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Search Results for " EMT "

ターゲット

阻害剤

天然化合物

リコンビナントタンパク質

カタログ番号	製品名	別名	ターゲット
T11190	EMT inhibitor-1		Wnt/beta-catenin
	EMT inhibitor-1 is an inhibitor of Hippo, Wnt signaling and TGF- macrophages (TGF-) with antitumor activity.		Wnt/beta-catenin
T11187	EMT inhibitor-2		Others
	EMT Inhibitor-2, targeting both CYP3A4 testosteron and CYP2C9, exhibits inhibitory effects with IC50 values of 49.72 and 5.54 μM, respectively. Furthermore, it effectively impedes the epithelial-mesenchymal transition (E...		Others
T21981	Phthalazinone pyrazole		Aurora Kinase
	Phthalazinone pyrazole is potent, selective, and orally bioavailable inhibitor of Aurora-A kinase. Aurora-A is overexpressed in a variety of tumor types and displays oncogenic activity.		Aurora Kinase
T9205	NCGC00378430		Phosphatase , Others
	NCGC00378430 is a potent SIX1/EYA2 interaction inhibitor that disrupts the SIX1/EYA2 complex, EMT, and Metastasis.		Phosphatase , Others
T15735	Leptomycin B	CI 940,LMB	CRM1 , Antibiotic , Antifungal
	Leptomycin B (LMB) is a potent inhibitor of the nuclear export of proteins and is a potent antifungal antibiotic blocking the eukaryotic cell cycle. Leptomycin B inactivates CRM1/exportin 1 by covalent modification at a ...		CRM1 , Antibiotic , Antifungal
T0459	Sulindac	Arthrocine,MK-231,Clinoril,Sulindac sulfoxide	COX , Autophagy
	Sulindac (Sulindac sulfoxide) is a sulfinylindene derivative prodrug with potential antineoplastic activity. Converted in vivo to an active metabolite, sulindac, a nonsteroidal anti-inflammatory drug (NSAID), blocks cycl...		COX , Autophagy
T9919	Alemtuzumab		Others
	Alemtuzumab is a humanized monoclonal antibody against CD52 an antigen found on the surface of normal and malignant lymphocytes.		Others
T64167	Ifebemtinib	IN-10018,BI-853520	FAK
	Ifebemtinib (BI-853520) is an orally active and potent inhibitor of adhesion plaque kinase (FAK) (IC50=1 nM) with anti-tumour activity that inhibits globule formation and in situ tumour growth in malignant pleural mesoth...		FAK
T76890	Petosemtamab	MCLA 158	EGFR
	Petosemtamab (MCLA 158) is a highly potent monoclonal antibody against EGFR (Kd: 0.22 nM) and LGR5 (Kd: 0.86 nM). Petosemtamab promotes EGFR signaling disruption and receptor breakdown in LGR5+ cancer cells. Petosemtamab...		EGFR
T64167L	Ifebemtinib FA	BI-853520 FA（1227948-82-4 Free base)	FAK
	Ifebemtinib FA (BI-853520 FA) is an orally active and potent inhibitor of adhesion patch kinase (FAK) with anticancer and antiproliferative activity for the study of ovarian and lung cancer.		FAK
T9901A-003	Gemtuzumab	CDP-771,CMA-676
	Gemtuzumab(CMA-676) is a monoclonal antibody directed against the CD33 antigen and consists of a recombinant humanized IgG4 antibody.Gemtuzumab can be used to synthesize Gemtuzumab ozogamicin, an antibody coupled compoun...
T16728	Reldesemtiv	CK-2127107	Others
	Reldesemtiv (CK-2127107) is a selective activator of fast skeletal muscle troponin with an EC50 of 3.4 μM. Reldesemtiv increases exercise performance in the heart failure model.		Others
T6214	Emtricitabine	FTC,Emtriva,BW1592	HIV Protease , Reverse Transcriptase
	Emtricitabine (FTC) (FTC), a nucleoside reverse transcriptase inhibitor, exhibits inhibition activity against human immunodeficiency virus (HIV) and hepatitis B virus.		HIV Protease , Reverse Transcriptase
T3966	Tirasemtiv	CK-2017357	Others
	Tirasemtiv (CK-2017357)(CK 2017357) is a small-molecule fast-skeletal-troponin activator, with a potential treatment for muscle weakness and neuromuscular dysfunction.		Others
T11189	Emtricitabine S-oxide	Emtricitabine Degradant-III,Emtricitabine sulfoxide	HIV Protease , Reverse Transcriptase
			HIV Protease , Reverse Transcriptase
T77179	Remtolumab
	Remtolumab (ABT-122), a dual-variable domain immunoglobulin, neutralizes tumor necrosis factor α (TNFα) and IL-17A, demonstrating dual inhibition of both. This compound is utilized in rheumatoid arthritis (RA) research [...
