|
T23383 |
SR11237
|
SR 11237 |
Others
,
RAR/RXR
|
|
SR11237 is a Pan retinoid X receptor (RXR) agonist. SR11237 causes RXR/RXR homodimers to form and transactivate a reporter gene containing a RXR-response element. |
|
T4043 |
ETC-159
|
ETC159,ETC-1922159,ETC 159 |
Wnt/beta-catenin
,
Porcupine
|
|
ETC-159 (ETC-1922159) is a potent, orally available PORCN inhibitor. It inhibits β-catenin reporter activity with an IC50 of 2.9 nM. |
|
T22101 |
ML-031
|
|
S1P Receptor
|
|
ML-031 activated S1P2 with an EC50 value of 1 μM in an S1P reporter assay. |
|
T22818 |
GSK9027
|
GR agonist 23a,GSK 9027,GSK-9027 |
Glucocorticoid Receptor
|
|
GSK9027 (GR agonist 23a) is a nonsteroidal glucocorticoid receptor (GR) agonist.GSK9027 is a partial agonist on the 2×GRE reporter gene compared to dexamethasone and is less active than dexamethasone activity. |
|
T14038L |
4-Azido-L-phenylalanine hydrochloride
|
p-Azido-L-phenylalanine hydrochloride,p-Azidophenylalanine hydrochloride |
Others
|
|
4-Azido-L-phenylalanine hydrochloride (p-Azido-L-phenylalanine hydrochloride) is an unnatural amino acid used as an effective vibrational reporter of local protein environments. |
|
T19850 |
Semaglutide
|
|
Glucagon Receptor
|
|
Semaglutide is a glucagon-like peptide 1 receptor (GLP-1R) agonist(EC50 of 6.2 pM in a reporter assay using BHK cells expressing the human receptor). |
|
T15677 |
KY1220
|
|
Wnt/beta-catenin
|
|
KY1220 destabilizes both β-catenin and Ras by targeting the Wnt/β-catenin pathway. It has an IC50 of 2.1 μM in HEK293 reporter cells. |
|
T4361 |
CBL0137 hydrochloride
|
CBL0137,CBLC137,Curaxin 137,CBL-C137 hydrochloride,Curaxin-137 hydrochloride |
Others
,
NF-κB
,
p53
|
|
CBL0137 hydrochloride (Curaxin-137 hydrochloride) activates p53 and inhibits NF-kB (EC50: 0.37/0.47 μM) in the cell-based p53 and NF-kB reporter assays, respectively. It also suppresses histone chaperone FACT. |
|
T4339 |
YU238259
|
|
DNA-PK
,
Others
|
|
YU238259 is a novel inhibitor of homology-dependent DNA repair(HDR), but does not inhibit non-homologous end-joining (NHEJ), in cell-based GFP reporter assays. |
|
T5636 |
Adavivint
|
Adavivint (SM04690) |
Wnt/beta-catenin
|
|
Adavivint (SM04690) is a selective inhibitor of the typical Wnt signaling pathway. In SW480 cells, EC50=19.5 nM was measured using high-throughput TCF/LEF reporter gene experiments. |
|
T4684 |
ML241 hydrochloride
|
|
p97
|
|
ML241 is a potent and selective inhibitors of p97 ATPase.ML241 inhibits degradation of a p97-dependent but not a p97-independent proteasome substrate in a dual-reporter cell line. ML241 may be a novel agent for the chemo... |
|
T8752 |
BAR 501 impurity
|
|
GPCR19
|
|
BAR501 impurity is an impurity found in the preparation of BAR501 that acts as an agonist of the G protein-coupled bile acid-activated receptor (GP-BAR1). BAR501 impurity (10 μM) induces a 150% increase in luciferase act... |
|
T77725 |
YAP-TEAD-IN-3
|
IAG933 |
YAP
|
|
YAP-TEAD-IN-3 is an inhibitor of YAP/TAZ-TEAD interactions with an IC50 of 9 nM for Avi-human TEAD (4217-434). YAP-TEAD-IN-3 inhibits YAP reporter gene expression (IC50 = 0.048 μM) and NCI-H2052 cell proliferation (IC50 ... |
