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T39727 |
ERα degrader-2
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ERK
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ERα degrader-2 is a selective and potent estrogen receptor (SERD) degrader with anticancer activity, inhibits ERα, and has an EC50 value for estrogen receptor degradation of 0.3 nM.ERα degrader-2 can be used for the prev... |
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T18605 |
PROTAC ERα Degrader-2
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Others
,
PROTACs
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PROTAC ERα Degrader-2 is composed of a cIAP1 ligand binding group, a linker, and an estrogen receptor α (ERα) binding group, serving as an ERα degrader. It achieves maximal ERα degradation in human mammary tumor MCF7 cel... |
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T18636 |
PROTAC ERα Degrader-1
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Others
,
PROTACs
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PROTAC ERα Degrader-1 is a chemical compound. It consists of a ubiquitin E3 ligase binding group, a linker, and a protein binding group. This compound serves as a degrader of estrogen receptor-alpha (ERα). |
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T63922 |
ERα degrader 5
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ERα degrader 5 is an orally active, selective estrogen receptor (ER) reducer that acts on ERα (EC50: 1.1 nM). ERα degrader 5 shows anti-tumour effects in vivo. |
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T64026 |
ERα antagonist 1
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ERα antagonist 1 is a selective, potent, covalent estrogen receptor alpha (ERα) antagonist that blocks the cell cycle of MCF-7 cells in G0/G1 phase and induces apoptosis. |
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T78676 |
ERα degrader 6
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Estrogen Receptor/ERR
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ERα degrader 6 (Compound 31q) is an ERα degrader with a K I of 75 nM and also inhibits ARO with an IC50 value of 37.7 nM. It effectively inhibits tumor growth in the MCF-7 tumor xenograft model and has applications in br... |
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T74375 |
PROTAC ERα Y537S degrader-1
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PROTAC ERα Y537S degrader-1 comprises a ubiquitin E3 ligase binding group, a linker and a protein binding group. PROTAC ERα Y537S degrader-1 is an estrogen receptor-alpha (ERα) Y537S degrader [1] . |
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T17940 |
Estrone-N-O-C1-amido
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ERα ligand 1 |
Others
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Estrone-N-O-C1-amido (ERα ligand 1) is an estrogen ligand derived from Estrone that specifically binds to estrogen receptor α (ERα). Through a linker, Estrone-N-O-C1-amido (ERα ligand 1) forms a complex with the cIAP1 li... |
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T79736 |
14-3-3σ/ERα stabilizer-1
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Estrogen Receptor/ERR
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Compound 181, also known as 14-3-3σ/ERα Stabilizer-1, is a covalent stabilizer targeting the 14-3-3σ/ERα proteins. It is utilized in research as a molecular glue [1]. |
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T2544 |
Bazedoxifene acetate
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WAY-TES 424,TSE 424,WAY-140424 |
Estrogen Receptor/ERR
,
Estrogen/progestogen Receptor
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Bazedoxifene acetate (WAY-TES 424) is a novel selective estrogen receptor modulator (SERM). |
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T6404 |
Bazedoxifene hydrochloride
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Bazedoxifene HCl,TSE-424 |
Estrogen Receptor/ERR
,
Estrogen/progestogen Receptor
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Bazedoxifene hydrochloride (TSE-424) is a novel, non-steroidal, indole-based estrogen receptor modulator (SERM) binding to both ERα and ERβ with IC50 of 23 nM and 89 nM, respectively. |
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T16566 |
Propyl pyrazole triol
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PPT |
Estrogen Receptor/ERR
,
Estrogen/progestogen Receptor
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Propyl pyrazole triol (PPT) is a selective agonist of estrogen receptor alpha. The relative binding affinity of Propyl pyrazole triol for ERα (ERα: 49%) around 410 times higher compared with estrogen receptor beta (ERβ: ... |
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T5633 |
H3B-5942
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Estrogen Receptor/ERR
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Estrogen/progestogen Receptor
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H3B-5942 belongs to a class of ERα antagonists referred to as selective estrogen receptor covalent antagonists (SERCA). |
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T26537 |
AC-186
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AC186,AC 186 |
Estrogen/progestogen Receptor
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AC-186 is a nonsteroidal estrogen receptor β (ERβ) agonist with different affinities for ERβ and ERα, with an EC50 of 6 nM for ERβ and 5000 nM for ERα. AC-186 has neuroprotective activity and has been used in the study o... |
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T13443 |
(R)-Equol
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(+)-Equol |
Estrogen/progestogen Receptor
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(R)-Equol ((+)-Equol) is an ERα and ERβ agonist with Kis of 27.4 and 15.4 nM, respectively. |
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T13674 |
Elacestrant
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RAD1901 |
Estrogen Receptor/ERR
,
Estrogen/progestogen Receptor
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Elacestrant (RAD1901) with IC50s of 48 and 870 nM for ERα and ERβ, respectively.Elacestrant is an orally available selective estrogen receptor degrader . |
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T6533 |
Hexestrol