T69639	Sevasemten
	Sevasemten is an allosteric inhibitor that targets skeletal muscle myosin. It displays selectivity in its inhibition, demonstrated by IC50 values of ≤10 μM for skeletal muscle myosin and >100 μM for cardiac myosin, respe...
T36647	Trastuzumab emtansine		Others
	Trastuzumab emtansine (Ado-Trastuzumab emtansine) is an antibody-drug conjugate (ADC) that combines the HER2-targeted antitumor properties of trastuzumab with the cytotoxic activity of DM1, a microtubule-inhibitory deriv...		Others
T77176	Elgemtumab
	Elgemtumab (LJM716) is a fully human IgG monoclonal antibody that specifically targets HER3, inhibiting both ligand-dependent and independent HER3 signal transduction and cell proliferation. This function showcases its s...
T70596	Emtricitabine triphosphate	(-)-Emtricitabine triphosphate
	Emtricitabine triphosphate ((-)-Emtricitabine triphosphate), the phosphorylated anabolite of Emtricitabine, serves as a nucleoside reverse transcriptase inhibitor and antiretroviral agent against HIV and HBV [1] [2].
T80566	Temtokibart
	Temtokibart is a humanized IgG1 λ2 antibody that specifically targets IL22RA1, and is expressed by cells that are deficient in the glutamine synthetase gene.
T81299	Remternetug	LY3372993
	Remternetug is a humanized IgG1-kappa monoclonal antibody that targets the N3pGlu peptide of the amyloid beta A4 precursor protein (APP) Aβ42. It specifically binds to the pyroglutamate-modified form of Aβ, which is impl...
T78131	Emtricitabine triphosphate tetrasodium salt	(-)-Emtricitabine triphosphate tetrasodium salt	Reverse Transcriptase
	Emtricitabine triphosphate tetrasodium salt is the tetrasodium salt form of the phosphorylated anabolite (-)-Emtricitabine triphosphate, an active nucleoside reverse transcriptase inhibitor that is effective against HIV ...		Reverse Transcriptase
T71868	Cemtirestat
	Cemtirestat is an aldose reductase inhibitor
T75029	HEMTAC CDK4/6 degrader 1
	HEMTAC CDK4/6 degrader 1 is a PROTAC connected by ligands for HSP90 and CDK4/6 with a K d value of 35.7 μM. HEMTAC CDK4/6 degrader 1 induces CDK4/6 degradation in B16F10 melanoma cells. HEMTAC CDK4/6 degrader 1 arrests c...
T78047	Gemtuzumab ozogamicin
	Gemtuzumab ozogamicin is an antibody-drug conjugate (ADC) that comprises a monoclonal antibody specific to CD33 conjugated to a cytotoxic agent derived from Calicheamicin. It is utilized in the investigation of acute mye...
T73009	Vemtoberant
	Vemtoberant, a β3 Adrenergic Receptor antagonist, is utilized in the research of disorders mediated by the β3 adrenergic receptor, including heart failure.
T4252	ML327		c-Myc , Autophagy
	ML327 is a MYC blocker. ML327 can also de-repress E-cadherin transcription and reverse Epithelial-to-Mesenchymal Transition (EMT).		c-Myc , Autophagy
T73300	AXL-IN-13		FLT , TAM Receptor , PDGFR , TGF-beta/Smad
	AXL-IN-13 is a potent and orally active AXL inhibitor with an IC50 value of 1.6 nM and a Kd value of 0.26 nM.AXL-IN-13 exhibits anticancer activity, reverses TGF-β1-induced epithelial-mesenchymal transition (EMT) and inh...		FLT , TAM Receptor , PDGFR , TGF-beta/Smad
T38752	EW-7195		ALK , TGF-beta/Smad
	EW-7195 is a selective and potent inhibitor of ALK5 (TGFβR1) with an IC50 value of 4.83 nM.EW-7195 has an affinity for ALK5 that is more than 300-fold higher than that of p38α.EW-7195 has an inhibitory effect on TGF-β1-i...		ALK , TGF-beta/Smad
T11793	KY-05009		Wnt/beta-catenin
	KY-05009 is a chemical compound that effectively suppresses TGF-β1-induced epithelial-to-mesenchymal transition (EMT) in human lung adenocarcinoma cells, reduces TNIK protein expression and the transcriptional activity o...		Wnt/beta-catenin
T36696	DMBA
	7,12-Dimethylbenz[a]anthracene (DMBA) is a polycyclic aromatic hydrocarbon (PAH) that has been found in tobacco smoke and diesel exhaust and has carcinogenic activity.1,2It undergoes metabolic activation by numerous enzy...
T70841	Osteosarcoma-IN-D14
