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Search Results for " Nicotinic "

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269

阻害剤

天然化合物

リコンビナントタンパク質

カタログ番号	製品名	別名	ターゲット
T0067	Nicotinic acid N-oxide	Nicotinic acid 1-oxide,Oxiniacic Acid	Others
	Nicotinic acid N-oxide (Nicotinic acid 1-oxide) is a nicotinic acid derivative, used to treat hyperlipoidemia.		Others
T0664	Nicotinic acid hydrazide		Others
	Nicotinic acid hydrazide (NAH) is a hydrazide derivative of nicotinic acid, a heterocyclic organic compound. It is a peroxidase inhibitor and can form solid metal complexes with strong biological activity.		Others
T20442	Nicotinic anhydride	AI3-15770,AI315770,AI3 15770
	Nicotinic anhydride is an agent of biochemical.
T25867	Nicodan Percutan	Nicotinic acid, propyl ester,Propylnicotinat,Propyl pyridine-3-carboxylate,n-Propyl nicotinate,NSC-78447,NSC 78447,NSC78447	Others
	Nicodan Percutan (Propylnicotinat) is the propyl ester form of niacin, which is found in various animal and plant tissues to form the coenzymes NAD and NADP.		Others
T72188	Nicotinamide Hydrochloride	Niacinamide Hydrochloride,Nicotinic acid amide Hydrochloride,Niacinamide Hydrochloride ; Nicotinic acid amide Hydrochloride
	Nicotinamide Hydrochloride is a form of vitamin B3 or niacin that inhibits sirtuin 2 ( SIRT2 ) activity in vitro , with an EC 50 of 2 μM. Nicotinamide Hydrochloride inhibits up to 90% melanoma cell number and increases c...
T9787	Suvn-911		AChR
	suvn-911 is a potent and selective antagonist of neuronal nicotinic acetylcholine α4β2 receptor (Ki = 1.5 nM) with antidepressant activity.		AChR
T83801	ε-NAADP+ sodium	Etheno-NAADP,β-Nicotinic Acid-1,N6-Ethenoadenine dinucleotide phosphate,Nicotinic Acid adenine dinucleotide phosphate
	ε-NAADP+ is a fluorescent derivative of NAADP, known for inducing calcium mobilization. It effectively induces calcium release in sea urchin egg homogenates with an EC50 of 5 µM. The compound exhibits excitation and emis...
T60080	TMPH	2,2,6,6-Tetramethylpiperidin-4-yl heptanoate	AChR
	TMPH is an inhibitor of nAChR and inhibits nAChRs lacking α5, α6, or β3 subunits. TMPH can be used in studies about nAChR dysfunction or neurological disorders.		AChR
T14094	Acetamiprid		AChR
	Acetamiprid is a nicotinic acetylcholine receptor (nAChR) agonist. Acetamiprid is a neonicotinoid insecticide used worldwide. It is shown to be associated with neuromuscular and reproductive disorders.		AChR
T20418	Tocopherol nicotinate	Vitamin E nicotinate,Vitamin E nicotinic acid ester,Tocopheryl nicotinate
	Tocopherol nicotinate is an antioxidant. It is used for skin conditioning.
T17300	(-)-(S)-B-973B		AChR
	(-)-(S)-B-973B is an effective allosteric agonist and a positive allosteric modulator of α7 nAChR.		AChR
T0072	Adiphenine hydrochloride	Adiphenine HCl,Spasnil,Patrovina,Sentiv	AChR
	Adiphenine hydrochloride (Patrovina), a nicotinic receptor inhibitor, can be used as an antispasmodic drug.		AChR
T28531	Facinicline hydrochloride	RG3487	5-HT Receptor , AChR
	Facinicline hydrochloride (RG3487) is both a novel nicotinic alpha-7 receptor (alpha7nAChR) partial agonist (Ki = 6 nM) and an antagonist of 5-HT3(Ki = 1.2 nM). Facinicline hydrochloride improves cognition and sensorimot...		5-HT Receptor , AChR
T2422	PNU-282987		AChR
	PNU-282987 is a selective α7 nicotinic acetylcholine receptor(α7 nAChR) agonist with Ki of 26 nM; no affinity for α1β1γδ and α3β4 nAChRs (IC50 ≥ 60 μM).		AChR
T8868	4BP-TQS		AChR
	4BP-TQS is an allosteric agonist of α7 nAChRs.		AChR
T23469	TQS	4-Naphthalen-1-yl-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-8-sulfonamide	AChR
	TQS (4-Naphthalen-1-yl-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-8-sulfonamide) is a positive allosteric modulator of α7 nACh receptors.		AChR
TQ0117	A-867744		AChR , Autophagy
	A-867744 is an effective and selective type II positive allosteric modulator of the α7 nAChR (EC50: 1.0 μM).		AChR , Autophagy
T37196	5-AAM-2-CP		AChR
	5-AAM-2-CP is one of the major metabolites of Acetamiprid. Acetamiprid, a nAChR agonist, is a neonicotinoid insecticide used worldwide.		AChR
T7193	Encenicline	EVP-6124	AChR
	Encenicline (EVP-6124) is a selective α7 nicotinic acetylcholine receptor (nAChRs) agonist in development for treating cognitive impairment in schizophrenia and Alzheimer's disease.		AChR
T28199	NS9283	NS 9283,NS-9283	AChR
	NS9283 is a positive allosteric modulator of α4β2 receptor.		AChR
T23146	PHA 568487 free base	PHA 568487	AChR
	The quinuclidine PHA 568487 free base is an agonist of the alpha 7 nicotinic acetylcholine receptor that was designed to mitigate the bioactivation associated with the core scaffold and subsequently remove associated lia...		AChR
T27624	Iptakalim Hydrochloride		Potassium Channel , AChR
	Iptakalim, a lipophilic para-amino compound, is a novel ATP-sensitive potassium channel (KATP) opener, as well as an α4β2-containing nicotinic acetylcholine receptor (nAChR) antagonist. Iptakalim is also a K(ir) 6.1/SUR2...		Potassium Channel , AChR
T8552	PSEM 89S TFA		AChR
	PSEM 89S TFA is a brain-penetrant and selective ion channels agonist, and is orthogonally selective for Q79G and L141F, respectively.		AChR
T9542	NS3861		AChR
	NS3861 is an agonist of nicotinic acetylcholine receptors (nAChRs) and bind with high affinity to heteromeric α3β4 and α4β2 nAChRs. NS3861 displays the β-subunit preference and a complete lack of activation at α4-contain...		AChR
T4246	Varenicline dihydrochloride		AChR
	Varenicline dihydrochloride is a Selective α4β2 nicotinic acetylcholine receptor partial agonist.		AChR
