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Search Results for " synaptic "

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83

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6

天然化合物

60

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1

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カタログ番号 製品名 別名 ターゲット
T9063 Clathrin-IN-1 HIV Protease
Clathrin-IN-1 is a inhibitor of clathrin, and inhibits clathrin-mediated endocytosis (CME) by associating with the terminal domain of clathrin. It has the potential for anti-cancer research.
T22012 7BIO FLT , DYRK , Aurora Kinase
7-bromoindirubin-3'-oxime (7BIO) is a caspase independent nonapoptotic cell death inducer. 7BIO is an inhibitor of FLT3, DYRK1A, DYRK2, Aurora B and Aurora C kinases.
T1092 Zolmitriptan 311C90,BW-311C90 5-HT Receptor
Zolmitriptan (311C90) selectively binds to and activates serotonin (5-HT) 1B receptors expressed in intracranial arteries and 5-HT 1D receptors located on peripheral trigeminal sensory nerve terminals in the meninges and...
T0192 Levetiracetam UCB L059,SIB-S1 DNA Methyltransferase , Others , Calcium Channel
Levetiracetam (SIB-S1) is a relatively unique anticonvulsant that is typically used in combination with other antiepileptic medications for partial onset seizures. Levetiracetam has been linked to rare instances of serum...
TP1559L Ziconotide Acetate (107452-89-1 free base) Prialt,Ziconotide Acetate Calcium Channel
Ziconotide Acetate (107452-89-1 free base) (Prialt) is an analgesic agent and has been used to treat neuropathic and non-neuropathic pain. Ziconotide Acetate (107452-89-1 free base) acts by binding to N-type calcium chan...
T1279 Vilazodone SB659746A,EMD 68843 5-HT Receptor , Serotonin Transporter
Vilazodone (SB659746A) is a selective serotonin (5-HT) reuptake inhibitor (SSRI) and a 5-HT-1A receptor partial agonist, with antidepressant and anti-anxiety activities. Vilazodone inhibits the reuptake of serotonin from...
TP1868 Proctolin Others
Proctolin is a bioactive neuropeptide that modulates interneuronal and neuromuscular synaptic transmission in a wide variety of arthropods.
T10893 CS-722 Free base Others
CS-722 Free base is a synthetic central muscle relaxant with muscle relaxant activity and inhibitory effect on spinal reflex. CS-722 Free base may inhibit spontaneous inhibitory post-synaptic current and excitatory post-...
T7516 ZD7288 ICI D7288 HCN Channel
ZD7288 (ICI D7288), a selective hyperpolarization-activated cyclic nucleotide-gated channel blocker, inhibits hippocampal synaptic plasticity.
T30549 BMY-21502 Bms-181168,Bms 181168,Bmy 21502,Bmy21502,Bms181168 Antioxidant
BMY-21502 is a potential cognitive enhancer that shows anti-hypoxia effects in the KCN-hypoxia model, delays the decay of hippocampal synaptic enhancement in vitro, and can be used to study Alzheimer's disease.
T19812 Propentofylline HWA-285,Karsivan,Propentophylline,Hextol,HWA 285,HWA285 PDE
Propentofylline (Hextol) is a methylxanthine derivative with neuroprotective, antiproliferative, and anti-inflammatory activity and enhanced synaptic adenosine signaling, which may be useful in the study of Alzheimer's d...
T0869 Atomoxetine hydrochloride Tomoxetine hydrochloride,(R)-Tomoxetine hydrochloride,LY 139603,Atomoxetine HCl,LY 139603 HCl Dopamine Receptor , 5-HT Receptor , Norepinephrine
Atomoxetine hydrochloride (LY 139603) is the hydrochloride salt of atomoxetine, a phenoxy-3-propylamine derivative and selective non-stimulant, norepinephrine reuptake inhibitor with cognitive-enhancing activity. Althou...
T11684 Isoguvacine hydrochloride 1,2,3,6-tetrahydro-4-pyridinecarboxylic acid hydrochloride GABA Receptor
Isoguvacine hydrochloride (1,2,3,6-tetrahydro-4-pyridinecarboxylic acid hydrochloride) is a GABA receptor agonist. Isoguvacine hydrochloride binds to rat synaptic cortical membranes and activates α1β2γ2S, α2β2γ2S, α3β2γ2...
T26357 Pitstop 2 Apoptosis
Pitstop2 is a selective inhibitor of amphiphysin association of clathrin terminal domain with an IC50 value of 12 μM. Pitstop2 acutely interferes with receptor-mediated endocytosis, entry of HIV, and synaptic vesicle rec...
T5512 JNJ16259685 .TN.T 16259685 GluR
JNJ16259685 (TN.T 16259685) is a selective mGluR1 antagonist, and inhibits the synaptic activation of mGluR1 in a concentration-dependent manner with IC50 of 19 nM.
T21153 Clothianidin TI435,TI-435,TI 435,Celero AChR
Clothianidin (TI 435), an insecticide, acts as an agonist of acetylcholine to stimulate nAChR, thereby activating post-synaptic acetylcholine receptors but not inhibiting AChE.
T1566 Aripiprazole OPC-14597 5-HT Receptor
Aripiprazole (OPC-14597) is an antipsychotic agent that is structurally related to piperazines and quinolones. It is a partial agonist of SEROTONIN RECEPTOR, 5-HT1A and DOPAMINE D2 RECEPTORS, where it also functions as a...
