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T22450 |
Tyrphostin B44, (+) enantiomer
|
|
EGFR
|
|
Tyrphostin B44, (+) enantiomer is an inhibitor of epidermal growth factor receptor (EGFR) kinase with IC50 of 0.86 μM and has less active than the (-) enantiomer. |
|
T76499 |
Lactalbumin B (50-53) Alpha [Lactorphin Alpha], bovine
|
|
|
|
Lactalbumin B (50-53) Alpha [Lactorphin Alpha], bovine, is a peptide composed of 4 amino acids recognized for its blood pressure-lowering properties and functions as an angiotensin-converting enzyme (ACE) inhibitor. This... |
|
T9759 |
MAO-B-IN-5
|
|
Others
|
|
MAO-B-IN-5 is a potent, selective and orally active MAO-B inhibitor with an IC 50 of 0.204 μM. MAO-B-IN-5 has the research potential in Parkinson's disease (PD) [1]. |
|
T63333 |
Uplarafenib
|
B-Raf IN 10 |
Raf
|
|
Uplarafenib (B-Raf IN 10) is a potent BRAF inhibitor with an IC50 in the range of 50-100 nM.B-Raf IN 10 has antitumor activity that may affect cell proliferation and differentiation did not, and can be used to study soli... |
|
T38960 |
QL-X-138
|
|
Virus Protease
,
MNK
,
BTK
|
|
QL-X-138 is a potent and selective BTK and MNK dual kinase inhibitor that binds covalently to BTK and non-covalently to MNK.The IC 50 s of QL-X-138 against BTK, MNK1 and MNK2 kinases are 9.4 nM, 107.4 nM and 26 nM, respe... |
|
T12953 |
Sodium copper chlorophyllin B
|
|
Influenza Virus
,
HIV Protease
|
|
Sodium copper chlorophyllin B exerts antiviral activities against Influenza virus and HIV. |
|
T9560 |
MAO-B-IN-2
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|
Others
|
|
MAO-B-IN-2 is a selective and competitive inhibitor of MAO-B and BChE with IC 50 values of 0.51 and 7.00 μM, respectively. MAO-B-IN-2 attenuates H2O2-induced cellular damage via good ROS scavenging property. |
|
T27527 |
HBF-0259
|
HBF 0259 |
Antiviral
|
|
HBF-0259 is an inhibitors of hepatitis B virus surface antigen (HBsAg) secretion with an EC50 of 11.3 μM and a CC50 value of >50 μM in HepG2.2.15 cells. HBF-0259 had a EC50 of approximately 1.5 microM in a secondary, HBV... |
|
T6458 |
CYC-116
|
|
VEGFR
,
FLT
,
CDK
,
S6 Kinase
,
Aurora Kinase
|
|
CYC116 is a potent inhibitor of Aurora A/B with Ki of 8.0 nM/9.2 nM, is less potent to VEGFR2 (Ki of 44 nM), with 50-fold greater potency than CDKs, not active against PKA, Akt/PKB, PKC, no effect on GSK-3α/β, CK2, Plk1 ... |
|
T9642 |
ZW4864 free base
|
|
Wnt/beta-catenin
|
|
ZW4864 (free base) is an orally active and selective β catenin/B-Cell lymphoma 9 protein protein interaction ( β catenin/BCL9 PPI ) inhibitor. ZW4864 (free base) inhibits β catenin/BCL9 PPI with a K i value of 0.76 μM an... |
|
T4121 |
Bicyclol
|
SY801 |
HBV
,
Autophagy
|
|
Bicyclol (SY801)(SY 801) is an anti-hepatitis drug. Oral administration of bicyclol normalizes the elevated serum transaminases (ALT, AST) by 50% in chronic viral hepatitis B and C, and also has a certain level of inhibi... |
|
T67791 |
BMS-903452
|
|
GPR
|
|
BMS-903452 is a potent and selective GPR119 agonist with EC50 of 14 nM. BMS-903452 is indicated for the treatment of acute and chronic rodent diabetes. GPR119 was mainly expressed in pancreatic b cells and gastrointestin... |
|
TP1281L1 |
Bombesin acetate(31362-50-2 free base)
|
|
Bombesin Receptor
|
|
