| TN6792 |
O-Acetylgalanthamine
|
|
Others
|
|
The O-Acetylgalanthamine is a natural product that have been found in bulbs of Narcissus pseudonarcissu. |
| TN6786 |
O-Desmethyl Galanthamine
|
Sanguinine |
AChE
|
|
O-Desmethyl Galanthamine (Sanguinine) is galanthamine-type alkaloid and it is an acetylcholinesterase (AChE) inhibitor, with an IC50 1.83 μM. |
| T7450 |
1-Phenylpropane-1,2-dione
|
1-Phenyl-1,2-propanedione,Acetyl benzoyl |
Others
|
|
1-Phenylpropane-1,2-dione (Acetyl benzoyl) is a eukaryotic metabolite produced in plant metabolic reactions. |
| TN1519 |
(S)-Coclaurine
|
Coclaurine |
AChR
|
|
(S)-Coclaurine (Coclaurine) is an antagonist of nAChR isolated from Sarcopetalum harveyanum. |
| T8016 |
N-Methylbenzylamine
|
N-Benzylmethylamine |
Others
|
|
N-Methylbenzylamine (N-Benzylmethylamine) is an Alkaloids |
| TN7232 |
Pegamine
|
|
|
|
pegamine is a natural product found in Peganum harmala and Peganum nigellastrum, which are novel alkaloids. |
| T32570 |
Lappaconine
|
20-ethyl-1,14,16-trimethoxyaconitane-4,6,8-triol,O(sup 1)-Methyllappaconidine |
Others
|
|
Lappaconine (20-ethyl-1,14,16-trimethoxyaconitane-4,6,8-triol) derivated from norditerpenoid alkaloids. |
| TQ0192 |
Senecionine
|
Aureine,Senecionan-11,16-dione, 12-hydroxy-,Senecionin |
Others
|
|
Senecionine (Senecionin) is the hepatotoxic pyrrolizidine alkaloids isolated from Senecio vulgaris. |
| TN2156 |
Rhombifoline
|
|
Antioxidant
|
|
Rhombifoline is a family of alkaloids isolated from the leaf stems of Anagyrus foetida and Genista tenera. |
| T8770 |
Harmalol
|
Harmidol |
AChR
|
|
Harmalol (Harmidol) is a bioactive beta-carboline and a member of the harmala alkaloids |
| T2797 |
Harmaline
|
|
Others
|
|
Harmaline is a fluorescent psychoactive indole alkaloid from the group of harmala alkaloids and beta-carbolines. It is the reduced hydrogenated form of harmine. |
| T2825 |
Cyclopamine
|
11-Deoxojervine |
Hedgehog/Smoothened
,
Endogenous Metabolite
,
Smo
|
|
Cyclopamine (11-Deoxojervine), a Smoothened (Smo) antagonist (IC50: 46 nM in TM3Hh12 cells), belongs to the group of steroidal jerveratrum alkaloids. |
| TN7061 |
Yuanamide
|
|
Others
|
|
Yuanamide is a natural compound that belongs to the class of alkaloids. |
| T67922 |
Lepidiline C
|
|
Others
|
|
Lepidiline C is a novel imidazoles alkaloids extracted from the root of Lepidium meenii Walpers of the brassaceae family. It has shown cytotoxic activity against HL-60 cells (IC50:27.7 μM). |
| T7324 |
Chelidonine hydrochloride
|
|
Others
|
|
Chelidonine hydrochloride is one of the alkaloids of Chelidonium majus, which has broad pharmacological activities |
| T5595 |
Tropine
|
3alpha-Tropanol,Pseudotropine |
Others
|
|
Tropine is a naturally-occurring tropane alkaloid extracted primarily from plants of the Solanaceae family. It serves as an intermediate in the synthesis of a variety of bioactive alkaloids. |
| T4953 |
Neotuberostemonine
|
|
NOS
|
|
Neotuberostemonine (NTS) is one of the main antitussive alkaloids in the root of Stemona tuberosa Lour, it has a significant protective effect on bleomycin (BLM)-induced pulmonary fibrosis through suppressing the recruit... |
| T6S0659 |
Rhynchophylline
|
Rhynchophyllin,Rhyncophylline,Mitrinermine,Mitrinermin |
Calcium Channel
,
NF-κB
|
|
1. Rhynchophylline (Mitrinermine) can protect against ischemic damage, probably via regulating the Akt/mTOR pathway. 2. Rhynchophylline can protect against glutamate-induced neuronal death, can inhibit MA impairment in c... |
| T8769 |
Harmaline hydrochloride
|
Harmidine hydrochloride |
Others
|
|
Harmaline hydrochloride (Harmidine hydrochloride) is a fluorescent indole alkaloid from the group of harmala alkaloids and beta-carbolines. It is the partially hydrogenated form of harmine.Harmaline produces a generalize... |
