesterase inhibitor which has been shown to stimulate gastric motility and improve gastric motility dysfunction in rats. Acotiamide Hydrochloride has...
T17283	Zamifenacin	UK-76654	Others
	Zamifenacin obviously decreases colonic motility in irritable bowel syndrome. Zamifenacin is an effective gut-selective muscarinic M3 receptor antagonist.		Others
T27120	D-AP7
	D-AP7 is a specific NMDA antagonist. D-AP7 enhances motility, exhibits anxiogenic-like effect and impairs consolidation in passive avoidance.
T6597L	Mosapride citrate dihydrate	GR-107719-B,Mosapride Citrate,GR 107719 B,AS 4370,AS-4370,TAK-370
	Mosapride Citrate is a 5-HT4 receptor agonist used to stimulate gastrointestinal motility via acetylcholine. Mosapride Citrate facilitates acetylcholine release from the enteric cholinergic neurons.
T11846	LHVS		Cysteine Protease
	LHVS effectively blocks T. gondii microneme protein secretion (IC50=10 μM), gliding motility, and cell invasion. LHVS is a potent, non-selective cysteine protease inhibitor.		Cysteine Protease
T70938	SN00799639
	SN00799639, also known as SN639, is a potent inhibitor of the motility and development of parasitic larvae of Haemonchus contortus, a blood-feeding parasitic nematode of major economic importance in ruminants. SN639 dis...
T69769	BDP8900
	BDP8900 is a potent and selective MRCK inhibitor, reducing substrate phosphorylation. BDP8900 leads to morphological changes in cancer cells along with inhibition of their motility and invasive character.
T35374L	(Ala13)-Apelin-13 acetate		Apelin receptor
	(Ala13)-Apelin-13 acetate, an APJ antagonist, modulates CRF-induced enhanced colonic motility, visceral sensation, and gut barrier.		Apelin receptor
T7487	Speract		Others , Mitochondrial Metabolism
	Speract, a peptide from sea urchin eggs, regulates sperm motility and stimulates sperm mitochondrial metabolism.		Others , Mitochondrial Metabolism
T69126	Clofeverine (free base)
	Clofeverine (free base) is a highly selective relaxant for gastrointestinal smooth muscles with a beta-receptor stimulative nature. On isolated ileum, the inhibitory effect of clofeverine for spontaneous motility was com...
T68735	Ciclotropium (free base)
	Ciclotropium (free base) is quaternary ammonium compound with anticholinergic and parasympatholytic activity. Oral Cyclotropium bromide inhibited fasting and meal-stimulated colonic motility significantly without causing...
T78109	(Ala13)-Apelin-13 TFA
	'(Ala13)-Apelin-13 TFA acts as a potent antagonist of the apelin receptors (APJ) and impedes gastric motility via the vagal cholinergic pathway [1].'
T61366	F-17
	F-17 is a promising virulence factor inhibitor, displaying substantial inhibitory effects on biofilm formation, elastase activity, pyocyanin production, and swarming motility. Additionally, F-17 exhibits a strong binding...
T69324	Clofeverine hydrochloride
	Clofeverine hydrochloride is the salt form of Clofeverine (free base), a highly selective relaxant for gastrointestinal smooth muscles with a beta-receptor stimulative nature. On isolated ileum, the inhibitory effect of ...
T39167	GS-493
	GS-493, a highly specific protein tyrosine phosphatase SHP2 (PTPN11) inhibitor, exhibits remarkable potency with an IC50 of 71 nM. It displays 29- and 45-fold greater affinity towards SHP2 compared to its related counter...
T82778	Cardioexcitatory peptide 1
	Cardioexcitatory peptide 1, a potent neuropeptide derived from Achatina atria, exerts significant excitatory effects on cardiac function, additionally influencing the motility of muscular tissues and neural activities [1...
TP1948	PBP10	PBP 10
	Selective formyl peptide receptor 2 (FPR2) antagonist; cell permeable. Selectively inhibits FPR2-mediated NADPH oxidase activity but has no effect on FPR1 signaling in neutrophils. Displays PIP2 binding activity in vitro...
T25912	Oxypyrronium bromide	L.D. 3055,Immetropan,LD 3055,LD3055,LD-3055
	Oxypyrronium bromide is an anticholinergic and spasmolytic agent containing quaternary ammonium. In animal models it inhibited gastric motility, hypotension induced by vagus stimulation or intravenation of acetylcholine;...
T78949	AM841		Cannabinoid Receptor
	AM841, a high-affinity electrophilic ligand, covalently interacts with a cysteine residue in helix six, thus activating the CB1 cannabinoid receptor. It diminishes forskolin-stimulated cAMP accumulation and slows gastroi...		Cannabinoid Receptor
T15946	MA-2029		Others
			Others
T71828	Syntelin
	Syntelin is a selectively CENP-E inhibitor. Syntelin inhibited CENP-E motility in a dose-dependent manner with an IC50 value of 160 nM. Among an extensive list of mitotic kinesins examined, syntelin was found to be highl...

