|
T7635 |
Raclopride
|
|
Dopamine Receptor
|
|
Raclopride is a selective antagonist of dopamine D2/D3 receptor. |
|
T9169 |
MPP+ iodide
|
|
Mitochondrial Metabolism
,
Autophagy
|
|
MPP+ iodide, the metabolite of a neurotoxin MPTP, causes symptom of Parkinson's disease (PD) in animal models by selectively destroying dopaminergic neurons in substantia nigra. MPP+ induces dopamine transporter (DAT) ex... |
|
T7626 |
Budipine
|
|
Others
|
|
Budipine is a low affinity, N-methyl-D-aspartate receptor antagonist,is an antiparkinsonian agent. |
|
T8637 |
DMNB
|
6-Nitroveratraldehyde |
DNA-PK
|
|
DMNB (6-Nitroveratraldehyde) is DNA-dependent protein kinase (DNA-PK) inhibitor with IC50 of 15 μM, an enzyme involved in the non-homologous end-joining (NHEJ) pathway of double-stranded DNA break (DSB) repair in human c... |
|
T8423 |
ML417
|
|
Dopamine Receptor
,
Arrestin
|
|
ML417 is a selective and brain penetrant agonist of D3 Dopamine (EC50 : 38 nM). |
|
T0322 |
Fipexide
|
|
Dopamine Receptor
,
AChR
|
|
Fipexide (Attentil, Vigilor), a psychoactive drug of the piperazine chemical class, was developed in Italy in 1983. It was served as a nootropic drug in France and Italy, mainly for the therapy of senile dementia, but is... |
|
T22026 |
AGK7
|
|
Others
,
Sirtuin
|
|
AGK7 is an inactive control of AGK2, a selective SIRT2 inhibitor that selectively inhibits SIRT3 over SIRT1 and SIRT2 (IC50 = >5 μM, >50 μM and >50 μM for SIRT3, SIRT1, and SIRT2, respectively). |
|
T8357 |
SB-200646
|
|
5-HT Receptor
|
|
SB-200646 is a selective and potent antagonist of 5-HT2B/5-HT2C receptor |
|
T0412 |
Idebenone
|
CV-2619 |
Apoptosis
,
Antioxidant
,
Mitochondrial Metabolism
|
|
Idebenone (CV-2619) is a synthetic analogue of ubiquinone (Coenzyme Q10), a vital cell antioxidant and essential component of the Electron Transport Chain (ETC). |
|
T12256 |
NS8593 hydrochloride
|
NS8593 HCl |
Potassium Channel
|
|
NS8593 hydrochloride (NS8593 HCl) is a potent and selective inhibitor of small conductance Ca2+-activated K+ channels (SK channels) . |
|
T11277 |
FG 7142
|
ZK 39106,LSU-65 |
GABA Receptor
|
|
FG 7142 (LSU-65) also modulates GABA-induced chloride flux at GABAA receptors expressing the α1 subunit (EC50= 137 nM). FG 7142 can increase tyrosine hydroxylation and cause upregulation of β-adrenoceptors in mouse cereb... |
|
T8653 |
DOPEXAMINE
|
|
Dopamine Receptor
|
|
Dopexamine is a dopaminergic agonist |
|
T34616 |
Seridopidine
|
ACR-343,ACR 343,ACR343 |
Dopamine Receptor
|
|
Seridopidine (ACR343) is a modulator of dopaminergic activity that is used as an oral therapy for schizophrenia, Parkinson's disease, and Tourette's syndrome. |
|
T4262 |
BisfluoroModafinil
|
|
Dopamine Receptor
|
|
CRL-40940 is a selective dopaminergic reuptake inhibitor |
|
T3106 |
C-DIM12
|
|
Apoptosis
,
Others
|
|
C-DIM12 induced expression of Nurr1-regulated genes. C-DIM12 increased expression of transfected human Nurr1, induced Nurr1 protein expression in primary dopaminergic neurons and enhanced neuronal survival from exposure ... |
|
T1443 |
Memantine hydrochloride
|
Namenda,Memantine HCl,D-145 (hydrochloride) |
P450
,
GluR
,
NMDAR
,
Autophagy
,
iGluR
|
|
Memantine hydrochloride (Memantine HCl) is an AMANTADINE derivative that has some dopaminergic effects. Memantine hydrochloride has been proposed as an antiparkinson agent. |
|
T7549 |
Talnetant
|
SB 223412 |
Neurokinin receptor
|
|
Talnetant (SB 223412) is a selective, competitive, brain-penetrant NK3 receptor antagonist with the ability to modulate mesolimbic and mesocortical dopaminergic neurotransmission |
|
T20993 |
Memantine
|
|
Others
|
|
Memantine, an amantadine derivative with some dopaminergic effects, has been proposed as an antiparkinson agent and has may be used to treat moderate to severe Alzheimer's disease. It acts on the glutamatergic system by ... |
|
T10674 |
Potassium Channel Activator 1
|
ZINC34634569 |
Potassium Channel
|
|
Potassium Channel Activator 1 can be used in studies about the treatment of disorders or conditions wherein the dopaminergic system is disrupted such as mood disorders ADHD, schizophrenia, and other psychotic states. |