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Bibenzyl,Hexanoestrol,meso-Hexestrol,Hexestrofen |
Estrogen Receptor/ERR
,
Estrogen/progestogen Receptor
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Hexestrol (Hexanoestrol) binds to ERα and ERβ with EC50 of 0.07 nM and 0.175 nM, respectively. |
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T3975 |
AZD9496
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Estrogen Receptor/ERR
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Estrogen/progestogen Receptor
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AZD9496 is an orally available selective estrogen receptor(ERα) antagonist, with potential antineoplastic activity. |
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T13675 |
Elacestrant dihydrochloride
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RAD1901 dihydrochloride |
Estrogen/progestogen Receptor
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Elacestrant dihydrochloride (DA-DKRAD1901 dihydrochloride) is an orally available selective estrogen receptor degrader with IC50s of 48 for ERα and 870 nM for ERβ, respectively. |
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T23540 |
Y134
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Y 134 |
Estrogen Receptor/ERR
,
Others
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Y134 is an estrogen receptor inhibitor that is selective and orally active, exhibiting strong antagonist activity against ERα and Erβ with Ki of 0.09 nM and 11.31 nM, respectively. The selectivity of Y134 for ERα is 121... |
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T10239 |
Acolbifene
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EM-652,SCH 57068 |
Estrogen Receptor/ERR
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Acolbifene (SCH 57068) is a selective antagonist of estrogen receptors with IC50s of 2 nM and 0.4 nM for estradiol-induced transcriptional activity of ERα and ERβ. Acolbifene shows an anticarcinogenic property. |
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T39980 |
ErSO
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Others
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ErSO is a selective activator of anticipatory unfolded protein response (UPR) via ERα receptor. ErSO can be used in studies about anti-cancer. |
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T12832 |
Amcenestrant
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SAR439859 |
Estrogen Receptor/ERR
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Estrogen/progestogen Receptor
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Amcenestrant (SAR439859) is an orally active, nonsteroidal and selective degrader of estrogen receptor (SERD). SAR439859 is a potent antagonist of ER (with an EC50 of 0.2 nM for ERα degradation). |
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T15788 |
LSZ-102
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LSZ102 |
Estrogen Receptor/ERR
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LSZ-102 is an effective and selective degrader of estrogen receptor (IC50 = 0.2 nM) and can be used in studies about ERα positive breast cancer. |
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T22794 |
G36
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G-36 |
Estrogen Receptor/ERR
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G36 is a cell-permeable non-steroidal antagonist of GPER. G36 inhibits activation by either 17β-estradiol or the GPER-selective agonist G-1 (IC50 = 112 and 165 nM, respectively). G36 has no detectable binding activity to... |
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T4388 |
PHTPP
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Estrogen Receptor/ERR
,
Estrogen/progestogen Receptor
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PHTPP is a selective ERβ antagonist. |
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T38894 |
IHVR-17028
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Influenza Virus
,
Glucosidase
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IHVR-17028 is a potent broad-spectrum ERα-glucosidase I (α-glucosidase? I) inhibitor with IC50 of 0.24 μM and antiviral activity. IHVR-17028 inhibited BVDV, TCRV and DENV, and EC50 values were 0.4 μM, 0.26 μM and 0.3 μM,... |
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T2250 |
DY131
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DY 131,GSK 9089,DY-131 |
Estrogen Receptor/ERR
,
Estrogen/progestogen Receptor
,
Smo
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DY131 (DY-131) is a novel selective agonist of ERRβ and ERRγ. |
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T11230 |
ERRα antagonist-1
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ERR+/- antagonist-1,ERRa antagonist-1 |
Estrogen/progestogen Receptor
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ERRα antagonist-1 (ERR+/- antagonist-1) is a high-affinity, selective antagonist of the estrogen-related receptor α (ERRα). It effectively prevents the interaction of ERRα with both Proliferator-activated Receptor γ Coac... |
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T8370 |
GSK5182
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Estrogen Receptor/ERR
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Estrogen/progestogen Receptor
,
Reactive Oxygen Species
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GSK5182 is a highly selective inverse estrogen-related receptor γ agonist (IC50 : 79 nM) |
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T2280 |
Endoxifen (Z-isomer)
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Endoxifen Z-isomer |
Estrogen Receptor/ERR
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EGFR
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Potassium Channel
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Estrogen/progestogen Receptor
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HER
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Endoxifen Z-isomer (EDX) is a key active metabolite of tamoxifen (TAM) with higher affinity and specificity to estrogen receptors that also inhibits aromatase activity. |
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T16923 |
SPP-86
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c-RET
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SPP-86 is an effective and selective cell-permeable inhibitor of RET tyrosine kinase with an IC50 of 8 nM. |