TP2063	α-Conotoxin MII		AChR
	α-Conotoxin MII is a highly potent and selective competitive antagonist for α3β2 subunit-containing nicotinic receptors (IC50 = 0.5 - 3.5 nM at α3β2 expressed in Xenopus oocytes). Also potently blocks β3-containing neuro...		AChR
T7124	Dinotefuran	MTI-446	Others , AChR , Parasite
	Dinotefuran (MTI-446) is an insecticide of the neonicotinoid class for control of insect pests such as aphids, whiteflies, thrips, leafhoppers, leafminers. Its mechanism of action involves disruption of the insect's nerv...		Others , AChR , Parasite
T0401	Benzethonium chloride	Hyamine,Phemeride,Quatrachlor	AChR
	Benzethonium chloride (Quatrachlor) is a synthetic quaternary ammonium salt with surfactant, antiseptic, and broad spectrum antimicrobial properties.		AChR
T12653	(Rac)-ABT-202 dihydrochloride		AChR
	(Rac)-ABT-202 dihydrochloride is a racemate of ABT-202. ABT-202 is an nicotinic acetylcholine receptors (nAChRs) agonist and can be used as an analgesic.		AChR
T6607	Nitenpyram	Niterndipoine,Bestguard,Capstar	AChR
	Nitenpyram (Capstar) is a nicotinic acetylcholine receptor (AchR) agonist, used as veterinary medicine to treat parasites of livestock and pets.		AChR
T7422	CCMI	AVL-3288	AChR
	CCMI (AVL-3288) is a potent and selective modulator of α7 nAChR-positive allosteric.		AChR
T0818	Decamethonium bromide	Decacuran,Syncurine	AChR , AChE
	Decamethonium bromide (Syncurine) is a neuromuscular blocker and nicotinic AChR partial agonist.		AChR , AChE
T23348	SEN12333	SEN 12333	AChR
	SEN12333 is an α7 nicotinic acetylcholine receptor (nAChR) agonist		AChR
T1459	Cisatracurium besylate	51W89	Adrenergic Receptor , AChR , Autophagy
	Cisatracurium besylate (51W89) is a nondepolarizing skeletal muscle relaxant for intravenous administration.		Adrenergic Receptor , AChR , Autophagy
T7884	NS 1738	NSC 213859	AChR
	NS 1738 (NSC-213859) is a positive allosteric modulator of the α7-containing neuronal nicotinic acetylcholine receptors (nAChRs)		AChR
T0395	Pyrantel tartrate	Banminth	Antibiotic , Parasite
	Pyrantel tartrate (Banminth) is broad spectrum anthelmintic for livestock.		Antibiotic , Parasite
T7695	PNU-282987 S enantiomer free base		AChR
	PNU-282987 S enantiomer free base is an agonist of α7 nicotinic acetylcholine receptor (α7 nAChR).		AChR
T19438	Myristyl nicotinate	Tetradecyl nicotinate	GPR
	Myristyl nicotinate (Tetradecyl nicotinate) is an ester prodrug being developed for delivery of nicotinic acid (NIC) into the skin for prevention of actinic keratosis and its progression to skin cancer.		GPR
T0166	Pancuronium dibromide	Pancuronium bromide,Pavulon	AChR
	Pancuronium dibromide (Pavulon), a competitive AChR antagonist (IC50 = 5.5 nM), acts as a skeletal muscle relaxant. Pancuronium dibromide(Pancuronium bromide) blocking neuromuscular transmission is achieved by competing ...		AChR
T1259	Pyrantel pamoate	Pyrantel embonate	Others , Antibiotic , Parasite
	Pyrantel pamoate (Pyrantel embonate) is a depolarizing neuromuscular blocking agent.		Others , Antibiotic , Parasite
T12165	NAChR agonist 1	DUN71755	AChR
	nAChR agonist 1 (DUN71755) is a brain-permeable and orally efficacious positive allosteric α7 nicotinic acetylcholine receptor (α7 nAChR)modulator.		AChR
T22448	Tropisetron	Tropisetronum,Tropisteron,ICS 205-930	5-HT Receptor , AChR
	Tropisetron (ICS 205-930) is an α7-nicotinic receptor agonist and 5-HT3 receptor antagonist with Kis of 6.9 nM and 5.3 nM, respectively.		5-HT Receptor , AChR
T2227	Hemicholinium 3	Hemicholinium-3,Hemicholine	Others , AChE
	Hemicholinium 3 is a potent and selective choline uptake blocker.		Others , AChE
T1162	Acipimox	Olbemox,K-9321	Others
	Acipimox (K-9321) is a niacin derivative and nicotinic acid analog with activity as a hypolipidemic agent. Acipimox has special application for the treatment of hyperlipidemia in non-insulin-dependent diabetic patients.		Others
T8448	ZSET1446	ZSET-1446,ST-101	Calcium Channel , AChR
	ZSET1446 (ST-101) is a T-type calcium channel activator potentially for the treatment of learning deficits in various types of Alzheimer disease (AD) models.		Calcium Channel , AChR
T1594	Vecuronium bromide	ORG NC 45	AChR
	Vecuronium bromide (ORG NC 45) is a synthetic, intermediate-acting mono-quaternary steroid and non-depolarizing neuromuscular blocking agent, with muscle relaxant activity.		AChR
T6397	Atracurium besylate	Tracrium,51W89,BW-33A	AChR
	Atracurium besylate (51W89) is a non-depolarizing neuromuscular blocking agent with short duration of action. Its lack of significant cardiovascular effects and its lack of dependence on good kidney function for eliminat...		AChR
T0287	Hexamethonium Bromide	Gangliostat,Simpatoblock,Hexamethonium Dibromide	Apoptosis , Dopamine Receptor , AChR
	Hexamethonium Bromide (Hexamethonium Dibromide), a specific antagonist of neuronal-type nicotinic AChR in ganglia, is poorly absorbed from the gastrointestinal tract and does not cross the blood-brain barrier.		Apoptosis , Dopamine Receptor , AChR
T0333	Aniracetam	Ro 13-5057	Dopamine Receptor , 5-HT Receptor , GluR , AChR , iGluR
	Aniracetam (Ro 13-5057)(Ro 13-5057), a nootropic and neuroprotective drug, selectively modulates the AMPA receptor and nAChR.		Dopamine Receptor , 5-HT Receptor , GluR , AChR , iGluR
T22371	Mivacurium dichloride	Mivacurium chloride	AChR
	Mivacurium dichloride (Mivacurium chloride) is a non-depolarising, rapid neuromuscular blocker of short duration, used therefore as anesthetic, to provide skeletal muscle relaxation in minor surgical operations, in emerg...		AChR