| TN1078 |
Seneciphylline
|
|
P450
,
GST
|
|
Seneciphylline, one of the hepatotoxic pyrolizidine alkaloids, has mutagenic activity in Drosophila and their transfer into rat milk.Seneciphylline can significantly increased the activities of epoxide hydrase and glutat... |
| T5S2361 |
Epiberberine
|
|
ERK
,
Beta-Secretase
,
MEK
,
BACE
,
AMPK
,
AChR
,
AChE
|
|
1. Epiberberine may be caused drug interactions based on CYP2D6 enzyme. 2. Epiberberine has anti-adipogenic effect is mediated by downregulation of the Raf/MEK1/ERK1/2 and AMPKα/Akt pathways during 3T3-L1 adipocyte diffe... |
| T0439 |
L-Tryptophan
|
(S)-Tryptophan,Tryptophan,L-Tryptophane,Tryptophane |
Amino Acids and Derivatives
,
Endogenous Metabolite
|
|
L-Tryptophan (Tryptophane), an essential amino acid, is necessary for normal growth in infants and for nitrogen balance in adults. It is a precursor of SEROTONIN (hence its use as an antidepressant and sleep aid) and of ... |
| TN4889 |
(R)-Reticuline
|
|
NADPH-oxidase
|
|
(R)-Reticuline is the biosynthetic precursor of the morphinan alkaloids. |
| T34599 |
Secologanin
|
NSC 640525 |
|
|
Secologanin is a monoterpene that has been found in V. rosea and is an intermediate in the synthesis of monoterpene indole alkaloids from geraniol. |
| TN4784 |
Picraline
|
|
SGLT
|
|
A series of a hydroxy substituted derivatives 21-28 at C-17 of the Picraline-type alkaloids have been derived as having potent SGLT inhibitory activity. |
| TN6686 |
Cyclo(Pro-Pro)
|
|
|
|
Cyclo(Pro-Pro) tasted bitter.Verpacamides A-D, a sequence of C11N5 diketopiperazines relating cyclo(Pro-Pro) to cyclo(Pro-Arg), from the marine sponge Axinella vaceleti is possible biogenetic precursors of pyrrole-2-amin... |
| TN4346 |
Jaconine
|
|
Others
|
|
Jaconine, jacoline,jacobine, and jacozine, the hepatotoxic alkaloids, are potentially carcinogenic, mutagenic, and teratogenic and may pose health hazards to the human consumer. |
| TN3237 |
7-Isopentenyloxy-gamma-fagarine
|
|
Others
|
|
7-Isopentenyloxy-gamma-fagarine has highly cytotoxicity against the MCF-7and Jurkat cell line. It has been used as a precursor for the chemical asymmetric synthesis of the enantiopure alkaloids: evoxine, anhydroevoxine a... |
| T19128 |
3-Pyridineacetic acid
|
|
Others
|
|
3-Pyridineacetic acid is a homolog of nicotinic acid, a breakdown product of nicotine and other tobacco alkaloids. |
| T4S0797 |
Berberine
|
Berberin,Umbellatine |
Reactive Oxygen Species
,
Topoisomerase
,
Endogenous Metabolite
,
Antibacterial
,
Antibiotic
,
Autophagy
|
|
1. Berberine (Umbellatine) is a potent oral hypoglycemic agent with beneficial effects on lipid metabolism. 2. Berberine may as a broad-spectrum anti-microbial medicine, a complementary therapeutic agent for HIV/AIDS. 3.... |
| T2974 |
Cyclovirobuxine D
|
CVB-D,Bebuxine,Cyclovirobuxin D |
Apoptosis
,
Others
,
Akt
,
mTOR
,
Autophagy
|
|
Cyclovirobuxine D (Bebuxine) is extracted from Buxus microphylla. |
| TN4171 |
Grossamide
|
|
NO Synthase
|
|
Grossamide (GSE) Grossamide is a lignan amide derived from thioguanosine.6-Thioguanosine (GSE) is a selective and potent miR-210 (miRNA-210) inhibitor.6-Thioguanosine (GSE) is a selective and potent miR-210 (miRNA-210) i... |
| TN7032 |
4'-O-Methylpyridoxine
|
4-methoxymethylpyridoxine,Ginkgotoxin |
Antioxidant
|
|
4'-O-Methylpyridoxine (MPN) is a vitamin-like compound discovered from Ginkgo biloba with antioxidant activity and cytotoxicity. |
| TN2086 |
Piperlotine A
|
|
Antibacterial
|
|
Piperlotine A is an alkaloid that can be extracted from Piperonyssinus rolfsii and has antiplatelet aggregation activity.Piperlotine A showed inhibition of Mycobacterium tuberculosis in an in vitro assay with a MIC value... |