|
T36527 |
IL-4-inhibitor-1
|
|
IL Receptor
|
|
IL-4 inhibitor is an inhibitor of IL-4.1It binds to IL-4 with a Kdvalue of 1.8 μM and inhibits IL-4 activity in a cell-based reporter assay (EC50= 1.81 μM). It is selective for IL-4 over IL-13 (EC50= 18.2 μM). IL-4 inhib... |
|
T37587 |
ML 209
|
|
ROR
|
|
ML-209 is an antagonist of retinoic acid receptor-related orphan receptor γt (RORγt; IC50= 1.1 μM in a reporter assay).1It inhibits RORγt-induced transcription in HEK293T cells expressing the human receptor (IC50= 300 nM... |
|
T4687 |
Ro5-3335
|
CBFβ-Runx1 inhibitor II,Ro 5-3335 |
DNA/RNA Synthesis
|
|
Ro5-3335 (CBFβ-Runx1 inhibitor II) is core binding factor (CBF) inhibitor; preferentially kills human leukemia cell lines with CBF fusion proteins (IC50 = 1.1 μM). Ro5-3335 represses RUNX1/CBFβ-dependent transactivation ... |
|
T36587 |
APTS
|
8-Aminopyrene-1,3,6-trisulfonic acid trisodium |
Others
|
|
8-Aminopyrene-1,3,6-trisulfonic acid (APTS) is an anionic fluorescent dye with excitation/emission spectra of 425/503 nm, respectively. It forms a ground state complex with viologen-type quenchers, inducing a red-shift i... |
|
T13067 |
TAK-828F
|
|
ROR
|
|
TAK-828F is a potent, selective, and orally available retinoic acid receptor-related orphan receptor γt (RORγt) inverse agonist (IC50=1.9 nM, reporter gene IC50=6.1 nM). |
|
T38238 |
2'-Deoxy-2'-fluorocytidine
|
|
Nucleoside Antimetabolite/Analog
,
Influenza Virus
|
|
2'-Deoxy-2'-fluorocytidine, an nucleoside analog, is a potent inhibitor of Crimean-Congo hemorrhagic fever virus (CCHFV) replication. 2′-deoxy-2′-fluorocytidine can act synergistically with T705 to increase the potency o... |
|
T23970 |
DDD00015314
|
DDD-00015314,DDD 00015314 |
|
|
DDD00015314 is the GUS reporter activity activator that acts by specifically increasing stumpy reporter gene expression. |
|
T68934 |
VT101 free base
|
|
|
|
VT101 is a TEAD Auto-palmitoylation inhibitor that Selectively Inhibit Proliferation and Tumor Growth of NF2-deficient Mesothelioma. VT101 inhibited the firefly luciferase reporter dose-dependently and had no 204 effect ... |
|
T10403 |
Atorvastatin ethyl ester
|
|
Others
|
|
Atorvastatin ethyl ester, a derivative of Atorvastatin, exhibits potent inhibition of 9-cis-RA-induced Gal4 reporter activity. |
|
T13562 |
Atorvastatin methyl ester
|
|
Others
|
|
Atorvastatin methyl ester is a derivative of Atorvastatin. It inhibits the 9-cis-RA-induced Gal4 reporter activity more strongly than Atorvastatin. |
|
T71424 |
VT-102 free base
|
|
|
|
VT-102 is a TEAD Auto-palmitoylation inhibitor that Selectively Inhibit Proliferation and Tumor Growth of NF2-deficient Mesothelioma. VT102 inhibited the firefly luciferase reporter dose-dependently and had no 204 effect... |
|
T29347 |
2-Ethynyl Adenosine
|
2-Ethynyl-Ade,2 Ethynyl Adenosine,2-Ethynyl-Adenosine |
|
|
2-Ethynyl Adenosine is an Adenosine derivative that is used to capture novel polyadenylated transcription and non-radiochemical reporter molecules of the protein AMPylation. |
|
T10374 |
ARS-1323-alkyne
|
|
Ras
|
|
ARS-1323-alkyne is a switch-II pocket (S-IIP) inhibitor and a conformational specific chemical reporter of KRASG12C nucleotide state in living cells. |