|
T24885L |
Tiaspirone hydrochloride
|
BMY-13859 hydrochloride,Tiaspirone hydrochloride（87691-91-6 Free base) |
Dopamine Receptor
,
5-HT Receptor
|
|
Tiaspirone hydrochloride (BMY-13859 hydrochloride) exhibits antipsychotic activity. Tiaspirone hydrochloride influences the electrophysiological activity of dopaminergic neurons in the substantia nigra zona compacta (A9 ... |
|
T33816 |
Ordopidine
|
ACR-325,ACR 325,ACR325 |
Dopamine Receptor
|
|
Ordopidine (ACR325) is a dopaminergic stabilizer that suppresses psychostimulant-induced hyperactivity disorder and stimulates behavior during inactivity. Ordopidine acts as a dopamine D2 receptor antagonist in vitro and... |
|
T50054 |
Opromazine hydrochloride
|
|
Others
|
|
Opromazine hydrochloride belongs to the phenothiazine class of antipsychotics and reduces the activity of dopaminergic pathways by blocking dopamine receptors in the brain. It is mainly used for the treatment of psychiat... |
|
TP1310 |
Neurotensin
|
|
Neurotensin Receptor
|
|
Neurotensin is a 13 amino acid neuropeptide that is implicated in the regulation of luteinizing hormone and prolactin release and has significant interaction with the dopaminergic system. |
|
T23733 |
Amperozide
|
FG 5606,Amperozida,Amperozidum |
5-HT Receptor
|
|
Amperozide (FG 5606) is a diphenylbutylpiperazine atypical antipsychotic which antagonizes 5-HT2A receptors. It inhibits dopamine release and alters the firing of dopaminergic neurons. Investigations regarding the use of... |
|
T4081 |
MPTP hydrochloride
|
MPTP-hydrochloride |
Apoptosis
,
Dopamine Receptor
|
|
MPTP hydrochloride is a precursor of MPP+, a dopamine neurotoxin with blood-brain barrier permeability. MPTP hydrochloride is toxic to dopaminergic neurons, which can lead to Parkinson's disease, and is widely used in th... |
|
T13048 |
SynuClean-D
|
SC-D |
Others
|
|
SynuClean-D (SC-D) is an α-synuclein aggregation inhibitor preventing fibril propagation, disrupting mature amyloid fibrils, and abolishing the degeneration of dopaminergic neurons in an animal model of Parkinson’s disea... |
|
T2546 |
Pimozide
|
R6238 |
Potassium Channel
,
Dopamine Receptor
,
Adrenergic Receptor
,
STAT
|
|
Pimozide (R6238) is a diphenylbutylpiperidine derivative and a dopamine antagonist with the antipsychotic property. Pimozide selectively inhibits type 2 dopaminergic receptors in the central nervous system (CNS), thereby... |
|
T22781L |
FFN 511 hydrochloride
|
FFN 511 hydrochloride(1004548-96-2 Free base) |
|
|
FFN 511 hydrochloride is a fluorescent pseudo-neurotransmitters (FFNs) targeting neuronal vesicular monoamine transporter 2 (VMA T2).FFN 511 hydrochloride inhibits the binding of 5-hydroxytryptamine to VMA T2-containing ... |
|
T3624 |
A-366
|
A 366,A366 |
Epigenetic Reader Domain
,
Histone Methyltransferase
|
|
A-366 is a highly selective peptide-competitive histone methyltransferase G9a inhibitor with IC50s of 3.3 and 38 nM for G9a and GLP, respectively.It is more than 1,000-fold selective for G9a and GLP over the other 21 met... |
|
T0455 |
Clozapine
|
HF 1854,LX 100-129 |
Dopamine Receptor
,
Adrenergic Receptor
,
AChR
|
|
Clozapine (HF 1854) is a tricylic dibenzodiazepine, classified as an atypical antipsychotic agent. It binds several types of central nervous system receptors, and displays a unique pharmacological profile. Clozapine is a... |
|
TP2309 |
NEUROTENSIN TFA (39379-15-2 free base)
|
Pyr-Leu-Tyr-Glu-Asn-Lys-Pro-Arg-Arg-Pro-Tyr-Ile-Leu-OH TFA（55508-42-4 free base),NEUROTENSIN TFA |
Others
|
|
Neurotensin TFA (39379-15-2 free base) is an endogenous 13 amino acid neuropeptide with profound opioid-independent analgesic effects. It behaves as a neurotransmitter in the brain, as a hormone in the gut, and also as a... |
|
T61268 |
Vutiglabridin
|
HSG4112 |
Phosphatase
|
|
Vutiglabridin (HSG4112) is a novel and safe modulator of PON2, a racemic compound. vutiglabridin is an optimized structural analogue of Glabridin and is superior to Glabridin in terms of weight loss and chemical stabilit... |
