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T5447 |
Anle138b
|
|
Beta Amyloid
,
Others
|
|
Anle138b: a novel oligomer modulator for disease-modifying therapy of neurodegenerative diseases such as prion and Parkinson's disease |
|
T9928 |
Ranibizumab
|
|
VEGFR
|
|
Ranibizumab is a humanized monoclonal antibody fragment designed to target and inhibit vascular endothelial growth factor (VEGF), including VEGF110, VEGF121, and VEGF165. Ranibizumab's ability to selectively target and n... |
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T10122 |
Anti-neurodegeneration agent 1
|
|
Others
|
|
|
|
T5359 |
RCGD423
|
|
Interleukin
|
|
RCGD423, a small molecule gp130 modulator, prevents articular cartilage degeneration and promotes repair. |
|
T13157 |
TG 100801
|
TG100801,TG 100572 |
VEGFR
,
Src
|
|
TG 100801 is a dual inhibitor of VEGFr2 and Src family (Src and YES) kinases and is a candidate compound for the treatment of age-related macular degeneration (AMD). |
|
T2706 |
Palomid 529
|
P529,SG 00529 |
Apoptosis
,
mTOR
|
|
Palomid 529 (SG 00529) has been used in trials studying the treatment of Age-Related Macular Degeneration. |
|
T27084 |
Crisdesalazine
|
AAD2004,AAD 2004,AAD-2004 |
Prostaglandin Receptor
|
|
Crisdesalazine (AAD 2004) is an inhibitor of microsomal prostaglandin E2 synthase-1 (mPGES-1). Crisdesalazine reduces autophagosome formation, axonopathy, and motor neuron degeneration, improving motor function and incre... |
|
T7493 |
AG-13958
|
AG-013958 |
VEGFR
|
|
AG-13958 (AG-013958) (AG-013958), a potent VEGFR tyrosine kinase inhibitor, for the treatment of age-related macular degeneration. |
|
T77600 |
Methyl-4-oxoretinoate
|
|
Apoptosis
|
|
Methyl-4-oxoretinoate is a synthetic retinoid compound with anticancer compounds that can induce differentiation and apoptosis in cancer cells.Methyl-4-oxoretinoate is used in the treatment of acne, psoriasis, and other ... |
|
T19739 |
Simazine
|
Tafazine,Aquazine,Radocon,Herbex |
Others
|
|
Simazine (Tafazine) is a chlorotriazine herbicide and pesticide. Simazine may lead to testicular degeneration, neuroendocrine disruption, mammary cancer, and fetal developmental delays. |
|
T34399 |
Rovatirelin
|
KPS-0373,S0373,S-0373,S 0373 |
AChE
|
|
Rovatirelin (S-0373) is a newly synthesized thyrotropin-releasing hormone (TRH) analog that ameliorates cytosine arabinoside-induced motor dysfunction in a rat model of spinal cerebellar degeneration via acetylcholine an... |
|
T10531 |
BGB-102
|
JNJ-26483327 |
EGFR
,
VEGFR
,
FLT
,
Src
|
|
BGB-102 (JNJ-26483327) is a kinase inhibitor targeting FLT3 and YES1 and an antagonist targeting EGFR and VEGFR3, which may be useful in the study of macular degeneration and diseases associated with genetic disorders an... |
|
T28273L |
OT-551 HCl
|
OT-551 HCl（627085-11-4 Free base） |
NF-κB
|
|
OT-551 HCl is an NF-Κb inhibitor, a disubstituted hydroxylamine with antioxidant properties can be used for the treatment of cataracts and age-related macular degeneration and geographic atrophy (GA). |
|
T8860 |
DSRM-3716
|
|
Androgen Receptor
|
|
Isoquinoline, 5-iodo- (9CI) is a potent and selective inhibitor of SARM1(IC50 = 75 nM) by preventing axonal degeneration and by allowing functional recovery of a metastable pool of damaged, but viable, axons. |
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T35182 |
Xinidamine
|
BRN 0891979,Xinidaminum,Xinidamino |
|
|
Xinidamine (BRN 0891979) has antitumor activity and can be used to study benign prostatic hyperplasia, macular degeneration and prostatic intraepithelial neoplasia .Xinidamine inhibits the proliferation of PWR-1E cells w... |
|
T13048 |
SynuClean-D
|
SC-D |
Others
|
|
SynuClean-D (SC-D) is an α-synuclein aggregation inhibitor preventing fibril propagation, disrupting mature amyloid fibrils, and abolishing the degeneration of dopaminergic neurons in an animal model of Parkinson’s disea... |
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T21300 |
Trientine-2HCl
|