	Osteosarcoma-IN-D14 is an inhibitor of migration and invasion of osteosarcoma cells mediated by p53, regulating EMT-related genes.
T83075	Anticancer agent 94
	Anticancer agent 94, a 4-Hydroxycoumarin derivative, inhibits lung cancer cell invasion and migration by modulating the expression of epithelial-mesenchymal transition (EMT) effectors [1].
T83076	Anticancer agent 93
	Anticancer Agent 93, a 4-Hydroxycoumarin derivative, inhibits the invasion and migration of lung cancer cells through modulation of epithelial-mesenchymal transition (EMT) effector expression [1].
T72880	PI3K/AKT-IN-2
	PI3K/AKT-IN-2, a dual inhibitor of PI3K and AKT, prevents the epithelial-mesenchymal transition (EMT) and promotes apoptosis. Additionally, it impedes tubulin polymerization.
T73035	STAT3-IN-15
	STAT3-IN-15, a potent and orally active inhibitor targeting STAT3, effectively combats idiopathic pulmonary fibrosis (IPF) by hindering STAT3 phosphorylation. Additionally, it impedes TGF-β1-induced migration and deforma...
T73039	CYP1B1-IN-3
	CYP1B1-IN-3 is a potent, selective inhibitor of CYP1B1, exhibiting IC50 values of 6.6 nM for CYP1B1, 347.3 nM for CYP1A1, and >10000 nM for CYP1A2. It also impedes cell migration and invasion, and inhibits the P-gp, AKT/...
T73547	CPUL1
	CPUL1, a TrxR inhibitor, exhibits proliferation-inhibitory and anti-metastatic effects on A549 cells by modulating epithelial-mesenchymal transition (EMT) through the induction of ROS-mediated ERK/JNK signaling, achieved...
T63768	Antitumor agent-78
	Antitumor agent-78 inhibits GPx-4 and elevates COX2, leading to ferroptosis. antitumor agent-78 activates the tumor cell intrinsic apoptotic pathway (Bax-Bcl-2-caspase-3) and inhibits the epithelial mesenchymal transitio...
T62822	CT1-3
	CT1-3 is a potent anti-cancer agent. CT1-3 regulates the JNK/Bcl-2/Bax/XIAP pathway, which induces mitochondria-mediated apoptosis. CT1-3 regulates the E-cadherin/Snail axis to inhibit epithelial mesenchymal transition (...
T62814	Antitumor agent-77
	Antitumor agent-77 inhibits the growth and migration of cancer cells and has anticancer effects. antitumor agent-77 inhibits GPx-4 and enhances COX2-induced iron sagging. antitumor agent-77 activates the intrinsic apopto...
T61585	Sulindac sodium
	Sulindac (sodium) (MK-231) is an orally active nonsteroidal anti-inflammatory agent. Sulindac (sodium) is used to reduce pain, swelling, and joint stiffness from arthritis. Sulindac is also used for the research of arthr...
T36497	CAY10735	CAY10735
	CAY10735 is an anticancer compound.1 It inhibits proliferation in a panel of melanoma and breast, pancreatic, and lung cancer cell lines (IC50s = 0.674-11.56 μM). CAY10735 inhibits migration of and the epithelial-to-mese...
T71884	ß-Carboline-1-carboxylic acid
	β-Carboline-1-carboxylic acid is an alkaloid that has been found in P. quassioides and has diverse biological activities. It reduces LPS-induced increases in MCP-1, TNF-α, IL-6, and IL-1β levels in RAW 264.7 cells when u...
T36460	CAY10736	CAY10736
	CAY10736 is an anticancer compound.1 It inhibits proliferation in a panel of melanoma and breast, pancreatic, and lung cancer cell lines (IC50s = 0.827-9.89 μM). CAY10736 inhibits migration and epithelial-to-mesenchymal ...
T79789	DT-6		TGF-beta/Smad
	DT-6, a potent TGF-β1 inhibitor, impedes M2 macrophage-induced epithelial-to-mesenchymal transition and the invasive migration of cancer cells, thereby showing potential for cancer research applications [1].		TGF-beta/Smad
T82673	CPF-7	Caerulein precursor fragment
	CPF-7 (Caerulein precursor fragment), an insulinotropic peptide, promotes insulin secretion and drives epithelial-mesenchymal transition via Snai1 upregulation in PANC-1 ductal cells. Moreover, it induces exocrine plasti...
T69685	AGPS-IN-2i		MMP
	AGPS-IN-2i is a potent and high-affinity inhibitor of alkylglycerol phosphate synthase that controls ether lipid utilization and metabolism in cells, reduces ether lipid levels and cell migration, and promotes proliferat...		MMP