T72420 MTK458 EP-0035985 PTEN
MTK458 (EP-0035985) is a brain-permeable and orally active PINK1 activator.MTK458 selectively activates PINK1 by stimulating dimerization and stabilization of the PINK1/TOM complexMTK458 drives the clearance of alpha-syn...
T50041 N-(4-methoxyphenyl)prop-2-enamide N-(4-Methoxyphenyl)acrylamide Others
N-(4-methoxyphenyl)prop-2-enamide (N-(4-Methoxyphenyl)acrylamide) is an acrylamide analog used as a molecular structural unit. It inhibits the enzyme acetylcholinesterase, increasing acetylcholine levels in the synaptic ...
T9172 Simufilam dihydrochloride PTI-125 dihydrochloride Others
Simufilam dihydrochloride (PTI-125 dihydrochloride) is a low toxicity, orally active filamin A (FLNA) activator, which can be used for the research of Alzheimer's disease. Simufilam dihydrochloride preferentially binds a...
T0991 Desipramine hydrochloride NSC-114901,Desmethylimipramine,JB-8181,EX-4355,Norimipramine,G-35020 Dopamine Receptor , 5-HT Receptor , Serotonin Transporter , Adrenergic Receptor
Desipramine hydrochloride (Norimipramine) ,a secondary amine tricyclic antidepressant (TCA), is the hydrochloride salt form of desipramine. In the central nervous system (CNS), Desipramine hydrochloride blocks the re-upt...
T7218 Endomorphin 2 Opioid Receptor
Endomorphins-2 (EM-2) could decrease both the frequency and amplitude of the sEPSC of the motoneurons in lamina IX, which was reversed by the MOR antagonist CTOP. EM-2-IR fibers originated from primary afferent fibers f...
T50008 2,2-Dimethyl-5-(2,5-xylyloxy)valeramide 5-(2,5-dimethylphenoxy)-2,2-dimethylpentanamide Others
2,2-Dimethyl-5-(2,5-xylyloxy)valeramide (5-(2,5-dimethylphenoxy)-2,2-dimethylpentanamide) is a compound of the phenoxy family. It has been shown to have stimulatory effects on the nervous system, including increased neur...
TP1895L1 KYL acetate(676657-00-4 free base) Ephrin Receptor
KYL acetate is an EphA4 receptor tyrosine kinase inhibitor (Kd = 0.8 μM); inhibits EphA4-EphrinA5 interactions (IC50 = 6.34 μM). Prevents AβO induced synaptic damage, dendritic spine loss and prevents the blocking of LTP...
T111959 IFB-088 acetate
IFB-088 acetate, a benzyl guanidine derivative, is used to treat diseases and cancers associated with the PPP1R15A pathway and associated with protein misfolding stress, Examples include tau disease, synaptic riboprotein...
T11800 L-803087 Somatostatin
T1602 Valproic acid sodium salt Sodium Valproate Mitophagy , Gamma-secretase , HIV Protease , GABA Receptor , HDAC , Autophagy
Valproic acid sodium salt (Sodium Valproate) is the sodium salt form of valproic acid with anti-epileptic activity. Valproic acid sodium salt is converted into its active form, valproate ion, in blood. Although the mecha...
TP1924L1 ZIP acetate(863987-12-6 free base) PKC
ZIP acetate is a novel, cell-permeable inhibitor of protein kinase Mζ (PKMζ), a constitutively active, atypical PKC isozyme involved in LTP maintenance. Selectively blocks PKMζ-induced synaptic potentiation in hippocampa...
T76863 Elezanumab AE12-1Y-QL,ABT-555 TGF-beta/Smad
Elezanumab(ABT-555) is a potent human anti-RGMa monoclonal antibody.Elezanumab exerts its inhibitory effect on RGMa-mediated BMP signaling through the SMAD1/5/8 pathway, with an IC50 of approximately 97 pM.Elezanumab pro...
T35856 BMS-986176 AAK1 (AP2 associated kinase 1)
AAK1-IN-1 (example 123) is an AAK1 (adaptor associated kinase 1) inhibitor with an IC50 of 2.2 nM. AAK1-IN-1 can be used for neurodegenerative diseases research[1]. Adaptor associated kinase 1 (AAK1) is a member of the A...
T17174 Troriluzole BHV-4157 Others
Troriluzole is an orally active glutamate modulator. Troriluzole reduces the synaptic glutamate level and increases synaptic glutamate absorption.
T32423 KS 5-2 KS-5-2
KS 5-2 has affinity to isolated synaptic membranes from rat brain.
T24934 Vesamicol AH-5183,AH 5183,AH5183
Vesamicol is an experimental drug. It acting presynaptically by inhibiting acetylcholine uptake into synaptic vesicles and reducing its release.
T69339 Org 24461
Org 24461 is a synaptic and nonsynaptic glycine transporter type-1 inhibitor.
T31903 Galphimine B
Galphimine B is a cyclodesiccated triterpenoid from Galphimia Glauca, which can regulate the synaptic transmission of dopaminergic ventral tegmental neurons and has a sedative effect.
T27326 FK960 FK 59960,FK-960,FK-59960,FK59960
FK962 is an enhancer of somatostatin release, which exerts cognitive-enhancing actions in rats. FK960 increases synaptic density in the hippocampal CA3 region of aged rats.
T39069 UCB-J
UCB-J is a radioligand for the synaptic vesicle protein 2A (SV2A), utilized in positron emission tomography (PET)[4].
