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カタログ番号 | 製品名 | 別名 | ターゲット |
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T9063 | Clathrin-IN-1 | HIV Protease | |
Clathrin-IN-1 is a inhibitor of clathrin, and inhibits clathrin-mediated endocytosis (CME) by associating with the terminal domain of clathrin. It has the potential for anti-cancer research. | |||
T22012 | 7BIO | FLT , DYRK , Aurora Kinase | |
7-bromoindirubin-3'-oxime (7BIO) is a caspase independent nonapoptotic cell death inducer. 7BIO is an inhibitor of FLT3, DYRK1A, DYRK2, Aurora B and Aurora C kinases. | |||
T1092 | Zolmitriptan | 311C90,BW-311C90 | 5-HT Receptor |
Zolmitriptan (311C90) selectively binds to and activates serotonin (5-HT) 1B receptors expressed in intracranial arteries and 5-HT 1D receptors located on peripheral trigeminal sensory nerve terminals in the meninges and... | |||
T0192 | Levetiracetam | UCB L059,SIB-S1 | DNA Methyltransferase , Others , Calcium Channel |
Levetiracetam (SIB-S1) is a relatively unique anticonvulsant that is typically used in combination with other antiepileptic medications for partial onset seizures. Levetiracetam has been linked to rare instances of serum... | |||
TP1559L | Ziconotide Acetate (107452-89-1 free base) | Prialt,Ziconotide Acetate | Calcium Channel |
Ziconotide Acetate (107452-89-1 free base) (Prialt) is an analgesic agent and has been used to treat neuropathic and non-neuropathic pain. Ziconotide Acetate (107452-89-1 free base) acts by binding to N-type calcium chan... | |||
T1279 | Vilazodone | SB659746A,EMD 68843 | 5-HT Receptor , Serotonin Transporter |
Vilazodone (SB659746A) is a selective serotonin (5-HT) reuptake inhibitor (SSRI) and a 5-HT-1A receptor partial agonist, with antidepressant and anti-anxiety activities. Vilazodone inhibits the reuptake of serotonin from... | |||
TP1868 | Proctolin | Others | |
Proctolin is a bioactive neuropeptide that modulates interneuronal and neuromuscular synaptic transmission in a wide variety of arthropods. | |||
T10893 | CS-722 Free base | Others | |
CS-722 Free base is a synthetic central muscle relaxant with muscle relaxant activity and inhibitory effect on spinal reflex. CS-722 Free base may inhibit spontaneous inhibitory post-synaptic current and excitatory post-... | |||
T7516 | ZD7288 | ICI D7288 | HCN Channel |
ZD7288 (ICI D7288), a selective hyperpolarization-activated cyclic nucleotide-gated channel blocker, inhibits hippocampal synaptic plasticity. | |||
T30549 | BMY-21502 | Bms-181168,Bms 181168,Bmy 21502,Bmy21502,Bms181168 | Antioxidant |
BMY-21502 is a potential cognitive enhancer that shows anti-hypoxia effects in the KCN-hypoxia model, delays the decay of hippocampal synaptic enhancement in vitro, and can be used to study Alzheimer's disease. | |||
T19812 | Propentofylline | HWA-285,Karsivan,Propentophylline,Hextol,HWA 285,HWA285 | PDE |
Propentofylline (Hextol) is a methylxanthine derivative with neuroprotective, antiproliferative, and anti-inflammatory activity and enhanced synaptic adenosine signaling, which may be useful in the study of Alzheimer's d... | |||
T0869 | Atomoxetine hydrochloride | Tomoxetine hydrochloride,(R)-Tomoxetine hydrochloride,LY 139603,Atomoxetine HCl,LY 139603 HCl | Dopamine Receptor , 5-HT Receptor , Norepinephrine |
Atomoxetine hydrochloride (LY 139603) is the hydrochloride salt of atomoxetine, a phenoxy-3-propylamine derivative and selective non-stimulant, norepinephrine reuptake inhibitor with cognitive-enhancing activity. Althou... | |||