Compounds

EMT inhibitor-1

T11190

Synonym:

Target: Wnt/beta-catenin

Phthalazinone pyrazole

T21981

Synonym:

Target: Aurora Kinase

NCGC00378430

T9205

Synonym:

Target: Phosphatase, Others

Leptomycin B

T15735

Synonym: CI 940,LMB

Target: CRM1, Antibiotic, Antifungal

Sulindac

T0459

Synonym: Arthrocine,MK-231,Clinoril,Sulindac sulfoxide

Target: COX, Autophagy

Synonym: IN-10018,BI-853520

Synonym: BI-853520 FA（1227948-82-4 Free base)

Target: FAK

Gemtuzumab

T9901A-003

Synonym: CDP-771,CMA-676

Synonym: FTC,Emtriva,BW1592

Target: HIV Protease, Reverse Transcriptase

Emtricitabine S-oxide

T11189

Synonym: Emtricitabine Degradant-III,Emtricitabine sulfoxide

Target: HIV Protease, Reverse Transcriptase

Trastuzumab emtansine

Emtricitabine triphosphate

T70596

Synonym: (-)-Emtricitabine triphosphate

Emtricitabine triphosphate tetrasodium salt

T78131

Synonym: (-)-Emtricitabine triphosphate tetrasodium salt

Target: Reverse Transcriptase

HEMTAC CDK4/6 degrader 1

T75029

Synonym:

Target:

Gemtuzumab ozogamicin

Target: c-Myc, Autophagy

AXL-IN-13

T73300

Synonym:

Target: FLT, TAM Receptor, PDGFR, TGF-beta/Smad

EW-7195

T38752

Synonym:

Target: ALK, TGF-beta/Smad

KY-05009

T11793

Synonym:

Target: Wnt/beta-catenin

ß-Carboline-1-carboxylic acid

Target: TGF-beta/Smad

CPF-7

T82673

Synonym: Caerulein precursor fragment

カタログ番号	製品名	別名	ターゲット
T13741	Isoviolanthin		Others
	Isoviolanthin reduces the migratory and invasive capacities of TGF-β1-treated HCC cells without cytotoxic effects on normal live cells and has potential as a therapeutic agent for the treatment of advanced-stage metastat...		Others
T0518	Methacycline hydrochloride	Rondomycin,Methacycline HCl	ribosome , Antibacterial , Antibiotic
	Methacycline hydrochloride (Rondomycin) is a broad-spectrum semisynthetic antibiotic related to TETRACYCLINE but excreted more slowly and maintaining effective blood levels for a more extended period.		ribosome , Antibacterial , Antibiotic
TN1088	3,5,6,7,8,3',4'-Heptemthoxyflavone	3,3',4',5,6,7,8-heptamethoxyflavone	Others
	3,5,6,7,8,3',4'-Heptemthoxyflavone has neuroprotective, chemopreventive, anti-allergic, anti-inflammatory, immunomodulatory, anti-aging and photoprotective effects; it inhibits collagenase activity and induces type I pro...		Others
T4S1050	Pristimerin	Celastrol methyl ester	NF-κB , Antibacterial
	1. Pristimerin (Celastrol methyl ester) has anticancer activity , treatment with Pristimerin may be a potential strategy for the suppression of hypoxia-induced metastasis through the reversal of hypoxia-induced stem cell...		NF-κB , Antibacterial
TN2229	Soyasaponin Ac		Others
	Soyasaponin Ac can decrease the drug resistance via EMT pathway and weaken the migration ability of ovarian cancer cells.		Others