|
T25247 |
Cianergoline
|
Cianergolinum |
|
|
Cianergoline is a dopaminergic agonist. |
|
T26151 |
RU 41656
|
RU-41656,RU41656 |
|
|
RU 41656 is a dopaminergic D2 agonist. |
|
T25786 |
Medifoxamine fumarate
|
LG-152,LG 152,LG152,Geraxyl,Cledial |
|
|
Medifoxamine fumarate, an atypical antidepressant, has additional anxiolytic properties acting by dopaminergic and serotonergic mechanisms. |
|
T68943 |
Mesulergine
|
|
|
|
Mesulergine is metabolized into dopaminergic agonists. |
|
T7626L |
Budipine Hydrochloride
|
BY-701,BY 701,BY701,Parkinsan |
|
|
Budipine is a non-dopaminergic antiparkinsonian drug. The primary action of budipine is an indirect dopaminergic effect as shown by facilitation of dopamine (DA) release, inhibition of monoamine oxidase type B (MAO-B) an... |
|
T11937L |
M-Tyramine hydrobromide
|
|
Others
|
|
m-Tyramine hydrobromide, an endogenous trace amine neuromodulator, influences both the adrenergic and dopaminergic receptors. |
|
T68606 |
Ciladopa hydrochloride
|
|
|
|
Ciladopa hydrochloride is a dopaminergic agonist that may be useful in the treatment of Parkinson's disease. |
|
T69921 |
BRF110
|
|
|
|
BRF110 is a brain penetrant, potent and selective agonist of nuclear receptor-related 1 (Nurr1):Retinoid X receptor α (RXRα) heterodimer. BRF110 is a neuroprotective agent that prevents dopaminergic neuron demise and str... |
|
T38202 |
PAQ
|
|
|
|
PAQ is a neuroprotective agent. It protects dopaminergic neurons from cell death without inhibiting glial cell proliferation in a rat midbrain culture model of Parkinson's disease when used at a concentration of 10 μM. P... |
|
T31903 |
Galphimine B
|
|
|
|
Galphimine B is a cyclodesiccated triterpenoid from Galphimia Glauca, which can regulate the synaptic transmission of dopaminergic ventral tegmental neurons and has a sedative effect. |
|
T26807 |
Bifeprunox Mesylate
|
Bifeprunox,DU 127090,DU-127090,DU127090 |
|
|
Bifeprunox is a partial dopamine and serotonin agonist potentially for the treatment of schizophrenia. Bifeprunox suppresses in vivo VTA dopaminergic neuronal activity via D2 and not D3 dopamine autoreceptor activation. ... |
|
T7352L |
Pridopidine hydrochloride
|
ASP2314 HCl,Pridopidine HCl,FR310826,ASP-2314 hydrochloride |
|
|
Pridopidine Hydrochloride is a dopaminergic stabilizer that has been shown to improve a variety of neurological and psychiatric disorders, including Huntington's disease. Pridopidine Hydrochloride stabilizes psychomotor ... |
|
T39565 |
L-Glutamic acid-15N
|
|
|
|
L-Glutamic acid-15N is the 15N-labeled version of L-Glutamic acid, an excitatory neurotransmitter and an agonist at metabotropic, kainate, NMDA, and AMPA glutamate receptor subtypes. It directly activates the release of ... |
|
T32701 |
Levodopa sodium
|
Levodopa |
|
|
Levodopa is the naturally occurring form of DIHYDROXYPHENYLALANINE and the immediate precursor of DOPAMINE. Unlike dopamine itself, it can be taken orally and crosses the blood-brain barrier, and rapidly taken up by dopa... |
|
T15743 |
Levomepromazine
|
Methotrimeprazine |
Others
|
|
Methotrimeprazine is an orally available neuroleptic agent. It is commonly used to relieve nausea and vomiting in palliative care settings. Levomepromazine has antagonist actions at multiple neurotransmitter receptor sit... |
|
T41192 |
CNV Dopamine
|
|
|
|
CNV Dopamine is a carboxynitroveratryl (CNV)-caged dopamine; releases dopamine upon ultraviolet light stimulation (365 nm). Induces dopaminergic currents upon photolysis in brain slices expressing wild-type or GFP-labele... |
|
T35670 |
Miro1 Reducer
|
|
|
|
Promotes proteasomal degradation of Miro1 (mitochondrial Rho GTPase 1). Reduces Miro1 levels in fibroblasts from Parkinson's disease (PD) patients (IC50 = 7.8 μM). Exhibits no significant effect on related outer mitochon... |
|
T40959 |
T0467
|
T0467 |
|
|
T0467 is a chemical compound that activates the translocation of parkin to the mitochondria in a PINK1-dependent manner in vitro. However, T0467 does not induce the accumulation of PINK1 in the mitochondria of dopaminerg... |
