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カタログ番号 | 製品名 | 別名 | ターゲット |
---|---|---|---|
T36983 | Cyclic-di-GMP disodium | Cyclic diguanylate,5GP-5GP disodium,3',5'-Cyclic diguanylic acid,Cyclic di-GMP (sodium salt),cyclic diguanylate disodium,c-di-GMP,c-di-GMP disodium | STING , Endogenous Metabolite |
Cyclic-di-GMP disodium (5GP-5GP disodium) is a bacterial second messenger and a STING agonist involved in a variety of prokaryotic processes including biofilm formation, motility, and cell cycle progression.Cyclic-di-GMP... | |||
T12472 | Pifithrin-α, p-Nitro, Cyclic | PFN-α | p53 |
Pifithrin-α, p-Nitro, Cyclic (PFN-α) (PFN-α) is cell-permeable and active-form inhibitor of p53. | |||
TP1501L | CTTHWGFTLC, CYCLIC acetate(244082-19-7 free base) | MMP | |
CTTHWGFTLC, CYCLIC acetate is an inhibitor for matrix metalloproteinases (MMP)-2 and MMP-9. It is also called type IV collagenase or gelatinase. Gelatinases are potential targets of therapeutic intervention in cancer, an... | |||
TP1035 | Cyclic somatostatin | SRIF-14,Somatostatin-14 | Others |
Cyclic somatostatin (SRIF-14) is a cyclic tetradecapeptide regulating many endocrine and nervous system functions. | |||
TP1035L | Cyclic somatostatin Acetate(38916-34-6(free base)) | Somatostatin (sheep), monoacetate (salt),Somatostatin-14,SRIF-14,monoacetate (salt) | Others |
Cyclic somatostatin Acetate(38916-34-6(free base)) (Somatostatin-14) is a cyclic tetradecapeptide regulating many endocrine and nervous system functions. | |||
T37475 | Cyclic ADP-Ribose (ammonium salt) | cADP-Ribose,cADPR,Cyclic ADP-Ribose (ammonium salt) | |
Cyclic ADP-ribose (cADP-ribose) is an endogenous metabolite of NAD+ that mobilizes the release of stored Ca2+ in the endoplasmic reticulum via ryanodine receptors in various cell types.[1],[2],[3],[4],[5] This second mes... | |||
T33516 | Msh (5-10), cyclic | Cyclic H-asp-his-phe-arg-trp-lys-NH2 | |
Msh (5-10), cyclic, as a synthetic peptide, can conjugate with fatty acids for enhanced potency. | |||
TP1501 | CTTHWGFTLC, CYCLIC | ||
This cyclic CTT Gelatinase Inhibitor peptide is an inhibitor for matrix metalloproteinases (MMP)-2 and MMP-9. It is also called type IV collagenase or gelatinase. Gelatinases are potential targets of therapeutic interven... | |||
T3637 | Pifithrin-β hydrobromide | Cyclic PFT-α,PFT-β,Cyclic Pifithrin-α hydrobromide,Pifithrin-β,PFT β (hydrobromide) | Ferroptosis , p53 |
Pifithrin-β hydrobromide (Cyclic PFT-α) is an inhibitor of p53; reversibly blocks p53-dependent transcriptional activation and apoptosis. Protects against neuronal death in models of stroke and neurodegenerative disorder... | |||
T35424 | 8-bromo-Cyclic AMP | ||
8-bromo-Cyclic AMP is a brominated derivative of cAMP that remains long-acting due to its resistance to degradation by cAMP phosphodiesterase. It can activate cAMP-dependent protein kinase, inhibiting growth, decreasing ... | |||
T64318 | Capecitabine-2',3'-cyclic Carbonate | Others | |
Capecitabine-2',3'-cyclic Carbonate is a antiproliferative agent. | |||
TP1620 | Cyclic MKEY | ||
MKEY, a synthetic cyclic peptide inhibitor of CXCL4-CCL5 heterodimer formation, has been shown to protect against atherosclerosis and aortic aneurysm formation by mediating inflammation, but whether it modulates neuroinf... | |||
T36985 | Cyclic di-UMP (sodium salt) | ||
Cyclic di-UMP is a pyrimidine-containing cyclic dinucleotide (CDN).1It is produced by bacterial cGAS/DncV-like nucleotidyltransferases (CD-NTases), such as LpCdnE02 fromL. pneumophila, and binds to cGAS, in the apo or ds... | |||
T35595 | Cyclic di-AMP (sodium salt) | ||
Cyclic di-AMP (c-di-AMP) is a second messenger produced by bacteria but not by mammals. Generated by a family of diadenylate cyclases, c-di-AMP can impact bacterial cell growth, cell wall homeostasis, pathogenicity, and ... | |||
T36984 | Cyclic di-IMP (sodium salt) | ||
Cyclic di-IMP (sodium salt) (c-di-IMP) is a synthetic second messenger structurally related to the bacterial second messengers cyclic di-GMP and cyclic di-AMP . C-di-IMP has adjuvant properties when co-administered with ... | |||
T36677 | Rp-8-bromo-Cyclic AMPS (sodium salt) | ||
Rp-8-bromo-Cyclic AMPS (Rp-8-bromo-cAMPS) is a cell-permeable cAMP analog that combines an exocyclic sulfur substitution in the equatorial position of the cyclophosphate ring with a bromine substitution in the adenine ba... | |||
