|
T21981 |
Phthalazinone pyrazole
|
|
Aurora Kinase
|
|
Phthalazinone pyrazole is potent, selective, and orally bioavailable inhibitor of Aurora-A kinase. Aurora-A is overexpressed in a variety of tumor types and displays oncogenic activity. |
|
T21867 |
BI-6015
|
|
Others
|
|
BI 6015 is an antagonist of HNF4α. HNF4α is a nuclear receptor that regulates gene expression in the intestine cells, liver cells, and pancreas-β cells. |
|
T39507L |
Fosgonimeton acetate
|
Fosgonimeton acetate (2093305-05-4 Free base) |
c-Met/HGFR
|
|
Fosgonimeton acetate is an agonist of hepatocyte growth factor (HGF). |
|
T5536 |
SJA710-6
|
|
Others
|
|
SJA710-6 is able to selectively differentiate MSCs toward hepatocyte-like cells. |
|
T37596 |
Terevalefim
|
|
c-Met/HGFR
|
|
Terevalefim (ANG-3777) is an hepatocyte growth factor (HGF) mimetic. Terevalefim selectively activates the c-Met receptor. |
|
T76758 |
Rilotumumab
|
AMG 102 |
c-Met/HGFR
|
|
Rilotumumab (AMG 102) is a monoclonal antibody targeting hepatocyte growth factor that inhibits HGF/ MET-driven signaling. Rilotumumab has antitumor effects and can be used to study castration-resistant prostate cancer (... |
|
T7376 |
Dihexa
|
PNB-0408,Hexanoyl-Tyr-Ile-Ahx-NH2,N-hexanoic-Try-Ile-(6)-amino hexanoic amide |
c-Met/HGFR
|
|
Dihexa (Hexanoyl-Tyr-Ile-Ahx-NH2) is an activator of the hepatocyte growth factor/c-Met (HGF/c-Met) system,it binds to HGF (Kd = 65 pM),and an analog of the peptide angiotensin IV. |
|
T77437 |
Telisotuzumab
|
ABT-700,Mab-224G11 |
c-Met/HGFR
|
|
Telisotuzumab(ABT-700) is a humanized recombinant antibody targeting the therapeutic hepatocyte growth factor receptor (MET) with high affinity for c-Met.Telisotuzumab has inhibitory effects on c-Met signaling and antitu... |
|
T17018 |
TCPOBOP
|
|
BCL
|
|
TCPOBOP is a constitutive androstane receptor agonist that induces robust hepatocyte proliferation and hepatomegaly. TCPOBOP decreases Fas-induced murine liver injury by altering Bcl-2 proteins. |
|
T77948 |
Tri-GalNAc-DBCO
|
|
PROTACs
|
|
Tri-GalNAc-DBCO, a compound with high affinity for the hepatocyte-specific asialoglycoprotein receptor (ASGPR), can bind to this receptor, facilitating targeted protein downregulation and degradation [1]. |
|
T35373L |
Bulevirtide (Myrcludex B) acetate
|
|
HBV
|
|
Bulevirtide (Myrcludex B) acetate is a virion entry inhibitor which blocks the virion's hepatocyte pathway of entry, the hepatic sodium/taurocholate cotransporting polypeptide (NTCP) receptor. Bulevirtide (Myrcludex B) a... |
|
T19389 |
L-Ascorbic acid 2-phosphate magnesium
|
2-Phospho-L-ascorbic acid magnesium |
Phosphatase
,
Phosphorylase
|
|
L-Ascorbic acid 2-phosphate magnesium (2-Phospho-L-ascorbic acid magnesium) acts as an antioxidant and a stimulator of hepatocyte growth factor (HGF) production.It is a long-acting vitamin C derivative that can stimulate... |
|
T6517 |
Golvatinib
|
E-7050 |
VEGFR
,
c-Met/HGFR
|
|
Golvatinib (E-7050) is an orally bioavailable dual kinase inhibitor of c-Met (hepatocyte growth factor receptor) and VEGFR-2 (vascular endothelial growth factor receptor-2) tyrosine kinases with potential antineoplastic ... |
|
T39507 |
Fosgonimeton
|
ATH-1017 |
|
|
Fosgonimeton is a hepatocyte growth factor receptor agonist (WO2017210489). |
|
T69218 |
PUMAi HCl
|
|
|
|
PUMAi is an inhibitor of p53 up-regulated modulator of apoptosis (PUMA), a BH3-only Bcl-2 family member, mitigating acetaminophen (APAP)-induced hepatocyte necrosis and liver injury. |
|
T1661L |
Crizotinib acetate
|
PF02341066,PF-2341066,PF 02341066,PF-02341066,PF2341066 |
|
|
Crizotinib, an orally bioavailable agent, belongs to the class of c-met/hepatocyte growth factor receptor (HGFR) tyrosine kinase inhibitors with potential antineoplastic activity. |
|
T40259 |
AB-729
|
|
|
|