天然物製品

Methacycline hydrochloride

T0518

Synonym: Rondomycin,Methacycline HCl

Target: ribosome, Antibacterial, Antibiotic

3,5,6,7,8,3',4'-Heptemthoxyflavone

TN1088

Synonym: 3,3',4',5,6,7,8-heptamethoxyflavone

Target: Others

Pristimerin

T4S1050

Synonym: Celastrol methyl ester

Target: NF-κB, Antibacterial

Recombinant Proteins

Species：

Expression System：

Tag：

カタログ番号	製品名	Species	Expression System
TMPY-04570	ITK Protein, Mouse, Recombinant (aa 351-619, His & GST)	Mouse	Baculovirus-Insect Cells
	IL-2-inducible T cell kinase is a member of the protein kinase superfamily, Tyr protein kinase family, and TEC subfamily. It contains 1 Btk-type zinc finger, 1 PH domain, 1 protein kinase domain, 1 SH2 domain, and 1 SH3 ...
TMPY-05249	ITK Protein, Human, Recombinant (Actived By LCK, GST)	Human	Baculovirus-Insect Cells
	IL-2-inducible T cell kinase is a member of the protein kinase superfamily, Tyr protein kinase family, and TEC subfamily. It contains 1 Btk-type zinc finger, 1 PH domain, 1 protein kinase domain, 1 SH2 domain, and 1 SH3 ...
TMPY-00322	DEC-205 Protein, Human, Recombinant (His)	Human	HEK293
	LY75 (Lymphocyte Antigen 75) is a Protein Coding gene. It is broadly expressed in the lymph node, appendix, and other tissues. LY75 knockdown in SKOV3 cells resulted in predominant upregulation of functional pathways imp...
TMPY-01020	Periostin/OSF-2 Protein, Human, Recombinant (His)	Human	HEK293
	Periostin ( POSTN ), also known as OSF2 (osteoblast specific factor 2), is a heterofunctional secreted extracellular matrix (ECM) protein comprised of four fasciclin domains that promotes cellular adhesion and movement, ...
TMPY-01613	Periostin/OSF-2 Protein, Mouse, Recombinant (His)	Mouse	HEK293
	Periostin ( POSTN ), also known as OSF2 (osteoblast specific factor 2), is a heterofunctional secreted extracellular matrix (ECM) protein comprised of four fasciclin domains that promotes cellular adhesion and movement, ...
TMPY-00413	TGF beta 2 Protein, Mouse, Recombinant (His)	Mouse	HEK293
	TGF beta 2 (Transforming growth factor beta 2), an extracellular glycosylated protein, which belongs to the TGF-beta family. TGF-beta regulates key mechanisms of tumor development, namely immunosuppression, metastasis, a...
TMPK-00743	LGR-5 Protein, Human, Recombinant (hFc)	Human	HEK293
	G protein-coupled receptor 5 (LGR5), known as a stem cell marker for colon cancer and gastric cancer, can serve as a novel GSC marker involved in EMT and a therapeutic target in glioma.LGR5 is a new functional GSC marker...
TMPK-00073	TDGF1/Cripto Protein, Human, Recombinant (His)	Human	HEK293
	TDGF1 (CRIPTO) is a member of the epidermal growth factor-Cripto-1/FRL-1/Cryptic (EGF/CFC) gene family and an obligate co-receptor involved in NODAL signaling, a developmental program implicated in midline, forebrain, an...
TMPJ-00260	Latent TGF-beta 2 Protein, Human, Recombinant (His & Avi), Biotinylated	Human	Human Cells
	Transforming growth factor beta (TGFβ) is a multifunctional cytokine that regulates cell growth, differentiation, adhesion, migration and death dependent on cell type, developmental stage, or tissue conditions. There are...
TMPJ-00259	TGF beta 2 Protein, Human, Recombinant (Avi), Biotinylated	Human	Human Cells
	Transforming growth factor beta (TGFβ) is a multifunctional cytokine that regulates cell growth, differentiation, adhesion, migration and death dependent on cell type, developmental stage, or tissue conditions. There are...
TMPK-00271	TPBG/5T4 Protein, Human, Recombinant (His & Avi)	Human	HEK293
	The oncofetal tumor-associated antigen 5T4 (TBGP) has been linked with CSC properties in several different malignancies. 5T4 has functional attributes that are relevant to the spread of tumors including through EMT, CXCR...
TMPK-00270	TPBG/5T4 Protein, Human, Recombinant (His & Avi), FITC-Labeled	Human	HEK293