T37803 | 8-bromo-Cyclic ADP-Ribose (sodium salt) | ||
Cyclic ADP-ribose (cADP-ribose) is a calcium mobilizing nucleotide that is biosynthesized from NAD+ by cADP-ribose synthases, including CD38. cADP-Ribose appears to activate calcium channels in intracellular membranes, w... | |||
T21697 | Sp-Cyclic AMPS (sodium salt) | ||
Sp-cAMPS sodium salt is an analog of cAMP that is a potent activator of cAMP-dependent PKA I and PKA II. Sp-cAMPS sodium salt is also a potent, competitive phosphodiesterase (PDE3A) inhibitor with a K i of 47.6 μM. Sp-cA... | |||
T21705 | 8-CPT-Cyclic AMP (sodium salt) | ||
8-CPT-Cyclic AMP (8-CPT-cAMP) sodium functions dually as a selective activator of cyclic AMP-dependent protein kinase (PKA) and as a potent inhibitor of the cyclic GMP-specific phosphodiesterase (PDE VA), demonstrating a... | |||
T60419 | Cyclic HPMPC | ||
Cyclic HPMPC is a potent antiviral agent that enhances arterial oxygen saturation in mice infected with the lethal vaccinia virus (IHD strain) and alleviates congenital guinea pig cytomegalovirus (GPCMV) infection outcom... | |||
T76017 | CTTHWGFTLC, CYCLIC TFA | ||
CTTHWGFTLC, also known as CYCLIC TFA, is a cyclic peptide that acts as an inhibitor of matrix metalloproteinases (MMP-2 and MMP-9), with an IC50 value of approximately 8 μM for MMP-9 [1]. | |||
T78011 | Cyclic MKEY TFA | ||
Cyclic MKEY TFA, a synthetic cyclic peptide, inhibits CXCL4-CCL5 heterodimer formation, thus guarding against atherosclerosis and aortic aneurysm by mitigating inflammation. Additionally, it affords protection against st... | |||
T82645 | Cyclic PSAP peptide | ||
Cyclic PSAP peptide (DWLPK) possesses properties akin to those of a therapeutic agent, demonstrating the potential to inhibit metastasis and suppress tumor growth in vivo [1]. | |||
T10642 | C-di-AMP | Cyclic diadenylate,Cyclic-di-AMP | Others |
c-di-AMP (Cyclic diadenylate) is a STING agonist. It binds to the transmembrane protein STING thereby activating the TBK3-IRF3 signaling pathway. | |||
T76544 | Cyclic SSTR agonist octreotide | ||
Cyclic SSTR agonist octreotide is a Octreotide , serving as the cyclic Somatostatin Receptor SSTR agonist [1] . | |||
T73362 | C-di-IMP | Cyclic-di-IMP | |
Cyclic-di-IMP (C-di-IMP), a STING agonist, serves as a research tool in tumor studies. | |||
T82760 | C-di-IMP disodium | Cyclic-di-IMP disodium | STING |
C-di-IMP disodium, a STING agonist, is utilized in tumor research [1]. | |||
T9213 | G140 | cGAS | |
G140 is a potent and selective inhibitor of cyclic GMP-AMP synthase (cGAS). | |||
T10065 | 2',3'-cGAMP | 2'-3'-cyclic GMP-AMP | STING , cGAS |
2',3'-cGAMP (2'-3'-cyclic GMP-AMP) is a second messenger in cellular innate immunity and is catalyzed by cGAMP synthase (cGAS) under DNA binding conditions. 2',3'-cGAMP binds to STING to form a dimer, inducing the produc... | |||
T13606 | CGAMP | 3',3'-cGAMP,Cyclic GMP-AMP | Others |
cGAMP is an endogenous second messenger in metazoans and triggers interferon production in response to cytosolic DNA. It also is a STING ligand. | |||
T83402 | 2′,3′-cGMP triethylamine | Guanosine 2',3'-cyclic phosphate triethylamine | |
Guanosine 2',3'-cyclic phosphate triethylamine, commonly known as 2′,3′-cGMP triethylamine, is an active compound utilizable in numerous research investigations [1]. | |||
T12432 | PF-06928215 | cGAS | |
PF-06928215 is an inhibitor of cGAS (cyclic GMP-AMP Synthase) (IC50 of 4.9 μΜ). | |||
T11673 | IRAK4-IN-4 | IRAK , cGAS | |
IRAK4-IN-4 (compound 15) inhibits cyclic GMP-AMP synthase (cGAS) with an IC50 of 2.1 nM.IRAK4-IN-4 is an interleukin-1 receptor–associated kinase 4 (IRAK4) inhibitor, has an IC50 of 2.8 nM. | |||
T5486 | RU.521 | RU320521 | DNA , cGAS |
RU.521 (RU3205217) is a potent dsDNA inhibitor (IC50 : 700 nM), inhibition of the dsDNA pathway by RU.521 requires the presence of cGAS. | |||
T11344 | G150 | DNA , cGAS | |
G150 inhibited interferon expression triggered by DSDNA with IC50 of 10.2 nM.G150 is an effective and highly selective inhibitor of human cyclic GMP-AMP synthase (H-CGAS). | |||
T83671 | CCP-biotin Peptide (non-cyclized) | Citrullinated Filaggrin (Q447H, S449C, G459R, E460G, S462C) (R455) (447-467)-biotin Peptide (non-cyclized),Cyclic Citrullinated Peptide-biotin Peptide (non-cyclized) | |