|
T39181 |
Cyanine 3 Tyramide
|
Cyanine 3 Tyramide,Tyramide-Cy3 |
|
|
Cyanine 3 Tyramide (Tyramide-Cy3), an orange fluorescent dye, serves as a reporter fluorescent substrate in horseradish peroxidase (HRP)-catalyzed deposition for signal amplification in immunoassays and in situ nucleic a... |
|
T40400 |
Enhanced Green Fluorescent Protein (EGFP) (200-208)
|
|
|
|
Enhanced Green Fluorescent Protein (EGFP) (200-208) is a reporter protein obtained from Aequorea Victoria jellyfish. EGFP is widely used as a marker gene product due to its strong fluorescence properties, making it easil... |
|
T38902 |
Cyanine 5 Tyramide
|
Tyramide-Cy5 |
|
|
Cyanine 5 Tyramide (Tyramide-Cy5), a red fluorescent dye, serves as a reporter fluorescent substrate in horseradish peroxidase (HRP)-catalyzed deposition, a signal amplification method employed in immunoassays and in sit... |
|
TD0086 |
ROX Reference Dye
|
|
|
|
ROX Reference Dye was designed to standardize fluorescent reporter gene signals in real-time quantitative PCR or RT-PCR |
|
T37833 |
CAY10767
|
|
|
|
CAY10767 is an agonist of peroxisome proliferator-activated receptor α (PPARα; EC50= 37 nM in a reporter assay).1It is greater than 2,700-fold selective for PPARα over PPARγ or PPARδ. |
|
T12916 |
Silvestrol aglycone
|
|
Others
|
|
Silvestrol aglycone is an analogue of Silvestrol, inhibits protein translation initiation in cancer cells(EC50s of 10 and 200 nM for myc-LUC and tub-LUC luciferase reporter protein translation, respectively), with nti-ca... |
|
T38158 |
StA-IFN-1
|
|
|
|
StA-IFN-1 is an inhibitor of the interferon (IFN) induction pathway with an IC50 value of 4.1 μM in a GFP reporter assay for IFN induction similar to TPCA-1 , which specifically inhibits the IKKβ component of the IFN ind... |
|
T27125 |
DBPR-110
|
MB110,MB 110,MB-110 |
|
|
DBPR-110 is a nonstructural protein 5A (NS5A) inhibitor. DBPR-110 reduced the reporter expression of the HCV1b replicon with a EC(50) and a selective index value of 3.9 ± 0.9 pM and >12,800,000, respectively. DBPR-110 re... |
|
T77926 |
PROTAC KRAS G12C degrader-1
|
|
PROTACs
|
|
PROTAC KRAS G12C degrader-1, a cereblon-based degrader, promotes CRBN/KRAS G12C dimerization and facilitates the degradation of GFP-KRAS G12C in reporter cells [1]. |
|
T37351 |
Desmethyl Bosentan
|
|
|
|
Desmethyl bosentan is an active metabolite of the endothelin receptor antagonist bosentan .1Desmethyl bosentan (25 μM) activates the pregnane X receptor (PXR) in CV-1 monkey kidney cells expressing the human receptor in ... |
|
T36365 |
KAPA (hydrochloride)
|
KAPA (hydrochloride),7-keto-8-Aminopelargomic Acid |
|
|
Biotin is a growth factor that plays an important role in numerous reactions that are critical to microorganisms, plants, and animals. Biotin has a strong affinity for the protein avidin, a trait that has been utilized f... |
|
T71925 |
Isonanangenine B
|
|
|
|
Isonanangenine B is a drimane sesquiterpene lactone that has been found in Aspergillus. It decreases survivin mRNA expression in a reporter assay when used at concentrations of 13.6, 18.42, and 26.31 µM. Isonanagenine B ... |
