24
14
30
1
カタログ番号 | 製品名 | 別名 | ターゲット |
---|---|---|---|
T7100 | PLX5622 | PLX-5622 | c-Fms , CSF-1R |
PLX5622 is a highly selective brain penetrant and oral active CSF1R inhibitor. | |||
T15199 | Edicotinib | JNJ-527,JNJ-40346527 | c-Fms , FLT , CSF-1R , c-Kit |
Edicotinib (JNJ-527) is a brain penetrant and orally active inhibitor of the colony-stimulating factor-1 receptor (IC50: 3.2 nM). It shows less inhibitory effects on KIT and FLT3 (IC50: 20 nM and 190 nM). It has the pote... | |||
T8811 | Tuftsin 3TFA | Endogenous Metabolite | |
Tuftsin 3TFA is a tetrapeptide. It is a macrophage/microglial activator. | |||
T14384 | AZD8797 | KAN-0440567,KAND567 | CXCR |
AZD8797 (KAND567) is an orally available, selective and potent human CX3CR1-converting antagonist with inhibitory effects on CX3CR1 and CXCR2, and potentially protects against SARS-CoV-2-induced neuronal damage, preventi... | |||
T60932 | MAO-B-IN-8 | MAO | |
MAO-B-IN-8 is a highly potent and reversible inhibitor of monoamine oxidase-B (MAO-B), which also exhibits inhibitory effects on the microglial production of neuroinflammatory mediators. This compound is specifically des... | |||
TP1786L | Amyloid β-Protein 10-20 acetate | Amyloid β-Protein 10-20 acetate(152286-31-2 free base) | Beta Amyloid |
Amyloid β-Protein 10-20 acetate (Amyloid β-Protein 10-20 acetate (152286-31-2 free base)) is a fragment of Amyloid-β peptide, maybe used in the research of neurological disease.Amyloid β protein fragment containing the α... | |||
T10809 | CHPG | Others | |
CHPG is a selective agonist of mGluR5. In BV2 microglial cells, it attenuates SO2-induced oxidative stress and inflammation through the TSG-6/NF-κB pathway. | |||
T70367 | SNU-BP | ||
SNU-BP is an agonist of PPAR-gamma, inhibiting lipopolysaccharide (LPS)-induced NO production and pro-inflammatory cytokines. SNU-BP potentiates interleukin-4-induced arginase-1 expression, and promotes microglial polari... | |||
T79371 | HDAC-IN-62 | Autophagy | |
HDAC-IN-62 (Compound 5), an HDAC inhibitor, exhibits IC50 values of 0.78, 1.0, and 1.2 μM for HDAC6, HDAC8, and HDAC11, respectively. This compound suppresses microglial activation via autophagy induction and reduces nit... | |||
T37815 | PM226 | PM 226 | |
Potent and selective CB2 receptor agonist (Ki = 12.8 nM; EC50 = 38.67 nM). Exhibits negligible affinity for the CB1 receptor (Ki > 40,000 nM) and no activity at the GPR55. Suppresses neuroinflammation by reducing microg... | |||
TP1846 | Tuftsin diacetate | ||
Tuftsin diacetate, a tetrapeptide, is a macrophage/microglial activator. Tuftsin is a tetrapeptide, Thr-Lys-Pro-Arg, which resides in the Fc-domain of the heavy chain of immunoglobulin G. Tuftsin possesses a broad spectr... | |||
T80682 | γ-Fibrinogen 377-395 TFA | ||
γ-Fibrinogen377-395 TFA is an inhibitory peptide derived from fibrinogen, which also functions as a fibrinogen epitope. It effectively blocks microglial activation and impedes fibrin-Mac-1 interactions in vitro. Addition... | |||
T81685 | NEP(1-40) TFA | ||
NEP(1-40) TFA is a peptide antagonist of the Nogo-66 receptor (NgR), which mitigates the shift in microglial morphology distributions due to injury by attenuating myelin-derived inhibition [1]. | |||
T37726 | MMP-9 Inhibitor I | ||
MMP-9 inhibitor I is an inhibitor of matrix metalloproteinase-9 (MMP-9) that is selective over MMP-1 and MMP-13 (IC50s = 5, 1,050, and 113 nM, respectively). It also decreases the activity of TNF-α converting enzyme (TAC... | |||
T80683 | γ-Fibrinogen 377-395 | ||
γ-Fibrinogen377-395 is a peptide derived from fibrinogen, functioning both as an inhibitory molecule and an epitope. It inhibits microglial activation, disrupts fibrin-Mac-1 interactions in vitro, and mitigates experimen... | |||
T62612 | CD33 splicing modulator 1 | ||
CD33 splicing modulator 1 (Compound 1) is a CD33 splicing modulator. CD33/Siglec 3 is a myeloid cell surface receptor known to regulate microglial cell activity. CD33 splicing modulator 1 has potential for the study of n... | |||