AB-729, a nucleoside analogue functioning as an RNA interference (RNAi), links to a GalNAc (N-acetylgalactosamine) trimer ligand facilitating hepatocyte uptake through the asialoglycoprotein receptor (ASGR). This compoun... |
|
T13108L |
Pamufetinib mesylate
|
TAS-115 mesylate,TAS-115 methanesulfonate |
Others
|
|
TAS-115 mesylate is a potent inhibitor of VEGFR and hepatocyte growth factor receptor (c-Met/HGFR)-targeted kinase(IC50s of 30 and 32 nM for rVEGFR2 and rMET, respectively). |
|
T39347 |
RG-101
|
|
|
|
RG-101 is a hepatocyte-targeted N-acetylgalactosamine conjugated oligonucleotide that functions as an antagonist for miR-122, an essential host factor in the replication of the hepatitis C virus (HCV). |
|
T83393 |
293P-1
|
|
|
|
293P-1 is a hepatocyte-specific homing peptide characterized by the sequence SNNNVRPIHIWP [1]. |
|
T83006 |
Antitumor agent-29
|
|
|
|
Antitumor agent-29 is a hepatocyte-targeting prodrug with demonstrated efficacy and minimal toxicity in anticancer applications. |
|
T35620 |
Ethoxyquin Dimer
|
|
|
|
Ethoxyquin dimer is an antioxidant and metabolite of ethoxyquin .1 It prevents oxidation of polyunsaturated fatty acids in fish meal and fish oil. Dietary administration of ethoxyquin dimer (0.1, 0.3, and 0.5% w/w) induc... |
|
T71636 |
Golvatinib tartrate
|
|
|
|
Golvatinib tartrate is an orally bioavailable dual kinase inhibitor of c-Met (hepatocyte growth factor receptor) and VEGFR-2 (vascular endothelial growth factor receptor-2) tyrosine kinases with potential antineoplastic ... |
|
T70318 |
AMG-337 monohydrate
|
|
|
|
AMG-337 monohydrate is a highly selective small molecule MET inhibitor. Aberrant hepatocyte growth factor (HGF)/MET signaling has been implicated in hepatocarcinogenesis, suggesting that MET may serve as an attractive th... |
|
T70844 |
CM-118
|
|
|
|
CM-118 is a potent and selective dual inhibitor of c-Met and ALK which potently abrogates hepatocyte growth factor (HGF)-induced c-Met phosphorylation and cell migration, as well as phosphorylation of ALK, EML4-ALK, and ... |
|
T69599 |
ABT-510
|
|
|
|
ABT-510 is synthetic peptide that mimics the anti-angiogenic activity of the endogenous protein thrombospondin-1 (TSP-1). ABT-510 inhibits the actions of several pro-angiogenic growth factors important to tumor neovascul... |
|
T61804 |
GSK-3β inhibitor 6
|
|
|
|
GSK-3β inhibitor 6 is a highly potent inhibitor of GSK-3β, with an IC50 value of 24.4 μM. It demonstrates significant enhancement of hepatocyte glucose uptake (38%). This compound holds great potential for studying vario... |
|
T71792 |
Quipazine maleate
|
|
|
|
Quipazine maleate is a selective 5-HT receptor agonist that promotes the proliferation and apoptosis of human hepatocyte strain of L-02 strain and could also exert an excitatory effect on raphe neurons via stimulation of... |
|
T71187 |
Foretinib phosphate
|
|
|
|
Foretinib phosphate is an orally bioavailable small molecule with potential antineoplastic activity. MET/VEGFR2 inhibitor GSK1363089 binds to and selectively inhibits hepatocyte growth factor (HGF) receptor c-MET and vas... |
|
T80884 |
Val-Cit-amide-Ph-Maytansine
|
|
|
|
Val-Cit-PAB-MMAE is a molecular entity designed to function as an antibody-drug conjugate (ADC) or as a component of bispecific antigen-binding molecules, specifically targeting the hepatocyte growth factor receptor know... |
|
T70434 |
Vabametkib
|
|
|
|
Vabametkib, a potent hepatocyte growth factor receptor (HGFR) inhibitor, exhibits anti-proliferative effects on Hs746T cells and selectively inhibits c-Met with an IC50 value of 7 nM, showcasing its potential as an antin... |
|
T28240 |
Ono 1301
|
Ono-1301,Ono1301 |
|
|
Ono 1301 is a prostaglandin I2 mimetic coumpound with inhibitory activity against thromboxane A2 synthase. Ono 1301 suppresses pancreatic fibrosis in the DBTC-induced CP model by inhibiting monocyte activity not only wit... |
|
T76745 |
Ficlatuzumab
|
|
|
|
