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T12345 |
CBP/p300-IN-3
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P300/CBP-IN-3 |
Histone Acetyltransferase
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CBP/p300-IN-3 (P300/CBP-IN-3) is an inhibitor of p300/CBP histone acetyltransferase. |
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T39826 |
CBP/p300-IN-8
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CBP/p300-IN-8 |
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CBP/p300-IN-8 is a potent inhibitor of the CBP/P300 family of bromodomains . CBP/p300-IN-8 inhibits CBP ( IC 50 =0.01-0.1 μΜ) and BRD4 ( IC 50 =1-1000 μΜ) activity. |
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T40344 |
CBP/p300-IN-14
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CBP/p300-IN-14 |
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CBP/p300-IN-14, efficiently inhibits CBP/EP300 (lysine acetyltransferase) with an IC50 value of 3.3 nM. |
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T40143 |
PROTAC CBP/P300 Degrader-1
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PROTAC CBP/P300 Degrader-1 |
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PROTAC CBP/P300 Degrader-1 is an effective compound that degrades CBP/P300 in a potent manner. It significantly reduces cell viability in various cancer cell lines. |
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T40142 |
Thalidomide-NH-CBP/p300 ligand 2
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Thalidomide-NH-CBP/p300 ligand 2 |
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Thalidomide-NH-CBP/p300 ligand 2 (P-007) is a PROTAC-based compound designed to degrade CBP and p300, acting as a functional antagonist (WO2020173440). |
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T12346 |
CBP/p300-IN-5
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P300/CBP-IN-5 |
Epigenetic Reader Domain
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P300/CBP-IN-5 is a potent inhibitor of p300/CBP histone acetyltransferase (IC50 of 18.8 nM). |
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T77560 |
Histone acetyltransferase p300 Inhibitor 4c
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Carbonic Anhydrase
,
AChE
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Histone acetyltransferase p300 Inhibitor 4c is a 2-aminothiazole derivative. Histone acetyltransferase p300 Inhibitor 4c inhibited hCA I, hCA II, AChE and BChE with Ki values of 0.008 ± 0.001, 0.124 ± 0.017, 0.129 ± 0.03... |
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T40144 |
CBP/p300 ligand 2
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CBP/p300 ligand 2 is a selective ligand that binds to the target protein for PROTAC of dCBP-1, a potent and selective heterobifunctional degrader of p300/CBP. |
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T10702 |
CBP/p300-IN-2
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CBP/EP300-IN-2 |
Epigenetic Reader Domain
,
c-Myc
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CBP/EP300-IN-2 is an inhibitor of CBP/EP300 (IC50s: 1.07 nM and 5.96 nM for CBP/HTRF and Myc). |
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T63122 |
CBP/p300-IN-19
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CBP/p300-IN-19 is a potent inhibitor of p300/CBP HAT, which can act on P300-HAT (IC50: 1.4 μM), CBP-HAT (IC50: 1.4 μm), 2.2 μM), PCAF (IC50>100 μM), and Myst3 (IC50>100 μM). CBP/p300-IN-19 has anti-tumor activity. |
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T63110 |
CBP/p300-IN-15
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CBP/p300-IN-15 (compound 13a) is a potent inhibitor of p300 (IC50: 2.5 nM) and CBP (IC50: 28.0 nM). p300-IN-15 inhibits OVCAR-3 cells (EC50: 0.865 μM) and A2780 cells (EC50. 2.71 μM). 2.71 μM). CBP/p300-IN-15 can be used... |
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T63767 |
P300 bromodomain-IN-1
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P300 bromodomain-IN-1 is a potent inhibitor of p300 (EP300) bromodomain (IC50: 49 nM). p300 bromodomain-IN-1 blocks c-Myc expression and induces cell cycle arrest at G1/G0 phase and apoptosis in OPM-2 cells. apoptosis). |
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T62720 |
CBP/p300-IN-18
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CBP/p300-IN-18 (compound 8) is a potent inhibitor of EP300/CBP HAT, acting on HAT EP300 (IC50: 0.056 μM) and LK2 H3K27 (IC50: 0.46 μM). |
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T62415 |
CBP/p300-IN-17
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CBP/p300-IN-17 (compound 7) is a potent inhibitor of EP300/CBP HAT, acting on HAT EP300 (IC50: 0.18 μM) and LK2 H3K27 (IC50: 0.69 μM). |
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T79395 |
CBP/p300-IN-21
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Epigenetic Reader Domain
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CBP/p300-IN-21 (Compound 5d), a selective inhibitor of CBP/p300 with IC50 values of 0.07 μM for p300 and 1.755 μM for CBP, reduces H3K18Ac levels and inhibits the growth of 4T1 tumors in mice [1]. |
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T62700 |
CBP/p300-IN-16
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CBP/p300-IN-16 (compound 1) is a potent inhibitor of EP300/CBP HAT, acting on HAT EP300 (IC50: 0.61 μM) and LK2 H3K27 (IC50: 2.24 μM). |
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T72815 |
CBP/p300-IN-10
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CBP/p300-IN-10, a potent inhibitor targeting histone acetyltransferase enzymes EP300 and CREBBP, exhibits IC50 values of 26 nM and 39 nM, respectively. This compound shows potential for anticancer research applications. |
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T63565 |
CBP/p300-IN-19 hydrochloride