Compounds

Nicotinic acid N-oxide

T0067

Synonym: Nicotinic acid 1-oxide,Oxiniacic Acid

Target: Others

Nicotinic acid hydrazide

T0664

Synonym:

Target: Others

Nicotinic anhydride

T20442

Synonym: AI3-15770,AI315770,AI3 15770

Target:

Nicodan Percutan

T25867

Synonym: Nicotinic acid, propyl ester,Propylnicotinat,Propyl pyridine-3-carboxylate,n-Propyl nicotinate,NSC-78447,NSC 78447,NSC78447

Target: Others

Nicotinamide Hydrochloride

T72188

Synonym: Niacinamide Hydrochloride,Nicotinic acid amide Hydrochloride,Niacinamide Hydrochloride ; Nicotinic acid amide Hydrochloride

Synonym: Etheno-NAADP,β-Nicotinic Acid-1,N6-Ethenoadenine dinucleotide phosphate,Nicotinic Acid adenine dinucleotide phosphate

Target:

TMPH

T60080

Synonym: 2,2,6,6-Tetramethylpiperidin-4-yl heptanoate

Tocopherol nicotinate

T20418

Synonym: Vitamin E nicotinate,Vitamin E nicotinic acid ester,Tocopheryl nicotinate

Adiphenine hydrochloride

T0072

Synonym: Adiphenine HCl,Spasnil,Patrovina,Sentiv

Target: AChR

Facinicline hydrochloride

T28531

Synonym: RG3487

Target: 5-HT Receptor, AChR

Synonym: 4-Naphthalen-1-yl-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-8-sulfonamide

Target: AChR, Autophagy

Synonym: NS 9283,NS-9283

Iptakalim Hydrochloride

T27624

Synonym:

