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T38612 |
Linaprazan glurate
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|
Others
|
|
Linaprazan glurate inhibits exogenously or endogenously stimulated gastric acid secretion. Linaprazan glurate can be used in studies about gastrointestinal inflammatory diseases and peptic ulcer diseases. |
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T0802 |
Procaine hydrochloride
|
Novocaine HCl,Procaine HCl |
Histone Demethylase
,
5-HT Receptor
,
DNA/RNA Synthesis
,
Sodium Channel
,
NMDAR
,
AChR
|
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Procaine hydrochloride (Novocaine HCl) is the hydrochloride salt form of procaine, a benzoic acid derivative with local anesthetic and antiarrhythmic properties. Procaine binds to and inhibits voltage-gated sodiumchannel... |
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T0029 |
Procaine
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Duracaine,Spinocaine,Novocaine,Vitamin H3 |
Histone Demethylase
,
DNA/RNA Synthesis
,
Sodium Channel
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Procaine (Vitamin H3) is a local anesthetic of the ester type that has a slow onset and a short duration of action. It is mainly used for infiltration anesthesia, peripheral nerve block, and spinal block. |
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T7806 |
Licarbazepine
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10,11-hydroxy-10,11 Dihydrocarbamezer |
Others
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Licarbazepine (10,11-hydroxy-10,11 Dihydrocarbamezer) is the pharmacologically active metabolite of oxcarbazepine, a drug indicated for the treatment of partial seizures and bipolar disorders. |
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T80855 |
Vonsetamig
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|
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Vonsetamig, a humanized immunoglobulin G4-kappa monoclonal antibody, targets both TNFRSF17 and CD3E. It serves as an antineoplastic agent. |
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T3285L |
Eslicarbazepine
|
Pazzul,EC 810-248-9,BIA 2-194,Stedesa,Erelib |
Beta-Secretase
,
Sodium Channel
|
|
Eslicarbazepine (Stedesa) can be used for adjunctive therapy for adults with partial-onset seizures. |
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T24932 |
Vatanidipine
|
AE-0047,AE 0047,AE0047 |
Calcium Channel
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Vatanidipine (AE0047) is a novel dihydropyridine (DHP)-type calcium channel blocker with slow-onset pharmacological actions.A slow-onset and long-lasting hypotensive action was observed in various experimental hypertensi... |
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T31716L |
Etidocaine
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Others
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Etidocaine is an amino acidamide that acts as a local anesthetic with fast onset and long-acting properties. |
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T31860 |
Fosdevirine
|
GSK-2248761A,IDX 899,GSK 2248761A,GSK 2248761,GSK-2248761,IDX-12899,GSK2248761,FDV,GSK2248761A |
HIV Protease
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|
Fosdevirine (GSK2248761) is a selective and potent non-nucleoside reverse transcriptase (NNRTI) inhibitor with anti-HIV activity for the study of neurological related disorders such as late-onset epilepsy. |
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T9284 |
Dexketoprofen trometamol
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COX
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Dexketoprofen trometamol is a modified non-selective COX inhibitor with a rapid onset of action that is available as both oral and parenteral formulations. |
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T1148 |
Menbutone
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Naftobil,Genabilic acid,Genabilin |
Others
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Menbutone (Genabilin) is a derivative of oxobutyric acid, and is a choleretic. Menbutone shows a rapid onset of action, reaching its maximum plasma level within 1 hour and lasting for roughly 10 hours. |
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T7942 |
Tranylcypromine hemisulfate
|
Tranylcypromine Sulfate,Tranylcypromine (hemisulfate) |
Histone Demethylase
,
MAO
,
Monoamine Oxidase
|
|
Tranylcypromine hemisulfate (Tranylcypromine Sulfate) is an inhibitor of monoamine oxidase (MAO) and lysine-specific demethylase 1 (LSD1) with a rapid onset of activity. |
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T4250 |
Bilastine
|
Bilaxten |
Histamine Receptor
|
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Bilastine (Bilaxten) is a novel new-generation antihistamine that is highly selective for the H1 histamine receptor, has a rapid onset and prolonged duration of action. |