CCP-biotin peptide (non-cyclized) is a linear, biotin-labeled derivative of the circular citrullinated peptide (CCP), mirroring the human filaggrin sequence from amino acids 447 to 467 with specific substitutions (Q447H,... | |||
T7511 | Cyclo(his-pro) | NF-κB , Endogenous Metabolite | |
Cyclo(his-pro) is an endogenous cyclic dipeptide that exerts oxidative damage protection by selectively activating the transcription factor Nrf2 signalling pathway. | |||
T2923 | Apremilast | CC-10004 | Apoptosis , TNF , PDE |
Apremilast (CC-10004) (CC-10004) is a potent and orally active PDE4 (IC50=74 nM) with anti-inflammation activities. | |||
T2535 | Ivabradine hydrochloride | S 16257-2,Ivabradine HCl | Adrenergic Receptor |
Ivabradine hydrochloride (S 16257-2) is a new If inhibitor (IC50: 2.9 μM). Ivabradine Hydrochloride is the hydrochloride salt form of ivabradine, an orally bioavailable, hyperpolarization-activated, cyclic nucleotide-gat... | |||
T35421 | 2'-O-Succinyl-cAMP | ||
2'-O-Monosuccinyladenosine-3',5'-cyclic monophosphate is an immunogenic derivative of cAMP that has been used to generate anti-cAMP antisera and antibodies.1,2 | |||
T36678 | Rp-8-CPT-cAMPS sodium | ||
Rp-8-CPT-cAMP is a structural combination of the lipophilic and non-hydrolyzable cAMP analogs, 8-CPT-cyclic AMP and Rp-cyclic AMPS .[1] It functions as a site-selective inhibitor of protein kinase A (PKA) type I and II, ... | |||
T2137 | Ibudilast | AV-411,KC-404,MN-166 | PDE |
Ibudilast (MN-166)(KC-404;AV-411;MN-166) is a relatively nonselective phosphodiesterase inhibitor. It is approved for use as an anti-inflammatory in Japan. | |||
T9137 | SN-011 | [1,1'-Biphenyl]-4-carboxamide, N-[3-[[(4-fluorophenyl)sulfonyl]amino]-4-hydroxyphenyl]-,GUN35901 | STING |
SN-011 (GUN35901) is a STING inhibitor, which inhibited the activation of the STING signal pathway and to prevent or treat a STING- mediated disease. It is a demethyl analogue of DUN99845. | |||
T7516 | ZD7288 | ICI D7288 | HCN Channel |
ZD7288 (ICI D7288), a selective hyperpolarization-activated cyclic nucleotide-gated channel blocker, inhibits hippocampal synaptic plasticity. | |||
T130205 | Dihydroterrecyclic acid | ||
Dihydroterrecyclic acid is a useful organic compound for research related to life sciences and the catalog number is T130205. | |||
T83937 | Tricyclic cytosine tC | ||
Tricyclic cytosine (tC) is a fluorescent analog of cytosine designed for RNA imaging within live cells, facilitating the study of RNA synthesis, degradation, and trafficking with single-cell precision through confocal im... | |||
T36548 | Carbocyclic Thromboxane A2 | ||
Carbocyclic Thromboxane A2 can be used in related research in the field of life sciences. Its product number is T36548 and CAS number is 74034-56-3. | |||
T36330 | Terrecyclic Acid | ||
Terrecyclic acid is a sesquiterpene originally isolated from A. terreus with antibiotic and anticancer activity. It is active against S. aureus, B. subtilis, and M. roseus (MICs = 25, 50, and 25 μg/ml, respectively). Ter... | |||
T6747 | 8-Bromo-cAMP sodium salt | 8-Br-Camp sodium salt,8-Bromo-cAMP(sodium salt),8-Bromo-cAMP | PKA |
8-Bromo-cAMP sodium salt (8-Br-Camp sodium salt) is a long-acting derivative of cyclic AMP. It is an activator of cyclic AMP-dependent protein kinase(PKA), but resistant to degradation by cyclic AMP phosphodiesterase. | |||
T29038 | KL8604166 | UCB11056,UCB-11056,UCB 11056 | Others |
Trometamol (UCB-11056) is a potential puzzle compound.UCB-11056 amplifies the formation of inducible cyclic AMP in rat brain tissue. |
カタログ番号 | 製品名 | 別名 | ターゲット |
---|---|---|---|
TCO2745 | Cyclic AMP | Adenosine 3',5'-cyclophosphate,cAMP,Cyclic 3',5'-monophosphate adenosine,3',5'-AMP,Adenosine Cyclophosphate | Others , Endogenous Metabolite |
Cyclic AMP (cAMP) (Adenosine 3',5'-cyclophosphate) combined with vitamin C treatment of children with viral myocarditis has exact curative effect, and it can improve cardiac function of patients and improve immune functi... | |||
T5065 | GUANOSINE 3':5'-CYCLIC MONOPHOSPHATE SOD | Monosodium-GMP,cGMP sodium salt,Cyclic GMP | PKA |
GUANOSINE 3':5'-CYCLIC MONOPHOSPHATE SOD (cGMP sodium salt) , also known as cGMP, is a cellular regulatory agent and has been described as a second messenger. Its levels increase in response to a variety of hormones, inc... | |||