T12505 | PLX5622 hemifumarate | c-Fms | |
PLX5622 hemifumarate is a highly selective brain penetrant and orally active CSF1R inhibitor with an IC 50 of 0.016 μM and Ki of 5.9 nM. PLX5622 hemifumarate allows for extended and specific microglial elimination, prece... | |||
T79484 | Nrf2 activator-8 | ||
Nrf2 Activator-8 (Compound 10e), with an EC50 of 37.9 nM, is a potent Nrf2 activator that demonstrates significant antioxidant and anti-inflammatory properties in BV-2 microglial cells. Furthermore, this compound notably... | |||
TP1786 | β-Amyloid (10-20) | Amyloid β-Protein 10-20 | |
Amyloid β-Protein (10-20) is a fragment of Amyloid-β peptide, maybe used in the research of neurological disease.Amyloid β protein fragment containing the α-secretase processing site (Lys16-Leu17 bond). It also contains ... | |||
T35864 | T-5342126 | ||
T-5342126 is a toll-like receptor 4 (TLR4) antagonist.1It reduces LPS-induced production of nitric oxide (NO) in RAW 264.7 cells (IC50= 27.8 μM), as well as decreases LPS-induced IL-8, TNF-α, and IL-6 production in isola... | |||
T83798 | 8-bromo NAD+ sodium | 8-bromo Nicotinamide adenine dinucleotide,N(8-bromo-A)D+ | |
8-Bromo NAD+ serves as a prodrug for the cyclic ADP-ribose (cADPR) inhibitor, 8-bromo cADPR, undergoing conversion to its active form by the enzyme CD38. At a concentration of 1 mM, it effectively inhibits the rise in in... | |||
T83777 | LAU-0901 | ||
LAU-0901, a platelet-activating factor (PAF) receptor antagonist, demonstrates efficacy in reducing infarct volume and enhancing neurological function in rats subjected to middle cerebral artery occlusion (MCAO)-induced ... | |||
T75339 | Methylene blue hydrate | ||
Methylene Blue (Basic Blue 9) hydrate functions as an inhibitor of guanylyl cyclase (sGC), monoamine oxidase A (MAO-A), and NO synthase (NOS). This compound, known for its vasopressor activity, is widely utilized as a dy... | |||
T83895 | NCI 126224 | NSC 126224 | |
NCI 126224, a toll-like receptor 4 (TLR4) antagonist, demonstrates selective inhibition of nitric oxide (NO) production in RAW 264.7 macrophages, triggered by the TLR4 agonist LPS (IC50 = 0.31 µM), as opposed to minimal ... |
カタログ番号 | 製品名 | 別名 | ターゲット |
---|---|---|---|
TN6714 | Geranylgeraniol | FT-0626663,Tetraprenol,CJ24095,CJ 24095,FT0626663,CJ-24095 | Apoptosis |
Geranylgeraniol (FT0626663) is an isoprenoid found in fruits, vegetables, and grains, including rice. Geranylgeraniol (FT0626663) inhibits growth and induces apoptosis of various tumor cells. Geranylgeraniol (FT0626663) ... | |||
T3896 | Shanzhiside methyl ester | Glucagon Receptor | |
Shanzhiside methylester reduces neuropathic pain by activating spinal GLP-1 receptors and subsequently stimulating microglial β-endorphin expression via the p38 MAPK signaling. | |||
TWS1977 | Kamebakaurin | Kamebakaurine | NF-κB |
1. Kamebakaurin (Kamebakaurine) has the ability to protect the liver from APAP-induced hepatotoxicity, presumably by both inhibiting the inflammatory response and oxidative stress. 2. Kamebakaurin inhibits the expression... | |||
T4S1962 | Beta-Asarone | Cis-Isoasarone,Cis-Asarone,Cis-Isoelemicin | NF-κB , JNK |
1. beta-Asarone (Cis-Isoelemicin) may be a potential preventive drug for Alzheimer's disease. 2. Beta-Asarone prevents autophagy and synaptic loss by reducing ROCK expression in SAMP8 mice. 3. The co-administration of be... | |||
T3824 | Jaceosidin | Apoptosis , BCL , COX , UGT | |
Jaceosidin has anti-oxidative activity. Jaceosidin has anti-inflammatory activity, also a microglial inhibitor with anti-neuroinflammation activity. aceosidin has anticancer activity, modulates the ERK/ATM/Chk1/2 pathway... | |||
T82211 | Herpotrichone B | ||
Herpotrichone B exhibits significant anti-neuroinflammatory activity by inhibiting lipopolysaccharide (LPS)-induced inflammation in BV-2 microglial cells, demonstrating a half maximal inhibitory concentration (IC50) of 0... | |||