Triethylenetetramine,Trientine HCl,Trientine,Triethylene tetramine,TETA,Trien |
Others
|
|
Trientine-2HCl (Trien), a chelating agent, is used to treat Wilson's disease by binding up and removing copper in the body. Trientine can also be used as a chelating agent for copper in hepatolenticular degeneration, as ... |
|
T35689 |
MTP 131 acetate
|
|
Others
|
|
MTP 131 is a mitochondria-targeted peptide antioxidant.1,2It localizes to the mitochondria and reducestert-butyl hydroperoxide-induced lipid peroxidation and apoptosis in SH-SY5Y cells when used at concentrations ranging... |
|
T27443 |
GSK 894281
|
GSK894281,GSK-894281 |
|
|
GSK 894281 is a ghrelin receptor agonist. It may produces myocardial degeneration/necrosis in rats. |
|
T34551 |
SC 32855
|
SC-32855,SC32855 |
|
|
SC 32855 is a 1,4-benzodiazepine that has been shown to arrest of spermatogenesis and degeneration of the germinal epithelium. |
|
T28273 |
OT-551
|
CPC 551,OT 551,CPC551,CPC-551 |
|
|
OT-551, a NF-κB inhibitor, is used potentially for the treatment of cataracts and age-related macular degeneration. |
|
T71715 |
CU239
|
|
|
|
CU239 is a selective non-retinoid inhibitor of RPE65 which suppresses visual cycle and prevents retinal degeneration. |
|
T40037 |
Timtraxanib
|
AVI-3207 |
|
|
Timtraxanib (AVI-3207) is a potent and specific inhibitor of VEGF-2, offering great potential for investigating senile macular degeneration. |
|
T27670 |
JNJ-26076713
|
JNJ26076713 |
|
|
JNJ-26076713, an orally active alpha V integrin antagonist, represents a potential therapeutic candidate for the treatment of macular edema, age-related macular degeneration, and proliferative diabetic retinopathy. |
|
T26665 |
AS604872
|
AS-604872,AS 604872 |
|
|
AS604872 is a selective antagonist of the FP receptor.. AS604872 significantly accelerated degeneration of the media in both cerebral artery and aorta as evidenced by thinning of the media and disruption of the elastic l... |
|
T34750 |
Sut 8701
|
Sut8701,Sut-8701 |
|
|
Sut 8701 is a cholecystokinin analog that prevents cholinergic degeneration in the rat cerebral cortex following basal forebrain lesioning and can slow down the degenerative processes in Alzheimer's disease. |
|
T28409 |
Photoregulin1
|
|
|
|
Photoregulin1 is a modulator of Nr2e3. Photoregulin1 slows the progression of photoreceptor degeneration in two common mouse models of autosomal dominant RP, the RhoP23H and the Pde6brd1 mutations. |
|
T39706 |
Pegaptanib sodium
|
|
|
|
Pegaptanib sodium, an RNA aptamer specifically targeting vascular endothelial growth factor (VEGF)-165, holds great promise for investigating neovascular age-related macular degeneration (AMD). |
|
TP1390 |
CEP dipeptide 1
|
|
|
|
CEP dipeptide 1, a potent angiogenic compound, exhibits robust activity in promoting angiogenesis. This compound is specifically implicated in the pathogenesis of age-related macular degeneration (AMD). |
|
T37081 |
HIOC
|
|
|
|
Selective TrkB receptor agonist. Protects neurons from excitotoxicity. Protects retinas from light-induced retinal degeneration (LIRD) in vivo. Blood brain barrier and blood-retinal barrier penetrant. |
|
T13524 |
9-cis-β-Carotene
|
|
Others
|
|
|
|
T28488 |
Quinuronium Sulfate
|
Pirevan,Zothelone,Acaprin |
|
|
Quinuronium sulfate is a drug used to treat Babesia divergens infections in calves. It did not prevent treated animals from being disease carriers. It may also cause hepatic centrilobular fatty degeneration, but no deple... |
|
T73476 |
YC-001
|
|
|
|
YC-001, an inverse agonist and antagonist of rod opsin, reversibly binds and stabilizes the rod opsin structure. This compound demonstrates protective effects against bright light-induced retinal degeneration in mice, su... |
|
T36092 |
Fenobucarb
|
|
|
|
Fenobucarb, a widely employed carbamate insecticide, poses potential risks to the cardiovascular and cerebrovascular systems in animals[1][2]. It triggers developmental neurotoxicity in zebrafish by engaging pathways rel... |
|
T9695L |
POT-4 acetate
|