| PDK0014 |
3-Methylxanthine
|
|
Endogenous Metabolite
|
|
3-Methylxanthine, a xanthine derivative, is a cyclic guanosine monophosphate (GMP) inhibitor, with an IC50 of 920 μM on guinea-pig isolated trachealis muscle.3-Methylxanthine inhibited xanthine crystallization, it could ... |
| T7671 |
Myosmine
|
|
Others
,
AChR
|
|
Myosmine is a minor tobacco alkaloid that is structurally related to nicotine. |
| T5S0994 |
N-Methylcytisine
|
Caulophylline |
Others
,
AChR
|
|
1. N-Methylcytisine (Caulophylline)'s nicotinic receptors have high affinity (KD = 5 nM)to nAChR from squid optical ganglia. 2. N-Methylcytisine and N, N-dimethylcytisine did not displace 14C-tubocurarine at a concentrat... |
| T3030 |
L-Sophoridine
|
Sophoridine,Matridin-15-one |
Others
|
|
L-Sophoridine (Matridin-15-one) , a natural product obtained from medicinal plants, which has a variety of pharmacological effects, including anti-Y effects, and selectively induces apoptotic cell death in a variety of h... |
| T3243 |
Betaine
|
Abromine,glycine betaine,oxyneurine,trimethylglycine,lycine |
Others
,
Endogenous Metabolite
|
|
Betaine (trimethylglycine) is a methyl derivative of glycine first isolated from sugar beets. It has been shown to have potential benefits for fighting heart disease, improving body composition, and helping promote muscl... |
| T6S0654 |
Isocorynoxeine
|
7-Isocorynoxeine |
5-HT Receptor
|
|
1. Isocorynoxeine (7-Isocorynoxeine) shows the effects of lowering blood pressure, vasodilatation, and protection against ischemia-induced neuronal damage. 2. Isocorynoxeine exhibits a significant neuroprotective effect ... |
| T2S0663 |
Humantenmine
|
|
P450
|
|
1. Humantenmine is a toxic compound isolated from Gelsemium elegans Benth . 2. Humantenmine and koumine may inhibit several CYP450 enzyme activities. |
| T0461L |
Berberine sulfate
|
AI3-61947,Berberin sulfate,Berberine sulphate,Berberal |
|
|
|
| T1644 |
Dopamine hydrochloride
|
Dopamine HCl,ASL279 |
Ferroptosis
,
Dopamine Receptor
,
5-HT Receptor
,
Endogenous Metabolite
|
|
Dopamine hydrochloride (ASL279) is a naturally occurring catecholamine formed by decarboxylation of dihydroxyphenylalanine and a precursor of norepinephrine and epinephrine. Dopamine hydrochloride binds to alpha-1- and b... |
| TN2027 |
Oxysanguinarine
|
8-Oxosanguinarine,Hydroxysanguinarine |
Parasite
|
|
Oxysanguinarine (Hydroxysanguinarine) possesses antiplatelet aggregation activity, it has potential inhibitory properties against the dengue virus. |
| TN2159 |
Robustine
|
|
PDE
|
|
Robustine is a natural product, exhibits inhibitory potency against human phosphodiesterase 5 (hPDE5A) in vitro. |
| T5799 |
Arecaidine hydrochloride
|
|
Others
|
|
Arecaidine hydrochloride may have carcinogenesis. |
| T5765 |
Ranaconitine
|
|
Apoptosis
,
Others
|
|
Ranaconitine is an important diterpenoid alkaloid from Aconitum sinomontanum Nakai,ranaconitine has cardiotoxicity. |
| TN7054 |
N-Formylcytisine
|
(-)-N-Formylcytisine |
Others
|
|
N-Formylcytisine ((-)-N-Formylcytisine) is a natural product isolated from the stem bark of Maackia amurensis. |
| T13302 |
Viquidil hydrochloride
|
Quinotoxine hydrochloride |
Others
|
|
Viquidil hydrochloride (Quinotoxine hydrochloride) is an isomer of Quinidine. Viquidil hydrochloride is an agent of cerebral vasodilator with antithrombotic activity. |
| T2S1792 |
Lycobetaine
|
Ungeremine |
Antibacterial
|
|
1. Lycobetaine (Ungeremine) is a potential biofungicide against Penicillium roqueforti and Aspergillus niger.2. Lycobetaine have strong antibacterial activity against Flavobacterium columnare . 3. Lycobetaine effectively... |