TN4182 | Hannokinol | Others | |
(+)-Hannokinol and MESO-hannokinol can significantly inhibit lipopolysaccharide-induced nitric oxide production in BV2 microglial cells at concentrations ranging from 1 microM to 100 microM. | |||
T83056 | Anti-inflammatory agent 5 | ||
Anti-inflammatory agent 5 effectively inhibits nitric oxide (NO) production in lipopolysaccharide-induced BV-2 microglial cells. | |||
T82212 | Herpotrichone A | ||
Herpotrichone A exhibits strong anti-neuroinflammatory effects in BV-2 microglial cells induced by lipopolysaccharide (LPS), achieving a half maximal inhibitory concentration (IC50) of 0.41 μM. | |||
T83553 | (4S)-10-Nor-calamenen-10-one | ||
(4S)-10-Nor-calamenen-10-one (Compound 15), an eudesmane sesquiterpene sourced from Alpinia oxyphylla [1], amplifies LPS-induced nitric oxide (NO) production in microglial cells. | |||
TN5248 | Voleneol | NOS , COX , Prostaglandin Receptor | |
1β,6α-Dihydroxyeudesm-4(15)-ene (Voleneol,DE) can attenuate the lipopolysaccharide (LPS)-induced inflammation in BV2 microglial cells, it also can dose-dependently suppress the protein expression of inducible nitric oxid... | |||
TN2641 | 15-Methoxypinusolidic acid | ERK , IL Receptor , p38 MAPK , Calcium Channel , NOS , NF-κB , COX , JNK , NMDAR , PPAR | |
15-Methoxypinusolidic acid has anti-inflammatory effects, it inhibits LPS-induced iNOS expression and NO production, independent on MAPK and NF-kappaB. 15-Methoxypinusolidic acid suppresses adipocyte differentiation thro... | |||
TN5011 | Shizukaol B | ERK , IL Receptor , p38 MAPK , TNF , NOS , NF-κB , COX , HIV Protease , DNA/RNA Synthesis , Prostaglandin Receptor , JNK | |
Shizukaol B exerts anti-inflammatory effects in LPS-activated microglia partly by modulating JNK-AP-1 signaling pathway; it also shows significant anti-neuroinflammatory effects by inhibiting nitric-oxide (NO) production... | |||
T36417 | Nargenicin | Antibiotic 47444 | |
Nargenicin is a macrolide antibiotic that selectively inhibits the growth of S. aureus, methicilin resistant S. aureus (MRSA), and M. luteus (MICs = 0.6, 0.3, and 2.5 μg/ml, respectively) over a panel of 11 Gram-positive... |
カタログ番号 | 製品名 | Species | Expression System |
---|---|---|---|
TMPK-00735 | CXCL13/BCA-1 Protein, Mouse, Recombinant (His) | Mouse | HEK293 |
Recent studies have implicated chemokines in microglial activation and pathogenesis of neuropathic pain. C-X-C motif chemokine 13 (CXCL13) is a B lymphocyte chemoattractant that activates CXCR5. Using the spinal nerve li... | |||
TMPY-03203 | CD40 Protein, Rat, Recombinant (His) | Rat | HEK293 |
CD40, also known as TNFRSF5, is a member of the TNF receptor superfamily which are single transmembrane-spanning glycoproteins. CD40 protein plays an essential role in mediating a broad variety of immune and inflammatory... | |||
TMPY-05957 | CD40 Protein, Mouse, Recombinant (His) | Mouse | HEK293 |
CD40, also known as TNFRSF5, is a member of the TNF receptor superfamily which are single transmembrane-spanning glycoproteins. CD40 protein plays an essential role in mediating a broad variety of immune and inflammatory... | |||
TMPY-01181 | CD40 Protein, Human, Recombinant (His) | Human | HEK293 |
CD40, also known as TNFRSF5, is a member of the TNF receptor superfamily which are single transmembrane-spanning glycoproteins. CD40 protein plays an essential role in mediating a broad variety of immune and inflammatory... | |||
TMPY-00432 | TREM-2 Protein, Mouse, Recombinant (hFc) | Mouse | HEK293 |
Triggering receptor expressed on myeloid cells 2 ( TREM2 ) is a single Ig domain receptor. It is expressed on macrophages and dendritic cells but not on granulocytes or monocytes. Its expression is most abundant in the b... | |||
TMPY-01148 | TREM-2 Protein, Human, Recombinant (His) | Human | HEK293 |
