FYN | TargetMol

カタログ番号	製品名	別名	ターゲット
T3183	SAX-187	WAY 181187,WAY181187	5-HT Receptor
	SAX-187 (SAX-187) has high-affinity binding at the human 5-HT6 receptor.		5-HT Receptor
T6920	ON123300		FGFR , c-RET , JAK , CDK , PDGFR , Src , AMPK
	ON123300 is a potent and multi-targeted kinase inhibitor for CDK4/Ark5/PDGFRβ/FGFR1/RET/Fyn (IC50: 3.9/5/26/26/9.2/11 nM).		FGFR , c-RET , JAK , CDK , PDGFR , Src , AMPK
T13007	ST1936 oxalate		5-HT Receptor
	ST1936 oxalate is a selective, nanomolar affinity agonist of 5-HT6 receptor(Ki values of 13 nM, 168 nM and 245 nM for human 5-HT6, 5-HT7 and 5-HT2B receptors, respectively).		5-HT Receptor
T6196	PP1	EI 275,AGL 1872	Apoptosis , EGFR , Bcr-Abl , Src , c-Kit
	PP1 (AGL 1872), a specific and effective Src inhibitor, is with IC50 for Lck/Fyn is 5 nM/ 6 nM, respectively.		Apoptosis , EGFR , Bcr-Abl , Src , c-Kit
T61360	ARN25068		GSK-3 , DYRK , Microtubule Associated , Src
	ARN25068 is a potent inhibitor of GSK-3β, FYN, and DYRK1A protein kinases, exerting its activity in the sub-micromolar range. This compound effectively addresses tau hyperphosphorylation [1].		GSK-3 , DYRK , Microtubule Associated , Src
T6266	PP2	AGL 1879,AG 1879,AGL 1879	EGFR , Tyrosine Kinases , JAK , Src
	PP2 (AG 1879,AGL 1879) is a effective inhibitor of Lck/Fyn (IC50:4/5 nM) , ~100-fold less potent to EGFR, inactive for ZAP-70, PKA and JAK2.		EGFR , Tyrosine Kinases , JAK , Src
T6997	SU6656		FAK , Akt , Src
	SU 6656 is a selective inhibitor of Src family kinases, with IC50 of 280 nM, 20 nM, 130 nM, and 170 nM for Src, Yes, Lyn, and Fyn, respectively.		FAK , Akt , Src
T3935	1-Naphthyl PP1	1-NA-PP 1	Src
	1-Naphthyl PP1 (1-NA-PP 1) is a selective src inhibitor(v-Src and c-Fyn, c-Abl, CDK2 and CAMK II with IC50s of 1.0, 0.6, 0.6, 18 and 22 μM, respectively)		Src
T6078	Saracatinib	AZD0530	EGFR , Src , BTK , Autophagy
	Saracatinib (AZD0530) (AZD0530) is an effective Src inhibitor (IC50: 2.7 nM), and effective to Lck, Fyn, Lyn, Blk, Fgr and c-Yes.		EGFR , Src , BTK , Autophagy
T23396	ST1936	ST 1936 oxalate	5-HT Receptor
	ST1936 (ST 1936 oxalate) is a selective and highly potent 5-HT6 receptor agonist that inhibits human 5-HT6, 5-HT7 and 5-HT2B receptors by fully activating cloned human 5-HT6 receptors. body to stimulate cAMP, Ca2+, ERK1/...		5-HT Receptor
T6093	AZD-7762	AZD7762	Chk
	AZD-7762, an effective and specific inhibitor of Chk1（IC50=5 nM）, is equally potent against Chk2 and less potent against CAM, Yes, Fyn, Lyn, Hck and Lck.		Chk
T6277	Doramapimod	BIRB 796	Raf , p38 MAPK , Autophagy
	Doramapimod (BIRB 796) is a highly potent inhibitor of p38 MAPK (Kd: 0.1 nM), but weakly inhibits c-RAF, Fyn, Lck, ERK-1, SYK, IKK2, and ZAP-70.		Raf , p38 MAPK , Autophagy
T7371	1-Naphthyl PP1 hydrochloride	1-NA-PP 1 hydrochloride	Src
	1-Naphthyl PP1 hydrochloride (1-NA-PP 1 hydrochloride) is a selective inhibitor of src family kinases v-Src		Src
T4263	BAY 61-3606	Syk inhibitor IV	Apoptosis , Syk
	BAY 61-3606 (Syk inhibitor IV) is a potent, ATP-competitive, reversible, and highly selective inhibitor of Syk tyrosine kinase activity (Ki= 7.5 nM), exhibiting no inhibitory effect against Btk, Fyn, Itk, Lyn, and Src.		Apoptosis , Syk
T2153	1-NM-PP1	PP1 Analog II,1 nM-PP1	Serine/threonin kinase , CDK , Src
	1-NM-PP1 (PP1 Analog II) is a cell-permeable PP1 analog that acts as a potent and selective inhibitor of mutant kinases over their wild-type progenitors.		Serine/threonin kinase , CDK , Src
T16364	Infigratinib phosphate	NVP-BGJ398 phosphate,BGJ-398 phosphate	FGFR
	Infigratinib phosphate (BGJ-398 phosphate) is an effective inhibitor of the FGFR family (IC50: 0.9 nM, 1.4 nM, 1 nM, and 60 nM for FGFR1, FGFR2, FGFR3, and FGFR4, respectively).		FGFR
T71819	RK-20448
	RK-20448 is an ATP-competitive inhibitor of Lck, Src, KDR/VEGF2R, and Tie-2. It also inhibits BLK, Csk, Fyn, and Lyn. RK-20448 is the cis isomer of A-419259
T38965	EPQpYEEIPIYL
	EPQpYEEIPIYL, a phosphopeptide, is a ligand for the Src homology 2 (SH2) domain. It activates members of the Src family, such as Lck, Hck, and Fyn, through the binding interaction with SH2 domains.
T13157L	TG 100801 Hydrochloride		VEGFR
	TG 100801 Hydrochloride is a prodrug to treat age-related macular degeneration. TG 100572 is a inhibitor of multi-targeted kinase(IC50s of 2, 7, 2, 16, 13, 5, 0.5, 6, 0.1, 0.4, 1, 0.2 for VEGFR1, VEGFR2, FGFR1, FGFR2, PD...		VEGFR
T13156	TG 100572		VEGFR
			VEGFR
T63038	WAY-181187 oxalate
	WAY-181187 (SAX-187) oxalate is a selective and potent agonist of the 5-HT6 receptor (Ki: 2.2 nM; EC50: 6.6 nM). wAY-181187 oxalate is a specific agonist that mediates 5-HT6 receptor-dependent signalling pathways (e.g. c...
T14074	A-770041		Src
	A-770041 is a selective and orally active inhibitor targeting the Src-family kinase, Lck, which plays a crucial role in T-cell signaling. With an IC50 value of 147 nM at 1 mM ATP, A-770041 demonstrates high specificity b...		Src
T13156L	TG 100572 Hydrochloride		VEGFR , FGFR , PDGFR , Src
			VEGFR , FGFR , PDGFR , Src
T16750	Rigosertib	ON-01910	Apoptosis , FLT , PLK , PI3K , Bcr-Abl , CDK , PDGFR , Src
	Rigosertib (ON-01910) is a selective and non-ATP-competitive inhibitor of PLK1 (IC50: 9 nM). Rigosertib is a multi-kinase inhibitor and a selective anti-cancer agent, which induces apoptosis by inhibition of the PI3 kina...		Apoptosis , FLT , PLK , PI3K , Bcr-Abl , CDK , PDGFR , Src
T36713	Streptochlorin
	Streptochlorin is a bacterial metabolite originally isolated from Streptomyces sp. SF2583 that has diverse biological activities, including antiangiogenic, antiproliferative, and anti-allergic properties. It inhibits TNF...
T5818	Rigosertib sodium	Rigosertib,Estybon,ON-01910	Apoptosis , PLK , PI3K
	Rigosertib sodium (ON-01910), a non-ATP-competitive inhibitor of PLK1(IC50=9 nM), exhibits 30-fold higher specificity activity over Plk2 and no effect on Plk3.		Apoptosis , PLK , PI3K