T11684 | Isoguvacine hydrochloride | 1,2,3,6-tetrahydro-4-pyridinecarboxylic acid hydrochloride | GABA Receptor |
Isoguvacine hydrochloride (1,2,3,6-tetrahydro-4-pyridinecarboxylic acid hydrochloride) is a GABA receptor agonist. Isoguvacine hydrochloride binds to rat synaptic cortical membranes and activates α1β2γ2S, α2β2γ2S, α3β2γ2... | |||
T26357 | Pitstop 2 | Apoptosis | |
Pitstop2 is a selective inhibitor of amphiphysin association of clathrin terminal domain with an IC50 value of 12 μM. Pitstop2 acutely interferes with receptor-mediated endocytosis, entry of HIV, and synaptic vesicle rec... | |||
T5512 | JNJ16259685 | .TN.T 16259685 | GluR |
JNJ16259685 (TN.T 16259685) is a selective mGluR1 antagonist, and inhibits the synaptic activation of mGluR1 in a concentration-dependent manner with IC50 of 19 nM. | |||
T21153 | Clothianidin | TI435,TI-435,TI 435,Celero | AChR |
Clothianidin (TI 435), an insecticide, acts as an agonist of acetylcholine to stimulate nAChR, thereby activating post-synaptic acetylcholine receptors but not inhibiting AChE. | |||
T1566 | Aripiprazole | OPC-14597 | 5-HT Receptor |
Aripiprazole (OPC-14597) is an antipsychotic agent that is structurally related to piperazines and quinolones. It is a partial agonist of SEROTONIN RECEPTOR, 5-HT1A and DOPAMINE D2 RECEPTORS, where it also functions as a... | |||
T72420 | MTK458 | EP-0035985 | PTEN |
MTK458 (EP-0035985) is a brain-permeable and orally active PINK1 activator.MTK458 selectively activates PINK1 by stimulating dimerization and stabilization of the PINK1/TOM complexMTK458 drives the clearance of alpha-syn... | |||
T50041 | N-(4-methoxyphenyl)prop-2-enamide | N-(4-Methoxyphenyl)acrylamide | Others |
N-(4-methoxyphenyl)prop-2-enamide (N-(4-Methoxyphenyl)acrylamide) is an acrylamide analog used as a molecular structural unit. It inhibits the enzyme acetylcholinesterase, increasing acetylcholine levels in the synaptic ... | |||
T9172 | Simufilam dihydrochloride | PTI-125 dihydrochloride | Others |
Simufilam dihydrochloride (PTI-125 dihydrochloride) is a low toxicity, orally active filamin A (FLNA) activator, which can be used for the research of Alzheimer's disease. Simufilam dihydrochloride preferentially binds a... | |||
T0991 | Desipramine hydrochloride | NSC-114901,Desmethylimipramine,JB-8181,EX-4355,Norimipramine,G-35020 | Dopamine Receptor , 5-HT Receptor , Serotonin Transporter , Adrenergic Receptor |
Desipramine hydrochloride (Norimipramine) ,a secondary amine tricyclic antidepressant (TCA), is the hydrochloride salt form of desipramine. In the central nervous system (CNS), Desipramine hydrochloride blocks the re-upt... | |||
T7218 | Endomorphin 2 | Opioid Receptor | |
Endomorphins-2 (EM-2) could decrease both the frequency and amplitude of the sEPSC of the motoneurons in lamina IX, which was reversed by the MOR antagonist CTOP. EM-2-IR fibers originated from primary afferent fibers f... | |||
T50008 | 2,2-Dimethyl-5-(2,5-xylyloxy)valeramide | 5-(2,5-dimethylphenoxy)-2,2-dimethylpentanamide | Others |
2,2-Dimethyl-5-(2,5-xylyloxy)valeramide (5-(2,5-dimethylphenoxy)-2,2-dimethylpentanamide) is a compound of the phenoxy family. It has been shown to have stimulatory effects on the nervous system, including increased neur... | |||
TP1895L1 | KYL acetate(676657-00-4 free base) | Ephrin Receptor | |