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CBP/p300-IN-19 hydrochloride is a selective and potent inhibitor of p300/CBP HAT, capable of acting on p300-HAT (IC50: 1.4 μM), CBP-HAT (IC50: 2.2 μM), PCAF (IC50>100 μM), Myst3 (IC50>100 μM). CBP/p300-IN-19 hydrochlorid... |
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T11807 |
L002
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Others
,
Histone Acetyltransferase
,
STAT
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L002, a potent, cell-permeable, reversible, and specific acetyltransferase p300 (KAT3B) inhibitor with an IC50 of 1.98 μM, directly binds the acetyl-CoA pocket and competitively inhibits the FATp300 catalytic domain. By ... |
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T9370 |
DCBP-1
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Epigenetic Reader Domain
,
Ligand for E3 Ligase
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dCBP-1 is a chemical degrader of p300/CBP. dCBP-1 hijacks the E3 ubiquitin ligase CRBN for selective degradation of p300/CBP. Degradation of p300/CBP by dCBP-1 leads to effective multiple myeloma cell killing. |
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T8778 |
TTK21
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Epigenetic Reader Domain
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TTK21 is an activator of CBP/p300 histone acetyltransferase activity. |
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T3635 |
IQ 1
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IQ1,IQ-1 |
Wnt/beta-catenin
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IQ 1 has multiple roles, such as maintaining the multifunctionality of mouse ESCs, decreasing Wnt-stimulated phosphorylation, blocking PP2A/Nkd interactions, and so on. |
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T8658 |
NEO2734
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EP31670 |
Epigenetic Reader Domain
,
Histone Acetyltransferase
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NEO2734 (EP31670) is an orally active and selective inhibitor of p300/CBP and BET bromodomain(IC50 of <30 nM for both p300/CBP and BET bromodomains). |
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T9373 |
DCH36_06
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(5E)-1-(3-chloro-4-methylphenyl)-5-[(2E)-3-(furan-2-yl)prop-2-en-1-ylidene]-2-thioxodihydropyrimidine-4,6(1H,5H)-dione |
Apoptosis
,
Epigenetic Reader Domain
,
Histone Acetyltransferase
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DCH36_06 ((5E)-1-(3-chloro-4-methylphenyl)-5-[(2E)-3-(furan-2-yl)prop-2-en-1-ylidene]-2-thioxodihydropyrimidine-4,6(1H,5H)-dione) as a bona fide is a potent p300/CBP inhibitor |
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T7264 |
CBP/EP300-IN-1
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Epigenetic Reader Domain
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CBP/EP300-IN-1 is a CBP/EP300 bromodomain inhibitor. |
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T73920 |
Ep300/CREBBP-IN-8
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Ep300/CREBBP-IN-8 (Example 37), a potent and orally active inhibitor of both Ep300 and CREBBP, exhibits IC50 values of 0.014 μM and 0.018 μM, respectively. This compound is utilized in cancer research [1]. |
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T41181 |
IP300v
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iP300v is a negative control for iP300w |
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T73923 |
Ep300/CREBBP-IN-4
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Ep300/CREBBP-IN-4 (Example 56), a highly effective inhibitor targeting both Ep300 and CREBBP, exhibits IC50 values of 0.024 μM and 0.064 μM, respectively. This compound is utilized in cancer research [1]. |
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T73921 |
Ep300/CREBBP-IN-2
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Ep300/CREBBP-IN-2 (Example 73), a powerful and orally bioavailable inhibitor targeting Ep300 and CREBBP, demonstrates IC50 values of 0.052 μM and 0.148 μM, respectively. This compound is employed in cancer research [1]. |
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T73922 |
Ep300/CREBBP-IN-3
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Ep300/CREBBP-IN-3 (Example 61), a potent inhibitor of Ep300 and CREBBP, exhibits IC50 values of 0.056 μM and 0.095 μM, respectively. This compound is applicable in cancer research [1]. |
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T14073 |
A-485
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Epigenetic Reader Domain
,
Histone Acetyltransferase
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A-485 is a potent and selective catalytic p300/CBP inhibitor(IC50s of 9.8 nM and 2.6 nM for p300 and CBP, respectively). |
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T2452 |
C646
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Apoptosis
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Epigenetic Reader Domain
,
Histone Acetyltransferase
,
Autophagy
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C646, a histone acetyltransferase inhibitor, inhibits p300 (Ki: 400 nM, in a cell-free assay). |
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T3969 |
I-CBP112
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Epigenetic Reader Domain
,
Histone Acetyltransferase
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I-CBP112 is a specific and potent acetyl-lysine competitive protein-protein interaction inhibitor targeting the CBP/p300 bromodomains. |
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T15216 |
EML 425
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Epigenetic Reader Domain
,
Histone Acetyltransferase
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EML 425 is a potent and selective inhibitor of CREB binding protein (CBP)/p300 (IC50s: 2.9 and 1.1 μM, respectively). |