T10909 | Cyclic-di-GMP | c-di-GMP,cyclic diguanylate,5GP-5GP | Others |
Cyclic-di-GMP is a STING agonist and ubiquitous second messenger, which regulates the formation, motility and virulence of biofilms in various bacterial species. | |||
T72243 | Cyclic-di-GMP diammonium | 5GP-5GP diammonium,c-di-GMP diammonium ; cyclic diguanylate diammonium ; 5GP-5GP diammonium,c-di-GMP diammonium,cyclic diguanylate diammonium | |
Cyclic di-GMP (c-di-GMP) diammonium is a STING activator and a global bacterial second messenger, which regulates biofilm formation, motility, and virulence in diverse bacterial species . | |||
T10065L | 2',3'-cGAMP sodium | 2'-3'-cyclic GMP-AMP sodium | STING , cGAS |
2',3'-cGAMP sodium (2'-3'-cyclic GMP-AMP sodium), a cGAMP synthase (cGAS) affecting cytoplasmic DNA production as a second messenger, is a transmembrane bridging protein that is a key component of the cellular innate imm... | |||
T37687 | Cyclic ADP-ribose ammonium | ||
Cyclic ADP-ribose ammonium (cADPR ammonium) is a powerful calcium mobilization second messenger synthesized from NAD+ by an ADP-ribosyl cyclase. It primarily raises cytosolic calcium levels through Ryanodine receptor-med... | |||
T19253 | Cyclic ADP-ribose | cADPR | Calcium Channel |
Cyclic ADP-ribose (cADPR) is an effective calcium mobilization second messenger, which is synthesized from NAD + by ADP-ribosyl cyclase. Cyclic ADP-ribose mainly increases cytosolic calcium through Ryanodine receptor-med... | |||
T64248 | Cyclic-di-GMP sodium | ||
Cyclic di-GMP sodium (c-di-GMP sodium) is a STING activator and a ubiquitous second messenger that regulates biofilm formation, motility and virulence of various bacteria. | |||
T5671 | Isophorone | Others | |
Isophorone is a clear liquid that smells like peppermint. It can be dissolved in water and evaporates somewhat faster than water. | |||
T4725 | N-Acetyl-D-mannosamine | 2-ACETAMIDO-2-DEOXY-D-MANNOPYRANOSE HYDRATE | Others , Endogenous Metabolite |
N-Acetyl-D-mannosamine (2-ACETAMIDO-2-DEOXY-D-MANNOPYRANOSE HYDRATE) is a monosaccharide that is used as a precursor in the chemical or enzymatic synthesis of the neuraminic acids found in glycolipids and glycoproteins. ... | |||
T1083 | Theophylline | Theo-24,1,3-Dimethylxanthine | Endogenous Metabolite , HDAC , PDE , Adenosine Receptor , Autophagy |
Theophylline (1,3-Dimethylxanthine) is a methyl xanthine derivative from tea with diuretic, smooth muscle relaxant, bronchial dilation, cardiac and central nervous system stimulant activities. Theophylline inhibits the 3... | |||
TN4510 | (+)-Medioresinol Di-O-β-D-glucopyranoside | (+)-Mediresinol Di-O-beta-D-glucopyranoside,(+)-Medioresinol Di-O-β-D-glucopyranoside | PDE |
(+)-Medioresinol Di-O-β-D-glucopyranoside has strong inhibitory activity of cyclic AMP phosphodiesterase. | |||
T13495 | 3-Amino-2-piperidinone | Cyclo-ornithine | Endogenous Metabolite |
3-Amino-2-piperidinone is a metabolite from all living organisms and can be used as a cyclic ornithine analogue. | |||
T1665 | Daptomycin | LY146032 | DNA/RNA Synthesis , Antibacterial , Antibiotic |
Daptomycin (LY146032) is a cyclic lipopeptide antibiotic that inhibits GRAM-POSITIVE BACTERIA. | |||
TN7068 | Sinomenine N-oxide | Others | |
Sinomenine N-oxide is one of the major metabolites of the cyclic metabolic mechanism of Sinomenine. | |||
T4805 | α-Pyridone | 2-Hydroxypyridine | Others , Endogenous Metabolite |
α-Pyridone (2-Hydroxypyridine)e is the catalyst for generating β-oxopropyl carbonates from cyclic carbonates and alcohols and in the aminolysis of a polyglutamate. | |||
TN6444 | Cyclo(Tyr-Leu) | Antifungal | |
T1441 | Capreomycin sulfate | Capastat sulfate | ribosome , Antibacterial , Antibiotic |
Capreomycin sulfate (Capastat sulfate) , a cyclic peptide antibiotic, binds to the 70S ribosomal unit leading to inhibition of protein synthesis. | |||
T21518 | Colistin methanesulfonate sodium salt | Colistin Methanesulfonate (sodium salt) | Cell wall , Antibacterial |
Colistin methanesulfonate sodium salt (Colistimethate Sodium) is a cyclic polypeptide antibiotic from Bacillus colistinus, composed of Polymyxins E1 and E2. | |||
T9267 | Aureobasidin A | Others , Antifungal | |
Aureobasidin A is a cyclic peptide and an antifungal antibiotic. Aureobasidin A is an inhibitor of the inositolphosphorylceramide synthase AUR1. | |||
