|
T7436 |
Cilofexor
|
|
FXR
,
Autophagy
|
|
Cilofexor inhibits binding of a synthetic peptide, Cilofexor is a farnesoid X receptor (FXR) agonist. |
|
T7596 |
Firocoxib
|
ML 1785713 |
COX
|
|
Firocoxib (ML 1785713) is a selective non-steroidal inhibitor of cycooxygenase-2 (COX-2) (IC50 of 0.13 μM), with anti-inflammatory for use in dogs and horses. |
|
T4989 |
Fosfomycin Tromethamine
|
|
Antibacterial
,
Antibiotic
|
|
An antibiotic produced by Streptomyces fradiae. |
|
T3131 |
Fosfomycin calcium
|
Phosphomycin calcium salt,Fosmicin |
Antibacterial
,
Antibiotic
|
|
Fosfomycin calcium (Phosphomycin calcium salt) is a blood-brain barrier penetrating, broad-spectrum antibiotic by irreversibly inhibiting an early stage in cell wall synthesis. |
|
T16501 |
PF-3644022
|
|
p38 MAPK
,
Serine Protease
,
MAPK
|
|
PF-3644022 is an effective, selective, and ATP-competitive MAPKAPK2 (MK2) inhibitor (IC50: 5.2 nM and a Ki of 3 nM). PF-3644022 potently inhibits TNFα production and has an anti-inflammatory effect. PF-3644022 also inhib... |
|
T26531 |
ABT-963
|
ABT963 |
|
|
ABT-963 is a cyclooxygenase 2 (COX-2) inhibitor potentially for the treatment of osteoarthritis and pain. ABT-963 has excellent selectivity in human whole blood, high oral anti-inflammatory potency in vivo, and gastric s... |
|
T11106 |
DSP-0565
|
2-(2'-fluorobiphenyl-2-yl)acetamide |
Others
|
|
DSP-0565 exhibits anti-convulsant activity and good safety margin in various models including scPTZ, 6 Hz, MES, and amygdala kindling. DSP-0565 can be used in studies about acting as a broad-spectrum anti-epileptic drug. |
|
T61518 |
TAK-653
|
|
iGluR
|
|
TAK-653, a selective positive allosteric modulator (PAM) of AMPA receptors exhibiting minimal agonistic activity, elicits an antidepressant-like response while maintaining a favorable safety profile in rat models. |
|
T25913L |
P-113 acetate
|
|
HIV Protease
,
Antibacterial
,
Antibiotic
|
|
P-113 acetate is an antimicrobial peptide (AMP) derived from the human salivary protein histatin 5, shows good safety and efficacy profiles in gingivitis and human immunodeficiency virus (HIV) patients with oral candidia... |
|
T15562 |
Imazamox
|
CL29926,(±)-Imazamox |
Others
|
|
Imazamox ((±)-Imazamox) is a systemic herbicide with high selectivity, high activity, safety and broadspectrum activity. Imazamox inhibits the production of acetolactate synthase (ALS) in plants, which would then inhibit... |
|
T7587 |
Tenapanor
|
RDX-5791,RDX 5791,AZD 1722,Tenapanor free base,RDX5791,AZD-1722,AZD1722 |
Sodium Channel
|
|
Tenapanor (RDX 5791) is an inhibitor of the sodium-proton (Na(+)/H(+)) exchanger NHE3, which plays a prominent role in sodium handling in the gastrointestinal tract and kidney. Tenapanor possesses an excellent preclinica... |
|
T72031 |
BI 1015550
|
|
PDE
|
|
BI 1015550 is an orally active inhibitor of PDE4B with an IC 50 value of 7.2 nM. BI 1015550 has good safety and potential applications in inflammation, allergic diseases, pulmonary fibrosis, and chronic obstructive pulmo... |
|
T0911 |
Cefotaxime sodium
|
Cefotaxim sodium salt,Cefotaxime sodium salt,Cefotaxim (sodium salt),HR-756 (sodium salt) |
Antibacterial
,
Antibiotic
|
|
