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DNA損傷・DNA修復 内分泌・ホルモン GPCR/Gタンパク質 免疫・炎症 JAK・STATシグナル MAPK 膜輸送体・イオンチャネル
代謝 微生物学・ウィルス学 神経科学 NF-Κb 酸化還元 PI3K/Akt/mTORシグナル プロテアーゼ・プロテアソーム
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検索結果

Search Results for " RSK "

32

阻害剤

9

天然化合物

3

リコンビナントタンパク質

カタログ番号 製品名 別名 ターゲット
T60922 RSK-IN-1
RSK-IN-1 (compound 7d) shows anti-tumor activity. RSK-IN-1 is an inhibitor of RSK that inhibits the phosphorylation of YB-1 [1].
T14779 BRD7389 SGK , FLT , Pim , CDK , S6 Kinase , DAPK
BRD7389 is an inhibitor of RSK family kinase with IC50s of 1.5 μM, 2.4 μM, and 1.2 μM for RSK1, RSK2, and RSK3, respectively.
T22422 S6K-18 S6 Kinase
S6K-18, a highly selective S6K1 inhibitor, inhibits S6K1 with IC50 of 52nM.
T5428 BIX 02565 LRRK2 , S6 Kinase
BIX 02565 is a potent inhibitor of ribosomal S6 kinase 2 (RSK2, IC50: 1.1 nM).
T6877 LJH685 Apoptosis , S6 Kinase
LJH685 is an effective pan-RSK inhibitor for RSK1/2/3 (IC50: 6/5/4 nM).
T2002 PF-4708671 PF4708671 S6 Kinase , Autophagy
PF-4708671 is a cell-permeable inhibitor of p70 ribosomal S6 kinase (S6K1 isoform) .In cell-free assays, PF-4708671(PF4708671) is potent for S6K1(Ki50=20 nM, IC50=160 nM).
T4301 AD80 Raf , c-RET , Src , S6 Kinase
AD80, a multikinase inhibitor, inhibits RET, RAF, SRCand S6K, with greatly reduced mTOR activity.
T6171 BI-D1870 S6 Kinase , Autophagy
BI-D1870 is a cell-permeable, ATP-competitive inhibitor of ribosomal S6 kinases (RSKs; IC50s: 31/24/18/15 nM for RSK1/2/3/4).
T6878 LJI308 S6 Kinase
LJI308 is a potent, and pan-RSK (p90 ribosomal S6 kinase) inhibitor with IC50 of 6 nM, 4 nM, and 13 nM for RSK1, RSK2, and RSK3, respectively.
T6948 Pluripotin SC1 ERK , Raf , S6 Kinase
Pluripotin (SC1) (SC1), which keep embryonic stem cell (ESC) self-renewal, is a dual inhibitor of extracellular signal-regulated kinase 1 (ERK1, MAPK3) and RasGAP.
T6304 AT7867 Akt , PKA , S6 Kinase
AT7867 is a potent ATP-competitive inhibitor of Akt1/2/3 and p70S6K/PKA with IC50 of 32 nM/17 nM/47 nM and 85 nM/20 nM, respectively; little activity outside the AGC kinase family.
T6159 LY-2584702 free base S6 Kinase , mTOR
LY2584702 is a selective, ATP-competitive p70S6K inhibitor(IC50: 4 nM).
T7790 Bisindolylmaleimide V PKC , S6 Kinase
Bisindolylmaleimide V, a bisindolylmaleimide derivative, is an inactive of a kinase inhibitor.
T1746 LY-2584702 tosylate salt LY2584702 tosylate S6 Kinase
LY-2584702 tosylate salt is a selective, ATP-competitive p70S6K inhibitor, used in trials studying the treatment of cancer.
T4488 GSK-25 GSK25 ROCK , S6 Kinase , mTOR
GSK-25 maintains good selectivity against a panel of 31 kinases, as well as RSK1 and p70S6K (RSK1 IC50 of 398 nM, p70S6K IC50 of 1000nM), and a dramatically improved P450 profile (>2.2 uM at all isozymes tested).
T2482 AT13148 ROCK , SGK , Akt , PKA , S6 Kinase
