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T11888 |
LtaS-IN-1
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Others
,
Antibacterial
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|
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T4989 |
Fosfomycin Tromethamine
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|
Antibacterial
,
Antibiotic
|
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An antibiotic produced by Streptomyces fradiae. |
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T3131 |
Fosfomycin calcium
|
Phosphomycin calcium salt,Fosmicin |
Antibacterial
,
Antibiotic
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Fosfomycin calcium (Phosphomycin calcium salt) is a blood-brain barrier penetrating, broad-spectrum antibiotic by irreversibly inhibiting an early stage in cell wall synthesis. |
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T1631 |
Sulbactam
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CP45899 |
Antibacterial
,
Antibiotic
|
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Sulbactam (CP45899) is a semi-synthetic beta-lactamase inhibitor. The beta-lactam ring of sulbactam irreversibly binds to beta-lactamase at or near its active site, thereby blocking enzyme activity and preventing metabol... |
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T6685 |
Sulbactam sodium
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CP-45899-2 |
Antibacterial
,
Antibiotic
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|
Sulbactam sodium (CP-45899-2) (Unasyn) is an irreversible β-lactamase inhibitor. |
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T10460 |
Batabulin
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T138067 |
Apoptosis
,
Microtubule Associated
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Batabulin (T138067) is an antitumor compound, which binds covalently and selectively to a subset of the β-tubulin isotypes, thereby disrupting microtubule polymerization. Batabulin affects cell morphology and leads to ce... |
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T22330 |
Fenamic acid
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2-Anilinobenzoic acid,Diphenylamine-2-carboxylic acid,2-(Phenylamino)benzoic acid,N-Phenylanthranilic acid |
Chloride channel
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Fenamic acid (N-Phenylanthranilic acid) is a chloride channel blocker that causes renal papillary necrosis in rats. Fenamic acid serves as a parent structure for several nonsteroidal anti-inflammatory drugs (NSAIDs), inc... |
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T9982 |
PU23
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MRP
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PU 23 is an inhibitor of multidrug-resistant protein 4 (MRP4). |
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T22269 |
Benzyldodecyldimethylammonium Chloride Dihydrate
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Antibacterial
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Benzyldodecyldimethylammonium chloride dihydrate can be used as an insecticide reagent. It can target drug-resistant bacteria, such as methicillin-resistant Staphylococcus aureus, multidrug-resistant Pseudomonas aerugino... |
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T15409 |
GNF179
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Parasite
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GNF179 is an optimized 8,8-dimethyl IP analog. It exhibited the potency(4.8 nM against the multidrug resistant strain W2) in vitro metabolic stability and in vivo oral bioavailability. |
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T9830 |
GSK2556286
|
GSK286 |
Antibacterial
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GSK2556286 (GSK286) is an orally active inhibitor of Mycobacterium tuberculosis (M. tuberculosis).GSK2556286 inhibits the growth of human macrophages with an IC50 value of 0.07 μM.GSK2556286 is effective against both mul... |
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T12343 |
Benzquinamide
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BZQ,P2647,Benzoquinamide |
Adrenergic Receptor
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Benzquinamide (P2647), an antiemetic agent with anticancer activity, inhibits p-glycoprotein-mediated drug efflux and potentiates the cytotoxicity of anticancer drugs in multidrug-resistant cells.The Ki values of Benzqui... |
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T35610 |
2,5-dimethyl Celecoxib
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|
Apoptosis
,
Wnt/beta-catenin
,
Prostaglandin Receptor
|
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2,5-dimethyl Celecoxib is a derivative of celecoxib that does not inhibit COX-2 (IC50 = >100 μM).1 It does inhibit microsomal prostaglandin E synthase-1 (mPGES-1) in HeLa cells (IC50 = 15.6 μM) and reduces prostaglandin ... |
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T33683 |
NITD-304
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NITD304 |
|
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NITD-304 is an anti-tuberculosis drug candidate for the treatment of multidrug-resistant tuberculosis (MDR-TB), showing effective activity against both MTB drug-sensitive and multidrug-resistant clinical isolates. |
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T27712 |
KAR425
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KAR-425,KAR 425 |
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KAR425 is a bipyrrole tambjamines. KAR425 has antimalarial activity against multidrug-resistant P. yoelii in mice. |
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T14780 |
BRD9185
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Dehydrogenase
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BRD9185 is an inhibitor of Dihydroorotate dehydrogenase (DHODH) with an EC50 of 16 nM against multidrug-resistant blood-stage parasites in vitro. |
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T68404 |
Azidopine
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|
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Azidopine is a photoactive dihydropyridine channel blocker which may also act as a multidrug resistant (MDR) modulator. |
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T70546 |
HI-346
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|