Compounds

Prolylleucine

TP1264

Synonym: ((Benzyloxy)carbonyl)-L-prolyl-D-leucine

Synonym: UK-76654 fumarate

Target: AChR

Acotiamide monohydrochloride trihydrate

T2319

Synonym: Acotiamide hydrochloride,YM-443 HCl,Z-338 HCl

Target: AChE

Nociceptin (1-13), amide

TP1793

Synonym:

Target: Opioid Receptor

Speract TFA(76901-59-2(free base))

Synonym: DQ2511,DQ 2511,DQ-2511

Palmitoyl glutamic acid

T33868

Synonym: N-Palmitoyl-L-glutamic acid,Palmitoylglutaminic acid

Target: Integrin, Complement System

Target: Opioid Receptor

Tegoprazan

T17030

Synonym:

Target: ATPase, Proton pump

Proglumide

T1052

Synonym:

Target: cholecystokinin

pp60 c-src (521-533) (phosphorylated) acetate

Cyclic-di-GMP disodium

T36983

Synonym: Cyclic diguanylate,5GP-5GP disodium,3',5'-Cyclic diguanylic acid,Cyclic di-GMP (sodium salt),cyclic diguanylate disodium,c-di-GMP,c-di-GMP disodium

Target: STING, Endogenous Metabolite

Alosetron hydrochloride

T2525

Synonym: Lotronex,GR 68755C,GR 68755,GR 68755X

Target: 5-HT Receptor

Ridaforolimus

T6334

Synonym: AP23573,Deforolimus,MK-8669

Target: mTOR, Autophagy

PF-3758309 hydrochloride

T4230

Synonym: PF-03758309 hydrochloride

Target: Apoptosis, PAK

Alvimopan

T1242

Synonym:

Target: Opioid Receptor

Propantheline bromide

T1006

Synonym: Neopepulsan,Pro-Banthine,Neometantyl

Synonym: Tachyplegin A,Tachyplegin-A

Synonym: tA 2,tA-2,tA2

Acotiamide Methyl Ether

Mosapride citrate dihydrate

T6597L

Synonym: GR-107719-B,Mosapride Citrate,GR 107719 B,AS 4370,AS-4370,TAK-370

Target: Cysteine Protease

(Ala13)-Apelin-13 acetate

T35374L

Synonym:

Target: Apelin receptor

Speract

T7487

Synonym:

Target: Others, Mitochondrial Metabolism

Clofeverine (free base)

T69126

Synonym:

Target:

Ciclotropium (free base)

T68735

Synonym:

Target:

(Ala13)-Apelin-13 TFA

Clofeverine hydrochloride

Cardioexcitatory peptide 1

Synonym: L.D. 3055,Immetropan,LD 3055,LD3055,LD-3055

Target: Cannabinoid Receptor

カタログ番号	製品名	別名	ターゲット
T7283	Sodium lauroyl-α-hydroxyethyl sulfonate		NF-κB , MAPK
	Sodium houttuyfonate is anti-pseudomonas agents, inhibits virulence-related motility of Pseudomonas.		NF-κB , MAPK
T3603	Sodium lauryl sulfoacetate	Sodium houttuyfonate	NF-κB , MAPK
	Sodium lauryl sulfoacetate (Sodium houttuyfonate) is anti-pseudomonas agents, inhibits virulence-related motility of Pseudomonas.		NF-κB , MAPK
TN6791	Palvanil	Hexadecanamide	TRP/TRPV Channel
	Palvanil (Hexadecanamide) is a fast desensitizing agonist of TRPV1. it may be promising agents in the therapy of IBS since it modulates intestinal motility and reduces visceral pain.		TRP/TRPV Channel
T5S1331	Herbacetin		c-Met/HGFR , Akt
	1. Herbacetin induces apoptosis in HepG2 cells, by ROS and PI3K/Akt pathway. 2. Herbacetin suppresses the HGF-induced motility of human breast cancer MDA-MB-231 cells by inhibiting c-Met and Akt phosphorylation.		c-Met/HGFR , Akt
T4S1619	L-Hyoscyamine sulfate	Hyoscyamine sulfate hydrate,Levsin Sulfate,Hyoscyamine Sulphate	AChR
	L-Hyoscyamine sulfate (Levsin Sulfate) is the sulfate salt of a belladonna alkaloid derivative and the levorotatory form of racemic atropine isolated from the plants Hyoscyamus niger or Atropa belladonna, which exhibits ...		AChR
T0962	L-Hyoscyamine	Daturine,Hyoscyamine	AChR
	L-Hyoscyamine (Daturine) functions as a non-selective, competitive antagonist of muscarinic receptors, thereby inhibiting the parasympathetic activities of acetylcholine on the salivary, bronchial, and sweat glands, as w...		AChR
T1437	D-Panthenol	D-Pantothenyl alcohol,Ilopan,Dexpanthenol,Pantothenol	Endogenous Metabolite
	D-Panthenol (D-Pantothenyl alcohol) is an alcoholic analogue of D-pantothenic acid and cholinergic agent. D-Panthenol acts as a precursor of coenzyme A necessary for acetylation reactions and is involved in the synthesis...		Endogenous Metabolite
T6S1684	8-Gingerol		Antioxidant , Antibacterial , TRP/TRPV Channel
	1. 8-Gingerol has antioxidant activity. 2. 8-Gingerol has antimycobacterial activity. 3. 8-Gingerol could be used as an effective skin-whitening agent. 4. 8-Gingerol shows antipyretic and anti-inflammation characteristic...		Antioxidant , Antibacterial , TRP/TRPV Channel
T10909	Cyclic-di-GMP	c-di-GMP,cyclic diguanylate,5GP-5GP	Others
	Cyclic-di-GMP is a STING agonist and ubiquitous second messenger, which regulates the formation, motility and virulence of biofilms in various bacterial species.		Others
TN4639	Neolitsine		Others
	Neolitsine has anthelmintic activity, it exhibits EC90 values (concentration at which 90% loss of larval motility is observed) of 6.4 microg/mL.Neolitsine and dicentrine have potent vasorelaxing effects on precontracted ...		Others
T40442	Propylparaben sodium	Propyl4-hydroxybenzoatesodium,Propylparahydroxybenzoatesodium
	Propylparaben sodium (propyl parahydroxybenzoate) is a naturally occurring antimicrobial preservative found in plants and bacteria. Widely utilized in cosmetics, pharmaceuticals, and foods, this compound impairs antral f...
T75556	8β,9α-Dihydroxylindan-4(5),7(11)-dien-8alpha,12-olide
	8β,9α-Dihydroxylindan-4(5),7(11)-dien-8alpha,12-olide (compound 3), a sesquiterpene, exhibits anti-LIMK1 activity and inhibits cell motility [1].
T72243	Cyclic-di-GMP diammonium	5GP-5GP diammonium,c-di-GMP diammonium ; cyclic diguanylate diammonium ; 5GP-5GP diammonium,c-di-GMP diammonium,cyclic diguanylate diammonium
	Cyclic di-GMP (c-di-GMP) diammonium is a STING activator and a global bacterial second messenger, which regulates biofilm formation, motility, and virulence in diverse bacterial species .
TN1550	Danshenxinkun A		Others
	Danshenxinkun A, Danshenxinkun B and Neocryptotanshinone may intervene thrombotic diseases by adjusting the targets mainly involved in pathways of endocrine system, signal transduction, signaling molecules and interactio...		Others
T64248	Cyclic-di-GMP sodium
	Cyclic di-GMP sodium (c-di-GMP sodium) is a STING activator and a ubiquitous second messenger that regulates biofilm formation, motility and virulence of various bacteria.
TN1834	Kobusin		Others , NOS , NF-κB
	Kobusin, a Calmodulin inhibitor, shows mild antiplasmodial,anti-inflammatory, and cytotoxic activities; it may be beneficial for the treatment of neuro-inflammatory diseases through the inhibition of iNOS expression and ...		Others , NOS , NF-κB
T75520	Aplyronine A
	Aplyronine A, an actin-depolymerizing agent, exhibits antitumor and apoptosis effects. It is valuable in cancer research and studies on muscle contraction, cell motility, and cell division [1].