T1226 | Bacitracin | Albac,Ziba-RX | Antibacterial , Antibiotic |
Bacitracin (Ziba-RX), a mixture of related cyclic polypeptides, disrupts bacteria by interfering with cell wall and peptidoglycan synthesis. | |||
T6S0627 | Mesaconitine | TNF | |
1. Mesaconitine has antiinflammatory activity. 2. Mesaconitine has antinociceptive activity through cyclic AMP and stimulation of the central β-adrenergic system. | |||
T0167 | Vinpocetine | RGH-4405,Ethyl apovincaminate | IκB/IKK , NF-κB , Sodium Channel , PDE |
Vinpocetine (RGH-4405) is a selective inhibitor of cyclic GMP phosphodiesterase (PDE). | |||
T1245 | Colistin sulfate | Colistin sulfate (1066-17-7 free base),Polymixin E Sulfate,Polymyxin E Sulfate | Cell wall , Antibacterial , Antibiotic , Autophagy |
Colistin sulfate (Colistin sulfate (1066-17-7 free base)) is a cyclic polypeptide antibiotic from Bacillus colistinus, composed of Polymyxins E1 and E2. | |||
T7933 | D(+)-LACTIDE | Others | |
D(+)-LACTIDE is a cyclic dimer of acetone used in the synthesis of a variety of drugs and other compounds, as well as in biochemical and physiological studies. | |||
T1679 | Thiostrepton | Thiactin,Bryamycin,Alaninamide | DNA/RNA Synthesis , Antibacterial , Antibiotic |
Thiostrepton (Alaninamide) is a one of the CYCLIC PEPTIDES from Streptomyces that is active against gram-positive bacteria. In veterinary medicine, it has been used in mastitis caused by gram-negative organisms and in de... | |||
T2723 | Ketoisophorone | 4-Oxoisophorone,2,6,6-Trimethyl-2-cyclohexene-1,4-dione | Others |
Ketoisophorone (2,6,6-Trimethyl-2-cyclohexene-1,4-dione) is the major ingredients of saffron spice. It is a cyclic olefin and was reported as a product of the thermal degradation of β-carotene in aqueous suspension. | |||
T1130 | Gramicidin | Gramicidinum,Gramicidine,Gramicidina | MRP , Antibacterial , Antibiotic |
A group of peptide antibiotics from BACILLUS brevis. Gramicidin (Gramicidine) C or S is a cyclic, ten-amino acid polypeptide and gramicidins A, B, D are linear. Gramicidin is one of the two principal components of TYROTH... | |||
T0945 | Cyclosporin A | Cyclosporine A,Ciclosporin,Cyclosporine | Phosphatase , Antibiotic , Complement System |
Cyclosporin A is a naturally occurring cyclic polypeptide that is the active metabolite of a fungus. Cyclosporin A is an immunosuppressant that binds to procyclins and inhibits calcineurin (IC50=7 nM). | |||
TP1072 | Valinomycin | NSC 122023 | Apoptosis , PTEN , Antibacterial , Antibiotic , Autophagy |
Valinomycin (NSC-122023) is a cyclic depsipeptide antibiotic and a potassium-specific ionophore.Valinomycin induces PINK1 activation and promotes Parkin phosphorylation at Ser65. | |||
T0933 | D-(+)-Glucono-1,5-lactone | Gluconic acid lactone,Delta-Gluconolactone,Gluconolactone | Others , Reactive Oxygen Species , Endogenous Metabolite |
D-(+)-Glucono-1,5-lactone (Gluconolactone) is a naturally-occurring food additive used as a sequestrant, an acidifier, or a curing, pickling, or leavening agent. It is a cyclic ester of D-gluconic acid. Pure gluconolacto... | |||
T4S0792 | Pinoresinol 4-O-β-D-glucopyranoside | (+)-pinor,(+)-pinoresinol-β-D-glucoside; (+)-pinor,(+)-pinoresinol-β-D-glucoside | Others |
(+)-Pinoresinol-β-D-glucoside, also known as (+)-pinor, is a major active lignan furanoid found in Forsythia. It exhibits antioxidative, antihypertensive activities, and acts as an inhibitor of cyclic adenosine monophosp... | |||
PDK0014 | 3-Methylxanthine | Endogenous Metabolite | |
3-Methylxanthine, a xanthine derivative, is a cyclic guanosine monophosphate (GMP) inhibitor, with an IC50 of 920 μM on guinea-pig isolated trachealis muscle.3-Methylxanthine inhibited xanthine crystallization, it could ... | |||
TN6900 | Reptoside | Others | |
Reptoside, which can be extracted from the roots and above-ground parts of Cortex Eucommiae and Ajuga chamaepitys (L.) Schreb, is one of the active cyclic enol ether terpene glycosides of Cortex Eucommiae for the treatme... | |||
T8787 | Drotaverine hydrochloride | PDE | |
Drotaverine hydrochloride is a type 4 cyclic nucleotide phosphodiesterase (PDE4) inhibitor,and is an antispasmodic drug, used to enhance cervical dilation during childbirth. Drotaverine hydrochloride is structurally rela... | |||