T41193 FFN 270
FFN 270 is a fluorescent false neurotransmitter (FFN). Fluorescent substrate for NET and VMAT2. Labels noradrenergic neurons and their synaptic vesicles, and enables imaging of synaptic vesicle content release from speci...
T34458 Ryanodol
Ryanodol is a complex diterpenoid that modulates intracellular calcium-ion release at ryanodine receptors, ion channels critical for skeletal and cardiac muscle excitation-contraction coupling and synaptic transmission.
T62127 AMPA-IN-1
AMPA-IN-1 is a potent inhibitor of AMPA receptors, a widely expressed receptor in the brain with a central role in the regulation of rapid excitatory synaptic transmission and synaptic plasticity. 14).
T26879 BNC-1 BNC 1
BNC-1 is a modulator of amyloid pathology. BNC-1 significantly decreases amyloid burden and improves markers of synaptic integrity in well-established mouse models of amyloid deposition by promoting phosphorylation and a...
T41088 Diadenosine pentaphosphate pentalithium
Diadenosine pentaphosphate pentalithium is an endogenous vasoactive purine dinucleotide, isolated from thrombocytes. It is a member of the diadenosine polyphosphates (ApnA, n=2–7) and is found in secretory vesicles of pl...
T68289 Nicotine hemicitrate
Nicotine hemicitrate is highly toxic alkaloid. It is the prototypical agonist at nicotinic cholinergic receptors where it dramatically stimulates neurons and ultimately blocks synaptic transmission. Nicotine is also impo...
T68439 Nicotine dicitrate
Nicotine dicitrate is highly toxic alkaloid. It is the prototypical agonist at nicotinic cholinergic receptors where it dramatically stimulates neurons and ultimately blocks synaptic transmission. Nicotine is also import...
T69804 Nicotine monomethiodide
Nicotine monomethiodide is highly toxic alkaloid. It is the prototypical agonist at nicotinic cholinergic receptors where it dramatically stimulates neurons and ultimately blocks synaptic transmission. Nicotine is also i...
T68960 F-15599 Fumarate
F-15599 Fumarate is a highly selective post-synaptic 5-HT(1A) receptor agonist: in-vivo profile in behavioural models of antidepressant and serotonergic activity.
T74759 18:0,18:1 PS sodium
18:0,18:1 PS sodium, a lipid found in synaptic vesicles and cholesterol, serves a role in metabolic research [1].
TP1471 Ziconotide TFA (107452-89-1 free base) Ziconotide TFA
Ziconotide TEA acts by binding to N-type calcium channels situated on the terminal part of primary afferent neurons of the nociceptive pathway therefore reducing synaptic transmission with potent antinociceptive effects.
T71854 AA43279
AA43279 is a novel selective Nav1.1 activator, increasing the firing activity of parvalbumin-expressing, fast-spiking GABAergic interneurons and increasing the spontaneous inhibitory post-synaptic currents (sIPSCs) recor...
T37310 Diadenosine pentaphosphate pentasodium
Diadenosine pentaphosphate pentasodium, an endogenous vasoactive purine dinucleotide isolated from thrombocytes, serves as a key component of secretory vesicles in platelets, chromaffin cells, Torpedo synaptic terminals,...

Compounds

Clathrin-IN-1
T9063
Synonym:
Target: HIV Protease
7BIO
T22012
Synonym:
Target: FLT, DYRK, Aurora Kinase
Zolmitriptan
T1092
Synonym: 311C90,BW-311C90
Target: 5-HT Receptor
Levetiracetam
T0192
Synonym: UCB L059,SIB-S1
Target: DNA Methyltransferase, Others, Calcium Channel
Ziconotide Acetate (107452-89-1 free base)
TP1559L
Synonym: Prialt,Ziconotide Acetate
Target: Calcium Channel
Vilazodone
T1279
Synonym: SB659746A,EMD 68843
Target: 5-HT Receptor, Serotonin Transporter
Proctolin
TP1868
Synonym:
Target: Others
CS-722 Free base
T10893
Synonym:
Target: Others
ZD7288
T7516
Synonym: ICI D7288
Target: HCN Channel
BMY-21502
T30549
Synonym: Bms-181168,Bms 181168,Bmy 21502,Bmy21502,Bms181168
Target: Antioxidant
Propentofylline
T19812
Synonym: HWA-285,Karsivan,Propentophylline,Hextol,HWA 285,HWA285
Target: PDE
Atomoxetine hydrochloride
T0869
Synonym: Tomoxetine hydrochloride,(R)-Tomoxetine hydrochloride,LY 139603,Atomoxetine HCl,LY 139603 HCl
Target: Dopamine Receptor, 5-HT Receptor, Norepinephrine
Isoguvacine hydrochloride
T11684
Synonym: 1,2,3,6-tetrahydro-4-pyridinecarboxylic acid hydrochloride
Target: GABA Receptor
Pitstop 2
T26357
Synonym:
Target: Apoptosis
JNJ16259685
T5512
Synonym: .TN.T 16259685
Target: GluR
Clothianidin
T21153