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T5118 |
Brilanestrant
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GDC0810,GDC 0810,GDC-0810,ARN-810,RG 6046 |
Estrogen Receptor/ERR
,
Estrogen/progestogen Receptor
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Brilanestrant (GDC-0810) is a selective estrogen receptor degrader (IC50: 0.7 nM). |
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T0384 |
Estradiol benzoate
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Benzoestrofol,Benzhormovarine,Benovocylin |
Estrogen Receptor/ERR
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Estrogen/progestogen Receptor
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Estradiol benzoate (Benzhormovarine) is the synthetic benzoate ester of estradiol, a steroid sex hormone vital to the maintenance of fertility and secondary sexual characteristics in females. |
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T8984 |
FLTX1
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Estrogen Receptor/ERR
,
Estrogen/progestogen Receptor
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FLTX1 is a fluorescent derivative of Tamoxifen, designed to efficiently target and label intracellular Tamoxifen-binding sites (estrogen receptors) both under permeabilized and non-permeabilized conditions. Additionally,... |
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T39118 |
AZD9496 maleate
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AZD9496 maleate is a highly potent and selective antagonist of the estrogen receptor alpha (ERα), exhibiting an IC50 value of 0.28 nM. This compound, AZD9496 maleate, is an orally bioavailable selective estrogen receptor... |
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T39368 |
GNE-149
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GNE-149 is an orally bioavailable compound that acts as a full antagonist of estrogen receptor α (ERα) with an IC50 of 0.053 nM. It is also classified as a selective estrogen receptor degrader (SERD). GNE-149 holds poten... |
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T18697 |
SNIPER(ER)-87
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Others
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SNIPER(ER)-87 is a chemical compound composed of a derivative of the inhibitor of apoptosis protein (IAP) ligand LCL161 conjugated to the estrogen receptor α (ERα) ligand 4-hydroxytamoxifen using a PEG linker. It effecti... |
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T14553 |
BHPI
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Others
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BHPI is a potent ERα inhibitor that blocks nuclear estrogen–ERα-regulated gene expression effectively. It triggers sustained ERα-dependent activation of the endoplasmic reticulum (EnR) stress sensor, notably the unfolded... |
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T23227 |
(R,R)-THC
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Others
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agonist at ERα receptor and antagonist at ERβ receptor |
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T40893 |
Estrogen receptor modulator 6
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Estrogen receptor modulator 6 (compound 3a) is a highly specific and potent agonist of the estrogen receptor (ER) β with a remarkable affinity (K i = 0.44 nM). This compound exhibits an impressive 19-fold selectivity for... |
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T12312 |
OP-1074
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Estrogen/progestogen Receptor
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OP-1074 is a pure antiestrogen and a selective degrader of ER, shows specific antiestrogenic activity for ERα and ERβ. |
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T31523 |
Diptoindonesin G
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Diptoindonesin G is an ERß stabilizer that regulates the stability of ERα and ERß by targeting CHIP E3 ubiquitin ligase. Diptoindonesin G could significantly increase the protein stability of ERß, and reduce the protein ... |
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T31936 |
GLL398
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GLL 398,GLL-398 |
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GLL398 is an oral selective estrogen receptor down-regulating agent that strongly binds to ERα (IC50 =1.14 nM) and effectively degrades ERα in MCF-7 breast cancer cells (IC50 = 0.21 μM). |
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T12101 |
MPP dihydrochloride (289726-02-9 Free base)
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Others
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MPP dihydrochloride is a highly selective antagonist of estrogen receptor alpha (ERα). |
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T60827 |
TPBM
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TPBM is a potent inhibitor of estrogen receptor α (ERα). The IC 50 value of TPBM for 17β-estradiol (E2)-ERα is 9 μM. TPBM is not toxic to cells and reduces E2·ERα recruitment to an endogenous estrogen-responsive gene. TP... |
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T62490 |
OBHS
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OBHS is an inhibitor of estrogen receptor alpha (ERα). |
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T21897 |
Methylpiperidino pyrazole
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Estrogen/progestogen Receptor
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Methylpiperidino pyrazole is an ERα inhibitor and can prevent the BPS-induced Rb phosphorylation and cell cycle progression. |
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T69982 |
VPC-16606
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VPC-16606 is a potent and selective inhibitor of ERα-dependent cell growth and gene expression. VPC-16606 prevents the interaction between ERα-LBD and SRC-3 fusion proteins in a dose-dependent manner. |
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T63045 |
(1S,3R)-GNE-502
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(1S,3R)-GNE-502 (compound 179) is a potent degradation agent of Erα and is able to degrade ERα in MCF7 HCS cells (EC50: 13 nM). (1S,3R)-GNE-502 can be used in the study of estrogen receptor-related cancers. |