T4814 | (R)-5-Oxopyrrolidine-2-carboxylic acid | D-Pyroglutamic acid,(R)-(+)-2-Pyrrolidone-5-carboxylic acid | Others , Endogenous Metabolite |
(R)-5-Oxopyrrolidine-2-carboxylic acid (D-Pyroglutamic acid) is a cyclic derivative of glutamic acid, physiologically present in mammalian tissues. It has been shown that PCA releases GABA from the cerebral cortex and di... | |||
T1009 | Estrone | Oestrone,Fluoroethyl,Aquacrine | Estrogen Receptor/ERR , Estrogen/progestogen Receptor , Endogenous Metabolite |
Estrone (Aquacrine) is an aromatized C18 steroid with a 3-hydroxyl group and a 17-ketone, a major mammalian estrogen. It is converted from ANDROSTENEDIONE directly, or from TESTOSTERONE via ESTRADIOL. In humans, it is pr... | |||
T3929 | Kaurenoic acid | Kauren-19-Oic Acid,kaurenoate,kaur-16-en-18-oic acid | Others |
Kaurenoic acid (kaurenoate) has anti-inflammatory potential in acetic acid-induced colitis, decreases in MDA level. Kaurenoic acid exerts a uterine relaxant effect acting principally through calcium blockade and in part,... | |||
TN3013 | 4,5-Dimethoxycanthin-6-one | Methylnigakinone | P450 , Antibacterial , PDE |
4,5-Dimethoxycanthin-6-one is an alkaloid isolated from Picrasma quassioides BENNET (Simaroubaceae).4,5-Dimethoxycanthin-6-one was isolated from Picrasma quassioides BENNET (Simaroubaceae) with antimicrobial activity.4,5... | |||
T16397 | Ophiobolin A | Others | |
Ophiobolin A is a fungal metabolite and a phytotoxin and is an effective and irreversibly inhibitor of calmodulin-activated cyclic nucleotide phosphodiesterase (IC50: 9 μM). Ophiobolin A also has antimicrobial and antica... | |||
T21098 | Decamethylcyclopentasiloxane | Dekamethylcyklopentasiloxan,Cyclopentasiloxane, decamethyl- | |
Decamethylcyclopentasiloxane is a cyclic methylsiloxane with volatile properties. | |||
T38650 | Lyciumin B | ||
Lyciumin B is a cyclic peptide isolated from Lysium chinense. | |||
T31141 | Cyclotheonamide A | ||
Cyclotheonamide A is a cyclic peptide isolated from the marine sponge Theonella. | |||
TN6447 | Cyclo(Leu-Val) | ||
Cyclo(Leu-Val) is a cyclic dipeptide from the fermentation broth of F8712 strain. | |||
T38649 | Lyciumin A | ||
Lyciumin A, a cyclic octapeptide, possesses inhibitory properties against proteases, renin, and angiotensin-converting enzyme. It holds potential for hypertension research. | |||
T38415 | Adenosine 5′-monophosphoramidate sodium | ||
Adenosine 5′-monophosphoramidate sodium is a derivative of adenosine used as an intermediate for nucleotide synthesis. It significantly influences the accumulation of cyclic AMP. | |||
T39649 | ε-Amanitin | ||
ε-Amanitin is a cyclic peptide obtained from various mushroom species. It exhibits a strong affinity for RNA polymerase II and effectively inhibits its activity. | |||
T37876 | Fengycin | ||
Fengycin, a cyclic lipopeptide, functions as an agricultural fungicide by exhibiting an anti-fungal infection effect through damaging the target's cell membrane[1]. | |||
T12448 | Phomopsin A | Others | |
Phomopsin A is a cyclic hexapeptide mycotoxin isolated from the fungus Phomopsis leptostomiformis. | |||
TMA2419 | Catalponol | cAMP | |
Catalponol can enhance dopamine biosynthesis by inducing TH activity and protect against L-DOPA-induced cytotoxicity in PC12 cells, which was mediated by the increased levels of cyclic AMP. | |||
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カタログ番号 | 製品名 | Species | Expression System |
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TMPJ-00190 | CD38 Protein, Mouse, Recombinant (hFc) | Mouse | HEK293 Cells |
CD38, also called ADP-ribosyl cyclase, is a Type II integral membrane protein with 301 amino acids in length that belongs to the ADP-ribosyl cyclase family.It synthesizes the second messagers cyclic ADP-ribose and nicoti... | |||
TMPJ-00202 | CD157 Protein, Human, Recombinant (hFc) | Human | HEK293 Cells |
The cluster of differentiation (CD) system is a glycosyl phosphatidylinositol anchored membrane protein that belongs to the CD38 family.It is generally used in immunophynotyping. CD157 was discovered in a bone marrow str... | |||
TMPJ-00886 | ATF1 Protein, Human, Recombinant (His) | Human | E. coli |
Cyclic AMP-dependent transcription factor ATF-1(ATF1) which contains 1 bZIP (basic-leucine zipper) domain and 1 KID (kinase-inducible) domain, belongs to the bZIP family. It influences cellular physiologic processes by r... | |||