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T3285 |
Eslicarbazepine Acetate
|
Zebinix,Aptiom,BIA 2-093,Exalief,Stedesa |
Beta-Secretase
,
Sodium Channel
|
|
Eslicarbazepine Acetate (Zebinix) is an anticonvulsant medication approved for use in Europe, the United States and Canada as an adjunctive therapy for partial-onset seizures that are not adequately controlled with conve... |
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T7502L |
PF 05089771
|
PF-05089771,PF05089771 |
Sodium Channel
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PF 05089771 is a Selective inhibitor of Nav1.7 (IC50 = 11 nM) that interacts with the voltage-sensor domain of domain IV. It shows a slow onset of the block that is depolarization and concentration-dependent. |
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T31860L |
(Iso)-Fosdevirine
|
(Iso)-Fosdevirine（Iso-1018450-26-4）,(Iso)-GSK2248761 |
HIV Protease
|
|
(Iso)-Fosdevirine ( (Iso)-GSK2248761) is a selective and potent non-nucleoside reverse transcriptase (NNRTI) inhibitor with anti-HIV activity for the study of neurological disorders such as late-onset epilepsy. |
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TP1127L1 |
Nemifitide acetate(173240-15-8 free base)
|
INN 00835 acetate |
5-HT Receptor
|
|
Nemifitide acetate(173240-15-8 free base) (INN 00835 acetate) is a synthetic pentapeptide antidepressant with a potential for rapid onset of action. It is a peptide analog of melanocyte-inhibiting factor (MIF). |
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T1439 |
Lacidipine
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SN-305,GX-1048,GR-43659X |
Apoptosis
,
Calcium Channel
,
Reactive Oxygen Species
|
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Lacidipine (SN-305) is a lipophilic dihydropyridine calcium antagonist with an intrinsically slow onset of activity. Due to its long duration of action, lacidipine does not lead to reflex tachycardia. It displays specifi... |
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T22037 |
AS 1892802
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ROCK
|
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AS 1892802 is a potent and selective inhibitor of ROCK. AS 1892802 exibits IC50 values of 52nM, 57nM and 122 nM for human ROCK2, rat ROCK2 and human ROCK1, respectively. The onset of antinociceptive effect of AS 1892802 ... |
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T0192 |
Levetiracetam
|
UCB L059,SIB-S1 |
DNA Methyltransferase
,
Others
,
Calcium Channel
|
|
Levetiracetam (SIB-S1) is a relatively unique anticonvulsant that is typically used in combination with other antiepileptic medications for partial onset seizures. Levetiracetam has been linked to rare instances of serum... |
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T64317 |
ZZL-7
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|
Serotonin Transporter
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ZZL-7 is a fast-onset antidepressant agent. ZZL-7 disrupts the interaction between the neuronal nitric oxide synthase (nNOS) and serotonin transporter (SERT) in the dorsal raphe nucleus (DRN). ZZL-7 can easily cross the ... |
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T21327 |
Uridine triacetate
|
RG 2133 triacetate,PN-401,Tri-O-acetyluridine,PN401,RG 2133,RG-2133,PN 401,RG2133,RG2133 triacetate |
Others
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|
Uridine triacetate (RG 2133 triacetate) (Tri-O-acetyl uridine), an orally active prodrug of uridine, is efficiently absorbed in the gut and swiftly deacetylated in the circulation to release free uridine. It is utilized ... |
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T15257 |
Etripamil
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MSP-2017,(-)-MSP-2017 |
Calcium Channel
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Etripamil (MSP-2017) displays atrioventricular nodal conduction and prolongs atrioventricular nodal refractory periods by inhibiting calcium ion influx through the calcium slow channels in the atrioventricular node cells... |
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T67956 |
Litoxetine
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|
5-HT Receptor
|
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Litoxetine is a selective 5-HT uptake inhibitor and is a 5-HT3 receptor antagonist. Litoxetine acts as an antidepressant and has shown antiemetic properties in ferrets. Litoxetine (1 and 10 mg/kg i.v.) dose-dependently r... |
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T3716 |
Rolapitant
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SCH619734 |
Neurokinin receptor
