|
T25180 |
Bromodiphenhydramine hydrochloride
|
|
Others
|
|
Bromodiphenhydramine hydrochloride is a new antihistaminic in the control of cutaneous. |
|
T39113L |
Povorcitinib phosphate
|
|
JAK
|
|
Povorcitinib phosphate is a selective JAK1 inhibitor and can be used in studies about the treatment of cutaneous lupus erythematosus and Lichen planus. |
|
T4570 |
Pipobroman
|
Vercyte,A-8103,Amedel |
Others
,
DNA Alkylator/Crosslinker
|
|
Pipobroman (Vercyte) is an anti-cancer drug that probably acts as an alkylating agent. Pipobroman has well documented clinical activity in polycythemia vera (PV) and essential thrombocythemia (ET). Pipobroman allows, wit... |
|
T6410 |
Bexarotene
|
Ro 26-4455,Targretin,LGD1069 |
Retinoid Receptor
,
Autophagy
|
|
Bexarotene (LGD1069) is a retinoid analogue that is used to treat the skin manifestations of cutaneous T cell lymphoma (CTCL). |
|
T90596 |
Sivifene
|
|
Others
|
|
Sivifene is a antitumor agent. Sivifene can be used for research on the treatment of cutaneous metastases from cancer. |
|
T20802 |
Flumethasone pivalate
|
Locacorten,NSC-107680,Lorinden,NSC 107680,NSC107680,Locorten |
Others
|
|
Flumethasone pivalate (Locorten) has antipruritic, anti-inflammatory, and vasoconstrictive properties and can be used in studies about adrenocortical suppression, cutaneous atrophy, plasma transcortin binding, and telang... |
|
T20444 |
Hexyl nicotinate
|
AI3 15769,AI3-15769,AI315769 |
Others
|
|
Hexyl nicotinate (AI3 15769) is a cutaneous vasodilator and can be used in research on non-immunologic contact urticaria on the scalp, face, and back. |
|
T25982 |
Pramiconazole
|
R-126638,R126638,R 126638,Azoline |
Antifungal
|
|
Pramiconazole (R126638) is an orally available antifungal compound.Pramiconazole is a candidate for the treatment of dermatophytes and cutaneous yeast infections in seborrheic dermatitis. |
|
T0033 |
Miltefosine
|
HePC,Hexadecyl phosphocholine |
Akt
,
HIV Protease
,
PKC
|
|
Miltefosine (HePC) is the treatment of visceral and cutaneous leishmaniasis drug , and is proceeding clinical trials for this in several countries. Several medical agents produce some potency against visceral or cutaneou... |
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T10295 |
Amantanium bromide
|
Amantanil bromidum |
Others
|
|
Amantanium bromide (Amantanil bromidum) is a quaternary ammonium antibacterial/antifugal agent useful as a surgical antiseptic and for the topical therapy of mucous and cutaneous infections. |
|
T6665 |
Sertaconazole nitrate
|
FI-7045,Ginedermofix,FI7056,Ertaczo |
Antibiotic
,
Antifungal
|
|
Sertaconazole nitrate (FI-7045), a topical broad-spectrum antifungal, is developed to supply an additional agent for the treatment of superficial cutaneous and mucosal infections. |
|
T16729 |
Remetinostat
|
SHP-141 |
HDAC
|
|
Remetinostat (SHP-141), a hydroxamic acid-based inhibitor of histone deacetylase enzymes, is currently being developed for the treatment of cutaneous T-cell lymphoma. |
|
T11581 |
HSR6071
|
|
Others
|
|
|
|
T77455 |
Burosumab
|
KRN23 |
Others
|
|
Burosumab(KRN23) is a human monoclonal antibody targeting fibroblast growth factor 23 (FGF23) for the treatment of cutaneous-skeletal hypophosphatemic syndrome (CSHS) and tumor-induced osteochondrosis. |
|
T39746 |
DNDI-6148
|
|
Parasite
|
|
DNDI-6148 has anti-experimental cutaneous leishmaniasis activity and can be used to study visceral leishmaniasis by inhibiting Leishmania protozoa cleavage and polyadenylation-specific factor (CPSF3) endonuclease. |
|
T12399 |
Peldesine
|
BCX 34 |
Nucleoside Antimetabolite/Analog
,
HIV Protease
|
|