AT13148 is an oral-active and ATP-competitive, multi-AGC kinase inhibitor for Akt1/2/3, p70S6K, PKA, and ROCKI/II.
T8978 DD1 3,3'-Diamino-4'-methoxyflavone,HUN85111 Proteasome
DD1 (HUN85111) is a proteasome inhibitor that induces human myeloid tumor-selective apoptosis.
T19913 CKI-7 CKI 7 2HCl,CKI-7 dihydrochloride,CKI7 2HCl,CKI 7 dihydrochloride,CKI7 dihydrochloride,CKI-7 2HCl ROCK , SGK , Casein Kinase , CDK , S6 Kinase
CKI-7 is a potent and ATP-competitive inhibitor of casein kinase 1 (CK1; IC50: 6 μM; Ki: 8.5 μM) and a selective Cdc7 kinase inhibitor. CKI-7 also inhibits SGK, ribosomal S6 kinase-1 (S6K1), and MSK1.
T62718 RSK2-IN-3
RSK2-IN-3 (Compound 26) is a covalent, reversible inhibitor of RPS6KA3 (RSK2) kinase.
T61766 RSK4-IN-1
RSK4-IN-1 is a compound exhibiting potent inhibition of RSK4, demonstrated by an IC50 value of 9.5 nM.
T22467 1,9-Dideoxyforskolin Others
The compound is an inactive analog of forskolin(an adenylyl cyclase activator).
T36720 Deacetylforskolin
Deacetylforskolin is a diterpene and a derivative of forskolin that has been found inC. forskohliiand has diverse biological activities.1,2,3,4It activates rat adipocyte adenylyl cyclase (IC50= 20 μM) and inhibits glucos...
T60585 RSK2-IN-2
RSK2-IN-2 (Compound 25) is a reversible covalent inhibitor of the RPS6KA3 ( RSK2 ) kinase which also inhibits MSK1, MSK2, and RSK3 [1].
TQ0310 FMK S6 Kinase
FMK is an irreversible inhibitor of RSK2 kinase.
T4327 Prexasertib dihydrochloride LY2606368 (dihydrochloride),Prexasertib HCl,LY2606368 Apoptosis , Chk , S6 Kinase
Prexasertib dihydrochloride (LY2606368) is an ATP-competitive CHK1 inhibitor (Ki: 0.9 nmol/L). in the cell-free assay, its IC50 values are 8 nM and 9 nM for CHK2 and RSK, respectively.
T7005 Ulixertinib BVD-523,VRT752271 ERK
Ulixertinib (VRT752271) (BVD-523, VRT752271) is an effective and reversible ERK1/ERK2 inhibitor. The IC50 of Ulixertinib is less than 0.3 nM for ERK2.
T68781 3Ac-SL0101
3Ac-SL0101 is a potent RSK-specific inhibitor. It facilitates the development of RSK inhibitors as anti-cancer chemotherapeutic agents.
T28695 SB-747651A SB 747651A
SB-747651A is a potent, ATP-competitive inhibitor of mitogen- and stress-activated kinase 1 (MSK1, IC50 = 11 nM). It targets the N-terminal kinase domain. SB-747651A inhibits MSK1, MSK2, PKA, PKB, RSK and p70S6K activity...
T26103 RMM-46
RMM-46 is a reversible and selective covalent inhibitor for MSK/RSK-family kinases.
T11310 FMK-MEA Others
T81041 TAS0612 Akt
TAS0612, a novel oral inhibitor of RSK, AKT, and S6K, exhibits broad-spectrum antitumor activity by impeding cell growth [1].
T15377 Ravoxertinib hydrochloride GDC-0994 (hydrochloride) ERK
Ravoxertinib hydrochloride is an orally bioavailable and selective inhibitor for ERK kinase activity (IC50: 6.1 nM and 3.1 nM for ERK1 and ERK2, respectively).