Ficlatuzumab, a monoclonal antibody (McAb) targeting human hepatocyte growth factor (HGF), impedes the HGF/c-Met signaling pathway. By blocking this pathway, it prevents c-Met receptor-mediated cancer cell proliferation,... |
|
T82719 |
Cisd2 agonist 2
|
|
|
|
Cisd2 agonist 2 (compound 6), with an EC50 of 191 nM, is an orally active activator of Cisd2, a protein whose levels are associated with nonalcoholic fatty liver disease (NAFLD). In vivo studies have demonstrated that Ci... |
|
T77144 |
Recaticimab
|
|
|
|
Recaticimab (SHR-1209) is a humanized monoclonal antibody targeting PCSK9 to enhance the degradation of this enzyme. By binding to PCSK9, Recaticimab elevates low-density lipoprotein (LDL) receptor presence on hepatocyte... |
|
T76051 |
NFF-3 TFA
|
|
|
|
NFF-3 TFA, a selective matrix metalloproteinase (MMP) substrate, specifically interacts with MMP-3 and MMP-10 for hydrolysis. Additionally, it undergoes cleavage by trypsin, hepatocyte growth factor activator, and factor... |
|
T75940 |
Norleual TFA
|
|
|
|
Norleual TFA, an analog of angiotensin (Ang) IV, functions as a hepatocyte growth factor (HGF)/c-Met inhibitor, displaying a potent inhibition capability with an IC50 of 3 pM. Additionally, it acts as an AT4 receptor ant... |
|
T62301 |
J-1063
|
|
|
|
J-1063 is a selective, orally active and potent inhibitor of ALK5 (IC50: 0.039 μM). J-1063 inhibits inflammatory infiltration, collagen deposition, hepatocyte necrosis and exhibits anti-fibrotic effects. j-1063 has poten... |
|
T80885 |
Val-Cit-amide-Cbz-N(Me)-Maytansine
|
|
|
|
Val-Cit-amide-Cbz-N(Me)-Maytansine is a molecule that functions both as an antibody and a bispecific antigen-binding entity, targeting the hepatocyte growth factor receptor c-Met (MET), and is used in the formulation of ... |
|
T36098 |
Isovaleryl-L-carnitine (chloride)
|
|
|
|
Isovaleryl-L-carnitine is a naturally occurring acylcarnitine that is formed via metabolic conversion of L-leucine. It increases survival and decreases apoptosis in hepatocyte growth factor-deprived murine C2.8 hepatocyt... |
|
T62741 |
DprE1-IN-1
|
|
|
|
DprE1-IN-1 is a potent, orally active DprE1 inhibitor that exhibits good hepatocyte stability, low cytotoxicity and low hERG channel inhibition. DprE1-IN-1 has good anti-branched bacilli activity in macrophages, reducing... |
|
T62598 |
Pitavastatin sodium
|
|
|
|
Pitavastatin (NK-104) sodium is a potent inhibitor of hydroxymethylglutaryl-CoA (HMG-CoA) reductase and a potent inducer of the hepatocyte low-density lipoprotein cholesterol (LDL-C) receptor. pitavastatin sodium inhibit... |
|
T35425 |
β-Apooxytetracycline
|
|
|
|
β-Apooxytetracycline is a potential impurity found in commercial preparations of oxytetracycline. β-Apooxytetracycline is a degradation product formed from oxytetracycline via acid hydrolysis. It has a relative potency o... |
|
T70988 |
Ibulocydine
|
|
|
|
Ibulocydine is a potent CDK inhibitor. Ibulocydine has high activity against Cdk7/cyclin H/Mat1 and Cdk9/cyclin T. Ibulocydine inhibited the growth of HCC cells more effectively than other Cdk inhibitors, including olomo... |
|
T7072 |
Pitavastatin
|
|
|
|
Pitavastatin (NK-104) is a potent inhibitor of hydroxymethylglutaryl-CoA (HMG-CoA) reductase, effectively inhibiting cholesterol synthesis from acetic acid in HepG2 cells with an IC 50 of 5.8 nM. It also acts as an effic... |
|
T35712 |
Debutyldronedarone hydrochloride
|
SR35021 hydrochloride |
|
|
N-Desbutyl dronedarone is an active metabolite of the antiarrhythmic agent dronedarone .1,2,3It is formed from dronedarone by cytochrome P450s (CYPs) and monoamine oxidase (MAO) in human hepatocyte preparations.4N-Desbut... |
|
T38844 |
MK-8245 Trifluoroacetate
|
|
|
|
MK-8245 trifluoroacetate is a phenoxy piperidine isoxazole derivative functioning as a potent, liver-targeting stearoyl-CoA desaturase (SCD) inhibitor, demonstrating significant anti-diabetic and anti-dyslipidemic effect... |