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HI-346 is a potent inhibitor of multidrug-resistant human immunodeficiency virus-1 (HIV-1). |
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T71458 |
Epetraborole
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|
|
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Epetraborole is a potent and selective leucyl-tRNA synthetase inhibitor. Epetraborole was in development for the treatment of infections caused by multidrug-resistant Gram-negative pathogens. |
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T26180 |
Sdz 280 446
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Sdz 280,446,Sdz 280-446 |
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Sdz 280 446 is one of the most active cyclopeptolide of many resistance-modifying agents in restoring rhodamine-123 retention within multidrug-resistant P388 cells. |
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T26413 |
A 30312
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A-30312,A30312 |
|
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A 30312 is a fused indole, which overcomes multidrug resistance in P388/Adr cells in vitro. It potentiates the cytotoxicity of the antitumor drugs Adriamycin, vincristine and vinblastine in multidrug-resistant cells with... |
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T12991 |
SPR206
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Others
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SPR206 is a polymyxin analogue and an important class of antibiotic for the treatment of bacterial infections due to multidrug resistant Gram-negative pathogen. |
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T39230 |
Contezolid acefosamil
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MRX-4,Contezolid acefosamil |
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Contezolid acefosamil (MRX-4), an orally active prodrug, is metabolized into Contezolid (MRX-I), an oxazolidinone derivative with potent in vitro efficacy against multidrug-resistant Gram-positive bacteria, including MRS... |
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T69388 |
PD 0305970
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|
|
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PD 0305970 is new bacterial gyrase and topoisomerase inhibitor that possess outstanding in vitro and in vivo activities against a wide spectrum of bacterial species including quinolone- and multidrug-resistant gram-posit... |
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T11445 |
GNF179 (Metabolite)
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GNF179 Metabolite |
Others
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GNF179 Metabolite, the derivative of GNF179—an optimized 8,8-dimethyl IP analog—demonstrates significant potency (4.8 nM against the multidrug-resistant W2 strain) alongside in vitro metabolic stability and in vivo oral ... |
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T80283 |
COB1 phermone
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|
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COB1 pheromone, a bacterial sex pheromone, effectively inhibits the multidrug-resistant Enterococcus faecalis V583 [1]. |
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T76501 |
Defensin HNP 4
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Defensin HNP 4 (HNP 4), an 11-amino acid segment derived from HNP-41-11, exhibits inhibitory effects against both multidrug-resistant and non-resistant strains [1]. |
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T68209 |
Kopsoffinol
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|
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Kopsoffinol is a bisindole alkaloid that has been shown to have in vitro growth inhibitory activity against human PC-3, HCT-116, MCF-7, and A549 cells and moderate effects in reversing multidrug-resistance in vincristine... |
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T62627 |
Antibacterial agent 69
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|
|
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Antibacterial agent 69 is a novel structural antimicrobial modulator that can be used against lethal multidrug-resistant bacterial infections (MIC: 2.978 μM). |
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T78717 |
Topoisomerase inhibitor 2
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Topoisomerase
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Topoisomerase Inhibitor 2 (18C) is a broad-spectrum bacterial topoisomerase inhibitor effective against multidrug-resistant Gram-negative bacteria [1]. |
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TP2286 |
Quinupristin (mesylate) (120138-50-3 free base)
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Quinupristin (mesylate) |
Others
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Quinupristin is a streptogramin antibiotic. Streptogramins, a class of antibiotics, is effective in the treatment of vancomycin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus, which are two of the ... |
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T76244 |
Amp1EP9
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|
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Amp1EP9, an antimicrobial peptide, serves as a potent and non-toxic candidate for the development of effective antimicrobial agents. It holds promise for research into multidrug-resistant bacterial infections [1]. |
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T69305 |
Milataxel
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|
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Milataxel is an orally bioavailable taxane with potential antineoplastic activity. Upon oral administration, milataxel and its major active metabolite M-10 bind to and stabilize tubulin, resulting in the inhibition of mi... |
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T39296 |
DS86760016
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|
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DS86760016 is a highly effective inhibitor of leucyl-tRNA synthetase (LeuRS), demonstrating potent activity against multidrug-resistant (MDR) Gram-negative bacteria including Escherichia coli, Klebsiella pneumoniae, and ... |
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T73095 |