Target: Potassium Channel, AChR

Varenicline dihydrochloride

Target: Others, AChR, Parasite

Benzethonium chloride

T0401

Synonym: Hyamine,Phemeride,Quatrachlor

Target: AChR

(Rac)-ABT-202 dihydrochloride

Synonym: Niterndipoine,Bestguard,Capstar

Decamethonium bromide

T0818

Synonym: Decacuran,Syncurine

Cisatracurium besylate

T1459

Synonym: 51W89

Target: Adrenergic Receptor, AChR, Autophagy

Target: Antibiotic, Parasite

PNU-282987 S enantiomer free base

Synonym: Tetradecyl nicotinate

Target: GPR

Pancuronium dibromide

T0166

Synonym: Pancuronium bromide,Pavulon

Target: AChR

Pyrantel pamoate

T1259

Synonym: Pyrantel embonate

Target: Others, Antibiotic, Parasite

Synonym: Tropisetronum,Tropisteron,ICS 205-930

Target: 5-HT Receptor, AChR

Hemicholinium 3

T2227

Synonym: Hemicholinium-3,Hemicholine

Target: Others, AChE

Acipimox

T1162

Synonym: Olbemox,K-9321

Target: Others

ZSET1446

T8448

Synonym: ZSET-1446,ST-101

Target: Calcium Channel, AChR

Synonym: Tracrium,51W89,BW-33A

Target: AChR

Hexamethonium Bromide

T0287

Synonym: Gangliostat,Simpatoblock,Hexamethonium Dibromide

Target: Apoptosis, Dopamine Receptor, AChR

Aniracetam

T0333

Synonym: Ro 13-5057

Target: Dopamine Receptor, 5-HT Receptor, GluR, AChR, iGluR

Mivacurium dichloride

T22371

Synonym: Mivacurium chloride

Target: AChR

カタログ番号	製品名	別名	ターゲット
T19477	Nicotinic acid mononucleotide		Others
	Nicotinic acid mononucleotide is formed from nicotinic acid (NA) via the nicotinic acid phosphoribosyltransferase in the biosynthesis of NAD+.		Others
T0879	Niacin	Vitamin B3,Nicotinic acid	Endogenous Metabolite , Autophagy
	Niacin (Nicotinic acid) is a water-soluble vitamin belonging to the vitamin B family, which occurs in many animal and plant tissues, with antihyperlipidemic activity. Niacin is converted to its active form niacinamide, w...		Endogenous Metabolite , Autophagy
T5233	N-Methylnicotinamide	N'-Methylnicotinamide,Nicotinic Acid Methylamide,N-Methylpyridine-3-carboxamide	Others , Endogenous Metabolite
	N-Methylnicotinamide (Nicotinic Acid Methylamide) is a metabolite of niacin (or nicotinamide) and is commonly found in human urine. However low levels of urinary excretion of N-Methylnicotinamide (Nicotinic Acid Methylam...		Others , Endogenous Metabolite
T67407	Nicotinic acid riboside
	Nicotinic acid riboside is a natural product for research related to life sciences. The catalog number is T67407 and the CAS number is 17720-18-2.
T2927	Trigonelline chloride	Gynesine Hydrochloride,Coffearine Hydrochloride,Nicotinic acid N-methylbetaine Hydrochloride,Trigonelline hydrochloride	Others , Antibacterial , Antifungal , HSV
	Trigonelline chloride (Coffearine Hydrochloride), an alkaloid with potential antidiabetic activity, is present in considerable amounts in coffee.		Others , Antibacterial , Antifungal , HSV
T7671	Myosmine		Others , AChR
	Myosmine is a minor tobacco alkaloid that is structurally related to nicotine.		Others , AChR
T9076	Spinosad		Others
	Spinosad is a naturally-occurring insecticide found in the the soil bacterium S. spinosa. It is a mixture of the macrocyclic lactones spinosyn A and spinosyn D, which act as agonists of insect nicotinic acetylcholinester...		Others
T1039	Choline chloride	Biocolina,Biocoline,Hepacholine	AChR
	Choline chloride (Biocoline) is a basic constituent of lecithin that is found in many plants and animal organs. It is important as a precursor of acetylcholine, as a methyl donor in various metabolic processes, and in li...		AChR
T2198	Arecoline hydrobromide	Arecoline HBr,Arecoline bromide	AChR
	Arecoline hydrobromide (Arecoline HBr) is a muscarinic acetylcholine receptor agonist.		AChR
T7853	(+)-Sparteine	Pachycarpine	AChR
	(+)-Sparteine (Pachycarpine) is a natural product extracted from scotch broom, is a sodium channel blocker and a class 1a antiarrhythmic agent		AChR
T5S0994	N-Methylcytisine	Caulophylline	Others , AChR
	1. N-Methylcytisine (Caulophylline)'s nicotinic receptors have high affinity (KD = 5 nM)to nAChR from squid optical ganglia. 2. N-Methylcytisine and N, N-dimethylcytisine did not displace 14C-tubocurarine at a concentrat...		Others , AChR
