Ba/F3 | TargetMol

カタログ番号	製品名	別名	ターゲット
T1817	GNF-2	GNF2	SARS-CoV , Bcr-Abl
	GNF-2 is a highly selective non-ATP competitive inhibitor of Bcr-Abl.		SARS-CoV , Bcr-Abl
T9072	Tuxobertinib	BDTX-189	EGFR , HER , BTK , RIP kinase
	Tuxobertinib (BDTX-189) is a potent and selective inhibitor of allosteric EGFR and HER2 oncogenic mutations(KDs of 0.2, 0.76, 13 and 1.2 nM for EGFR, HER2, BLK and RIPK2, reapectively). BDTX-189 exhibits anticancer activ...		EGFR , HER , BTK , RIP kinase
T2490	Osimertinib	AZD-9291,Mereletinib	EGFR
	Osimertinib (AZD-9291) is an EGFR third-generation inhibitor that inhibits the T790M resistance mutation produced by second-generation EGFR inhibitors with irreversible and oral activity. Osimertinib has antitumor activi...		EGFR
T3634	Osimertinib mesylate	Mereletinib mesylate,AZD-9291 mesylate	EGFR
	Osimertinib mesylate (Mereletinib mesylate) is an irreversible and mutant selective EGFR inhibitor (IC50s: 12/1 nM for EGFR(L858R) and EGFR(L858R/T790M)).		EGFR
T71857	GTP-14564		FLT , Tyrosine Kinases
	GTP-14564 is a novel tyrosine kinase inhibitor that also inhibits wt-FLT3 and ITD-FLT3. GTP-14564 inhibits the growth of interleukin-3-independent Ba/F1 expressing ITD-FLT3 at 3 μ m, whereas a 30-fold higher concentratio...		FLT , Tyrosine Kinases
T80676	AKE-72		Bcr-Abl
	AKE-72 is a Pan-BCR-ABL inhibitor with anti-leukemic activity.AKE-72 inhibits the proliferation of Ba/F3 cells expressing natural BCR-ABL or its T315I mutant.		Bcr-Abl
T67894	Butyzamide		Thrombopoietin Receptor , JAK
	Butyzamide is an effective and oral Mpl activator. It is a novel non-peptide-based molecule with antagonistic effects on thrombopoietin (TPO) receptors, which promotes proliferation of human Mpl (hMpl) expression and mou...		Thrombopoietin Receptor , JAK
T17927	(S,R,S)-AHPC TFA	VH032-NH2 TFA,VHL ligand 1 TFA	Others , Ligand for E3 Ligase
	(S,R,S)-AHPC TFA (VHL ligand 1 TFA) (VH032-NH2 TFA) is a VH032-based ligand designed for von Hippel-Lindau (VHL) protein recruitment. This compound can be linked to protein ligands (e.g., BCR-ABL1) using a linker to crea...		Others , Ligand for E3 Ligase
T5177	Asciminib	ABL001	Bcr-Abl
	Asciminib (ABL001) (ABL001) is a potent and selective Bcr-Abl inhibitor (Kd: 0.5–0.8nM).		Bcr-Abl
T35900	JAK2-IN-7	JAK2-IN-7	JAK
	JAK2-IN-7, a selective inhibitor targeting Janus Kinase 2 (JAK2), exhibits inhibitory concentrations (IC50) of 3 nM for JAK2, 11.7 nM for SET-2 cells, and 41 nM for Ba/F3 V617F cells, indicative of its potency and select...		JAK
T6097	GNF-5837	GNF 5837	Trk receptor , PDGFR , c-Kit
	GNF-5837 is a specific, and orally bioavailable pan-TRK inhibitor for TrkA/TrkB (IC50: 8/12 nM).		Trk receptor , PDGFR , c-Kit
T15480	HG6-64-1	HMSL 10017-101-1	Others
	HG6-64-1 is a potent and selective inhibitor of B-Raf (IC50: 0.09 μM on B-raf V600E transformed Ba/F3 cells).		Others
T39732	BCR-ABL-IN-3
	BCR-ABL-IN-3 is a highly effective and irreversibly binding inhibitor of Bcr-Abl, displaying a remarkable potency with an IC50 value of ≤100 nM for Ba/F3 Bcr-Abl T3151. This compound exhibits significant anti-cancer acti...