PNU-101603
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|
|
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PNU-101603 is a sulfoxide metabolite of Sutezolid . PNU-101603 alone or combined with SQ109 shows excellent activity against Mycobacterium tuberculosis (MTB), as well as against drug-susceptible and multidrug-resistant ... |
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T39983 |
SPR206 acetate
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|
|
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SPR206 acetate is a polymyxin analog that exhibits antibiotic activity against Gram-negative pathogens, including multidrug-resistant (MDR) variants. By interacting with the outer membrane of the bacterium, SPR206 acetat... |
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T83758 |
SAAP 148 TFA
|
Synthetic Antimicrobial and Antibiofilm Peptide 148 |
|
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SAAP 148, an antimicrobial peptide, effectively combats various multidrug-resistant bacteria in vitro and, in vivo, reduces skin colony-forming units (CFUs) in mouse models of A. baumannii or methicillin-resistant S. aur... |
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T70808 |
Cabazitaxel-d6
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|
|
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Cabazitaxel-d6 is a deuterium labeled cabazitaxel. Cabazitaxel is a semi-synthetic derivative of the natural taxoid 10-deacetylbaccatin III with potential antineoplastic activity. Cabazitaxel binds to and stabilizes tubu... |
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T80535 |
AMPR-22
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|
|
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AMPR-22, an antimicrobial peptide, binds to bacterial membranes to induce permeabilization and has demonstrated efficacy in a murine sepsis model induced by multidrug-resistant (MDR) strains [1]. |
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T78732 |
BO-1
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|
|
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BO-1, a benzoate ester, exhibits antibacterial properties, effectively inhibiting multidrug-resistant Staphylococcus aureus. It synergizes with antibiotics like Ciprofloxacin, reversing resistance in antibiotic-resistant... |
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T72678 |
P-gp inhibitor 4
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|
|
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P-gp inhibitor 4 is a selective P-glycoprotein modulator with an EC 50 of 94 nM. P-gp inhibitor 4 increases drug transport across gastro-intestinal barrier and recovers doxorubicin toxicity in multidrug resistant cancer... |
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T61170 |
Antibacterial agent 96
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|
|
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Antibacterial Agent 96 (Compound 4k) is a potent antibacterial and antitubercular compound effective against both drug-susceptible and multidrug-resistant Mycobacterium tuberculosis (M. tuberculosis) strains. However, it... |
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T62786 |
HDAC1-IN-3
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|
|
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HDAC1-IN-3 is a potent inhibitor of Pf HDAC1. HDAC1-IN-3 is antimalarial in both wild-type and multidrug-resistant strains of the parasite. HDAC1-IN-3 exhibits a significant in vivo killing effect on all life cycles of t... |
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T69480 |
Sagopilone
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|
|
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Sagopilone is a fully synthetic low-molecular-weight epothilone with potential antineoplastic activity. Sagopilone binds to tubulin and induces microtubule polymerization while stabilizing microtubules against depolymeri... |
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T73120 |
MptpB-IN-1
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|
|
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MptpB-IN-1 is a potent, orally active MptpB inhibitor that targets the Mycobacterium tuberculosis protein-tyrosine-phosphatase B (MptpB), a secreted virulence factor evading host antimicrobial mechanisms. It effectively ... |
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T67948 |
OY-101
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|
|
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OY-101, an orally active compound, serves as a potent and specific inhibitor of P-glycoprotein (P-gp). It has the capability to sensitize drug-resistant tumors and counteract tumor multidrug resistance efficiently. Compa... |
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T74591 |
Ceftaroline fosamil (hydrate)(acetate)
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|
|
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Ceftaroline fosamil hydrate acetate is a powerful cephalosporin antibiotic that exhibits broad-spectrum efficacy against both Gram-positive pathogens, such as methicillin-resistant Staphylococcus aureus (MRSA) and multid... |
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T76219L |
MDP1 acetate
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|
|
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MDP1 acetate, a derivative of Melittin, compromises the membrane integrity of both Gram-positive and Gram-negative bacteria leading to bacterial death through membrane damage. It exhibits potent antibacterial activity ag... |
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T76219 |
MDP1
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|
|
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MDP1, derived from Melittin, disrupts the membrane integrity of both Gram-positive and Gram-negative bacteria, leading to bacterial death through membrane damage. This compound exhibits potent antibacterial activity agai... |
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T63786 |
WX-081
|
|
|
|
WX-081 is an anti-tuberculosis agent that exhibits significant anti-mycobacterial effects against M. tuberculosisH37Rv and is able to act on drug-susceptible (DS-TB) mycobacteria (MIC: 0.083 μg/ml) and multidrug-resistan... |