|
|
T77491 |
Prezalumab
|
AMG 557 |
Others
|
|
Prezalumab (AMG 557) is a human IgG2 monoclonal antibody against ICOSL and BAFF. Prezalumab can be used to study sjogren's syndrome cutaneous lupus erythematosus, psoriasis, systemic lupus erythematosus arthritis and sys... |
|
T17315 |
(±)-CPSI-1306
|
cpsi-1306,2-(3-(2,4-Difluorophenyl)-4,5-dihydroisoxazol-5-yl)-1-morpholinoethan-1-one |
Others
|
|
(±)-CPSI-1306 (2-(3-(2,4-Difluorophenyl)-4,5-dihydroisoxazol-5-yl)-1-morpholinoethan-1-one) is a macrophage migration inhibitory factor (MIF) antagonist and can be used in studies about non-insulin-dependent diabetes mel... |
|
T6006 |
Romidepsin
|
FR 901228,FK 228,Depsipeptide,NSC 630176 |
Apoptosis
,
HDAC
|
|
Romidepsin (FR 901228) is an HDAC inhibitor that inhibits HDAC1/2/4/6 (IC50=36/47/510/1400 nM). Romidepsin has antitumor activity and can be used for the treatment of peripheral T-cell lymphoma and cutaneous T-cell lymph... |
|
T76782 |
Mogamulizumab
|
KW-0761 |
CXCR
|
|
Mogamulizumab (KW-0761) is a monoclonal antibody against T cell CC chemokine receptor 4. Mogamulizumab has anticancer activity, eliminating tumor cells through antibody dependent cytotoxicity (ADCC), and can be used to s... |
|
T6529 |
Halobetasol propionate
|
Halobetasol Propionate,Ulobetasol propionate,BMY-30056,CGP-14458 |
Phospholipase
|
|
Halobetasol propionate (BMY-30056) is the propionate salt form of halobetasol, a synthetic corticosteroid with anti-inflammatory, antipruritic, and vasoconstrictor activities. Halobetasol, a topical steroid, diffuses acr... |
|
T67385 |
Neratinib maleate
|
HKI-272 maleate |
EGFR
,
HER
|
|
Neratinib maleate (HKI-272 maleate) is an irreversible, orally active and highly selective inhibitor of HER2 and EGFR with IC50 values of 59 nM and 92 nM, respectively.Neratinib maleate has antitumor activity and can be ... |
|
T28777 |
Silicon Phthalocyanine 4
|
Pc-4,Pc 4,Pc4 |
|
|
Silicon Phthalocyanine 4 is a drug with anti-cutaneous neoplasms activity. |
|
T29990 |
Aminoquinol diphosphate
|
|
|
|
Aminoquinol diphosphate may be useful in the treatment of acute necrotising cutaneous leishmaniasis. |
|
T13172 |
TMP780
|
|
ROR
|
|
TMP780 is an inverse RORγt agonist (IC50: 13 nM). RORγt is a tractable drug target for the treatment of cutaneous inflammatory disorders. |
|
T29991 |
Aminoquinol triphosphate
|
Aminochinol triphosphate |
|
|
Aminoquinol triphosphate may be useful in the treatment of acute necrotising cutaneous leishmaniasis. |
|
T21035 |
Rufloxacin
|
MF 934 |
|
|
Rufloxacin is a drug that belongs to the class of fluoroquinolones, which act mainly as specific inhibitors of bacterial Topoisomerase II. These drugs involve in various diseases including cutaneous reactions, aging, etc... |
|
T23783 |
Benzoxonium chloride
|
Bradophen,Bialcol,D 301,D301,Cohortan |
|
|
Benzoxonium chloride, The topical treatment of anthroponotic cutaneous leishmaniasis with the tincture of thioxolone plus benzoxonium chloride (Thio-Ben) along with cryotherapy. |
|
T40270 |
MrgprX2 antagonist-1
|
MrgprX2 antagonist-1 |
|
|
MrgprX2 antagonist-1, is a novel MrgprX2 antagonist compound. It exhibits potential for exploration in studying cutaneous inflammatory disorders. |
|
T39295 |
Remlarsen
|
MRG-201 |
|
|
Remlarsen (MRG-201), a miR-29b mimic, functions as a miR-29b agonist with the potential to prevent the formation of fibrotic scars or cutaneous fibrosis. |
|
T39113 |
Povorcitinib
|
|
|
|
Povorcitinib is a highly potent and selective JAK1 inhibitor with significant potential for the investigation of cutaneous lupus erythematosus (CLE) and Lichen planus (LP). |