T63643	BI-4142		HER
	BI-4142 is an orally active, potent and selective HER2 inhibitor that inhibits cancer cell proliferation, suppresses her2-dependent cell lines and inhibits downstream signalling.		HER
T63226	Asciminib hydrochloride
	Asciminib (ABL001) hydrochloride is a selective and potent mutant BCR-ABL1 inhibitor that inhibits Ba/F3 cell growth (IC50: 0.25 nM).
T62531	TRK-IN-12
	TRK-IN-12 (Compound 9e), a macrocyclic derivative, is a potent TRK inhibitor, with efficacy against TRK G595R (IC 50 = 13.1 nM). It demonstrates significant antiproliferative activity in the Ba/F3-LMNA-NTRK1 cell line (I...
T83146	ALK-IN-27
	ALK-IN-27 (compound 1) is a potent ALK inhibitor exhibiting antitumor activity, with an IC50 of 2.7 nM in Ba/F3 CLIP1-LTK cells [1].
T78968	TRK-IN-23		Trk receptor
	TRK-IN-23 (compound 24b) is a potent, orally active inhibitor of TRK with IC50s of 0.5 nM for TRKA, 9 nM for TRKC, 14 nM for TRKA G595R, 4.4 nM for TRKA F589L, and 4.8 nM for TRKA G667C. It induces apoptosis in Ba/F3-TRK...		Trk receptor
T39896	ALK-IN-9
	ALK-IN-9 (compound 40) is a highly effective ALK inhibitor. It demonstrates remarkable inhibitory activity against cell proliferation, with IC50 values of <0.2 nM for Ba/F3-EML4-ALK, KM 12 (TPM3-TRKA), and KG-l cell (OP2...
T67699L	ALK/ROS1 inhibitor 2e HCL	(R)-1-(2-((2-methoxy-4-(piperazin-1-yl)phenyl)amino)pyridin-4-yl)-N-(4-(trifluoromethoxy)benzyl)piperidine-3-carboxamide hydrochloride(2365497-12-5 Free base)	Apoptosis
	ALK/ROS1 inhibitor 2e HCL possesses anti-apoptotic, anti-proliferative and anti-tumour activities.		Apoptosis
T63932	BCR-ABL-IN-4
	BCR-ABL-IN-4 is a BCR-ABLL inhibitor that exhibits anticancer activity.BCR-ABL-IN-4 has an inhibitory effect on cancer cell growth and is able to act on K562 cells (IC50: 0.67 nM) and BCR-ABL T315I-transfected Ba/F3 cell...
T72289	Type II TRK inhibitor 1		Trk receptor
	Type II TRK Inhibitor 1 is a potent inhibitor targeting multiple tropomyosin receptor kinase (TRK) fusion protein variants as well as the wild type. It demonstrates notable antiproliferative effects on Ba/F3 cells expres...		Trk receptor
T79420	FLT3-IN-22
	FLT3-IN-22 (compound 22f) is a potent inhibitor of FLT3, demonstrating IC50 values of 0.941 nM for FLT3 and 0.199 nM for the FLT3/D835Y mutant. This compound displays significant antiproliferative effects against MV4-11 ...
T37443	Aspochalasin D
	Aspochalasin D is a co-metabolite originally isolated from A. microcysticus with aspochalasins A, B, and C, that was initially thought to be inactive. It has antibacterial activity against Gram-positive and Gram-negative...
T63573	WF-47-JS03
	WF-47-JS03 is a selective and potent inhibitor of RET kinase that crosses the blood-brain barrier and is more than 500-fold more selective for the kinase insertion domain receptor (KDR).WF-47-JS03 acts on Ba/F3 cells tra...
T79706	TRK-IN-24		Trk receptor
	TRK-IN-24 (compound 10g) is a selective inhibitor of Trk receptors, effectively targeting TRKA, TRKC, and mutant forms TRKA G595R, TRKA G667C, and TRKA F589L, with IC50 values of 5.21, 4.51, 6.77, 1.42, and 6.13 nM, resp...		Trk receptor
T68581	AP23464
	AP23464 is a potent adenosine 5'-triphosphate (ATP)-based inhibitor of Src and Abl kinases, displays antiproliferative activity against a human CML cell line and Bcr-Abl-transduced Ba/F3 cells (IC(50) = 14 nM. AP23464 ab...