Synonym: TI435,TI-435,TI 435,Celero
Target: AChR
Aripiprazole
T1566
Synonym: OPC-14597
Target: 5-HT Receptor
MTK458
T72420
Synonym: EP-0035985
Target: PTEN
N-(4-methoxyphenyl)prop-2-enamide
T50041
Synonym: N-(4-Methoxyphenyl)acrylamide
Target: Others
Simufilam dihydrochloride
T9172
Synonym: PTI-125 dihydrochloride
Target: Others
Desipramine hydrochloride
T0991
Synonym: NSC-114901,Desmethylimipramine,JB-8181,EX-4355,Norimipramine,G-35020
Target: Dopamine Receptor, 5-HT Receptor, Serotonin Transporter, Adrenergic Receptor
Endomorphin 2
T7218
Synonym:
Target: Opioid Receptor
2,2-Dimethyl-5-(2,5-xylyloxy)valeramide
T50008
Synonym: 5-(2,5-dimethylphenoxy)-2,2-dimethylpentanamide
Target: Others
KYL acetate(676657-00-4 free base)
TP1895L1
Synonym:
Target: Ephrin Receptor
IFB-088 acetate
T111959
Synonym:
Target:
L-803087
T11800
Synonym:
Target: Somatostatin
Valproic acid sodium salt
T1602
Synonym: Sodium Valproate
Target: Mitophagy, Gamma-secretase, HIV Protease, GABA Receptor, HDAC, Autophagy
ZIP acetate(863987-12-6 free base)
TP1924L1
Synonym:
Target: PKC
Elezanumab
T76863
Synonym: AE12-1Y-QL,ABT-555
Target: TGF-beta/Smad
BMS-986176
T35856
Synonym:
Target: AAK1 (AP2 associated kinase 1)
Troriluzole
T17174
Synonym: BHV-4157
Target: Others
KS 5-2
T32423
Synonym: KS-5-2
Target:
Vesamicol
T24934
Synonym: AH-5183,AH 5183,AH5183
Target:
Org 24461
T69339
Synonym:
Target:
Galphimine B
T31903
Synonym:
Target:
FK960
T27326
Synonym: FK 59960,FK-960,FK-59960,FK59960
Target:
UCB-J
T39069
Synonym:
Target:
FFN 270
T41193
Synonym:
Target:
Ryanodol
T34458
Synonym:
Target:
AMPA-IN-1
T62127
Synonym:
Target:
BNC-1
T26879
Synonym: BNC 1
Target:
Diadenosine pentaphosphate pentalithium
T41088
Synonym:
Target:
Nicotine hemicitrate
T68289
Synonym:
Target:
Nicotine dicitrate
T68439
Synonym:
Target:
Nicotine monomethiodide
T69804
Synonym:
Target:
F-15599 Fumarate
T68960
Synonym:
Target:
18:0,18:1 PS sodium
T74759
Synonym:
Target:
Ziconotide TFA (107452-89-1 free base)
TP1471
Synonym: Ziconotide TFA
Target:
AA43279
T71854
Synonym:
Target:
Diadenosine pentaphosphate pentasodium
T37310
Synonym:
Target:
1 2
カタログ番号 製品名 別名 ターゲット
T9299 D-Leucine (R)-Leucine Endogenous Metabolite
D-Leucine ((R)-Leucine) potently terminates seizures even after the onset of seizure activity. D-leucine reduces long-term potentiation but had no effect on basal synaptic transmission in vitro.
TN1202 (-)-α-Pinene (1S)-(-)-Alpha-Pinene Virus Protease , GABA Receptor , Endogenous Metabolite , Antibacterial
(-)-α-Pinene ((1S)-(-)-Alpha-Pinene) enhances the quantity of NREMS without affecting the intensity of NREMS by prolonging GABAergic synaptic transmission, acting as a partial modulator of GABAA-BZD receptors and directl...
T0958 Penicillin G sodium salt Penicillin G Sodium,Benzylpenicillin sodium salt,Benzylpenicillin Sodium GABA Receptor , Antibacterial , Antibiotic
Penicillin G sodium(Benzylpenicillin sodium) salt is a penicillin derivative commonly used in the form of its sodium or potassium salts in the treatment of a variety of infections. It is effective against most gram-posit...
T10191L 7-Chlorokynurenic acid 7-chloro-4-hydroxy-2-carboxyquinoline,7-CKA GluR , NMDAR
7-Chlorokynurenic acid (7-chloro-4-hydroxy-2-carboxyquinoline) is an effecitve and selective antagonist of NMDA receptor with IC50 of 0.56 μM for the glycine B coagonist site. 7-Chlorokynurenic acid inhibits the reuptake...
T4S1962 Beta-Asarone Cis-Isoasarone,Cis-Asarone,Cis-Isoelemicin NF-κB , JNK
1. beta-Asarone (Cis-Isoelemicin) may be a potential preventive drug for Alzheimer's disease. 2. Beta-Asarone prevents autophagy and synaptic loss by reducing ROCK expression in SAMP8 mice. 3. The co-administration of be...
T4881 Phosphorylethanolamine O-Phosphorylethanolamine Others , Endogenous Metabolite
Phosphorylethanolamine (O-Phosphorylethanolamine) is a phosphomonoester metabolite of the phospholipid metabolism. Phosphorylethanolamine is a precursor of phospholipid synthesis and a product of phospholipid breakdown. ...

Recombinant Proteins

カタログ番号 製品名 Species Expression System
TMPJ-00281 CADM1 Protein, Mouse, Recombinant (hFc) Mouse HEK293 Cells
Cell adhesion molecule 1(CADM1) is a single-pass type I membrane protein and belongs to the nectin family. It contains 2 Ig-like C2-type (immunoglobulin-like) domains and 1 Ig-like V-type (immunoglobulin-like) domain. C...