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T11563 |
Histone Acetyltransferase Inhibitor II
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Epigenetic Reader Domain
,
Histone Acetyltransferase
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Histone Acetyltransferase Inhibitor II is a selective and cell permeable inhibitor of p300 histone acetyltransferase(IC50 : 5 μM).with anti-acetylase activity in mammalian cells. |
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T3973 |
PF-CBP1
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Epigenetic Reader Domain
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PF-CBP1 HCl is a highly selective inhibitor of the bromodomain of CREB-binding protein(CREBBP). It inhibits CREBBP (IC50: 125 nM) and p300 bromodomains (IC50: 363 nM). |
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T28471 |
PU139
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PU 139,PU-139 |
Histone Acetyltransferase
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PU139 is a novel inhibitor of histone acetyltransferase (HAT). |
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T15014 |
CTPB
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Histone Acetyltransferase
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CTPB is a potent p300 histone acetyltransferase (HAT) activator that can be used in the preparation of hair growth promoters and/or hair loss treatments. |
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T69691 |
Pocenbrodib
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FT-7051,P-300 |
Epigenetic Reader Domain
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Pocenbrodib (FT-7051) is a potent inhibitor of the bromodomain of the CBP/p300 family with potential antitumour activity and is palatable for cancer research. |
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T10717 |
Inobrodib
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CBP-IN-1 |
Epigenetic Reader Domain
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Inobrodib (CBP-IN-1) is a potent inhibitor of p300/CBP bromodomain. |
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T9541 |
CTB
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Cholera Toxin B subunit |
Epigenetic Reader Domain
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CTB (Cholera Toxin B subunit) is an activator of p300 histone acetyltransferase and induces apoptosis in MCF-7 cells. |
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T9194 |
UMB298
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Epigenetic Reader Domain
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UMB298 is a potent and selective CBP/P300 bromodomain inhibitor. UMB298 inhibits BRD4 with IC50 of 5193nM. |
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T2237 |
ICG001
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Epigenetic Reader Domain
,
Wnt/beta-catenin
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ICG001 (PRI-724 isomer) antagonizes Wnt/β-catenin/TCF-mediated transcription and specifically binds to element-binding protein (CREB)-binding protein (CBP) with IC50 of 3 μM, but is not the related transcriptional coacti... |
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T6113 |
ICG-001
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Apoptosis
,
Epigenetic Reader Domain
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Wnt/beta-catenin
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ICG-001 antagonizes Wnt/β-catenin/TCF-mediated transcription and specifically binds to element-binding protein (CBP) with IC50 of 3 μM, but is not the related transcriptional coactivator p300. |
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T3217 |
PF-CBP1 hydrochloride
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PF-CBP1 HCl |
Epigenetic Reader Domain
,
Histone Acetyltransferase
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PF-CBP1 hydrochloride (PF-CBP1 HCl) is a highly selective inhibitor of the bromodomain of CREB-binding protein(CREBBP).It inhibits CREBBP and p300 bromodomains with IC50 of 125 and 363 nM respectively. |
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T60558 |
NSC 694623
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Histone Acetyltransferase
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NSC 694623 is a potent histone acetyltransferase (HAT) inhibitor with IC50 of 15.9 μM against recombinant HAT p300/CBP associated factor (PCAF). NSC 694623 shows anti-proliferative activity against some cancer cells, whi... |
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T10641 |
C-82
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Epigenetic Reader Domain
,
Wnt/beta-catenin
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C-82 is a specific CBP/β-catenin antagonist. It inhibits the binding between β-catenin and CBP and increases the binding between β-catenin and p300. |
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T6668 |
SGC-CBP30
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Epigenetic Reader Domain
,
Histone Acetyltransferase
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SGC-CBP30 is an effective CREBBP/EP300 inhibitor (IC50: 21/38 nM). |
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T23820 |
BRD32048
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BRD-32048,BRD 32048 |
DNA/RNA Synthesis
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BRD32048 is the ETV1 transcription factor oncoprotein inhibitor. |
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T4247 |
I-CBP112 hydrochloride
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Epigenetic Reader Domain
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I-CBP112 is a selective inhibitor of the bromodomain-containing transcription factors. I-CBP112 (1 mM) has little activity against other bromodomains. I-CBP112 targets the CBP/p300 bromodomains. I-CBP112 significantly re... |