天然物製品

sodium lauroyl-α-hydroxyethyl sulfonate

T7283

Synonym:

Target: NF-κB, MAPK

Sodium lauryl sulfoacetate

T3603

Synonym: Sodium houttuyfonate

Target: NF-κB, MAPK

Palvanil

TN6791

Synonym: Hexadecanamide

Target: TRP/TRPV Channel

Herbacetin

T5S1331

Synonym:

Target: c-Met/HGFR, Akt

L-Hyoscyamine sulfate

T4S1619

Synonym: Hyoscyamine sulfate hydrate,Levsin Sulfate,Hyoscyamine Sulphate

Target: AChR

L-Hyoscyamine

T0962

Synonym: Daturine,Hyoscyamine

Target: AChR

D-Panthenol

T1437

Synonym: D-Pantothenyl alcohol,Ilopan,Dexpanthenol,Pantothenol

Target: Endogenous Metabolite

8-Gingerol

T6S1684

Synonym:

Target: Antioxidant, Antibacterial, TRP/TRPV Channel

Cyclic-di-GMP

T10909

Synonym: c-di-GMP,cyclic diguanylate,5GP-5GP

Synonym: Propyl4-hydroxybenzoatesodium,Propylparahydroxybenzoatesodium

Target:

8β,9α-Dihydroxylindan-4(5),7(11)-dien-8alpha,12-olide

T75556

Synonym:

Target:

Cyclic-di-GMP diammonium

T72243

Synonym: 5GP-5GP diammonium,c-di-GMP diammonium ; cyclic diguanylate diammonium ; 5GP-5GP diammonium,c-di-GMP diammonium,cyclic diguanylate diammonium