TMPY-05510 BDNF Protein, Mouse, Recombinant (His) Mouse HEK293 Cells
BDNF is a member of thenerve growth factorfamily. It is highly expressed in hippocampus, amygdala, cerebral cortex and cerebellum. It also can be detected in heart, lung, skeletal muscle, testis, prostate and placenta. B...
TMPJ-00135 BDNF Protein, Human/Murine/Rat, Recombinant Human,Mouse,Rat E. coli
Brain-Derived Neurotrophic Factor (BDNF) is a member of the neurotrophin family. Along with other structurally related neurotrophic factors NGF, NT-3 and NT-4, BDNF binds with high affinity to the TrkB kinase receptor. I...
TMPY-02245 SNAP-25 Protein, Human, Recombinant (His) Human E. coli
Synaptosomal-associated protein 25, also known as Super protein, Synaptosomal-associated 25 kDa protein, SNAP25 and SNAP, is a cytoplasm and cell membrane protein that belongs to the SNAP-25 family. SNAP25 / SUP contains...
TMPH-02807 NPTXR Protein, Mouse, Recombinant (His & Myc) Mouse Baculovirus Insect Cells
May be involved in mediating uptake of synaptic material during synapse remodeling or in mediating the synaptic clustering of AMPA glutamate receptors at a subset of excitatory synapses.
TMPH-02808 NPTX1 Protein, Mouse, Recombinant (His) Mouse E. coli
May be involved in mediating uptake of synaptic material during synapse remodeling or in mediating the synaptic clustering of AMPA glutamate receptors at a subset of excitatory synapses.
TMPH-03379 Synaptogyrin-1/SYNGR1 Protein, Rat, Recombinant (His) Rat E. coli
May play a role in regulated exocytosis. Modulates the localization of synaptophysin/SYP into synaptic-like microvesicles and may therefore play a role in synaptic-like microvesicle formation and/or maturation. Involved ...
TMPH-00929 APBA2 Protein, Human, Recombinant (His & Myc) Human HEK293 Cells
Putative function in synaptic vesicle exocytosis by binding to STXBP1, an essential component of the synaptic vesicle exocytotic machinery. May modulate processing of the amyloid-beta precursor protein (APP) and hence fo...
TMPH-03399 VAMP2 Protein, Rat, Recombinant (His) Rat E. coli
Involved in the targeting and/or fusion of transport vesicles to their target membrane. Major SNARE protein of synaptic vesicles which mediates fusion of synaptic vesicles to release neurotransmitters. Essential for fast...
TMPH-02166 STXBP1 Protein, Human, Recombinant Human E. coli
Participates in the regulation of synaptic vesicle docking and fusion through interaction with GTP-binding proteins. Essential for neurotransmission and binds syntaxin, a component of the synaptic vesicle fusion machiner...
TMPK-01233 LAMP5 Protein, Human, Recombinant (hFc) Human HEK293 Cells
Lysosome-associated membrane protein 5 (LAMP5) is a mammalian ortholog of the Caenorhabditis elegans protein, UNC-46, which functions as a sorting factor to localize the vesicular GABA transporter UNC-47 to synaptic vesi...
TMPH-03381 Synaptoporin/SYNPR Protein, Rat, Recombinant (His) Rat E. coli
Intrinsic membrane protein of small synaptic vesicles. Probable vesicular channel protein. Synaptoporin/SYNPR Protein, Rat, Recombinant (His) is expressed in E. coli expression system with N-10xHis tag. The predicted mol...
TMPH-02165 STXBP1 Protein, Human, Recombinant (His) Human HEK293 Cells
Participates in the regulation of synaptic vesicle docking and fusion through interaction with GTP-binding proteins. Essential for neurotransmission and binds syntaxin, a component of the synaptic vesicle fusion machiner...
TMPY-01820 Munc18-1/STXBP1 Protein, Human, Recombinant (His & GST) Human Baculovirus Insect Cells
Syntaxin-binding protein 1, also known as N-Sec1, Protein unc-18 homolog 1, MUNC18-1 and STXBP1, is a peripheral membrane protein that belongs to the STXBP / unc-18 / SEC1 family. STXBP1 is an evolutionally conserved neu...
TMPH-03146 LAMP5 Protein, Pongo abelii, Recombinant (His & Myc) Pongo abelii E. coli
Plays a role in short-term synaptic plasticity in a subset of GABAergic neurons in the brain. LAMP5 Protein, Pongo abelii, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. Th...
TMPK-00659 LAMP5 Protein, Cynomolgus, Recombinant (His) Cynomolgus HEK293 Cells
Lysosome-associated membrane protein 5 (LAMP5) is a mammalian ortholog of the Caenorhabditis elegans protein, UNC-46, which functions as a sorting factor to localize the vesicular GABA transporter UNC-47 to synaptic vesi...
TMPH-03741 BoNT/F Protein, Clostridium botulinum, Recombinant (His) Clostridium botulinum E. coli
Botulinum toxin causes flaccid paralysis by inhibiting neurotransmitter (acetylcholine) release from the presynaptic membranes of nerve terminals of the eukaryotic host skeletal and autonomic nervous system, with frequen...
TMPH-03234 Acetylcholinesterase Protein, Rat, Recombinant (His) Rat E. coli
Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft. Acetylcholinesterase Protein, Rat, Recombinant (His) is expressed in E. coli express...
TMPH-02161 Synapsin-1 Protein, Human, Recombinant (GST) Human E. coli
Neuronal phosphoprotein that coats synaptic vesicles, binds to the cytoskeleton, and is believed to function in the regulation of neurotransmitter release. The complex formed with NOS1 and CAPON proteins is necessary for...
