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T22346 |
Indomethacin sodium hydrate
|
Indometacin sodium hydrate |
COX
|
|
Indomethacin sodium hydrate (Indometacin sodium hydrate) is an orally active, competitive and reversible COX1/2 inhibitor with potential anti-inflammatory activity in induced migraines, induced gastrointestinal injuries,... |
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T35707 |
3'-Sialyllactose sodium
|
3'-SL sodium |
NF-κB
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|
3'-Sialyllactose sodium is a prebiotic with anti-inflammatory activity that maintains immune homeostasis. 3'-Sialyllactose sodium reduces stressor-induced anxiety-like behaviors and can be used in studies of inflammation... |
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T19063 |
Sulforhodamine B sodium salt
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Acid Red 52,Kiton Red 620 |
Others
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Sulforhodamine B sodium salt (Acid Red 52) is a fluorescent dye. It can be used from laser-induced fluorescence to the quantification of cellular proteins of cultured cells. |
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T65070 |
Chenodeoxycholic Acid sodium salt
|
CDCA sodium salt |
FXR
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Chenodeoxycholic Acid sodium salt (CDCA sodium salt) is a bile acid in humans that activates the nuclear receptor FXR, rescues axonal degeneration of induced pluripotent stem cell-derived neurons in patients with spastic... |
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T30249 |
AZD 7009
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AZD-7009,AZD7009 |
Sodium Channel
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AZD 7009 is a novel antiarrhythmic compound that inhibits the sodium current of hNav1.5 in CHO K1 cells with an IC50 of 11 uM. AZD 7009 inhibited late sodium current in isolated rabbit atrial and ventricular myocytes, an... |
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T26822 |
Bisaramil hydrochloride
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RGH-2957,NK 1556,NK1556,Bisaramil,NK-1556,RGH 2957 |
Potassium Channel
,
Adrenergic Receptor
|
|
Bisaramil hydrochloride (Bisaramil) is a novel diazabicyclononane antiarrhythmic compound that inhibits the generation of free radicals.Bisaramil hydrochloride blocks sodium currents and inhibits the slow Ca(2+) action p... |
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T28285 |
P-2281
|
P 2281,P2281 |
mTOR
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|
P-2281 is an mTOR inhibitor with anticancer and anti-inflammatory properties.P-2281 inhibits dextran sulfate sodium (DSS)-induced colitis by suppressing T-cell function and is effective in a mouse model of human colitis. |
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T26778 |
Besipirdine
|
HP 749 free base,P-867493,P867493,HP 749,HP749,P 867493 |
Sodium Channel
,
Adrenergic Receptor
|
|
Besipirdine (HP 749 free base) is a non-receptor-dependent cholinomimetic compound with alpha-adrenergic and cardiovascular activities.Besipirdine inhibits voltage-dependent sodium-potassium channels and inhibits biogeni... |
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T2403 |
Bromfenac sodium hydrate
|
Bromfenac sodium,Bromfenac monosodium salt sesquihydrate |
COX
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Bromfenac sodium hydrate (Bromfenac monosodium salt sesquihydrate) is the sodium salt form of bromfenac, a nonsteroidal anti-inflammatory drug (NSAID) with analgesic and anti-inflammatory activities. Upon ophthalmic admi... |
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T2160 |
Suramin Sodium Salt
|
BAY-205,Suramin hexasodium salt,NF-060 |
Apoptosis
,
Phosphatase
,
SARS-CoV
,
Sirtuin
,
Reverse Transcriptase
,
Topoisomerase
,
Parasite