T0479	Cytisinicline	Baptitoxine,Cytisine,Baphitoxine,Sophorine	AChR
	Cytisinicline (Sophorine), an alkaloid, is found naturally in several plants.		AChR
TN1643	Ferulamide	4-Hydroxy-3-methoxycinnamide	PAFR , AChR
	Ferulamide (4-Hydroxy-3-methoxycinnamide), a Ferulic acid derivative, shows potent inhibitory activity against arachidonic acid-induced platelet aggregation.		PAFR , AChR
T0086	Galanthamine hydrobromide	Galantamine hydrobromide,Galanthamine HBr	AChR , AChE
	Galanthamine hydrobromide (Galantamine hydrobromide), a long-acting and centrally active AChE inhibitor (IC50:410 nM), is an allosteric potentiator at neuronal nicotinic ACh receptors.		AChR , AChE
T1221	Acetylcholine chloride	ACh chloride,Pilofrin	Calcium Channel , Endogenous Metabolite , AChR
	Acetylcholine Chloride is the chloride salt form of acetylcholine, a synthetic, quaternary amino alcohol with cholinergic properties. Acetylcholine chloride (Pilofrin) mimics the parasympathomimetic effect of the endogen...		Calcium Channel , Endogenous Metabolite , AChR
T0268	Lobeline hydrochloride	α-Lobeline hydrochloride,L-Lobeline hydrochloride	AChR
	Lobeline hydrochloride (α-Lobeline hydrochloride) is a nicotinic receptor agonist, acting as an effective antagonist at both α4β2 and α3β2 neuronal nicotinic receptor subtypes.		AChR
T8040	Cholesterol myristate	Cholesteryl myristate,Cholesteryl tetradecanoate	Others , Potassium Channel , GABA Receptor , Endogenous Metabolite , AChR
	Cholesterol Myristate (Cholesteryl Myristate) is a natural steroid found in traditional Chinese medicine that interacts with various ion channels, including the GABAA receptor, nicotinic acetylcholine receptor, and the i...
TN1519	(S)-Coclaurine	Coclaurine	AChR
	(S)-Coclaurine (Coclaurine) is an antagonist of nAChR isolated from Sarcopetalum harveyanum.		AChR
Fr13756	Isonicotinic acid		Endogenous Metabolite , Drug Metabolite
	Isonicotinic acid is a metabolite of Isoniazid.Isonicotinic acid is a useful isomer of nicotinic acid. Isoniazid is converted to Isonicotinic acid by hydrazinolysis, with the biotransformation also to be catalyzed by cyt...		Endogenous Metabolite , Drug Metabolite
T4816	6-Hydroxynicotinic acid	6-Hydroxypyridine-3-carboxylic acid,2-Hydroxy-5-pyridinecarboxylic acid	Others , Endogenous Metabolite
	6-Hydroxynicotinic acid (6-Hydroxypyridine-3-carboxylic acid) is exploited in the use of NMR spectroscopy or gas chromatography--mass spectrometry for the diagnosis of Pseudomonas aeruginosa in urinary tract infection. A...		Others , Endogenous Metabolite
T7919	6-Aminonicotinic acid		Others
	6-Aminonicotinic acid is a natural product.		Others
T3023	Catharanthine sulfate		AChR
	Catharanthine inhibits nicotinic receptor-mediated diaphragm contractions.		AChR
T2782	Catharanthine	(+)-3, 4-Didehydrocoronaridine,(+)-3,4-Didehydrocoronaridine	Calcium Channel , AChR
	Catharanthine ((+)-3,4-Didehydrocoronaridine) suppresses nicotinic receptor-mediated diaphragm contractions (IC50=59.6 μM).		Calcium Channel , AChR
T7224	Anabasine	(S)-Anabasine,(-)-Anabasine	AChR
	Anabasine ((S)-Anabasine) is an alkaloid extracted from tobacco. Anabasine is a full agonist of nicotinic acetylcholine receptors (nAChRs) with insecticidal activity. Anabasine depolarizes TE671 cells endogenously expres...		AChR
T1231	Pilocarpine nitrate	Pilagan,Pilofrin	AChR
	Pilocarpine nitrate (Pilagan) is a slowly hydrolyzed muscarinic agonist with no nicotinic effects. Pilocarpine is used as a miotic and in the treatment of glaucoma.		AChR
T3865	Beta-Eudesmol	Beta-Selinenol	TRP/TRPV Channel , AChR
	beta-Eudesmol (Beta-Selinenol) is a noncompetitive antagonist of nicotinic acetylcholine receptors (nAChRs). It is a sesquiterpene that has been found in a variety of plants, including Cannabis, and has diverse biologica...		TRP/TRPV Channel , AChR
TN1081	Hirsuteine		Dopamine Receptor
	Hirsuteine is a natural product. It non-competitively antagonizes nicotine-mediated dopamine release by blocking ion permeation through nicotinic receptor channel complexes.		Dopamine Receptor