Target: Others, NOS, NF-κB

Recombinant Proteins

Species：

Expression System：

Tag：

カタログ番号	製品名	Species	Expression System
TMPH-01259	AMFR Protein, Human, Recombinant (His)	Human	E. coli
	E3 ubiquitin-protein ligase that mediates the polyubiquitination of lysine and cysteine residues on target proteins, such as CD3D, CYP3A4, CFTR, INSIG1, SOAT2/ACAT2 and APOB for proteasomal degradation. Component of a VC...
TMPH-01260	AMFR Protein, Human, Recombinant (hFc)	Human	HEK293 Cells
	E3 ubiquitin-protein ligase that mediates the polyubiquitination of lysine and cysteine residues on target proteins, such as CD3D, CYP3A4, CFTR, INSIG1, SOAT2/ACAT2 and APOB for proteasomal degradation. Component of a VC...
TMPK-00811	L1CAM Protein, Mouse, Recombinant (His)	Mouse	HEK293 Cells
	L1 cell adhesion molecule (L1CAM) is one of the first neural adhesion molecules described with important functions in the development of the nervous system. Subsequent work discovered that L1CAM is expressed in many huma...
TMPJ-00375	HGF Protein, Human, Recombinant (His)	Human	HEK293 Cells
	HGF, is a pleiotropic protein in the Plasminogen subfamily of S1 peptidases and contains 4 kringle domains, 1 PAN domain and 1 peptidase S1 domain. HGF is secreted as an inactive 728 amino acid (aa) single chain propepti...
TMPY-02028	RON/CD136 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	The tyrosine kinase receptor, macrophage-stimulating 1 receptor (MST1R), a c-met-related tyrosine kinase, also known as the Ron receptor or CD136, controls cell survival and motility programs related to invasive growth. ...
TMPY-01806	CD9 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	The cluster of differentiation (CD) system is commonly used as cell markers in Immunophenotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules associating with the immu...
TMPY-04552	AKT1 Protein, Human, Recombinant (His)	Human	Baculovirus Insect Cells
	v-akt murine thymoma viral oncogene homolog 1 (AKT1), or protein kinase B-alpha (PKB-ALPHA) is a serine-threonine protein kinase, belonging to the Protein Kinase Superfamily. AKT1 is a major mediator of the responses to ...
TMPH-01614	LDHC Protein, Human, Recombinant (His & SUMO)	Human	E. coli
	Possible role in sperm motility.
TMPH-02541	Beta Defensin 1/DEFB1 Protein, Mouse, Recombinant (His & SUMO)	Mouse	E. coli
	Has bactericidal activity. May act as a ligand for C-C chemokine receptor CCR6. Positively regulates the sperm motility and bactericidal activity in a CCR6-dependent manner. Binds to CCR6 and triggers Ca2+ mobilization i...
TMPH-03101	DEFB1 Protein, Pig, Recombinant (GST)	Sus scrofa (Pig)	E. coli
	Has bactericidal activity. May act as a ligand for C-C chemokine receptor CCR6. Positively regulates the sperm motility and bactericidal activity in a CCR6-dependent manner. Binds to CCR6 and triggers Ca2+ mobilization i...
TMPH-00006	Actin-1 Protein, Absidia glauca, Recombinant (His & Myc)	Absidia glauca	E. coli
	Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
TMPH-02193	Tetraspanin-7/TSPAN7 Protein, Human, Recombinant (His)	Human	P. pastoris (Yeast)
	May be involved in cell proliferation and cell motility. Tetraspanin-7/TSPAN7 Protein, Human, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 14.5 kDa and the accession number ...
TMPH-03033	P200 Protein, Mycoplasma pneumoniae, Recombinant (His & Myc)	Mycoplasma pneumoniae	E. coli
	Protein cytoskeleton-associated which plays a role in gliding motility and perhaps also in mucociliary clearance.
TMPH-02192	Tetraspanin-7/TSPAN7 Protein, Human, Recombinant (E. coli, His)	Human	E. coli
	May be involved in cell proliferation and cell motility. Tetraspanin-7/TSPAN7 Protein, Human, Recombinant (E. coli, His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 15.6 ...
TMPH-02305	VCAN Protein, Human, Recombinant (B2M & His & Myc)	Human	E. coli
	May play a role in intercellular signaling and in connecting cells with the extracellular matrix. May take part in the regulation of cell motility, growth and differentiation. Binds hyaluronic acid.
TMPH-00882	ACTA2 Protein, Human, Recombinant (His)	Human	E. coli
	Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. ACTA2 Protein, Human, Recombinant (His) is expressed in E. coli expression ...
TMPH-00881	ACTA1 Protein, Human, Recombinant (His)	Human	E. coli
	Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. ACTA1 Protein, Human, Recombinant (His) is expressed in E. coli expression ...
TMPJ-01079	TFF2 Protein, Mouse, Recombinant (His)	Mouse	HEK293 Cells
	Recombinant Murine TFF-2 is an 11.9 kDa polypeptide of 106 amino acid residues, which includes a 40-amino acid trefoil motif containing three conserved intramolecular disulfide bonds. The Trefoil Factor peptides (TFF1, T...
TMPJ-00111	CD9 Protein, Human, Recombinant (hFc)	Human	HEK293 Cells
	CD9, also known as Tspan29, 5H9 antigen, Leukocyte antigen MIC3 (MIC3), Motility-related protein, is a multi-pass membrane protein which belongs to the tetraspanin (TM4SF) family or the transmembrane 4 superfamily. CD9 i...
TMPJ-01036	Beta-Actin Protein, Human, Recombinant (His)	Human	E. coli
	Actins are ubiquitous globular and highly conserved proteins that are involved in various types of cell motility, structure, and integrity. Three main groups of actin isoforms, alpha, beta and gamma have been identified....
TMPY-03465	Flagellin Protein, Listeria monocytogenes, Recombinant (His)	Listeria monocytogenes	E. coli
	The role of flagella and motility in the attachment of the foodborne pathogen Listeria monocytogenes to various surfaces is mixed with some systems requiring flagella for an interaction and others needing only motility...
TMPY-04207	Motilin Protein, Human, Recombinant (His)	Human	HEK293 Cells
	MLN (Motilin) is a Protein Coding gene. 3 alternatively spliced human isoforms have been reported. This gene encodes a small peptide hormone that is secreted by cells of the small intestine to regulate gastrointestinal c...
TMPH-02969	VCAN Protein, Mouse, Recombinant (His & Myc)	Mouse	E. coli
	May play a role in intercellular signaling and in connecting cells with the extracellular matrix. May take part in the regulation of cell motility, growth and differentiation. Binds hyaluronic acid. VCAN Protein, Mouse, ...
TMPH-01610	LINGO1 Protein, Human, Recombinant (His)	Human	E. coli
	Functional component of the Nogo receptor signaling complex (RTN4R/NGFR) in RhoA activation responsible for some inhibition of axonal regeneration by myelin-associated factors. Is also an important negative regulator of ...
TMPH-00224	APOA1 Protein, Bovine, Recombinant (E. coli, His)	Bovine	E. coli
	Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). A...
TMPH-00225	APOA1 Protein, Bovine, Recombinant (His)	Bovine	P. pastoris (Yeast)
	Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). A...
TMPK-00392	FGFR1 beta (IIIc) Protein, Human, Recombinant (His & Avi)	Human	HEK293 Cells