	The oncofetal tumor-associated antigen 5T4 (TBGP) has been linked with CSC properties in several different malignancies. 5T4 has functional attributes that are relevant to the spread of tumors including through EMT, CXCR...
TMPY-05160	PFKP Protein, Human, Recombinant (His & GST)	Human	Baculovirus-Insect Cells
	PFKP plays a critical role in cell proliferation in breast cancer cells. PFKP is necessary for starvation-mediated autophagy, glycolysis, and EMT, thereby promoting the malignant progression of OSCC. The Snail-PFKP axis ...
TMPK-00820	AREG Protein, Human, Recombinant (hFc)	Human	HEK293
	Amphiregulin (AREG) is a member of the epidermal growth factor (EGF) family and is expressed in a plethora of cancers. Tumour growth and metastasis were decreased by AREG silencing in an orthotopic model of pancreatic ca...
TMPK-00563	EPHB2 Protein, Cynomolgus, Recombinant (His)	Cynomolgus	HEK293
	EphB2, a receptor tyrosine kinase for ephrin ligands, is overexpressed in various cancers and plays an important role in tumor progression. EPHB2 promotes endothelial-mesenchymal transition (EMT) and elicits associated p...
TMPJ-01161	CTGF/CCN2 Protein, Human, Recombinant	Human	Human Cells
	CTGF belongs to the CCN (CTGF/Cyr61/Cef10/NOVH) protein family, which is comprised of six secreted proteins that reside in the extracellular matrix (ECM). CTGF causes a variety of cellular responses including reduced cel...
TMPY-00299	FAM3C Protein, Human, Recombinant (His)	Human	HEK293
	FAM3C, also known as ILEI, is a member of theFAM3 family. It can be detected in resent in most secretory epithelia. FAM3C may be involved in retinal laminar formation. It promotes epithelial to mesenchymal transition. A ...
TMPY-03757	FAM3C Protein, Human, Recombinant (hFc)	Human	HEK293
	FAM3C, also known as ILEI, is a member of theFAM3 family. It can be detected in resent in most secretory epithelia. FAM3C may be involved in retinal laminar formation. It promotes epithelial to mesenchymal transition. A ...
TMPJ-01162	CTGF/CCN2 Protein, Human, Recombinant (hFc)	Human	Human Cells
	CTGF belongs to the CCN (CTGF/Cyr61/Cef10/NOVH) protein family, which is comprised of six secreted proteins that reside in the extracellular matrix (ECM). CTGF causes a variety of cellular responses including reduced cel...
TMPH-02226	TEAD3 Protein, Human, Recombinant (His & SUMO)	Human	E. coli
	Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is...
TMPH-02223	TEAD4 Protein, Human, Recombinant (His)	Human	E. coli
	Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is...
TMPY-04203	RAB1B Protein, Human, Recombinant (hFc)	Human	HEK293
	RAB1B, a member of the RAS oncogene family, was significantly down-regulated in highly metastatic breast cancer cells. Moreover, down-regulation of RAB1B was also found to promote the proliferation and migration of TNBC ...
TMPH-02225	TEAD2 Protein, Human, Recombinant (His & Myc)	Human	E. coli
	Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is...
TMPY-06655	PSCA Protein, Mouse, Recombinant (His & Avi), Biotinylated	Mouse	HEK293
	Prostate Stem Cell Antigen (PSCA) is frequently expressed in prostate cancer. Prostate stem cell antigen (PSCA) is a cell-membrane glycoprotein consisting of 123 amino acids. Knockdown of PSCA induced EMT and reduced met...
TMPH-02943	TEAD4 Protein, Mouse, Recombinant	Mouse	E. coli
	Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is...
TMPH-02224	TEAD4 Protein, Human, Recombinant (His & Myc)	Human	Baculovirus
	Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is...
TMPY-06710	PSCA Protein, Mouse, Recombinant (His)	Mouse	HEK293
	Prostate Stem Cell Antigen (PSCA) is frequently expressed in prostate cancer. Prostate stem cell antigen (PSCA) is a cell-membrane glycoprotein consisting of 123 amino acids. Knockdown of PSCA induced EMT and reduced met...
TMPJ-00157	CD82 Protein, Human, Recombinant (hFc)	Human	Human Cells