Cefotaxime is a third-generation cephalosporin antibiotic. Like other third-generation cephalosporins, it has broad spectrum activity against Gram positive and Gram negative bacteria. In most cases, it is considered to b... |
|
T16125 |
MMV390048
|
|
Parasite
,
PI4K
|
|
MMV390048 is an antimalarial agent and is a representative of a new chemical class of Plasmodium PI4K inhibitor (Kdapp=0.3 μM). MMV390048 binds to the ATP binding site of Plasmodium PI4K and does not bind to other P. fal... |
|
T38683 |
SCD1 inhibitor-3
|
SCD1-IN-3,SCD1 inhibitor-3,SCD1 inhibitor 17a |
Dehydrogenase
|
|
SCD1 inhibitor-3 (ML-270) is a highly effective and orally available compound that inhibits SCD1 with remarkable safety. SCD1 inhibitor-3 demonstrates strong potential for research in metabolic diseases, including obesit... |
|
T0056 |
Oxeladin citrate
|
|
Others
|
|
Oxeladin citrate is a highly potent and effective cough suppressant, which can treat all types of cough of various etiologies. It is not related to opium or its derivatives, so treatment with oxeladin is no risk of add... |
|
T3560 |
Desmethylanethol trithione
|
ADT-OH |
VEGFR
,
Akt
|
|
Desmethylanethol trithione (ADT-OH) is a derivative of anethole dithiolethione (ADT) and synthetic hydrogen sulfide (H2S) donor. In the in vitro glucose-oxygen deprivation (OGD) model, Desmethylanethol trithione markedly... |
|
T4615 |
Balsalazide sodium hydrate
|
Balsalazide disodium dihydrate,Balsalazide disodium salt dihydrate,Balsalazide disodium |
STAT
,
Interleukin
|
|
Balsalazide sodium hydrate (Balsalazide disodium) is an anti-inflammatory compound used in the treatment of Inflammatory Bowel Disease.Balsalazide sodium hydrate is a new 5-aminosalicylic acid (5-ASA) containing prodrug.... |
|
T4616 |
Metoclopramide
|
5-Chloro-2-methoxyprocainamide |
Dopamine Receptor
,
5-HT Receptor
|
|
Metoclopramide (5-Chloro-2-methoxyprocainamide) is a dopamine D2 antagonist which has been used for treatment of a variety of gastrointestinal symptoms over the last thirty years. In various countries, metoclopramide is ... |
|
T0910 |
Terpin hydrate
|
Terpin Monohydrate,cis-Terpin hydrate |
Others
|
|
Terpin hydrate, a cis-form hydrate, is derived from sources such as oil of turpentine, oregano, thyme, and eucalyptus. It is used as an insect repellent and expectorant. Terpin hydrate(cis-Terpin hydrate) is commonly use... |
|
T13548 |
AN7973
|
|
Others
|
|
AN7973 blocks intracellular parasite development and inhibits Cryptosporidium growth. It is orally active, possesses favorable safety, stability, and PK parameters. |
|
T23986 |
Dezinamide
|
ADD94057,ADD-94057,ADD 94057 |
|
|
Dezinamide is a potential antiepileptic drug. It shows preliminary evidence of efficacy and safety in an open-label study. |
|
T33392 |
MIP-1095 I-123
|
123-I-MIP-1095,(123I)MIP 1095 |
|
|
MIP-1095 I-123, as a radiotracer, is under investigation in clinical trial NCT00712829 (Evaluating the Safety, Pharmacokinetics, Tissue Distribution, Metabolism and Dosimetry of Two Prostate Cancer Imaging Agents). |
|
T11687 |
Itacitinib adipate
|
|
Phosphatase
|
|
Itacitinib adipate is an orally bioavailable and selective JAK1 inhibitor,Itacitinib adipate has been tested for efficacy and safety in a phase II trial in myelofibrosis. |
|
T30513 |
