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T15656 |
KGA-2727
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|
SGLT
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|
KGA-2727 is a potent and selective SGLT1 inhibitor, with Kis of 97.4 nM and 43.5 nM for human and rat SGLT1, respectively. The selectivity ratios (Ki for SGLT2/Ki for SGLT1) of KGA-2727 are 140 (human) and 390 (rat). KGA... |
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T0255 |
Clomipramine hydrochloride
|
Clomipramine HCl,Anafranil |
Dopamine Receptor
,
5-HT Receptor
,
Serotonin Transporter
,
Norepinephrine
,
GST
|
|
Clomipramine hydrochloride (Anafranil) is a tricyclic antidepressant similar to IMIPRAMINE that selectively inhibits the uptake of serotonin in the brain. It is readily absorbed from the gastrointestinal tract and demeth... |
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T21013 |
Clomipramine
|
Chlorimipramine,Anafranil,Clomicalm,Anafranil (free base),Clomipramina |
5-HT Receptor
|
|
Clomipramine (Clomicalm) is a tricyclic antidepressant (TCA). It is used for the treatment of the panic disorder, obsessive-compulsive disorder, major depressive disorder, and chronic pain. It may decrease the risk of su... |
|
T1293 |
Gatifloxacin
|
BMS 206584-01,PD 135432,CG5501,BMS-206584,AM-1155 |
Topoisomerase
,
Antibacterial
,
Antibiotic
|
|
Gatifloxacin (CG5501) is an antibiotic of the fourth-generation fluoroquinolone family, that like other members of that family, inhibits the bacterial enzymes DNA gyrase and topoisomerase IV. |
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T68174 |
Sergliflozin A
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|
SGLT
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|
Sergliflozin A is a selective SGLT2 inhibitor that induces diabetes in a dose-dependent manner. It reduces hyperglycemia. |
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T22683 |
CP-316819
|
CP 316819,GPi 819 |
Others
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CP-316819 (GPi 819) is a potent inhibitor of glycogen phosphorylase (GPase) with hypoglycemic effects, inhibits huSMGPa and huLGPa, maintains neuronal activity during hypoglycemia, and can be used in the study of hypergl... |
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T77784 |
WAY-297848
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Glucokinase
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WAY-297848 is a novel glucokinase activator for the prevention or treatment of hyperglycemia, diabetes mellitus, obesity, dyslipidemia, and metabolic syndrome. |
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T8221 |
Insulin (human)
|
INSULIN,Insulin(human) |
IGF-1R
|
|
Insulin (human) is a peptide hormone that promotes glycogen synthesis and regulates glucose levels in the blood. Insulin (human) has hypoglycemic activity and is used clinically to treat hyperglycemia in diabetic patient... |
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T76941 |
Carotuximab
|
DE-122,TRC105 |
TGF-beta/Smad
,
Immunology/Inflammation related
|
|
Carotuximab (DE-122) is a novel endocholine antibody with strong antiangiogenic and anti-inflammatory activity. Carotuximab blocks endothelial glycoprotein (CD105) and its downstream Smad signaling pathway. Carotuximab h... |
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T3685 |
SR9009
|
Stenabolic,REV-ERB Agonist II |
Autophagy
|
|
SR9009 (Stenabolic), a REV-ERB agonist, increases the constitutive repression of genes regulated by REV-ERBα/ERBβ (IC50: 670/800 nM). Through activation of REV-ERB, SR9009 can decrease circadian locomotor activity during... |
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T30035 |
Ampelopsin C
|
|
|
|
Ampelopsin C protects endothelial cells from hyperglycemia-induced oxidative damage by inducing autophagy via the AMPK signaling pathway. |
|
T33945 |
PF-06260933 HCl
|
PF06260933 dihydrochloride,PF-06260933 dihydrochloride,PF 06260933 dihydrochloride |
|
|
PF-06260933 Dihydrochloride is a MAP4K4 (HGK) inhibitor (IC50 = 140 nM). It can improve the fasting hyperglycemia in mice. In addition, it inhibited Mink and Tnik (IC50 values of 8 and 13 nM, respectively). |
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T30450 |
Biguanide
|
AI352571,AI3-52571,AI3 52571 |
|
|
Biguanide can reduce oxidative stress in rats with hyperglycemia. |
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T76421 |
Protein Kinase C β Peptide
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|
|
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Protein Kinase C (beta) Peptide, a fragment of Protein Kinase Cβ, is associated with hyperglycemia-induced decreases in endothelium-derived nitric oxide. Inhibiting Protein Kinase Cβ forestalls the impairment of endothel... |
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T36016 |
PF 06260933 dihydrochloride
|
|
|
|
MAP4K4 (HGK) inhibitor (IC50 = 140 nM). Also inhibits MINK and TNIK (IC50 values are 8 and 13 nM, respectively). Improves fasting hyperglycemia in mice. Orally active.