Triggering receptor expressed on myeloid cells 2 ( TREM2 ) is a single Ig domain receptor. It is expressed on macrophages and dendritic cells but not on granulocytes or monocytes. Its expression is most abundant in the b... | |||
TMPY-01703 | TREM-2 Protein, Mouse, Recombinant (His) | Mouse | HEK293 |
Triggering receptor expressed on myeloid cells 2 ( TREM2 ) is a single Ig domain receptor. It is expressed on macrophages and dendritic cells but not on granulocytes or monocytes. Its expression is most abundant in the b... | |||
TMPK-00734 | CXCL13/BCA-1 Protein, Mouse, Recombinant (hFc) | Mouse | HEK293 |
Recent studies have implicated chemokines in microglial activation and pathogenesis of neuropathic pain. C-X-C motif chemokine 13 (CXCL13) is a B lymphocyte chemoattractant that activates CXCR5. Using the spinal nerve li... | |||
TMPK-00018 | CXCL13/BCA-1 Protein, Human, Recombinant (His & Sumo) | Human | E. coli |
Recent studies have implicated chemokines in microglial activation and pathogenesis of neuropathic pain. C-X-C motif chemokine 13 (CXCL13) is a B lymphocyte chemoattractant that activates CXCR5. Using the spinal nerve li... | |||
TMPK-00017 | CXCL13/BCA-1 Protein, Human, Recombinant (hFc) | Human | HEK293 |
Recent studies have implicated chemokines in microglial activation and pathogenesis of neuropathic pain. C-X-C motif chemokine 13 (CXCL13) is a B lymphocyte chemoattractant that activates CXCR5. Using the spinal nerve li... | |||
TMPK-00188 | JAM-A Protein, Mouse, Recombinant (His) | Mouse | HEK293 |
junctional adhesion molecule A (JAM-A), a cell adhesion molecule, is highly elevated in human GBM cancer stem cells and predicts poor patient prognosis. While JAM-A is also highly expressed in other cells in the tumor mi... | |||
TMPH-02231 | NRROS Protein, Human, Recombinant (E. coli, His & Myc) | Human | E. coli |
Key regulator of transforming growth factor beta-1 (TGFB1) specifically required for microglia function in the nervous system. Required for activation of latent TGF-beta-1 in macrophages and microglia: associates specifi... | |||
TMPH-02803 | NRROS Protein, Mouse, Recombinant (His) | Mouse | E. coli |
Key regulator of transforming growth factor beta-1 (TGFB1) specifically required for microglia function in the nervous system. Required for activation of latent TGF-beta-1 in macrophages and microglia: associates specifi... | |||
TMPH-02230 | NRROS Protein, Human, Recombinant (His & Myc) | Human | Baculovirus |
Key regulator of transforming growth factor beta-1 (TGFB1) specifically required for microglia function in the nervous system. Required for activation of latent TGF-beta-1 in macrophages and microglia: associates specifi... | |||
TMPY-04089 | CD40 Protein, Canine, Recombinant (His) | Canine | HEK293 |
CD40, also known as TNFRSF5, is a member of the TNF receptor superfamily which are single transmembrane-spanning glycoproteins. CD40 protein plays an essential role in mediating a broad variety of immune and inflammatory... | |||
TMPY-03212 | CD40 Protein, Rhesus, Recombinant (His) | Rhesus | HEK293 |
CD40, also known as TNFRSF5, is a member of the TNF receptor superfamily which are single transmembrane-spanning glycoproteins. CD40 protein plays an essential role in mediating a broad variety of immune and inflammatory... | |||
TMPY-03944 | CD40 Protein, Canine, Recombinant | Canine | HEK293 |
CD40, also known as TNFRSF5, is a member of the TNF receptor superfamily which are single transmembrane-spanning glycoproteins. CD40 protein plays an essential role in mediating a broad variety of immune and inflammatory... | |||
TMPY-06024 | CD40 Protein, Mouse, Recombinant (His & Avi), Biotinylated | Mouse | HEK293 |
CD40, also known as TNFRSF5, is a member of the TNF receptor superfamily which are single transmembrane-spanning glycoproteins. CD40 protein plays an essential role in mediating a broad variety of immune and inflammatory... | |||