|
|
Suramin Sodium Salt (BAY-205) is a sodium salt form of suramin, a polysulphonated naphthylurea with potential antineoplastic activity. Suramin blocks the binding of various growth factors, including insulin-like growth f... |
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T26778L |
Besipirdine hydrochloride
|
HP 749 hydrochloride,Besipirdine hydrochloride（119257-34-0 Free base) |
Adrenergic Receptor
|
|
Besipirdine hydrochloride is a non-receptor-dependent cholinomimetic compound with alpha-adrenergic and cardiovascular activities.Besipirdine hydrochloride inhibits voltage-dependent sodium-potassium channels and inhibit... |
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T37215 |
5α,6β-Dihydroxycholestanol
|
|
|
|
5α,6β-Dihydroxycholestanol is an oxysterol metabolite of cholesterol formed from conversion of cholesterol epoxides by 5,6-epoxysterol hydrolase. It inhibits NMDA-mediated calcium influx in HEK293 cells expressing NR1/NR... |
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T0260L |
Meclofenamate sodium hydrate
|
INF 4668,CI583,CI-583,INF-4668,CI 583,INF4668 |
|
|
Meclofenamate sodium is a potent non-steroidal anti-inflammatory agent, which can specifically inhibit chemokine-induced human polymorphonuclear leukocyte function: chemotaxis, degranulation, and superoxide anion free ra... |
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T65440 |
Sodium Thiosulfate Pentahydrate
|
|
|
|
Sodium thiosulfate (Pentahydrate) is an antioxidant and antifungal. Sodium thiosulfate protects against cisplatin-induced hearing loss in children and is not associated with serious adverse events attributed to its use[3... |
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T11207 |
Entacapone sodium salt
|
|
Others
|
|
Entacapone sodium salt inhibits catechol-O-methyltransferase(COMT) with similar IC50 in different tissues including live, duodenum, kidney and lung, but entacapone is more active than tolcapone in those tissues. Entacapo... |
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T10442 |
A 83-01 sodium salt
|
|
ALK
|
|
A 83-01 sodium salt is a potent inhibitor of TGF-β type I receptor ALK5 kinase, ALK4 and ALK7, with IC 50 s of 12 nM, 45 nM and 7.5 nM against the ALK5, ALK4 and ALK7 induced transcription, respectively [1]. |
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T72004 |
Azumolene sodium anhydrous
|
|
|
|
Azumolene sodium anhydrous is a muscle relaxant that inhibits the release of calcium from skeletal muscle sarcoplasmic reticulum. Azumolene inhibits a component of store-operated calcium entry coupled to the skeletal mus... |
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T71088 |
AM-211 sodium
|
|
|
|
AM-211 sodium is a novel and potent antagonist of the prostaglandin D2 receptor type 2. AM-211 is active in animal models of allergic inflammation. AM211 has high affinity for human, mouse, rat, and guinea pig DP2 and it... |
|
T68225 |
Fc 11a-2
|
|
|
|
Fc 11a-2, a benzimidazole compound, functions as an orally active, potent inhibitor of the NLRP3 inflammasome. It effectively hinders the NLRP3 inflammasome formation by blocking caspase-1 activation and consequently the... |
|
T15670 |
KT5823
|
|
Apoptosis
,
PKA
|
|
KT5823 is a selective and potent cGMP-dependent protein kinase (PKG) inhibitor with inhibitory effects on PKA and PKC.KT5823 increases thyroid-stimulating hormone-induced (Na+/I- symporter) NIS expression and iodide ion ... |
|
T61585 |
Sulindac sodium
|
|
|
|
Sulindac (sodium) (MK-231) is an orally active nonsteroidal anti-inflammatory agent. Sulindac (sodium) is used to reduce pain, swelling, and joint stiffness from arthritis. Sulindac is also used for the research of arthr... |
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T68808 |
11-Dehydrocorticosterone
|
|
|
|