|
T10528 |
Bexarotene D4
|
LGD1069 D4 |
Others
|
|
Bexarotene D4 is a deuterium-labeled Bexarotene (LGD1069). Bexarotene is a selective RXR agonist used in the treatment of cutaneous T-cell lymphoma. |
|
T38127 |
PNPS-DHA
|
|
|
|
pNPS-DHA is an arylamide derivative of docosahexaenoyl ethanolamide that has anti-allergic activity.1It inhibits degranulation of RBL-2H3 mast cells (IC50= 15 μM).pNPS-DHA (1,000 mg/kg) inhibits IgE-dependent passive cut... |
|
T78209 |
Nedometinib
|
|
MEK
|
|
Nedometinib, a tyrosine kinase inhibitor, specifically targets MEK1 and exhibits antineoplastic effects. It is utilized in research related to dermatosis, cutaneous fibroneruroma, and neurofibromatosis [1]. |
|
T70930 |
GSK SYK inhibitor
|
|
|
|
The immunoregulator spleen tyrosine kinase (SYK) is upregulated in cutaneous lupus erythematosus (CLE). This double-blind, multicentre, Phase Ib study evaluated the safety, tolerability, pharmacokinetics, pharmacodynamic... |
|
T61013 |
Bromodiphenhydramine
|
|
|
|
Bromodiphenhydramine (Ambodryl) has antimicrobial activities which can be used in the cutaneous allergies research. Bromodiphenhydramine is an effective antihistamine that can inhibit a large number of Gram-negative and ... |
|
T78329 |
Litifilimab
|
BIIB059 |
|
|
Litifilimab, a humanized IgG1-κ antibody, targets the C-type lectin domain family 4 member C (CLEC4C) and has potential applications in the study of cutaneous lupus erythematosus (CLE) [1] [2]. |
|
T63284 |
PAD-IN-2
|
|
|
|
PAD-IN-2 is a potent inhibitor of pad4 with an IC50 value <1 μM and can be used to study autoimmune diseases and cancers such as rheumatoid arthritis, vasculitis, systemic lupus erythematosus, cutaneous lupus erythematos... |
|
T80744 |
Zanolimumab
|
Anti-Human CD4 Recombinant Antibody |
|
|
Zanolimumab (Anti-Human CD4 Recombinant Antibody) is a fully human monoclonal antibody that targets the CD4 molecule and effectively inhibits T-cell receptor (TCR) signal transduction. It is used in the research of rheum... |
|
T70377 |
BAY 61-3606 HCl
|
|
|
|
BAY 61-3606 HCl is a cell-permeable, reversible inhibitor of spleen tyrosine kinase. BAY 61-3606 HCl can inhibit degranulation and block cytokine release from mast cells. Oral administration of BAY 61-3606 to rats was sh... |
|
T60836 |
PT4
|
|
|
|
PT4 is a treatment agent for Cutaneous leishmaniasis (CL). PT4 decreases of mitochondrial membrane potential and increases reactive oxygen species production, therefore leads to parasite death. PT4 is effective against b... |
|
T35552 |
Ganglioside GD3 Mixture (sodium salt)
|
|
|
|
Ganglioside GD3 is synthesized by the addition of two sialic acid residues to lactosylceramide and can serve as a precursor to the formation of more complex gangliosides by the action of glycosyl- and sialyltransferases.... |
|
T72865 |
Sofnobrutinib
|
AS-0871 |
|
|
Sofnobrutinib (AS-0871) is an orally active, selective inhibitor of Bruton's tyrosine kinase (BTK) demonstrating IC50 values of 4.2 nM (activated BTK) and 0.39 nM (unactivated BTK). Additionally, it displays an IC50 of 2... |
|
T60799 |
Peldesine dihydrochloride
|
|
|
|
Peldesine (BCX 34) dihydrochloride is a potent, competitive, reversible, and orally active inhibitor of purine nucleoside phosphorylase (PNP), exhibiting IC50 values of 36 nM, 5 nM, and 32 nM against human, rat, and mous... |
|
T80234 |
SFNGGP-NH2
|
|
|
|
SFNGGP-NH2 is a biologically active peptide that interacts with Protease-Activated Receptor 3 (PAR-3), a high-affinity thrombin receptor. Human cutaneous mast cells express PAR-3 mRNA, implicating a role in itch mechanot... |