Bombesin acetate is a 14-amino acid peptide originally isolated from the skin of the European fire-bellied toad (Bombina bombina). It has two known homologs in mammals called neuromedin B and gastrin-releasing peptide. |
|
T5995 |
Larotrectinib
|
LOXO-101,ARRY-470 |
Apoptosis
,
Trk receptor
|
|
Larotrectinib (LOXO-101) is an orally administered inhibitor of the TRK kinase and is highly selective only for the TRK family of receptors(IC50s = 2-20 nM). |
|
T29058 |
UMB68 sodium
|
UMB-68 sodium,UMB68,UMB-68,UMB 68 |
Others
|
|
UMB-68 is a GHB receptor ligand with no affinity (IC(50) >100 microM) at GABA(A) or GABA(B) receptors. |
|
T60651 |
MAO-B-IN-16
|
|
Others
|
|
MAO-B-IN-16 is a selective inhibitor of monoamine oxidase B (MAO-B ) (IC 50 = 1.55 μM) that can be used in the central nervous disorders study, for example, parkinson's disease [1]. |
|
T80380 |
Cyclopetide 2
|
|
|
|
Cyclopeptide 2 (Compound 2) is a moderately active antimicrobial peptide against B. subtilis, exhibiting a minimum inhibitory concentration (MIC) of 50 μg/mL [1]. |
|
T76670 |
HMC1R agonist 1
|
|
|
|
hMC1R agonist 1, with an EC 50 of 3 nM, exhibits at least 300-fold higher selectivity for hMC1R compared to hMC3R (EC 50 >902 nM), hMC4R (EC 50 >915 nM), and hMC5R (EC 50 >1000 nM). This compound demonstrates potential f... |
|
T60660 |
MAO-B-IN-14
|
|
Others
|
|
MAO-B-IN-14 (Compound 9) is a potent and selective inhibitor of monoamine oxidase-B (MAO-B) with an IC 50 of 0.95 μM and a Ki of 0.55 μM for human MAO-B. |
|
T36484 |
BCL6-IN-4
|
BCL6-IN-4 |
Others
|
|
BCL6-IN-4, a potent inhibitor of B-cell lymphoma 6 (BCL6), exhibits anti-tumor activities with an inhibitory concentration 50 (IC50) value of 97 nM[1]. |
|
T27772 |
L-736380
|
L-736,380,L 736380,L736,380,L 736,380 |
Others
|
|
L-736380 is a CCK-B receptor antagonist. L-736,380 dose-dependently inhibited gastric acid secretion in anesthetized rats (ID(50), 0.064 mg/kg) and ex vivo binding of [(125)I]CCK-8S in BKTO mice brain membranes (ED(50), ... |
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T60727 |
B-Raf IN 8
|
|
Others
|
|
B-Raf IN 8 (compound 7g) is a potent inhibitor of B-Raf (IC 50 = 70.65 nM). B-Raf IN 8 shows antitumor activity which has IC 50 values of 9.78, 13.78, 18.52 and 29.85 μM against hepatocellular carcinoma (HEPG-2), colon ... |
|
T60678 |
HMAO-B-IN-2
|
|
Others
|
|
hMAO-B-IN-2 (compound 6j) is an orally active, potent, selective and BBB penetrated and competitive reversible inhibitor of hMAO-B (IC 50 = 4 nM) that can be used for the research of alzheimer’s disease. hMAO-B-IN-2 exhi... |
|
T80301 |
Aurein 3.1
|
|
Antibiotic
|
|
Aurein 3.1 is an antibiotic antimicrobial peptide, whereas Aurein 2.6 demonstrates activity against Gram-positive bacteria, exhibiting minimum inhibitory concentrations (MIC) of 80 μM for M. luteus and 50 μM for S. aureu... |
|
T60573 |
MAO-B-IN-15
|
|
Others
|
|
MAO-B-IN-15 is a selective inhibitor of MAO-B that forms π-π interaction with Tyr 326 residue (IC 50 = 13.5 μM) which can be used in Parkinson’s disease research[1]. |
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T64977 |
Naphthol green B
|
|
Others
|
|
Naphthol green B is a useful organic compound for research related to life sciences. The catalog number is T64977 and the CAS number is 19381-50-1. |