TMPY-01842 Neuroligin-3/NLGN3 Protein, Human, Recombinant (His) Human HEK293 Cells
Neuroligin 3 (NLGN3) is a member of the type-B carboxylesterase/lipase family. Neuroligins (NLGNs) are a family of presumptive postsynaptic cell adhesion molecules. Neuroligins (NLs) constitute a family of cell-surface p...
TMPH-02278 PTPN5 Protein, Human, Recombinant (His & SUMO) Human E. coli
May regulate the activity of several effector molecules involved in synaptic plasticity and neuronal cell survival, including MAPKs, Src family kinases and NMDA receptors. PTPN5 Protein, Human, Recombinant (His & SUMO) i...
TMPJ-01130 NPTX1 Protein, Human, Recombinant (His) Human HEK293 Cells
Neuronal Pentraxin (NPTX1, NP1) is a secreted glycoprotein within the Pentraxin family. NPTX1 is co‑expressed and forms heteromultimers with the related secreted protein, NPTX2/NARP, NPTXR (Neuronal Pentraxin Receptor) a...
TMPY-02025 CPLX2 Protein, Human, Recombinant (His) Human E. coli
Complexin-2 (CPLX2), a member of the complexin/synaphin family, is a soluble pre-synaptic protein believed to regulate neurotransmitter release from pre-synaptic terminals. Complexins are soluble proteins that regulate t...
TMPK-00612 CSPG5 Protein, Mouse, Recombinant (His) Mouse HEK293 Cells
CALEB also known as chondroitin sulfate proteoglycan (CSPG)5 or neuroglycan C, is a neural chondroitin sulfate-containing and epidermal growth factor (EGF)-domain-containing transmembrane protein that is implicated in sy...
TMPH-01231 DIP2A Protein, Human, Recombinant (His) Human Baculovirus Insect Cells
Catalyzes the de novo synthesis of acetyl-CoA in vitro. Promotes acetylation of CTTN, possibly by providing the acetyl donor, ensuring correct dendritic spine morphology and synaptic transmission. Binds to follistatin-re...
TMPH-02187 Tenascin Protein, Human, Recombinant (E. coli, His) Human E. coli
Extracellular matrix protein implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity as well as neuronal regeneration. Promotes neurite outgrowth from cortical neurons grown o...
TMPH-03380 Synaptophysin/SYP Protein, Rat, Recombinant (His) Rat E. coli
Possibly involved in structural functions as organizing other membrane components or in targeting the vesicles to the plasma membrane. Involved in the regulation of short-term and long-term synaptic plasticity. Synaptoph...
TMPH-01609 LGI1 Protein, Human, Recombinant (His & Myc) Human E. coli
Regulates voltage-gated potassium channels assembled from KCNA1, KCNA4 and KCNAB1. It slows down channel inactivation by precluding channel closure mediated by the KCNAB1 subunit. Ligand for ADAM22 that positively regula...
TMPH-03400 SLC17A6 Protein, Rat, Recombinant (His) Rat P. pastoris (Yeast)
Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. May also mediate the transport of inorganic phosphate. Involved in the regulation of retinal hyaloid vess...
TMPH-03383 Synaptotagmin-12 Protein, Rat, Recombinant (His) Rat E. coli
Synaptic vesicle phosphoprotein that enhances spontaneous neurotransmitter release but does not effect induced neurotransmitter release. Unlike other synaptotagmins, it does not bind Ca(2+) or phospholipids. Essential fo...
TMPH-03280 Dystrophin Protein, Rat, Recombinant (His) Rat P. pastoris (Yeast)
Anchors the extracellular matrix to the cytoskeleton via F-actin. Ligand for dystroglycan. Component of the dystrophin-associated glycoprotein complex which accumulates at the neuromuscular junction (NMJ) and at a variet...
TMPH-01209 DENND1A Protein, Human, Recombinant (His & SUMO) Human E. coli
Guanine nucleotide exchange factor (GEF) regulating clathrin-mediated endocytosis through RAB35 activation. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB35 into its active GTP-bound form. Regulat...
TMPH-01230 DIP2A Protein, Human, Recombinant (hFc) Human HEK293 Cells
Catalyzes the de novo synthesis of acetyl-CoA in vitro. Promotes acetylation of CTTN, possibly by providing the acetyl donor, ensuring correct dendritic spine morphology and synaptic transmission. Binds to follistatin-re...
TMPH-01036 Caprin-1/CAPRIN1 Protein, Human, Recombinant (His) Human Baculovirus Insect Cells
May regulate the transport and translation of mRNAs of proteins involved in synaptic plasticity in neurons and cell proliferation and migration in multiple cell types. Binds directly and selectively to MYC and CCND2 RNAs...
TMPK-01161 LAMP5 Protein, Mouse, Recombinant (hFc) Mouse HEK293 Cells
Lysosome-associated membrane protein 5 (LAMP5) is a mammalian ortholog of the Caenorhabditis elegans protein, UNC-46, which functions as a sorting factor to localize the vesicular GABA transporter UNC-47 to synaptic vesi...
TMPY-01992 Kallikrein 8/KLK8 Protein, Human, Recombinant (His) Human HEK293 Cells
Kallikrein-8, also known as Neuropsin, Serine protease 19, Serine protease TADG-14, Tumor-associated differentially expressed gene 14 protein, and KLK8 is a secreted protein that belongs to the peptidase S1 family and Ka...