|
T83878 |
Z-CITCO
|
|
|
|
Z-CITCO acts as an agonist for the constitutive androstane receptor (CAR; with an EC50 of 3.9 µM in human receptor reporter assays) and is the cis isomer of the CAR agonist CITCO. |
|
T62726 |
Phenylpyropene C
|
|
|
|
Phenylpyropene C (S14-95) is a JAK/STAT pathway inhibitor that exhibits inhibition of IFN-γ-mediated reporter gene expression (IC50: 5.4-10.8 μM) and is also an inhibitor of acyl coenzyme A (IC50: 16.0 μM). |
|
T37466 |
CAY10766
|
|
|
|
CAY10766 is an antiviral compound.1It inhibits entry of influenza virus-like particles pseudotyped with hemagglutinin A (HA) from H5N1 influenza A virus into A549 cells (EC50= 0.24 μM). CAY10766 (1 μM) reduces H1N1 and H... |
|
T37092 |
20-HEPE
|
|
|
|
20-HEPE is a metabolite of eicosapentaenoic acid that is formed via ω-oxidation of EPA by cytochrome P450 (CYP) ω-oxidases, including human CYP4F3B. It activates peroxisome proliferator-activated receptor α (PPARα) in CO... |
|
T74073 |
Cyanine 5 Tyramide methyl indole
|
|
|
|
Cyanine 5 Tyramide (Tyramide-Cy5) methyl indole, a red fluorescent dye, is used as a reporter fluorescent substrate for horseradish peroxidase (HRP)-catalyzed deposition, facilitating signal amplification in immunoassay ... |
|
T29176 |
YKL-04-085
|
YKL 04085,YKL04-085,YKL 04-085,YKL-04085 |
|
|
YKL-04-085 is a potent inhibitor of viral translation. YKL-04-085 has cellular antiviral activity at 35-fold lower concentrations relative to inhibition of host-cell proliferation. YKL-04-085 demonstrated good inhibition... |
|
T38159 |
STING Agonist 12b
|
|
|
|
STING agonist 12b is an agonist of stimulator of interferon genes (STING).1It binds to STING (Kd= 26.4 μM) and induces interferon reporter gene expression in cells expressing human or mouse STING (EC50s = 7.45 and 10.23 ... |
|
T69408 |
GW590735 sodium
|
|
|
|
GW590735 is a potent and selective agonist of PPARα with an EC50 value of 4 nM for the expression a GAL4-responsive reporter gene and at least 500-fold selectivity versus PPARγ and PPARδ. GW590735 significantly increased... |
|
T36936 |
Prodan
|
|
|
|
Prodan, a solvatochromic fluorophore, serves as a sensitive reporter for microenvironment changes in membranes. Utilizing Prodan's chemistry, researchers have designed and synthesized fluorescent nucleosides that exhibit... |
|
T37414 |
CAY10771
|
|
|
|
CAY10771 is a dual agonist of farnesoid X receptor (FXR) and peroxisome proliferator-activated receptor δ (PPARδ).1It activates FXR and PPARδ in reporter assays using HEK293T cells (EC50s = 0.94 and 1.5 μM, respectively)... |
|
T38223 |
N-(1-(3,4-Dihydroxyphenyl)propan-2-yl)oleamide
|
|
|
|
N-(1-(3,4-Dihydroxyphenyl)propan-2-yl)oleamide binds to the cannabinoid 1 (CB1) receptor with a Ki value of 365 nM in a radioligand binding assay using rat brain homogenate. It has an EC50 value of 698 nM for the peroxis... |
|
T73869 |
BCL6 PROTAC 1
|
|
|
|
BCL6 PROTAC 1 is a selective B-cell lymphoma 6 (BCL6) proteolysis targeting chimera (PROTAC) that inhibits the BCL6 cell reporter with an IC50 value of 8.8 µM and significantly degrades BCL6 in diffuse large B-cell lymph... |