TMPH-02993 | DisA Protein, Mycobacterium paratuberculosis, Recombinant (His & Myc) | Mycobacterium paratuberculosis | E. coli |
Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions.; Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules int... | |||
TMPH-02614 | CREB5 Protein, Mouse, Recombinant (His) | Mouse | E. coli |
Binds to the cAMP response element and activates transcription. | |||
TMPH-01165 | CREB1 Protein, Human, Recombinant (His) | Human | E. coli |
CREB1 Protein, Human, Recombinant (His) is expressed in E. coli. | |||
TMPH-01164 | ATF-3 Protein, Human, Recombinant (His) | Human | E. coli |
ATF3 Protein, Human, Recombinant (His) is expressed in E. coli. | |||
TMPH-01166 | CGAS Protein, Human, Recombinant (His) | Human | E. coli |
CGAS Protein, Human, Recombinant (His) is expressed in E. coli. | |||
TMPH-03274 | ATF-4 Protein, Rat, Recombinant (His & Myc) | Rat | E. coli |
ATF-4 Protein, Rat, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 43.2 kDa and the accession number is Q9ES19. | |||
TMPJ-00840 | ANXA3 Protein, Human, Recombinant | Human | E. coli |
Annexin A3(ANXA3)contains 4 annexin repeats and belongs to the annexin family. Members of this calcium-dependent phospholipid-binding protein family play a role in the regulation of cellular growth and in signal transduc... | |||
TMPH-00936 | ANXA3 Protein, Human, Recombinant (His) | Human | E. coli |
ANXA3 Protein, Human, Recombinant (His) is expressed in E. coli. | |||
TMPH-02613 | ATF-5 Protein, Mouse, Recombinant (His & Myc) | Mouse | E. coli |
Transcription factor that either stimulates or represses gene transcription through binding of different DNA regulatory elements such as cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), ATF5-specific respo... | |||
TMPY-02081 | PDE2A Protein, Human, Recombinant (aa 215-900, His) | Human | Baculovirus Insect Cells |
cGMP-dependent 3',5'-cyclic phosphodiesterase, also known as cyclic GMP-stimulated phosphodiesterase and PDE2A, is a peripheral membrane protein that belongs to the cyclic nucleotide phosphodiesterase family and PDE2 sub... | |||
TMPY-01819 | PDE1B Protein, Human, Recombinant (His & GST) | Human | Baculovirus Insect Cells |
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B, also known as Cam-PDE 1B and PDE1B, is a cytoplasm protein that belongs to the cyclic nucleotide phosphodiesterase family and PDE1 subfamily. Pho... | |||
TMPY-02977 | PDE1C Protein, Human, Recombinant (His & GST) | Human | Baculovirus Insect Cells |
PDE1C belongs to the cyclic nucleotide phosphodiesterase family, PDE1 subfamily. Phosphodiesterases (PDEs) are a family of related phosphohydrolyases that selectively catalyze the hydrolysis of 3' cyclic phosphate bonds ... | |||
TMPH-00732 | RtcB Protein, E. coli, Recombinant (His) | E. coli | P. pastoris (Yeast) |
GTP-dependent RNA ligase that is involved in tRNA splicing and RNA repair. Joins RNA with 2',3'-cyclic-phosphate or 3'-phosphate ends to RNA with 5'-hydroxy ends. Also acts as a DNA ligase in case of DNA damage by splici... | |||
TMPH-00633 | Heat-stable enterotoxin A2 Protein, E. coli, Recombinant (His & Myc & SUMO) | E. coli | E. coli |
Toxin which activates the particulate form of guanylate cyclase and increases cyclic GMP levels within the host intestinal epithelial cells. | |||
TMPH-00635 | Heat-stable enterotoxin ST-IA/ST-P Protein, E. coli, Recombinant (GST) | E. coli | E. coli |
Toxin which activates the particulate form of guanylate cyclase and increases cyclic GMP levels within the host intestinal epithelial cells. | |||
TMPH-03715 | Y-STB Protein, Yersinia enterocolitica, Recombinant (His & SUMO) | Yersinia enterocolitica | E. coli |
Toxin which activates the particulate form of guanylate cyclase and increases cyclic GMP levels within the host intestinal epithelial cells. Could play an important role in pathogenesis. | |||
TMPH-01024 | Calbindin Protein, Human, Recombinant (His) | Human | P. pastoris (Yeast) |
Buffers cytosolic calcium. May stimulate a membrane Ca(2+)-ATPase and a 3',5'-cyclic nucleotide phosphodiesterase. Calbindin Protein, Human, Recombinant (His) is expressed in yeast with C-6xHis tag. The predicted molecul... | |||