Compounds

SAX-187

T3183

Synonym: WAY 181187,WAY181187

Target: 5-HT Receptor

ON123300

T6920

Synonym:

Target: FGFR, c-RET, JAK, CDK, PDGFR, Src, AMPK

ST1936 oxalate

T13007

Synonym:

Target: 5-HT Receptor

PP1

T6196

Synonym: EI 275,AGL 1872

Target: Apoptosis, EGFR, Bcr-Abl, Src, c-Kit

ARN25068

T61360

Synonym:

Target: GSK-3, DYRK, Microtubule Associated, Src

PP2

T6266

Synonym: AGL 1879,AG 1879,AGL 1879

Target: EGFR, Tyrosine Kinases, JAK, Src

SU6656

T6997

Synonym:

Target: FAK, Akt, Src

Target: EGFR, Src, BTK, Autophagy

ST1936

T23396

Synonym: ST 1936 oxalate

Target: 5-HT Receptor

Target: Raf, p38 MAPK, Autophagy

1-Naphthyl PP1 hydrochloride

T7371

Synonym: 1-NA-PP 1 hydrochloride

Target: Src

BAY 61-3606

T4263

Synonym: Syk inhibitor IV

Target: Apoptosis, Syk

1-NM-PP1

T2153

Synonym: PP1 Analog II,1 nM-PP1

Target: Serine/threonin kinase, CDK, Src

Infigratinib phosphate

T16364

Synonym: NVP-BGJ398 phosphate,BGJ-398 phosphate

TG 100801 Hydrochloride

TG 100572 Hydrochloride

T13156L

Synonym:

Target: VEGFR, FGFR, PDGFR, Src

Rigosertib

T16750

Synonym: ON-01910

Target: Apoptosis, FLT, PLK, PI3K, Bcr-Abl, CDK, PDGFR, Src

Synonym: Rigosertib,Estybon,ON-01910

Target: Apoptosis, PLK, PI3K

カタログ番号	製品名	Species	Expression System
TMPJ-01186	TRIM Protein, Human, Recombinant (His)	Human	E. coli
	T-Cell Receptor-Associated Transmembrane Adapter 1 (TRAT1) is a single-pass type III membrane protein. TRAT1 exists as a disulfide-linked homodimer and is strongly expressed in the thymus, and to a lesser extent in the s...
TMPJ-00406	EphA8 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	EphA8, also known as Hek3 and Eek, is a 120 kDa glycosylated member of the Eph family of transmembrane receptor tyrosine kinases. The A and B classes of Eph proteins are distinguished by Ephrin ligand binding preference ...

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ターゲット

阻害剤

リコンビナントタンパク質

Compounds

Recombinant Proteins