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Rolapitant (SCH619734) Hydrochloride is the hydrochloride salt form of rolapitant, an orally bioavailable, centrally-acting, selective, neurokinin 1 receptor (NK1-receptor) antagonist with potential antiemetic activity. ... |
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T14884 |
CBR-5884
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Others
,
Dehydrogenase
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CBR-5884 is an selective, active of phosphoglycerate dehydrogenase (PHGDH) inhibitor with an IC50 of 33 μM. CBR-5884 inhibits de novo serine synthesis in cancer cells and is selectively toxic to cancer cell lines with h... |
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T0267 |
Zonisamide
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AD 810,CI 912 |
Calcium Channel
,
Sodium Channel
,
Carbonic Anhydrase
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Zonisamide (AD 810), a sulfonamide anticonvulsant, is approved for use as an adjunctive treatment in adults with partial-onset seizures. It may inhibit a carbonic anhydrase although this is not one of the main mechanisms... |
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T4615 |
Balsalazide sodium hydrate
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Balsalazide disodium dihydrate,Balsalazide disodium salt dihydrate,Balsalazide disodium |
STAT
,
Interleukin
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Balsalazide sodium hydrate (Balsalazide disodium) is an anti-inflammatory compound used in the treatment of Inflammatory Bowel Disease.Balsalazide sodium hydrate is a new 5-aminosalicylic acid (5-ASA) containing prodrug.... |
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T5148 |
Atosiban acetate
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RW22164,Atosiban acetate (90779-69-4 free base),RWJ22164 |
Oxytocin Receptor
,
Vasopressin Receptor
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Atosiban acetate (RW22164) is an inhibitor of the hormones oxytocin and vasopressin. It is used as an intravenous medication as a labour repressant (tocolytic) to halt premature labor. Atosiban acetate (RW22164) inhibits... |
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T6707 |
Tiotropium Bromide hydrate
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BA-679 BR hydrate,BA 679BR |
AChR
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Tiotropium Bromide hydrate (BA-679 BR hydrate) is a potent anticholinergic and bronchodilator, serving as a muscarinic receptor antagonist, specifically targeting mAChR. It is developed for treating chronic obstructive a... |
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T13673 |
EGTA-AM
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EGTA Acetoxymethyl ester |
Others
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EGTA-AM (EGTA Acetoxymethyl ester) is a calcium chelator, a metabolic biomarker of early-onset preeclampsia and late-onset preeclampsia. |
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T31732 |
Evogliptin HCl
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Evogliptin hydrochloride,DA 1229,DA1229,Evogliptin,DA-1229 |
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Evogliptin(DA-1229) is a potent and selective DPP4 inhibitor (dipeptidyl peptidase 4 inhibitor) that can improve insulin resistance and delays the onset of diabetes. Evogliptin delays the onset of diabetes in young db/db... |
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T23710 |
Watanidipine dihydrochloride
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|
|
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Watanidipine dihydrochloride is a novel dihydropyridine (DHP)-type calcium channel blocker with slow-onset pharmacological actions. |
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T71836 |
2-FPBA
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|
|
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2-FPBA is a potent, reversible and slow-onset inhibitor of mandelate racemase (MR). |
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T30250 |
AZD0865
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AZD-0865,AZD 0865 |
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AZD0865 is an effective drug that inhibits gastric H(+), K(+) -ATPase activity and acid formation in vitro, with rapid onset. |
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T71541 |
ASP9133
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|
|
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ASP9133 is a long-acting muscarinic antagonist (LAMA) which shows more selective inhibition of bronchoconstriction against salivation and more rapid onset of action than tiotropium bromide. |
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T26683 |
AUTEN-67
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Autophagy enhancer 67,MTMR14 inhibitor,AUTEN67 |