TMPH-00634 | Heat-stable enterotoxin ST-2 Protein, E. coli, Recombinant | E. coli | E. coli |
Toxin which activates the particulate form of guanylate cyclase and increases cyclic GMP levels within the host intestinal epithelial cells. Heat-stable enterotoxin ST-2 Protein, E. coli, Recombinant is expressed in E. c... | |||
TMPH-03159 | DODA Protein, Portulaca grandiflora, Recombinant (His & Myc & SUMO) | Portulaca grandiflora | E. coli |
Opens the cyclic ring of dihydroxy-phenylalanine (DOPA) between carbons 4 and 5, thus producing an unstable seco-DOPA that rearranges nonenzymatically to betalamic acid. DODA Protein, Portulaca grandiflora, Recombinant (... | |||
TMPH-02575 | PDE5A Protein, Mouse, Recombinant (His & Myc) | Mouse | E. coli |
Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase catalyzes the specific hydrolysis of cGMP to 5'-GMP. Specifically regulates nitric-oxide-gen... | |||
TMPH-02498 | AKR1C3 Protein, Mouse, Recombinant (His & Myc) | Mouse | E. coli |
Catalyzes the dehydrogenation of 17-beta-hydroxysteroids. May also exhibit significant activity with a variety of cyclic and alicyclic alcohols. Uses both NAD and NADP, but the activity is much greater with NAD than with... | |||
TMPH-00047 | DODA Protein, Amanita muscaria, Recombinant (His & Myc) | Amanita muscaria | E. coli |
Extradiol dioxygenase that opens up the cyclic ring of DOPA between carbons 4 and 5 thus producing an unstable seco-DOPA that rearranges non-enzymatically to betalamic acid. Can also catalyze the formation of muscaflavin... | |||
TMPH-00147 | IBV (strain KB8523) Replicase polyprotein 1ab (His) | IBV | Baculovirus Insect Cells |
The replicase polyprotein of coronaviruses is a multifunctional protein: it contains the activities necessary for the transcription of negative stranded RNA, leader RNA, subgenomic mRNAs and progeny virion RNA as well as... | |||
TMPJ-01112 | PRKG1 Protein, Human, Recombinant (His) | Human | HEK293 Cells |
cGMP-Dependent Protein Kinase 1 (PRKG1) belongs to the protein kinase superfamily and AGC Ser/Thr protein kinase family. PRKG1 contains one AGC-kinase C-terminal domain, two cyclic nucleotide-binding domains, and one pro... | |||
TMPJ-00971 | PPIC Protein, Human, Recombinant (Trx & His) | Human | E. coli |
Cyclophilin C is an enzyme (EC 5.2.1.8) found in both prokaryotes and eukaryotes that interconverts the cis and trans isomers of peptide bonds with the amino acid proline. Proline has an unusually conformationally restra... | |||
TMPY-03180 | Ribonuclease A Protein, Human, Recombinant (His) | Human | HEK293 Cells |
RNase A, also known as ribonuclease A and RNASE1, belongs to ribonuclease A superfamily. It is a pancreatic-type of secretory ribonuclease. RNase A is a basic protein and its many positive charges are consistent with its... | |||
TMPY-04402 | CSNK1G1 Protein, Human, Recombinant (His & GST) | Human | Baculovirus Insect Cells |
Casein kinase I isoform gamma-1, also known as CSNK1G1, is a member of the protein kinase superfamily, CK1 Ser/Thr protein kinase family and casein kinase I subfamily. Thecasein kinase I family of protein kinases are ... | |||
TMPY-01816 | Pentraxin 3 Protein, Human, Recombinant (His) | Human | HEK293 Cells |
Pentraxin-related protein PTX3, also known as Tumor necrosis factor alpha-induced protein 5, Tumor necrosis factor-inducible gene 14 protein, TSG-14, PTX3 and TNFAIP5, is a secreted protein that contains one pentaxin dom... |
カタログ番号 | 製品名 | ||
---|---|---|---|
L9610 | Cyclic Peptide Library | 55 compounds | |
55 species of cyclic peptide molecules for high-throughput and high-content screening; | |||
L9300 | Macrocyclic Compound Library | 210 compounds | |
210 macrocyclic compounds of known activity for high-throughput, high-content screening; | |||
L7860 | Mini Electrophilic Heterocyclic Fragment Library | 369 compounds | |
369 compounds in total in the Highly Solubility Covalent Heterocyclic Fragment Library | |||
L7700 | Neural Regeneration Compound Library | 524 compounds | |
A unique collection of 149 neuroregeneration related compounds for high throughput and high content screening; | |||
L6750 | PBCRBS Traditional Chinese Medicine Compound Library | 580 compounds | |
A unique collection of 580 compounds derived from traditional Chinese medicines (TCMs) for promoting blood circulation and removing blood stasis. |