11-Dehydrocorticosterone is an endogenous mineralocorticoid. It increases Na+/K+-ATPase mRNA expression in vascular smooth muscle cells and inhibits aldosterone action in B. marinus toad bladder tissue in a concentration... |
|
T69652 |
Relutrigine
|
PRAX-562 |
|
|
Relutrigine (PRAX-562), an orally active persistent sodium channel inhibitor, potently and selectively targets persistent I Na, induced either by ATX-II (Nav 1.5 activator) or SCN8A mutation N1768D, with IC 50 values of ... |
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T36679 |
Rp-cAMPS sodium salt
|
|
|
|
Rp-cAMPS sodium salt, a cAMP analog, is a potent, competitive cAMP-induced activation of cAMP-dependent PKA I and II (Kis of 12.5 μM and 4.5 μM, respectively) antagonist. Rp-cAMPS sodium salt is resistant to hydrolysis b... |
|
T61607 |
Laquinimod sodium
|
|
|
|
Laquinimod (ABR-215062) sodium is a carboxamide derivative administered orally that serves as a powerful immunomodulator, designed to prevent inflammation and neurodegeneration within the central nervous system. This com... |
|
T79385 |
PDE1-IN-5
|
|
|
|
PDE1-IN-5 (Compound 10c) is a selective PDE1C inhibitor with an IC50 of 15 nM, exhibiting anti-inflammatory properties through the inhibition of iNOS, TNF-α, IL-1α, IL-1β, and IL-6 expression induced by LPS. It has demon... |
|
T79671 |
NF-κB-IN-11
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|
NF-κB
|
|
NF-κB-IN-11 (Compound 3i) is an inhibitor of NF-κB, effectively blocking TNF-α-induced NF-κB pathway activation and the nuclear translocation of NF-κB. It also reduces the expression levels of phospho-IKK, IκBα, and NF-κ... |
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T73337 |
Articaine
|
Hoe-045 free base |
|
|
Articaine (Hoe-045 free base), an amide anesthetic featuring an ester group, effectively relieves pain by reversibly binding to the α-subunit of the voltage-gated sodium channels located in the nerve's inner cavity. Furt... |
|
T80519 |
M3-Huwentoxin IV
|
m3-HwTx-IV |
Sodium Channel
|
|
m3-Huwentoxin IV (m3-HwTx-IV) is a potent inhibitor of sodium channels (NaV), exhibiting half-maximal inhibitory concentrations (IC50s) of 3.3 nM for hNaV1.7, 6.8 nM for hNaV1.6, 7.2 nM for hNaV1.3, 8.4 nM for hNaV1.1, 1... |
|
T37052 |
Tetranactin
|
|
|
|
Tetranactin is a macrotetrolide and a monovalent cation ionophore that has been found in S. aureus and has antibacterial, insecticidal, and mitogenic activities. It exhibits an equilibrium permeability ratio 1,000-fold g... |
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T83739 |
Myr-Tat-CBD3 TFA
|
Myr-Tat-Calcium Channel-binding Domain 3,N-myristate-Tat-CBD3 |
|
|
Myr-Tat-CBD3 is a chemical compound that serves as an inhibitor of the protein-protein interaction between the N-type voltage-gated calcium channel Cav2.2 and collapsin response mediator protein 2 (CRMP2). This compound ... |
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T35876 |
Chlorthalidone Impurity G
|
|
|
|
Chlorthalidone impurity G is a potential impurity found in commercial preparations of chlorthalidone that has moderate antihypertensive effects. Chlorthalidone is a thiazide-like diuretic that inhibits the Na+/Cl- cotran... |
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T83697 |
PAMP-12 (human, mouse, rat, porcine, bovine) TFA
|
Proadrenomedullin N-terminal 12 Peptide,PAMP (9-20) |
|
|
Proadrenomedullin N-terminal 12 peptide (PAMP-12), an endogenous fragment originating from the adrenal medulla and spanning amino acids 9-20 of human PAMP-20, plays a role in causing hypotension. It functions as an agoni... |
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T36660 |
Olsalazine-13C6
|
Olsalazine-13C6 |
|
|
Olsalazine-13C6is intended for use as an internal standard for the quantification of olsalazine by GC- or LC-MS. Olsalazine is an orally bioavailable prodrug form of the anti-inflammatory agent 5-aminosalicylic acid that... |