T65135	Kynurenic acid	Fibrostop 2,Quinurenic acid	GPR , GluR , NMDAR
	Kynurenic acid (Quinurenic acid) is an endogenous tryptophan active metabolite, a triple antagonist of NMDA, glutamate, α7 nicotinic acetylcholine receptor, and an agonist of GPR35/CXCR8 with neuroprotective and anticonv...		GPR , GluR , NMDAR
TN3695	Coniine hydrochloride		Others
	Coniine hydrochloride, a polyketide-derived alkaloid, is poisonous to humans and animals. It is a nicotinic acetylcholine receptor antagonist, which leads to inhibition of the nervous system.		Others
T21532	Anisodamine	6-Hydroxyhyoscyamine,6-beta-Hydroxyhyoscyamine	AChR
	Anisodamine (6-beta-Hydroxyhyoscyamine) is an antagonist of muscarinic and nicotinic cholinoceptor with similar affinities at the muscarinic receptor as scopolamine and atropine. Anisodamine improve the microcirculation ...		AChR
T4721	β-Nicotinamide mononucleotide	β-NM	Others , Endogenous Metabolite
	β-Nicotinamide mononucleotide (β-NM) is an important intermediate metabolite in the nicotinate and nicotinamide metabolism pathway. Mammals predominantly use nicotinamide rather than nicotinic acid as a precursor for NAD...		Others , Endogenous Metabolite
T2S1464	Thiocolchicoside	Thiocolchicine 2-glucoside analog,Coltramyl	Others , GABA Receptor
	Thiocolchicoside (Thiocolchicine 2-glucoside analog) (Muscoril, Myoril, Neoflax) is a muscle relaxant with anti-inflammatory and analgesic effects. It acts as a competitive GABAA receptor antagonist and also glycine rece...		Others , GABA Receptor
T72382	Dihydro-β-erythroidine
	Dihydro-β-erythroidine, a competitive nicotinic receptor antagonist, effectively blocks the discriminative stimulus properties and inhibits the anxiolytic effects induced by nicotine.
T22357	Lobeline sulfate	Lobelin sulphate	Others
	Lobelin sulphate is an alkaloid that has actions similar to nicotine on nicotinic cholinergic receptors but is less potent. It has a variety of therapeutic uses including in insomnia, and smoking cessation, peripheral va...		Others
T11041	Dihydro-β-erythroidine hydrobromide	DHβE hydrobromide	Others
	Dihydro-β-erythroidine hydrobromide(DHβE) is a potent, oral active and competitive antagonist of neuronal nicotinic acetylcholine receptors (nAChRs). Dihydro-β-carotene hydrobromide showed selectivity to α4β4 and α4β2nAC...		Others
T19128	3-Pyridineacetic acid		Others
	3-Pyridineacetic acid is a homolog of nicotinic acid, a breakdown product of nicotine and other tobacco alkaloids.		Others
T75644	Lupanine hydrochloride
	Lupanine hydrochloride, a natural ketonic derivative of Sparteine ((+)-Sparteine), exhibits ganglioplegic activity and binds to the nicotinic receptor (nAChR) with a K i value of 500 nM [1].
TN6500	Microgrewiapine A
	Microgrewiapine A is a selective cytotoxic agent for colon cancer cells over normal colon cells and to exhibit nicotinic receptor antagonistic activity for both the hα3β4 and hα4β2 receptor subtypes.
T62265	(+)-Sparteine sulfate pentahydrate
	(+)-sparteine (sulfate pentahydrate) is a ganglion blocker that competitively blocks nicotinic acetylcholine receptors in neurons.
TN6028	Gardneramine
	Gardneramine has a mild central depressive effect. Gardneramine and hirsutine show a local anesthetic action, they also can inhibit the ganglionic transmission of the dog urinary bladder and that the blockade of the nico...
T75539	Nereistoxin
	Nereistoxin (Nereistoxine), a neurotoxin derived from Lumbriconereis heteropoda, a marine annelid, functions by inhibiting nicotinic acetylcholine receptors [1].
T37609	(rel)-Asperparaline A
	Aspergillimide is a fungal metabolite originally isolated from A. japonicus.1 It reduces nicotinic acetylcholine receptor (nAChR) peak and slowly-desensitizing amplitudes induced by acetylcholine in silkworm (B. mori) la...
T73856	Anagyrine hydrochloride
	Anagyrine hydrochloride ((-)-Anagyrine hydrochloride), a quinolizidine alkaloid discovered in Lupinus albus, interacts with both muscarinic and nicotinic acetylcholine receptors, demonstrating IC50 values of 132 and 2096...