Compounds

RSK-IN-1
T60922
Synonym:
Target:
BRD7389
T14779
Synonym:
Target: SGK, FLT, Pim, CDK, S6 Kinase, DAPK
S6K-18
T22422
Synonym:
Target: S6 Kinase
BIX 02565
T5428
Synonym:
Target: LRRK2, S6 Kinase
LJH685
T6877
Synonym:
Target: Apoptosis, S6 Kinase
PF-4708671
T2002
Synonym: PF4708671
Target: S6 Kinase, Autophagy
AD80
T4301
Synonym:
Target: Raf, c-RET, Src, S6 Kinase
BI-D1870
T6171
Synonym:
Target: S6 Kinase, Autophagy
LJI308
T6878
Synonym:
Target: S6 Kinase
Pluripotin
T6948
Synonym: SC1
Target: ERK, Raf, S6 Kinase
AT7867
T6304
Synonym:
Target: Akt, PKA, S6 Kinase
LY-2584702 free base
T6159
Synonym:
Target: S6 Kinase, mTOR
Bisindolylmaleimide V
T7790
Synonym:
Target: PKC, S6 Kinase
LY-2584702 tosylate salt
T1746
Synonym: LY2584702 tosylate
Target: S6 Kinase
GSK-25
T4488
Synonym: GSK25
Target: ROCK, S6 Kinase, mTOR
AT13148
T2482
Synonym:
Target: ROCK, SGK, Akt, PKA, S6 Kinase
DD1
T8978
Synonym: 3,3'-Diamino-4'-methoxyflavone,HUN85111
Target: Proteasome
CKI-7
T19913
Synonym: CKI 7 2HCl,CKI-7 dihydrochloride,CKI7 2HCl,CKI 7 dihydrochloride,CKI7 dihydrochloride,CKI-7 2HCl
Target: ROCK, SGK, Casein Kinase, CDK, S6 Kinase
RSK2-IN-3
T62718
Synonym:
Target:
RSK4-IN-1
T61766
Synonym:
Target:
1,9-Dideoxyforskolin
T22467
Synonym:
Target: Others
Deacetylforskolin
T36720
Synonym:
Target:
RSK2-IN-2
T60585
Synonym:
Target:
FMK
TQ0310
Synonym:
Target: S6 Kinase
Prexasertib dihydrochloride
T4327
Synonym: LY2606368 (dihydrochloride),Prexasertib HCl,LY2606368
Target: Apoptosis, Chk, S6 Kinase
Ulixertinib
T7005
Synonym: BVD-523,VRT752271
Target: ERK
3Ac-SL0101
T68781
Synonym:
Target:
SB-747651A
T28695
Synonym: SB 747651A
Target:
RMM-46
T26103
Synonym:
Target:
FMK-MEA
T11310
Synonym:
Target: Others
TAS0612
T81041
Synonym:
Target: Akt
Ravoxertinib hydrochloride
T15377
Synonym: GDC-0994 (hydrochloride)
Target: ERK
カタログ番号 製品名 別名 ターゲット
T6S1302 Carnosol Nrf2 , Endogenous Metabolite , S6 Kinase
Carnosol is an Nrf2 activator, increasing Nrf2 levels and promoting heme oxygenase 1 (HMOX1) expression. It is a ribosomal S6 kinase (RSK2) inhibitor and can be used in gastric cancer-related research with an IC50 value ...
T3836 Eudesmin MAPK , S6 Kinase
Eudesmin shows antiinflammatory, neuritogenic, anticonvulsant and sedative effects, the mechanism of eudesmin may be related to up-regulation of GABAA and GAD65 expressions, and anti-apoptosis of neuron the in brain.50 m...
T2871 Quercitrin Sophoretin,3-rhamnosyl quercetin,Quercetin 3-rhamnoside,Xanthaurine,Meletin Reactive Oxygen Species , S6 Kinase , Autophagy
Quercitrin (3-rhamnosyl quercetin) is a plant-derived flavonoid compound, displays antioxidant and anti-inflammatory activities. Quercitrin can be found in a number of food items such as garden tomato (var. ), German cam...
T0335 Sodium salicylate Salicylic acid sodium salt,2-Hydroxybenzoic acid sodium salt Apoptosis , NF-κB , COX , S6 Kinase , Autophagy
Sodium salicylate (2-Hydroxybenzoic acid sodium salt), a metabolite of acetylsalicylic acid, can inhibit NF-kB and reduce oxidative stress.
TN1520 Isoforskolin Coleonol B IL Receptor , TNF
Isoforskolin is derived from Coleus forskohlii and reduces the secretion of TNF-α, IL-1β, IL-6 and IL-8 in human mononuclear leukocytes. Isoforskolin can be used in studies about the treatment of Lyme arthritis.
T2939 Forskolin Coleonol,Colforsin FXR , Adenylyl cyclase , AChR , Autophagy
Forskolin (Coleonol) is a natural product, an adenylate cyclase activator (EC50=0.5 μM). Forskolin increases cAMP levels, activates PXR and FXR, and induces autophagy. Forskolin produces positive inotropic effects in the...
TN4073 Forskolin G Others
Forskolin is known to elevate intracellular cAMP levels.
TN4074 Forskolin J Others
Forskolin J is a natural product for research related to life sciences. The catalog number is TN4074 and the CAS number is 81873-08-7.
T16896 SL 0101-1 SL0101 S6 Kinase
SL 0101-1 (SL0101) is a selective, efficient, reversible and ATP-competitive inhibitor of p90 ribosomal S6 kinase (RSK) that can permeate cell membranes, with an IC50 value of 89 nM for RSK.SL 0101-1 (SL0101) is also a p...