|
T68529 |
Blapsin B
|
|
Others
|
|
Blapsin B is a potent 14-3-3 inhibitor. Blapsin B is a naturally occurring compound isolated from the ethanol extract of the stink beetle, Blaps japanensis. Blapsin B potently inhibited 14-3-3 protein-protein interaction... |
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T75921 |
[Ala11,D-Leu15]-Orexin B(human) TFA
|
|
|
|
[Ala11,D-Leu15]-Orexin B(human) TFA is a potent, selective agonist for the orexin-2 receptor (OX2), demonstrating 400-fold higher selectivity for OX2 (EC 50 =0.13 nM) compared to the orexin-1 receptor (OX1) with an EC 50... |
|
T75172 |
Antibacterial agent 143
|
|
Others
|
|
Compound 5a (Antibacterial agent 143) is an antibacterial agent exhibiting minimum inhibitory concentrations (MICs) of 25 μg/mL against B. subtilis ATCC6633 and S. aureus ATCC6538, and 50 μg/mL against P. aeruginosa ATCC... |
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T35736 |
Drimentine B
|
|
Others
|
|
Drimentine B is a terpenylated diketopiperazine antibiotic originally isolated from Actinomycete bacteria. It is active against Gram-positive and Gram-negative bacteria, fungi, and yeast, and has anthelmintic properties.... |
|
T60374 |
L-Fd4A
|
|
Others
|
|
L-Fd4A (compound 36) is an adenine derivative that has anti-human immunodeficiency virus (HIV) (EC 50 =1.5 μM) and anti- hepatitis B virus (HBV) ( EC 50 =1.7 μM) activity. L-Fd4A has low cytotoxicity [1]. |
|
T61002 |
HMAO-B-IN-3
|
|
Others
|
|
hMAO-B-IN-3 (Compound 15) is a potent hMAO-B inhibitor (IC 50 = 47.4 nM) with favourable drug-like properties and a broad safety window. Therefore, hMAO-B-IN-3 is a suitable candidate for lead optimization and multitarge... |
|
T62043 |
Dyrk1A/B-IN-1
|
|
Others
|
|
Dyrk1A/B-IN-1 (compound 3n) is a potent, selective and cell-permeable inhibitor of DYRK1A and DYRK1B. Dyrk1A/B-IN-1 inhibits DYRK1A and DYRK1B with Kis of 67.8 nM and 237.9 nM, and IC 50 s of 1.1 μM and 0.8 μM, respectiv... |
|
T84413 |
Cdk4 Inhibitor
|
Cyclin-dependent kinase 4 Inhibitor |
Others
|
|
PD 0332991, an unsymmetrical indolocarbazole compound, is cell-permeable and exhibits antiproliferative effects by functioning as a potent, selective, reversible, and ATP-competitive inhibitor of Cdk4/D1 (IC 50 = 76 nM).... |
|
T40572 |
Lesogaberan napadisylate
|
AZD-3355 napadisylate |
Others
|
|
Lesogaberan (AZD-3355) napadisylate is a potent and selective agonist of GABA B receptors, with an EC 50 of 8.6 nM for human recombinant GABA B receptors. It demonstrates an affinity (Ki) of 5.1 nM for rat GABA B recepto... |
|
T60811 |
CXCR4 antagonist 7
|
|
Others
|
|
CXCR4 antagonist 7 (Compound PARA-B) is able to be used in the HIV infection, inflammatory diseases, cancer, and WHIM syndrome research which is a antagonist of CXCR4 (IC 50 = 9.3 nM) [1]. |
|
T37731 |
TPU-0037A
|
|
Others
|
|
TPU-0037A is an antibiotic and a congener of lydicamycin . It inhibits the growth of Gram-positive bacteria, including methicillin-resistant S. aureus (MRSA), B. subtilis, and M. luteus (MICs = 1.56-12.5 μg/ml), but not ... |
|
T61772 |
PknB-IN-1
|
|
Others
|
|
PknB-IN-1 (Compound 2) is an inhibitor of protein kinase B (PknB) with a concentration causing 50% inhibition (IC50) of 14.4 μM. This compound demonstrates anti-mycobacterial activity by effectively suppressing the growt... |