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AUTEN-67 is a specific inhibitor of MTMR14 and autophagy enhancer with potent antiaging and neuroprotective effects. AUTEN-67 also delays the onset and decreases the severity of Huntington's disease. |
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T69472 |
Edrophonium
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|
|
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Edrophonium is a rapid-onset, short-acting cholinesterase inhibitor used in cardiac arrhythmias and in the diagnosis of myasthenia gravis. It has also been used as an antidote to curare principles. |
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T32054 |
Heme arginate
|
Hemearginat,Heme arginate complex,Normosang |
|
|
Heme arginine (or heme arginine) is a compound of heme and arginine used to treat acute porphyria by reducing the excessive production of δ-aminolevulinic acid, which causes acute symptoms during the onset of acute porph... |
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T14682 |
BMS-962212
|
|
Others
|
|
BMS-962212, a direct, reversible, and selective factor XIa (FXIa) inhibitor, demonstrates fast pharmacodynamic (PD) response onset and rapid elimination with a well-tolerated profile. It dependently increases activated p... |
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T26920 |
Bucindolol hydrochloride
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MJ 131051,Bucindolol HCl,MJ131051,MJ-13105-1,MJ-131051 |
|
|
Bucindolol is a beta-adrenergic receptor antagonist. Bucindolol is a fourth-generation β-blocker. Bucindolol prevented new-onset AF; β₁ and α(2c) polymorphisms predicted therapeutic response; and the 47% of patients who ... |
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T25698 |
Levoprotiline
|
Levoprotilinum |
|
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Levoprotiline an antidepressant compound that is the R-(-) enantiomer of Oxaprotiline, acts comparably to Oxaprotiline and has a shorter latency to onset of action. It is the successor to the second-generation antidepres... |
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T76938 |
Camoteskimab
|
|
|
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Camoteskimab (AVTX-007), a fully human, high-affinity anti-IL-18 monoclonal antibody, holds promise for research into autoinflammatory diseases, such as adult-onset Still’s disease (AOSD) [1]. |
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T36858 |
C12 Galactosylceramide (d18:1/12:0)
|
|
|
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C12 Galactosylceramide is a bioactive sphingolipid. It inhibits IL-4 production by 53.84% in EL4 T cells when used at a concentration of 10 μM. C12 Galactosylceramide reduces the growth of human papillomavirus type 16-as... |
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T61091 |
P38-α MAPK-IN-4
|
|
|
|
p38-α MAPK-IN-4 (Compound 69) is a selective inhibitor of p38α MAPK, demonstrating potent inhibition with an IC50 of 1.5 μM. It effectively and swiftly mitigates the onset of mechanical allodynia (MA) in vivo [1]. |
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T82470 |
Endokinin C
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|
|
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Endokinin C, a peptide constituent of endokinin, functions as a neurotransmitter or modulator within the pain pathway. Pretreatment with this compound impedes the onset of scratching behavior and thermal hyperalgesia ind... |
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T63793 |
Tauro-ω-muricholic acid sodium
|
|
|
|
Tauro-ω-muricholic acid sodium (TωMCA sodium) is an analogue of tauro-α-muricholic acid, a bile acid of hepatic origin. Tauro-ω-muricholic acid sodium can be used as a serum marker for early onset neonatal sepsis (EOS) a... |
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T37319 |
5β-Dihydroprogesterone
|
|
|
|
5β-Dihydroprogesterone (5β-DHP) is a progesterone receptor agonist and metabolite of progesterone .1,2It is formed from progesterone by 5β-reductase.25β-DHP inhibits spontaneous contractions in isolated rat uterus when u... |
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T37367 |
Amyloid-β (1-42) Peptide (trifluoroacetate salt)
|
|
|
|
Amyloid-β (1-42) (Aβ42) is a neurotoxic 42-amino acid protein fragment found in amyloid plaques in postmortem cerebral cortex from patients with Alzheimer's disease.1,2,3Aggregation of Aβ42 results in the formation of ne... |
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T74284 |
SH379
|
|
|
|
SH379, a potent and orally active derivative of 2-methylpyrimidine-fused tricyclic diterpene, serves as an effective agent against late-onset hypogonadism. It significantly enhances the expression of StAR and 3β-HSD, cru... |