TMPH-01663 GRM5 Protein, Human, Recombinant (His & Myc) Human E. coli
G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Sign...
TMPJ-00652 PSD-95 Protein, Rat, Recombinant (His) Rat E. coli
Disks large homolog 4(DLG4) is a cell membrane protein and it is a member of the membrane-associated guanylate kinase (MAGUK) family. The protein contains 1 guanylate kinase-like domain,3 PDZ (DHR) domains and 1 SH3 dom...
TMPK-01234 LAMP5 Protein, Human, Recombinant (His) Human HEK293 Cells
Lysosome-associated membrane protein 5 (LAMP5) is a mammalian ortholog of the Caenorhabditis elegans protein, UNC-46, which functions as a sorting factor to localize the vesicular GABA transporter UNC-47 to synaptic vesi...
TMPY-01172 CDH12 Protein, Human, Recombinant (His) Human HEK293 Cells
Classic Cadherins represent a family of calcium-dependent homophilic cell-cell adhesion molecules. They confer strong adhesiveness to animal cells when they are anchored to the actin cytoskeleton via their cytoplasmic bi...
TMPY-01692 NETO1 Protein, Human, Recombinant (His) Human HEK293 Cells
Neuropilin tolloid-like 1 (NETO1), a complement C1r/C1s, Uegf, Bmp1 (CUB) domain-containing transmembrane protein, is a novel component of the NMDAR complex critical for maintaining the abundance of NR2A-containing NMDAR...
TMPH-01272 TRIM9 Protein, Human, Recombinant (His & SUMO) Human E. coli
E3 ubiquitin-protein ligase which ubiquitinates itself in cooperation with an E2 enzyme UBE2D2/UBC4 and serves as a targeting signal for proteasomal degradation. May play a role in regulation of neuronal functions and ma...
TMPK-01048 Aggrecan Protein, Human, Recombinant (His) Human HEK293 Cells
Aggrecan is a large proteoglycan that forms giant hydrated aggregates with hyaluronan in the extracellular matrix (ECM). The extraordinary resistance of these aggregates to compression explains their abundance in articul...
TMPH-01754 L1CAM Protein, Human, Recombinant (His & Myc) Human HEK293 Cells
Neural cell adhesion molecule involved in the dynamics of cell adhesion and in the generation of transmembrane signals at tyrosine kinase receptors. During brain development, critical in multiple processes, including neu...
TMPJ-01401 NTNG1 Protein, Human, Recombinant (hFc) Human HEK293 Cells
Netrin-G1, known as NTNG-1, and is a member of the UNC-6/Netrin family of proteins. The NTNG1 gene is located on chromosome 1p13.3 and encodes a glycosylphosphatidylinositol protein anchored to the presynaptic membrane. ...
TMPH-02637 Embigin Protein, Mouse, Recombinant (His) Mouse E. coli
Plays a role in targeting the monocarboxylate transporters SLC16A1 and SLC16A7 to the cell membrane. Plays a role in the outgrowth of motoneurons and in the formation of neuromuscular junctions. Following muscle denervat...
TMPH-02162 Synaptotagmin-1 Protein, Human, Recombinant (His) Human E. coli
Calcium sensor that participates in triggering neurotransmitter release at the synapse. May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. I...
TMPY-03604 VAMP3 Protein, Human, Recombinant (His) Human E. coli
VAMP3, also known as cellubrevin, is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein are the main components...
TMPY-06815 SYAP1 Protein, Human, Recombinant (His) Human Baculovirus Insect Cells
Synapse-associated protein 1 (SYAP1), also known as PRO3113 and BSTA, belongs to the synapse-associated BSD domain family, featuring three α-helices and two conserved tryptophan and phenylalanine residues located at the ...
TMPJ-00883 EGR1 Protein, Human, Recombinant (His) Human E. coli
EGR-1 belongs to the EGR family of C2H2-type zinc finger proteins. It is a nuclear protein and functions as a transcriptional regulator. EGR-1 recognizes and binds to the DNA sequence 5'-CGCCCCCGC-3'(EGR-site).The produc...