Ammirati et al (2015) Discovery of an in vivo tool t... |
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TP2033 |
[Des-His1,Glu9]-Glucagon amide
|
des-His1-[Glu9]-Glucagon (1-29) amide |
|
|
Glucagon receptor antagonist (pA2 = 7.2 for inhibition of glucagon-induced adenylyl cyclase activation in rat liver membranes); displays no agonist activity. Enhances glucose-stimulated pancreatic insulin release in vitr... |
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T76655 |
Prokineticin 2 Isoform 2 (human)
|
|
|
|
Prokineticin 2 Isoform 2 (human), a hypothalamic neuropeptide, regulates thermoregulation and energy metabolism while decreasing food intake in rodents. This isoform is implicated in the study of metabolic syndrome (MetS... |
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T72859 |
11β-HSD1-IN-10
|
|
|
|
11β-HSD1-IN-10, a potent inhibitor of 11β-HSD1 with an IC50 value of 1.8 µM for humans, is suitable for research into obesity, hyperglycemia, and cognitive impairment. |
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T78864 |
α-Glucosidase-IN-33
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|
Glucosidase
|
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α-Glucosidase-IN-33 (compound 7c), with an IC50 of 2.39 μM, is a potent inhibitor of α-glucosidase and is relevant in research on type 2 diabetes and hyperglycemia [1]. |
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T71340 |
Mizagliflozin sebacate
|
|
|
|
Mizagliflozin sebacate is a sodium-glucose transporter inhibitor. It is expected to improve postprandial hyperglycemia by suppressing glucose absorption from the intestine with a novel mechanism of action different from... |
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T72911 |
11β-HSD1-IN-9
|
|
|
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11β-HSD1-IN-9 is a potent inhibitor of 11β-HSD1, displaying IC50 values of 0.48 µM for human and 1.3 µM for murine variants, respectively. It exhibits competitive interaction with rat 11β-HSD1. This compound holds potent... |
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T78865 |
α-Glucosidase-IN-34
|
|
Glucosidase
|
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α-Glucosidase-IN-34 (compound 7f) is a potent inhibitor of α-glucosidase, exhibiting an IC50 of 2.90 μM, and is applicable in research related to type 2 diabetes and hyperglycemia [1]. |
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T80817 |
WAY-328127
|
|
|
|
WAY-328127 is an active molecule, exhibiting an inhibitory effect on the (11β-hydroxysteroid dehydrogenase type 1) [(11β-HSD1)] enzyme. This modulation potentially leads to therapeutic applications in metabolic disorders... |
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T28542 |
Rivoglitazone HCl
|
CI-1037,CI1037,CS011,CS-011,CI 1037 |
|
|
Rivoglitazone, also known as CI-1037; CS-011; DE-101; R-119702; Rivo, is a peroxisome proliferator-activated receptor γ agonist (PARPγ agonist) potentially for the treatment of type 2 diabetes. Rivoglitazone has been sho... |
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T78066 |
BBT
|
|
Calcium Channel
|
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BBT enhances glucose-stimulated insulin secretion (GSIS) in compromised conditions, demonstrates anti-hyperglycemia effects, and shields β-cells from cytokine- or streptozotocin (STZ)-triggered apoptosis in type 2 diabet... |
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T78655 |
Ferric nitrilotriacetate
|
|
|
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Ferric nitrilotriacetate (Fe-NTA), an iron complex of nitriloacetic acid, is widely used to provoke oxidative stress (OS)-linked degenerative disorders. This compound has also been utilized in research to induce hypergly... |
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T60255 |
α-Amylase/α-Glucosidase-IN-1
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|
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α-Amylase/α-Glucosidase-IN-1 (compound 33) is an effective inhibitor of α-amylase/α-glucosidase with IC 50 s of 2.01, 2.09 μM for α-amylase and α-glucosidase, respectively. Kinetic studies predict that α-Amylase/α-Glucos... |
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T28897 |
T-1095A
|
T 1095A,J1.265.331J |
|
|
T-1095A is an active metabolite of T-1095, a potent and selective inhibitor of Na+-glucose cotransporters (SGLTs). Chronic administration of T-1095 (0.1% w w(-1) pellet chow, for 12 weeks) decreased blood glucose and hae... |
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T71251 |
DS-1558
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|
|
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DS-1558 is a potent and orally available GPR40 agonist.DS-1558 was found to have potent glucose lowering effects during an oral glucose tolerance test in ZDF rats. DS-1558 significantly and dose-dependently improved hyp... |
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T36408 |
Rhein-13C4
|
Rhein-13C4 |
|
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Rhein-13C4 is intended for use as an internal standard for the quantification of rhein by GC- or LC-MS. Rhein is an anti-inflammatory anthraquinone found in rhubarb and is the bioactive derivative of its prodrug diacerei... |
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T72034 |
LI-2242
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|
Others
|
|
LI-2242 is a potent inositol hexakisphosphate kinase (IP6K) inhibitor with IC50s of 31 nM, 42 nM, 8.7 nM, and 1944 nM for IP6K1, IP6K2, IP6K3, and IPMK, respectively.LI-2242 ameliorated hepatic steatosis by reducing the ... |
|
T37522 |
Teneligliptin
|
|
|
|
Teneligliptin (MP-513) is a potent chemotype prolylthiazolidine-based DPP-4 inhibitor, which competitively inhibits human plasma, rat plasma, and human recombinant DPP-4 in vitro, with IC50s of approximately 1 nM.
Teneli... |