天然物製品

Carnosol
T6S1302
Synonym:
Target: Nrf2, Endogenous Metabolite, S6 Kinase
Eudesmin
T3836
Synonym:
Target: MAPK, S6 Kinase
Quercitrin
T2871
Synonym: Sophoretin,3-rhamnosyl quercetin,Quercetin 3-rhamnoside,Xanthaurine,Meletin
Target: Reactive Oxygen Species, S6 Kinase, Autophagy
Sodium salicylate
T0335
Synonym: Salicylic acid sodium salt,2-Hydroxybenzoic acid sodium salt
Target: Apoptosis, NF-κB, COX, S6 Kinase, Autophagy
Isoforskolin
TN1520
Synonym: Coleonol B
Target: IL Receptor, TNF
Forskolin
T2939
Synonym: Coleonol,Colforsin
Target: FXR, Adenylyl cyclase, AChR, Autophagy
Forskolin G
TN4073
Synonym:
Target: Others
Forskolin J
TN4074
Synonym:
Target: Others
SL 0101-1
T16896
Synonym: SL0101
Target: S6 Kinase

Recombinant Proteins

Species：
Human (3)
Expression System：
Baculovirus-Insect Cells (3)
Tag：
GST (3)
カタログ番号 製品名 Species Expression System
TMPY-04392 RSK3 Protein, Human, Recombinant (GST) Human Baculovirus-Insect Cells
Ribosomal protein S6 kinase alpha-2, also known as 9 kDa ribosomal protein S6 kinase 2, MAP kinase-activated protein kinase 1c, MAPK-activated protein kinase 1c, Ribosomal S6 kinase 3, RSK-3, RPS6KA2 and MAPKAPK1C, is a ...
TMPY-04357 RSK4 Protein, Human, Recombinant (GST) Human Baculovirus-Insect Cells
Ribosomal protein S6 kinase alpha-6, also known as Ribosomal S6 kinase 4, 9 kDa ribosomal protein S6 kinase 6,RSK-4, RSK4 and RPS6KA6, is a protein that belongs to the protein kinase superfamily, AGC Ser/Thr protein kina...
TMPY-04540 S6K1/RPS6KB1 Protein, Human, Recombinant (GST) Human Baculovirus-Insect Cells
PS6K, also known as RPS6KB1, is a serine/threonine-protein kinase. It belongs to the RSK (ribosomal s6 kinase) family. Members of this family function in signal transduction. PS6K is an isoform of p70 ribosomal S6 kinase...
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