BMS-317180
|
BMS317180 |
|
|
BMS-317180 is a potent, novel, orally effective growth hormone secretagogue (GHS) that shows an excellent safety profile in preclinical studies. The compound was advanced into clinical development. |
|
T70754 |
NMS-P953
|
|
|
|
NMS-P953 is a JAK2 inhibitor, displaying significant tumor growth inhibition in SET-2 xenograft tumor model. NMS-P953 has a mechanism of action confirmed in vivo by typical modulation of known biomarkers, and with a favo... |
|
T30539 |
BMS-711939
|
BMS 711939,BMS711939 |
|
|
BMS-711939 is a potent and specific peroxisome proliferator-activated receptor (PPARα) agonist that has demonstrated excellent efficacy and safety in vivo in preclinical studies with an EC50 of 4 nM for PPARα in humans. |
|
T0157L |
Roxatidine acetate
|
|
|
|
Roxatidine acetate is an anti-ulcer agent and histamine antagonist that inhibits gastric acid secretion. Compared to other similar drugs, Roxatidine acetate has an improved safety profile, in part because lower doses of ... |
|
T27400 |
Ganaplacide
|
KAF 156,KAF-156,GNF-156,GNF 156,GNF156,KAF156 |
|
|
Ganaplacide is an antimalarials with activity against asexual and sexual blood stages and the preerythrocytic liver stages of malarial parasites. KAF156 showed antimalarial activity without evident safety concerns in a s... |
|
T74703 |
5'-ODMT cEt G Phosphoramidite (Amidite)
|
|
|
|
5'-ODMT cEt G Phosphoramidite Amidite is a powerful nucleic acid analog that demonstrates exceptional safety and potent antisense activity, as evidenced in studies [1] [2]. |
|
T68200 |
Roxatidine hydrochloride
|
|
|
|
Roxatidine hydrochloride is an anti-ulcer agent and histamine antagonist that suppresses gastric acid secretion. It effectively heals duodenal and gastric ulcers and reduces ulcer pain. Roxatidine acetate has an improved... |
|
T70616 |
ACT-672125
|
|
|
|
ACT-672125 is a Potent CXCR3 Antagonist with Therapeutic Potential in Autoimmune Diseases. ACT-672125 showed good physicochemical properties and safety profile. In a proof-of-mechanism model of lung inflammation, ACT-672... |
|
T61388 |
HAChE/Aβ1-42-IN-1
|
|
|
|
Compound 16 (hAChE/Aβ1-42-IN-1) is a potent inhibitor targeting both hAChE and Aβ1-42 aggregation, demonstrating considerable safety in hepG2 cell lines and excellent brain-blood barrier (BBB) penetration with a broad sa... |
|
T15651 |
KDU731
|
|
Others
|
|
KDU731 is a promising drug candidate for the treatment of diarrhea caused by Cryptosporidium and meets a broad range of safety. KDU731is an orally active C. parvum inhibitor of PI4K (IC50: 25 nM). KDU731 blocks Cryptospo... |
|
T74705 |
5'-ODMT cEt m5U Phosphoramidite (Amidite)
|
|
|
|
5'-ODMT cEt m5U Phosphoramidite Amidite, a locked nucleic acid (LNA) analog, exhibits remarkable safety and antisense activity [1] [2]. |
|
T70308 |
PLX7683
|
|
|
|
PLX7683 is a paradox breaker. Paradox breakers overcame several known mechanisms of resistance to first-generation RAF inhibitors. Dissociating MAPK pathway inhibition from paradoxical activation might yield both impro... |
|
T70930 |
GSK SYK inhibitor
|
|
|
|
The immunoregulator spleen tyrosine kinase (SYK) is upregulated in cutaneous lupus erythematosus (CLE). This double-blind, multicentre, Phase Ib study evaluated the safety, tolerability, pharmacokinetics, pharmacodynamic... |