	CD82 antigen, also known as Kai-1, is a widely expressed palmitoylated molecule of the tetraspanin superfamily. KAI1/CD82 is localized on cell membrane and form interactions with other tetraspanins, integrins and chemoki...
TMPH-02942	TEAD4 Protein, Mouse, Recombinant (His & Myc)	Mouse	E. coli
	Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is...
TMPY-01576	Artemin Protein, Mouse, Recombinant (hFc)	Mouse	HEK293
	Artemin (ARTN) is a member of glial cell line-derived neurotrophic factor (GDNF) family of ligands, and its signaling is mediated via a multi-component receptor complex including the glycosylphosphatidylinositol-anchored...
TMPY-04930	Notch 2 Protein, Human, Recombinant (His)	Human	Baculovirus-Insect Cells
	NOTCH2 (Notch Receptor 2) is a Protein Coding gene. This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics and play a role in a variety of dev...
TMPY-00231	TGF beta 2 Protein, Canine, Recombinant (His)	Canine	HEK293
	TGF beta 2 (Transforming growth factor beta 2), an extracellular glycosylated protein, which belongs to the TGF-beta family. TGF-beta regulates key mechanisms of tumor development, namely immunosuppression, metastasis, a...
TMPY-05314	TGF beta 2 Protein, Mouse, Recombinant (His), Biotinylated	Mouse	HEK293
	TGF beta 2 (Transforming growth factor beta 2), an extracellular glycosylated protein, which belongs to the TGF-beta family. TGF-beta regulates key mechanisms of tumor development, namely immunosuppression, metastasis, a...
TMPH-02222	TEAD1 Protein, Human, Recombinant (His)	Human	E. coli
	Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is...
TMPY-04577	TGF beta 2 Protein, Rhesus, Recombinant (His)	Rhesus	HEK293
	TGF beta 2 (Transforming growth factor beta 2), an extracellular glycosylated protein, which belongs to the TGF-beta family. TGF-beta regulates key mechanisms of tumor development, namely immunosuppression, metastasis, a...
TMPY-04381	CAMK1D Protein, Human, Recombinant (GST)	Human	Baculovirus-Insect Cells
	Calcium/calmodulin-dependent protein kinase orCaM kinases are serine/threonine-specific protein kinasesthat are primarily regulated by the Calcium/calmodulin complex. These kinases show a memory effect on activation. ...
TMPY-04415	CAMKI Protein, Human, Recombinant	Human	E. coli
	Calcium/calmodulin-dependent protein kinase orCaM kinases are serine/threonine-specific protein kinasesthat are primarily regulated by the Calcium/calmodulin complex. These kinases show a memory effect on activation. ...
TMPY-03046	APCDD1 Protein, Human, Recombinant (hFc)	Human	HEK293
	Osteosarcoma (OS) is the most common type of bone tumor in children and adults. The expression of APCDD1, a Wnt antagonist, was reduced in OS tissues and cells compared to adjacent normal tissue and osteoblast cells, res...
TMPY-01000	BVES Protein, Human, Recombinant (GST)	Human	E. coli
	Blood vessel epicardial substance (BVES), or POPDC1, is a tight junction-associated transmembrane protein that modulates epithelial-to-mesenchymal transition (EMT) via junctional signaling pathways. BVES plays a protecti...
TMPH-03764	YAP1 Protein, Human, Recombinant (His)	Human	Yeast
	Transcriptional regulator which can act both as a coactivator and a corepressor and is the critical downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor su...
TMPH-00382	TGF-beta 1 Protein, Chicken, Recombinant (His & SUMO)	Chicken	E. coli
	Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1,...
TMPH-00841	SMARCA4 Protein, Human, Recombinant (His)	Human	E. coli
	Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic acti...
TMPH-02217	SMARCA4 Protein, Human, Recombinant (His)	Human	Yeast
	Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic acti...
TMPH-00305	TGF-beta 1 Protein, Bovine, Recombinant (His)	Bovine	E. coli
	Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1,...