	Fibroblast growth factor receptor 1 (FGFR1) transmits signals through the plasma membrane regulating essential cellular processes like division, motility, metabolism, and death. Overexpression of FGFR1 is observed in num...
TMPK-00518	CD44 Protein, Cynomolgus, Recombinant (His)	Cynomolgus	HEK293 Cells
	CD44 is a hyaluronan binding cell surface signal transducing receptor that influences motility, cell survival and proliferation as well as the formation of tumor microenvironment. CD44 contains two variable regions encod...
TMPY-03978	TSPAN31 Protein, Human, Recombinant (mFc)	Human	HEK293 Cells
	TSPAN31 is a member of the transmembrane 4 superfamily. Most members of this family are cell-surface proteins that are characterized by the presence of four hydrophobic domains. They mediate signal transduction events th...
TMPK-01081	Glypican 2/GPC2 Protein, Mouse, Recombinant (His)	Mouse	HEK293 Cells
	Glypicans can function as coreceptors for multiple signaling molecules known for regulating cell growth, motility, and differentiation. Some members of the glypican family, including glypican 2 (GPC2) and glypican 3 (GPC...
TMPY-02046	PFDN1 Protein, Mouse, Recombinant (His)	Mouse	E. coli
	PFDN1 expression positively correlated with tumor size and tumor invasion. The inhibitory effect of PFDN1 on tumor cell growth and motility was partially due to G2/M cell cycle blockage and cytoskeletal deficiency. PFDN1...
TMPY-03989	PFDN1 Protein, Human, Recombinant (His)	Human	E. coli
	PFDN1 expression positively correlated with tumor size and tumor invasion. The inhibitory effect of PFDN1 on tumor cell growth and motility was partially due to G2/M cell cycle blockage and cytoskeletal deficiency. PFDN1...
TMPK-00394	FGFR1 beta (IIIc) Protein, Human, Recombinant (His & Avi), Biotinylated	Human	HEK293 Cells
	Fibroblast growth factor receptor 1 (FGFR1) transmits signals through the plasma membrane regulating essential cellular processes like division, motility, metabolism, and death. Overexpression of FGFR1 is observed in num...
TMPH-01536	ITGB4 Protein, Human, Recombinant (His & Myc)	Human	E. coli
	Integrin alpha-6/beta-4 is a receptor for laminin. Plays a critical structural role in the hemidesmosome of epithelial cells. Is required for the regulation of keratinocyte polarity and motility. ITGA6:ITGB4 binds to NRG...
TMPK-00658	IGF1R/CD221 Protein, Cynomolgus, Recombinant (His)	Cynomolgus	HEK293 Cells
	The type 1 IGF receptor (IGF1R) is a transmembrane tyrosine kinase that is frequently overexpressed by tumours, and mediates proliferation and apoptosis protection. IGF signalling also influences hypoxia signalling, prot...
TMPH-02753	LINGO1 Protein, Mouse, Recombinant (His)	Mouse	E. coli
	Functional component of the Nogo receptor signaling complex (RTN4R/NGFR) in RhoA activation responsible for some inhibition of axonal regeneration by myelin-associated factors. Is also an important negative regulator of ...
TMPY-03863	CAPG Protein, Human, Recombinant	Human	E. coli
	CAPG, also known as actin Regulatory Protein CAPG, is a a member of the gelsolin/villin family. Members of this family are actin-regulatory proteins. CAPG reversibly blocks the barbed ends of F-actin filaments in a Ca2+ ...
TMPK-00455	IGF1R/CD221 Protein, Human, Recombinant (His & Avi)	Human	HEK293 Cells
	The type 1 IGF receptor (IGF1R) is a transmembrane tyrosine kinase that is frequently overexpressed by tumours, and mediates proliferation and apoptosis protection. IGF signalling also influences hypoxia signalling, prot...
TMPH-02522	GHRL Protein, Mouse, Recombinant (His)	Mouse	E. coli
	Ghrelin is the ligand for growth hormone secretagogue receptor type 1 (GHSR). Induces the release of growth hormone from the pituitary. Has an appetite-stimulating effect, induces adiposity and stimulates gastric acid se...
TMPJ-00348	CD316 Protein, Human, Recombinant (hFc)	Human	HEK293 Cells
	Immunoglobulin Superfamily Member 8 (IGSF8) is a single-pass membrane protein. IGSF8 contains four Ig-like C2 type domains. The Ig-like C2-type domains 3 and 4 are required for interactions with CD81. IGSF8 may regulate ...
TMPH-02677	GPI Protein, Mouse, Recombinant (B2M & His)	Mouse	E. coli
	In the cytoplasm, catalyzes the conversion of glucose-6-phosphate to fructose-6-phosphate, the second step in glycolysis, and the reverse reaction during gluconeogenesis. Besides it's role as a glycolytic enzyme, also ac...
TMPK-00456	IGF1R/CD221 Protein, Human, Recombinant (aa 31-932, His & Avi), Biotinylated	Human	HEK293 Cells
	The type 1 IGF receptor (IGF1R) is a transmembrane tyrosine kinase that is frequently overexpressed by tumours, and mediates proliferation and apoptosis protection. IGF signalling also influences hypoxia signalling, prot...
TMPH-02678	GPI Protein, Mouse, Recombinant (His)	Mouse	P. pastoris (Yeast)
	In the cytoplasm, catalyzes the conversion of glucose-6-phosphate to fructose-6-phosphate, the second step in glycolysis, and the reverse reaction during gluconeogenesis. Besides it's role as a glycolytic enzyme, also ac...
TMPH-01539	ILK Protein, Human, Recombinant (His)	Human	Baculovirus Insect Cells
	Receptor-proximal protein kinase regulating integrin-mediated signal transduction. May act as a mediator of inside-out integrin signaling. Focal adhesion protein part of the complex ILK-PINCH. This complex is considered ...
TMPH-01391	GPI Protein, Human, Recombinant (His)	Human	E. coli
	In the cytoplasm, catalyzes the conversion of glucose-6-phosphate to fructose-6-phosphate, the second step in glycolysis, and the reverse reaction during gluconeogenesis. Besides it's role as a glycolytic enzyme, also ac...
TMPH-01729	Myosin-9/MYH9 Protein, Human, Recombinant (GST)	Human	E. coli
	Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Required for cortical actin clearance prior to oocyte exocytosis. Promotes cell motility in...
TMPJ-01078	TFF2 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Trefoil Factor 2 (TFF2) is a member of the trefoil family and contains two P-type (trefoil) domains. Members of this family are characterized by having at least one copy of the trefoil motif, a 40-amino acid domain that ...
TMPJ-00524	SORD Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Sorbitol dehydrogenase, also known as L-iditol 2-dehydrogenase and SORD, is a member of the zinc-containing alcohol dehydrogenase family. SORD exsits in a homotetramer and binds one zinc ion per subunit. SORD is expresse...
TMPY-03261	CNPY2 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	CNPY2 is a novel MIR-interacting protein that enhances neurite outgrowth and increases myosin regulatory light chain. CNPY2 enhances migration of C6 glioma cells through phosphorylation of the myosin regulatory light cha...
TMPY-00517	LSP1 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	LSP1 (Lymphocyte Specific Protein 1) is a Protein Coding gene. This gene encodes an intracellular F-actin binding protein. The protein is expressed in lymphocytes, neutrophils, macrophages, and endothelium and may regula...
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AMFR Protein, Human, Recombinant (His)