TMPY-03907 | CD40 Protein, Canine, Recombinant (hFc) | Canine | HEK293 |
CD40, also known as TNFRSF5, is a member of the TNF receptor superfamily which are single transmembrane-spanning glycoproteins. CD40 protein plays an essential role in mediating a broad variety of immune and inflammatory... | |||
TMPY-05425 | CD40 Protein, Mouse, Recombinant (hFc) | Mouse | HEK293 |
CD40, also known as TNFRSF5, is a member of the TNF receptor superfamily which are single transmembrane-spanning glycoproteins. CD40 protein plays an essential role in mediating a broad variety of immune and inflammatory... | |||
TMPY-05614 | CD40 Protein, Human, Recombinant (His & Avi), Biotinylated | Human | HEK293 |
CD40, also known as TNFRSF5, is a member of the TNF receptor superfamily which are single transmembrane-spanning glycoproteins. CD40 protein plays an essential role in mediating a broad variety of immune and inflammatory... | |||
TMPY-05599 | CD40 Protein, Human, Recombinant (hFc & Avi), Biotinylated | Human | HEK293 |
CD40, also known as TNFRSF5, is a member of the TNF receptor superfamily which are single transmembrane-spanning glycoproteins. CD40 protein plays an essential role in mediating a broad variety of immune and inflammatory... | |||
TMPY-04994 | CD40 Protein, Mouse, Recombinant (rFc) | Mouse | HEK293 |
CD40, also known as TNFRSF5, is a member of the TNF receptor superfamily which are single transmembrane-spanning glycoproteins. CD40 protein plays an essential role in mediating a broad variety of immune and inflammatory... | |||
TMPY-05359 | CD40 Protein, Human, Recombinant (mFc) | Human | HEK293 |
CD40, also known as TNFRSF5, is a member of the TNF receptor superfamily which are single transmembrane-spanning glycoproteins. CD40 protein plays an essential role in mediating a broad variety of immune and inflammatory... | |||
TMPY-03083 | CD40 Protein, Rat, Recombinant (hFc) | Rat | HEK293 |
CD40, also known as TNFRSF5, is a member of the TNF receptor superfamily which are single transmembrane-spanning glycoproteins. CD40 protein plays an essential role in mediating a broad variety of immune and inflammatory... | |||
TMPY-00482 | CD40 Protein, Human, Recombinant (hFc) | Human | HEK293 |
CD40, also known as TNFRSF5, is a member of the TNF receptor superfamily which are single transmembrane-spanning glycoproteins. CD40 protein plays an essential role in mediating a broad variety of immune and inflammatory... | |||
TMPY-03211 | CD40 Protein, Rhesus, Recombinant (hFc) | Rhesus | HEK293 |
CD40, also known as TNFRSF5, is a member of the TNF receptor superfamily which are single transmembrane-spanning glycoproteins. CD40 protein plays an essential role in mediating a broad variety of immune and inflammatory... | |||
TMPY-06566 | TREM-2 Protein, Human, Recombinant (hFc) | Human | HEK293 |
Triggering receptor expressed on myeloid cells 2 ( TREM2 ) is a single Ig domain receptor. It is expressed on macrophages and dendritic cells but not on granulocytes or monocytes. Its expression is most abundant in the b... | |||
TMPY-06598 | TREM-2 Protein, Human, Recombinant (His & Avi), Biotinylated | Human | HEK293 |
Triggering receptor expressed on myeloid cells 2 ( TREM2 ) is a single Ig domain receptor. It is expressed on macrophages and dendritic cells but not on granulocytes or monocytes. Its expression is most abundant in the b... | |||
TMPH-01364 | Galectin-9/LGALS9 Protein, Human, Recombinant (GST & His) | Human | E. coli |
Binds galactosides. Has high affinity for the Forssman pentasaccharide. Ligand for HAVCR2/TIM3. Binding to HAVCR2 induces T-helper type 1 lymphocyte (Th1) death. Also stimulates bactericidal activity in infected macropha... |
カタログ番号 | 製品名 | ||
---|---|---|---|
L9840 | Anti-Alzheimer's Disease Compound Library | 986 compounds | |
A unique collection of 986 compounds with anti-AD activities or acting on main drug targets of AD can be used for HTS and HCS. |