天然物製品

Nicotinic acid mononucleotide

Synonym: Vitamin B3,Nicotinic acid

Target: Endogenous Metabolite, Autophagy

N-Methylnicotinamide

T5233

Synonym: N'-Methylnicotinamide,Nicotinic Acid Methylamide,N-Methylpyridine-3-carboxamide

Target: Others, Endogenous Metabolite

Nicotinic acid riboside

T67407

Synonym:

Target:

Trigonelline chloride

T2927

Synonym: Gynesine Hydrochloride,Coffearine Hydrochloride,Nicotinic acid N-methylbetaine Hydrochloride,Trigonelline hydrochloride

Target: Others, Antibacterial, Antifungal, HSV

Synonym: Biocolina,Biocoline,Hepacholine

Target: AChR

Arecoline hydrobromide

T2198

Synonym: Arecoline HBr,Arecoline bromide

Target: AChR

(+)-Sparteine

T7853

Synonym: Pachycarpine

Target: AChR

N-Methylcytisine

T5S0994

Synonym: Caulophylline

Target: Others, AChR

Cytisinicline

T0479

Synonym: Baptitoxine,Cytisine,Baphitoxine,Sophorine

Target: AChR

Ferulamide

TN1643

Synonym: 4-Hydroxy-3-methoxycinnamide

Target: PAFR, AChR

Galanthamine hydrobromide

T0086

Synonym: Galantamine hydrobromide,Galanthamine HBr

Target: AChR, AChE

Acetylcholine chloride

T1221

Synonym: ACh chloride,Pilofrin

Target: Calcium Channel, Endogenous Metabolite, AChR

Lobeline hydrochloride

T0268

Synonym: α-Lobeline hydrochloride,L-Lobeline hydrochloride

Target: AChR

Cholesterol myristate

T8040

Synonym: Cholesteryl myristate,Cholesteryl tetradecanoate

Target: Others, Potassium Channel, GABA Receptor, Endogenous Metabolite, AChR

Target: Endogenous Metabolite, Drug Metabolite

6-Hydroxynicotinic acid

T4816

Synonym: 6-Hydroxypyridine-3-carboxylic acid,2-Hydroxy-5-pyridinecarboxylic acid

Target: Others, Endogenous Metabolite

6-Aminonicotinic acid

T7919

Synonym:

Target: Others

Catharanthine sulfate

Synonym: (+)-3, 4-Didehydrocoronaridine,(+)-3,4-Didehydrocoronaridine

Target: Calcium Channel, AChR

Anabasine

T7224

Synonym: (S)-Anabasine,(-)-Anabasine

Target: AChR

Pilocarpine nitrate

T1231

Synonym: Pilagan,Pilofrin

Target: AChR

beta-Eudesmol

T3865

Synonym: Beta-Selinenol

Target: TRP/TRPV Channel, AChR

Hirsuteine

TN1081

Synonym:

Target: Dopamine Receptor

Kynurenic acid

T65135

Synonym: Fibrostop 2,Quinurenic acid

Target: GPR, GluR, NMDAR

Coniine hydrochloride

Synonym: 6-Hydroxyhyoscyamine,6-beta-Hydroxyhyoscyamine

Target: AChR

β-Nicotinamide mononucleotide

T4721

Synonym: β-NM

Target: Others, Endogenous Metabolite

Thiocolchicoside

T2S1464

Synonym: Thiocolchicine 2-glucoside analog,Coltramyl

Target: Others, GABA Receptor

Dihydro-β-erythroidine

Synonym: Lobelin sulphate

Target: Others

Dihydro-β-erythroidine hydrobromide

T11041

Synonym: DHβE hydrobromide

Target: Others

3-Pyridineacetic acid

T19128

Synonym:

Target: Others

Lupanine hydrochloride

(+)-Sparteine sulfate pentahydrate

(rel)-Asperparaline A

T37609

Synonym:

Target:

Anagyrine hydrochloride

T73856

Synonym:

Target:

Recombinant Proteins

Species：

Expression System：

Tag：

カタログ番号	製品名	Species	Expression System
TMPY-00554	CHRNB3 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Cholinergic nicotinic receptor (CHRN) gene family has been known to mediate the highly additive effects of nicotine in the body, and implicated nicotine dependence (ND) and related phenotypes. Cigarette smoking is protec...
TMPY-04195	CHRNB3 Protein, Human, Recombinant (hFc)	Human	HEK293 Cells
	Cholinergic nicotinic receptor (CHRN) gene family has been known to mediate the highly additive effects of nicotine in the body, and implicated nicotine dependence (ND) and related phenotypes. Cigarette smoking is protec...
TMPY-04321	CHRNA5 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Genetic variation in the cluster on chromosome 15, encoding the nicotinic acetylcholine receptor subunits (CHRNA5-CHRNA3-CHRNB4), has shown strong associations with tobacco consumption and an additional risk increase in ...
TMPH-02811	NRK1 Protein, Mouse, Recombinant (His)	Mouse	E. coli
	Catalyzes the phosphorylation of nicotinamide riboside (NR) and nicotinic acid riboside (NaR) to form nicotinamide mononucleotide (NMN) and nicotinic acid mononucleotide (NaMN).
TMPH-03219	Rabies virus (RABV) (strain India) Glycoprotein (His)	RABV	P. pastoris (Yeast)
	Attaches the virus to host cellular receptor, inducing endocytosis of the virion. In the endosome, the acidic pH induces conformational changes in the glycoprotein trimer, which trigger fusion between virus and cell memb...
TMPH-03222	Rabies virus (RABV) (strain ERA) Glycoprotein (His)	RABV	E. coli
	Attaches the virus to host cellular receptor, inducing endocytosis of the virion. In the endosome, the acidic pH induces conformational changes in the glycoprotein trimer, which trigger fusion between virus and cell memb...
TMPH-03221	Rabies virus (RABV) (strain CVS-11) Glycoprotein (His & Myc & SUMO)	RABV	E. coli
	Attaches the virus to host cellular receptor, inducing endocytosis of the virion. In the endosome, the acidic pH induces conformational changes in the glycoprotein trimer, which trigger fusion between virus and cell memb...
TMPH-03224	Rabies virus (RABV) (strain HEP-Flury) Glycoprotein (E. coli, His)	RABV	E. coli
	Attaches the virus to host cellular receptor, inducing endocytosis of the virion. In the endosome, the acidic pH induces conformational changes in the glycoprotein trimer, which trigger fusion between virus and cell memb...
TMPH-03220	Rabies virus (RABV) (strain India) Glycoprotein (His & SUMO)	RABV	E. coli
	Attaches the virus to host cellular receptor, inducing endocytosis of the virion. In the endosome, the acidic pH induces conformational changes in the glycoprotein trimer, which trigger fusion between virus and cell memb...
TMPY-03406	NMNAT1 Protein, Human, Recombinant (His)	Human	Baculovirus Insect Cells
	NMNAT, also known as NMNAT1, is a member of the Nicotinamide-nucleotide adenylyltransferases. It is widely expressed with high levels in skeletal muscle, heart, liver, and kidney. NMNAT appears to have the ability to pro...
TMPH-03223	Rabies virus (RABV) (strain HEP-Flury) Glycoprotein (His)	RABV	Baculovirus Insect Cells
	Attaches the virus to host cellular receptor, inducing endocytosis of the virion. In the endosome, the acidic pH induces conformational changes in the glycoprotein trimer, which trigger fusion between virus and cell memb...
TMPH-00430	VxXIIC Protein, Conus vexillum, Recombinant (His & Myc & SUMO)	Conus vexillum	E. coli
	Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them. This toxin specifically blocks mammalian neuronal nAChR of the alpha-7/CHRNA7, alpha-3-bet...
TMPH-03037	Alpha-cobratoxin Protein, Naja kaouthia, Recombinant (GST & His & Myc)	Naja kaouthia	E. coli
	Monomer: binds with high affinity to muscular (alpha-1-beta-1-gamma-delta/CHRNA1-CHRNB1-CHRNG-CHRND) nAChR (tested on Torpedo californica, Kd=0.2-4.5 nM) and neuronal alpha-7/CHRNA7 nicotinic acetylcholine receptors (Kd=...