TMPH-01259

Species: Human

Expression System: E. coli

AMFR Protein, Human, Recombinant (hFc)

TMPH-01260

Species: Human

Expression System: HEK293 Cells

L1CAM Protein, Mouse, Recombinant (His)

TMPK-00811

Species: Mouse

Expression System: HEK293 Cells

HGF Protein, Human, Recombinant (His)

TMPJ-00375

Species: Human

Expression System: HEK293 Cells

RON/CD136 Protein, Human, Recombinant (His)

TMPY-02028

Species: Human

Expression System: HEK293 Cells

CD9 Protein, Human, Recombinant (His)

TMPY-01806

Species: Human

Expression System: HEK293 Cells

AKT1 Protein, Human, Recombinant (His)

TMPY-04552

Species: Human

Expression System: Baculovirus Insect Cells

LDHC Protein, Human, Recombinant (His & SUMO)

TMPH-01614

Species: Human

Expression System: E. coli

Beta Defensin 1/DEFB1 Protein, Mouse, Recombinant (His & SUMO)

TMPH-02541

Species: Mouse

Expression System: E. coli

DEFB1 Protein, Pig, Recombinant (GST)

TMPH-03101

Species: Sus scrofa (Pig)

Expression System: E. coli

Actin-1 Protein, Absidia glauca, Recombinant (His & Myc)

TMPH-00006

Species: Absidia glauca

Expression System: E. coli

Tetraspanin-7/TSPAN7 Protein, Human, Recombinant (His)

TMPH-02193

Species: Human

Expression System: P. pastoris (Yeast)

P200 Protein, Mycoplasma pneumoniae, Recombinant (His & Myc)

TMPH-03033

Species: Mycoplasma pneumoniae

Expression System: E. coli

Tetraspanin-7/TSPAN7 Protein, Human, Recombinant (E. coli, His)

TMPH-02192

Species: Human

Expression System: E. coli

VCAN Protein, Human, Recombinant (B2M & His & Myc)

TMPH-02305

Species: Human

Expression System: E. coli

ACTA2 Protein, Human, Recombinant (His)

TMPH-00882

Species: Human

Expression System: E. coli

ACTA1 Protein, Human, Recombinant (His)

TMPH-00881

Species: Human

Expression System: E. coli

TFF2 Protein, Mouse, Recombinant (His)

TMPJ-01079

Species: Mouse

Expression System: HEK293 Cells

CD9 Protein, Human, Recombinant (hFc)

TMPJ-00111

Species: Human

Expression System: HEK293 Cells

Beta-Actin Protein, Human, Recombinant (His)