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CADM1 Protein, Mouse, Recombinant (hFc)
TMPJ-00281
Species: Mouse
Expression System: HEK293 Cells
BDNF Protein, Mouse, Recombinant (His)
TMPY-05510
Species: Mouse
Expression System: HEK293 Cells
BDNF Protein, Human/Murine/Rat, Recombinant
TMPJ-00135
Species: Human,Mouse,Rat
Expression System: E. coli
SNAP-25 Protein, Human, Recombinant (His)
TMPY-02245
Species: Human
Expression System: E. coli
NPTXR Protein, Mouse, Recombinant (His & Myc)
TMPH-02807
Species: Mouse
Expression System: Baculovirus Insect Cells
NPTX1 Protein, Mouse, Recombinant (His)
TMPH-02808
Species: Mouse
Expression System: E. coli
Synaptogyrin-1/SYNGR1 Protein, Rat, Recombinant (His)
TMPH-03379
Species: Rat
Expression System: E. coli
APBA2 Protein, Human, Recombinant (His & Myc)
TMPH-00929
Species: Human
Expression System: HEK293 Cells
VAMP2 Protein, Rat, Recombinant (His)
TMPH-03399
Species: Rat
Expression System: E. coli
STXBP1 Protein, Human, Recombinant
TMPH-02166
Species: Human
Expression System: E. coli
LAMP5 Protein, Human, Recombinant (hFc)
TMPK-01233
Species: Human
Expression System: HEK293 Cells
Synaptoporin/SYNPR Protein, Rat, Recombinant (His)
TMPH-03381
Species: Rat
Expression System: E. coli
STXBP1 Protein, Human, Recombinant (His)
TMPH-02165
Species: Human
Expression System: HEK293 Cells
Munc18-1/STXBP1 Protein, Human, Recombinant (His & GST)
TMPY-01820
Species: Human
Expression System: Baculovirus Insect Cells
LAMP5 Protein, Pongo abelii, Recombinant (His & Myc)
TMPH-03146
Species: Pongo abelii
Expression System: E. coli
LAMP5 Protein, Cynomolgus, Recombinant (His)
TMPK-00659
Species: Cynomolgus
Expression System: HEK293 Cells
BoNT/F Protein, Clostridium botulinum, Recombinant (His)
TMPH-03741
Species: Clostridium botulinum
Expression System: E. coli
Acetylcholinesterase Protein, Rat, Recombinant (His)
TMPH-03234
Species: Rat
Expression System: E. coli
Synapsin-1 Protein, Human, Recombinant (GST)
TMPH-02161
Species: Human
Expression System: E. coli
Neuroligin-3/NLGN3 Protein, Human, Recombinant (His)
TMPY-01842
Species: Human
Expression System: HEK293 Cells
PTPN5 Protein, Human, Recombinant (His & SUMO)
TMPH-02278
Species: Human
Expression System: E. coli
NPTX1 Protein, Human, Recombinant (His)
TMPJ-01130
Species: Human
Expression System: HEK293 Cells
CPLX2 Protein, Human, Recombinant (His)
TMPY-02025
Species: Human
Expression System: E. coli
CSPG5 Protein, Mouse, Recombinant (His)
TMPK-00612
Species: Mouse
Expression System: HEK293 Cells
DIP2A Protein, Human, Recombinant (His)
TMPH-01231
Species: Human
Expression System: Baculovirus Insect Cells
Tenascin Protein, Human, Recombinant (E. coli, His)
TMPH-02187
Species: Human
Expression System: E. coli
Synaptophysin/SYP Protein, Rat, Recombinant (His)
TMPH-03380
Species: Rat
Expression System: E. coli
LGI1 Protein, Human, Recombinant (His & Myc)
TMPH-01609
Species: Human
Expression System: E. coli
SLC17A6 Protein, Rat, Recombinant (His)
TMPH-03400
Species: Rat
Expression System: P. pastoris (Yeast)
Synaptotagmin-12 Protein, Rat, Recombinant (His)
TMPH-03383
Species: Rat
Expression System: E. coli
Dystrophin Protein, Rat, Recombinant (His)
TMPH-03280
Species: Rat
Expression System: P. pastoris (Yeast)
DENND1A Protein, Human, Recombinant (His & SUMO)
TMPH-01209
Species: Human
Expression System: E. coli
DIP2A Protein, Human, Recombinant (hFc)
TMPH-01230
Species: Human
Expression System: HEK293 Cells
Caprin-1/CAPRIN1 Protein, Human, Recombinant (His)
TMPH-01036
Species: Human
Expression System: Baculovirus Insect Cells
LAMP5 Protein, Mouse, Recombinant (hFc)
TMPK-01161
Species: Mouse
Expression System: HEK293 Cells
Kallikrein 8/KLK8 Protein, Human, Recombinant (His)
TMPY-01992
Species: Human
Expression System: HEK293 Cells
GRM5 Protein, Human, Recombinant (His & Myc)
TMPH-01663
Species: Human
Expression System: E. coli
PSD-95 Protein, Rat, Recombinant (His)
TMPJ-00652
Species: Rat
Expression System: E. coli
LAMP5 Protein, Human, Recombinant (His)
TMPK-01234
Species: Human
Expression System: HEK293 Cells
CDH12 Protein, Human, Recombinant (His)
TMPY-01172
Species: Human
Expression System: HEK293 Cells
NETO1 Protein, Human, Recombinant (His)
TMPY-01692
Species: Human
Expression System: HEK293 Cells
TRIM9 Protein, Human, Recombinant (His & SUMO)
TMPH-01272
Species: Human
Expression System: E. coli
Aggrecan Protein, Human, Recombinant (His)
TMPK-01048
Species: Human
Expression System: HEK293 Cells
L1CAM Protein, Human, Recombinant (His & Myc)
TMPH-01754
Species: Human
Expression System: HEK293 Cells
NTNG1 Protein, Human, Recombinant (hFc)
TMPJ-01401
Species: Human
Expression System: HEK293 Cells
Embigin Protein, Mouse, Recombinant (His)
TMPH-02637
Species: Mouse
Expression System: E. coli
Synaptotagmin-1 Protein, Human, Recombinant (His)
TMPH-02162
Species: Human
Expression System: E. coli
VAMP3 Protein, Human, Recombinant (His)
TMPY-03604
Species: Human
Expression System: E. coli
SYAP1 Protein, Human, Recombinant (His)
TMPY-06815
Species: Human
Expression System: Baculovirus Insect Cells
EGR1 Protein, Human, Recombinant (His)
TMPJ-00883
Species: Human
Expression System: E. coli
カタログ番号 製品名
L9830 Anti-Parkinson's Disease Compound Library

857 compounds
A unique collection of 857 compounds with anti-PD activities or acting on main drug targets of PD can be used for HTS and HCS.