|
T73878 |
NOSO-502
|
|
|
|
NOSO-502, exhibiting inhibitory activity against (Enterobacteriaceae), is a bacterial translation inhibitor that demonstrates good safety and antibacterial properties [1]. |
|
T32402 |
KLS-13019
|
|
|
|
KLS-13019 is a Cannabidiol-Derived Neuroprotective Agent with Improved Potency, Safety, and Permeability. (EC50=40nM; T1=7500). KLS-13019 was 50-fold more potent and >400-fold safer than cannabidiol and exhibited an i... |
|
T75176 |
Antifungal agent 53
|
|
|
|
Antifungal Agent 53 (A03), a potent Candida albicans CYP51 inhibitor, exhibits antifungal activity by preventing fungi biofilm formation and demonstrates good safety [1]. |
|
T69250 |
JMX0312
|
|
|
|
JMX0312 is a salicylamide derivative used as a potent inhibitor of HAdV infection. JMX0312 showed significantly improved anti-HAdV activities with nanomolar to submicromolar IC50 values and high selectivity indexes (SI >... |
|
T62864 |
Hetrombopag
|
|
|
|
Hetrombopag is a potent agonist of the thrombopoietin receptor. Hetrombopag is well tolerated and has a controlled safety profile. hetrombopag has potential for studies in immune thrombocytopenia. |
|
T39587 |
APJ receptor agonist 4
|
|
|
|
APJ Receptor Agonist 4 is a potent, orally active apelin receptor (APJ) agonist, demonstrating an EC50 of 0.06 nM and a Ki of 0.07 nM. It exhibits excellent pharmacokinetic profiles in rodent heart failure (HF) models an... |
|
T28510 |
REDX05358
|
REDX 05358,REDX-05358 |
|
|
REDX05358 is a highly selective and potent pan RAF inhibitor with a potential therapeutic for BRAF and RAS mutant tumors. REDX05358 has improved therapeutic potential and predicted safety profile. REDX05358 demonstrates ... |
|
T79087 |
Antifungal agent 59
|
|
|
|
Antifungal agent 59 exhibits potent activity, reflected by MIC values ranging from 0.01 to 1 μg/mL, and inhibits the formation of fungal biofilms, while maintaining safety [1]. |
|
T60761 |
PF-06305591 dihydrate
|
|
|
|
PF-06305591 dihydrate is a potent and highly selective voltage gated sodium channel NaV1.8 blocker (IC 50 = 15 nM) with an excellent preclinical in vitro ADME and safety profile [1]. |
|
T60959 |
As-358 hydrochloride
|
|
|
|
As-358 (hydrochloride) shows well in vivo safety as well as inhibits Ebola virus and Marburg virus with IC 50 values of 9.1 μM and 18.1 μM [1]. |
|
T73875 |
Fotagliptin benzoate
|
|
|
|
Fotagliptin benzoate, a Dipeptidyl Peptidase IV (DPP-4) inhibitor with an inhibitory concentration (IC50) of 2.27 nM, demonstrates significant safety in both rat and dog models. It is utilized in Type 2 diabetes mellitus... |
|
T33950 |
PF-06767832
|
PF-6767832,PF6767832,PF 6767832,PF 06767832 |
|
|
PF-06767832 is a high quality M1 selective PAM (M1 PAM EC50 = 60 nM; M2-M5 PAM EC50 > 10 microM; CNS MPO = 4.9). PF-06767832 has well aligned physicochemical properties, good brain penetration and pharmacokinetic prop... |
|
T61797 |
HIV-1 inhibitor-15
|
|
|
|
HIV-1 inhibitor-15 (compound 9d) is a potent and broad-spectrum inhibitor targeting HIV-1. It exhibits inhibitory activity against HIV-1 WT, L100I, K103N, Y181C, and E138K with respective EC50 values of 1.7 nM, 4 nM, 2 n... |