TMPJ-01036

Species: Human

Expression System: E. coli

Flagellin Protein, Listeria monocytogenes, Recombinant (His)

TMPY-03465

Species: Listeria monocytogenes

Expression System: E. coli

Motilin Protein, Human, Recombinant (His)

TMPY-04207

Species: Human

Expression System: HEK293 Cells

VCAN Protein, Mouse, Recombinant (His & Myc)

TMPH-02969

Species: Mouse

Expression System: E. coli

LINGO1 Protein, Human, Recombinant (His)

TMPH-01610

Species: Human

Expression System: E. coli

APOA1 Protein, Bovine, Recombinant (E. coli, His)

TMPH-00224

Species: Bovine

Expression System: E. coli

APOA1 Protein, Bovine, Recombinant (His)

TMPH-00225

Species: Bovine

Expression System: P. pastoris (Yeast)

FGFR1 beta (IIIc) Protein, Human, Recombinant (His & Avi)

TMPK-00392

Species: Human

Expression System: HEK293 Cells

CD44 Protein, Cynomolgus, Recombinant (His)

TMPK-00518

Species: Cynomolgus

Expression System: HEK293 Cells

TSPAN31 Protein, Human, Recombinant (mFc)

TMPY-03978

Species: Human

Expression System: HEK293 Cells

Glypican 2/GPC2 Protein, Mouse, Recombinant (His)

TMPK-01081

Species: Mouse

Expression System: HEK293 Cells

PFDN1 Protein, Mouse, Recombinant (His)

TMPY-02046

Species: Mouse

Expression System: E. coli

PFDN1 Protein, Human, Recombinant (His)

TMPY-03989

Species: Human

Expression System: E. coli

FGFR1 beta (IIIc) Protein, Human, Recombinant (His & Avi), Biotinylated

TMPK-00394

Species: Human

Expression System: HEK293 Cells

ITGB4 Protein, Human, Recombinant (His & Myc)

TMPH-01536

Species: Human

Expression System: E. coli

IGF1R/CD221 Protein, Cynomolgus, Recombinant (His)

TMPK-00658

Species: Cynomolgus

Expression System: HEK293 Cells

LINGO1 Protein, Mouse, Recombinant (His)

TMPH-02753

Species: Mouse

Expression System: E. coli

CAPG Protein, Human, Recombinant

TMPY-03863

Species: Human

Expression System: E. coli

IGF1R/CD221 Protein, Human, Recombinant (His & Avi)

TMPK-00455

Species: Human

Expression System: HEK293 Cells

GHRL Protein, Mouse, Recombinant (His)

TMPH-02522

Species: Mouse

Expression System: E. coli

CD316 Protein, Human, Recombinant (hFc)

TMPJ-00348

Species: Human

Expression System: HEK293 Cells

GPI Protein, Mouse, Recombinant (B2M & His)

TMPH-02677

Species: Mouse

Expression System: E. coli

IGF1R/CD221 Protein, Human, Recombinant (aa 31-932, His & Avi), Biotinylated

TMPK-00456

Species: Human

Expression System: HEK293 Cells

GPI Protein, Mouse, Recombinant (His)

TMPH-02678

Species: Mouse

Expression System: P. pastoris (Yeast)

ILK Protein, Human, Recombinant (His)

TMPH-01539

Species: Human

Expression System: Baculovirus Insect Cells

GPI Protein, Human, Recombinant (His)

TMPH-01391

Species: Human

Expression System: E. coli

Myosin-9/MYH9 Protein, Human, Recombinant (GST)

TMPH-01729

Species: Human

Expression System: E. coli

TFF2 Protein, Human, Recombinant (His)

TMPJ-01078

Species: Human

Expression System: HEK293 Cells

SORD Protein, Human, Recombinant (His)

TMPJ-00524

Species: Human

Expression System: HEK293 Cells

CNPY2 Protein, Human, Recombinant (His)

TMPY-03261

Species: Human

Expression System: HEK293 Cells

LSP1 Protein, Human, Recombinant (His)

TMPY-00517

Species: Human

Expression System: HEK293 Cells

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カタログ番号	製品名
L1310	Cytoskeletal Signaling Pathway Compound Library	759 compounds
	A unique collection of 759 cytoskeleton-related compounds, can be used for HTS and HCS；
L1400	MAPK Inhibitor Library	365 compounds
	A unique collection of 365 compounds targeting MAPK signaling for drug discovery in MAPK related diseases;

ライブラリー

Cytoskeletal Signaling Pathway Compound Library

L1310

Compounds: 759

MAPK Inhibitor Library

L1400

Compounds: 365