POT-4 acetate (934461-40-2 free base) |
Complement System
|
|
POT-4 acetate inhibits Complement C3 activation. POT-4 acetate can be used for studies about age-related macular degeneration. |
|
T36620 |
ALK4290
|
ALK4290 |
|
|
ALK4290 (AKST4290) is a potent and orally actively CCR3 inhibitor, compound Example 2, with a Ki of 3.2 nM for hCCR3[1]. ALK4290 can be used for the research of neovascular age-related macular degeneration and Parkinsoni... |
|
T71988 |
Moxaverine hydrochloride
|
|
|
|
Moxaverine hydrochloride is a derivative of papaverine, a phosphodiesterase inhibitor. Moxaverine has been studied in phase III of a clinical trial for the treatment of ocular blood flow in patients with age- related mac... |
|
T13157L |
TG 100801 Hydrochloride
|
|
VEGFR
|
|
TG 100801 Hydrochloride is a prodrug to treat age-related macular degeneration. TG 100572 is a inhibitor of multi-targeted kinase(IC50s of 2, 7, 2, 16, 13, 5, 0.5, 6, 0.1, 0.4, 1, 0.2 for VEGFR1, VEGFR2, FGFR1, FGFR2, PD... |
|
TP1464 |
Risuteganib hydrochloride
|
|
|
|
Risuteganib hydrochloride is an anti-integrin that downregulates oxidative stress and restores homeostasis, and targets three integrin receptors that are implicated in dry age-related macular degeneration (AMD) in order ... |
|
T77016 |
Galegenimab
|
|
|
|
Galegenimab (FHTR 2163; RG 6147; RO 7171009), an antibody fragment targeting High-temperature requirement A1 (HTRA1), is utilized in the research of age-related macular degeneration (AMD) [1]. |
|
T76887 |
Rinucumab
|
|
|
|
Rinucumab (REGN 2176), a monoclonal antibody that acts as a PDGF inhibitor, holds potential for researching neovascular age-related macular degeneration [1]. |
|
T35670 |
Miro1 Reducer
|
|
|
|
Promotes proteasomal degradation of Miro1 (mitochondrial Rho GTPase 1). Reduces Miro1 levels in fibroblasts from Parkinson's disease (PD) patients (IC50 = 7.8 μM). Exhibits no significant effect on related outer mitochon... |
|
T76210 |
POT-4 TFA
|
|
|
|
POT-4 TFA (AL-78898A TFA), a derivative of Compstatin, effectively inhibits the activation of complement factor C3. This compound is utilized in research related to age-related macular degeneration [1] [2]. |
|
T75156L |
Bevasiranib sodium
|
|
|
|
Bevasiranib sodium, an siRNA compound, targets and silences the genes responsible for producing vascular endothelial growth factor (VEGF). The suppression of VEGF, a critical factor in the development of choroidal neo-va... |
|
T75156 |
Bevasiranib
|
|
|
|
Bevasiranib, a siRNA, is specifically engineered to suppress the expression of genes responsible for the production of vascular endothelial growth factor (VEGF), a critical factor in the development of choroidal neo-vasc... |
|
T76987 |
Tarcocimab
|
|
|
|
Tarcocimab (OG1953), a humanized IgG1-type anti-VEGFA monoclonal antibody, is utilized in research targeting conditions such as retinal vein occlusion (RVO) and wet age-related macular degeneration (AMD). |
|
T69452 |
AG-13958 monohydrochloride
|
|
|
|
AG-13958 monohydrochloride is the HCl salt of AG-13958 --- a VEGFA inhibitor potentially for the treatment of age-related macular degeneration. Neovascular AMD, a subtype characterized by the growth of new, pathologic bl... |
|
T79010 |
Lp-PLA2-IN-12
|
|
Phospholipase
|
|
Lp-PLA2-IN-12 (compound 19), an Lp-PLA2 inhibitor, is utilized in researching neurodegenerative diseases including Alzheimer's disease (AD), glaucoma, age-related macular degeneration (AMD), and cardiovascular conditions... |
|
T74551 |
Avacincaptad pegol sodium
|
|
|
|
Avacincaptad pegol (ARC1905), an anti-C5 RNA aptamer, prevents the cleavage of complement factor 5 (C5) into fragments C5a and C5b. It is currently under investigation for the treatment of age-related macular degeneratio... |
|
T60243 |
Glycyl-L-glutamic acid
|
|
|
|
Glycyl-L-glutamic acid, acting as a neurotrophic factor (NF) in vivo, maintains AChE content and activity without directly influencing AChE synthesis. It may also prevent preganglionic neuronal degeneration [1] [2]. |