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T37750 |
Benanomicin B (formate)
|
|
Others
|
|
Benanomicin B is a microbial metabolite that has been found inActinomycetesand has antifungal, fungicidal, and antiviral activities.1,2It is active against a variety of mammalian and plant pathogenic fungi, includingC. a... |
|
T41331 |
Cyprodinil
|
|
Others
|
|
Cyprodinil, an anilinopyrimidine broad-spectrum fungicide, inhibits methionine biosynthesis in phytopathogenic fungi, effectively limiting cell growth of B. cinerea, P. herpotrichoides, and H. oryzae on amino acid-free m... |
|
T68235 |
Beclabuvir HCl
|
|
Others
|
|
Beclabuvir, also known as BMS-791325, is an allosteric inhibitor that binds to thumb site 1 of the hepatitis C virus (HCV) NS5B RNA-dependent RNA polymerase. BMS-791325 inhibits recombinant NS5B proteins from HCV genotyp... |
|
T36397 |
TAN 420E
|
|
Others
|
|
TAN 420E is a bacterial metabolite originally isolated from Streptomyces. It scavenges 2,2-diphenyl-1-picrylhydrazyl radicals in a cell-free assay (IC50 = 1.3 μM) and reduces thiobarbituric acid reactive substances (TBAR... |
|
T60933 |
B-Raf IN 7
|
|
Others
|
|
B-Raf IN 7 (compound 6a) is a potent inhibitor of B-Raf with an IC 50 of 110.23 nM. B-Raf IN 7 has antitumor activity against colon carcinoma cells(HCT-116), mammary gland cells(MCF-7), hepatocellular carcinoma cells(HEP... |
|
T79228 |
SARS-CoV-2-IN-50
|
|
SARS-CoV
|
|
SARS-CoV-2-IN-50 (Compound X77C) is a potent inhibitor of the SARS-CoV-2 main protease (M^pro), exhibiting high affinity for the enzyme's catalytic site [1]. |
|
T35771 |
Destruxin B2
|
|
Others
|
|
Destruxin B2 is a cyclic hexadepsipeptide mycotoxin that has been found in M. anisopliae and has antiviral, insecticidal, and phytotoxic activities.1,2,3 It inhibits secretion of hepatitis B virus surface antigen (HBsAg)... |
|
T36330 |
Terrecyclic Acid
|
|
Others
|
|
Terrecyclic acid is a sesquiterpene originally isolated from A. terreus with antibiotic and anticancer activity. It is active against S. aureus, B. subtilis, and M. roseus (MICs = 25, 50, and 25 μg/ml, respectively). Ter... |
|
T76803 |
Elsilimomab
|
|
|
|
Elsilimomab (B-E8), an IgG1 monoclonal antibody targeting interleukin-6 (IL-6), exhibits a dissociation constant (K D) of 22 pM and an inhibitory concentration (IC 50) of 1.4 nM. It is applicable in researching multiple ... |
|
T36650 |
Ansatrienin B
|
|
Others
|
|
Ansatrienin B is an ansamycin antibiotic and antifungal agent first isolated from S. collinus and S. rishiriensis., In fetal rat long bones, it is an inhibitor of parathyroid hormone-induced calcium release (IC50 = 21 nM... |
|
T72215 |
Lesogaberan hydrochloride
|
AZD-3355 hydrochloride |
Others
|
|
Lesogaberan (AZD-3355) hydrochloride is a potent and selective GABA B receptor agonist with an EC 50 of 8.6 nM for human recombinant GABA B receptor. The affinity ( K i s) of Lesogaberan hydrochloride for rat GABA B and ... |
|
T38710 |
JH295
|
|
Others
|
|
JH295 is a highly potent and selective inhibitor of NIMA-related kinase 2 (Nek2), exhibiting irreversible inhibition activity with an IC 50 value of 770 nM. This compound effectively inhibits cellular Nek2 using the alky... |