KYL acetate is an EphA4 receptor tyrosine kinase inhibitor (Kd = 0.8 μM); inhibits EphA4-EphrinA5 interactions (IC50 = 6.34 μM). Prevents AβO induced synaptic damage, dendritic spine loss and prevents the blocking of LTP... | |||
T111959 | IFB-088 acetate | ||
IFB-088 acetate, a benzyl guanidine derivative, is used to treat diseases and cancers associated with the PPP1R15A pathway and associated with protein misfolding stress, Examples include tau disease, synaptic riboprotein... | |||
T11800 | L-803087 | Somatostatin | |
T1602 | Valproic acid sodium salt | Sodium Valproate | Mitophagy , Gamma-secretase , HIV Protease , GABA Receptor , HDAC , Autophagy |
Valproic acid sodium salt (Sodium Valproate) is the sodium salt form of valproic acid with anti-epileptic activity. Valproic acid sodium salt is converted into its active form, valproate ion, in blood. Although the mecha... | |||
TP1924L1 | ZIP acetate(863987-12-6 free base) | PKC | |
ZIP acetate is a novel, cell-permeable inhibitor of protein kinase Mζ (PKMζ), a constitutively active, atypical PKC isozyme involved in LTP maintenance. Selectively blocks PKMζ-induced synaptic potentiation in hippocampa... | |||
T76863 | Elezanumab | AE12-1Y-QL,ABT-555 | TGF-beta/Smad |
Elezanumab(ABT-555) is a potent human anti-RGMa monoclonal antibody.Elezanumab exerts its inhibitory effect on RGMa-mediated BMP signaling through the SMAD1/5/8 pathway, with an IC50 of approximately 97 pM.Elezanumab pro... | |||
T35856 | BMS-986176 | AAK1 (AP2 associated kinase 1) | |
AAK1-IN-1 (example 123) is an AAK1 (adaptor associated kinase 1) inhibitor with an IC50 of 2.2 nM. AAK1-IN-1 can be used for neurodegenerative diseases research[1]. Adaptor associated kinase 1 (AAK1) is a member of the A... | |||
T17174 | Troriluzole | BHV-4157 | Others |
Troriluzole is an orally active glutamate modulator. Troriluzole reduces the synaptic glutamate level and increases synaptic glutamate absorption. | |||
T32423 | KS 5-2 | KS-5-2 | |
KS 5-2 has affinity to isolated synaptic membranes from rat brain. | |||
T24934 | Vesamicol | AH-5183,AH 5183,AH5183 | |
Vesamicol is an experimental drug. It acting presynaptically by inhibiting acetylcholine uptake into synaptic vesicles and reducing its release. | |||
T69339 | Org 24461 | ||
Org 24461 is a synaptic and nonsynaptic glycine transporter type-1 inhibitor. | |||
T31903 | Galphimine B | ||
Galphimine B is a cyclodesiccated triterpenoid from Galphimia Glauca, which can regulate the synaptic transmission of dopaminergic ventral tegmental neurons and has a sedative effect. | |||
T27326 | FK960 | FK 59960,FK-960,FK-59960,FK59960 | |
FK962 is an enhancer of somatostatin release, which exerts cognitive-enhancing actions in rats. FK960 increases synaptic density in the hippocampal CA3 region of aged rats. | |||
T39069 | UCB-J | ||
UCB-J is a radioligand for the synaptic vesicle protein 2A (SV2A), utilized in positron emission tomography (PET)[4]. | |||
T41193 | FFN 270 | ||
FFN 270 is a fluorescent false neurotransmitter (FFN). Fluorescent substrate for NET and VMAT2. Labels noradrenergic neurons and their synaptic vesicles, and enables imaging of synaptic vesicle content release from speci... | |||
T34458 | Ryanodol | ||
Ryanodol is a complex diterpenoid that modulates intracellular calcium-ion release at ryanodine receptors, ion channels critical for skeletal and cardiac muscle excitation-contraction coupling and synaptic transmission. | |||
T62127 | AMPA-IN-1 | ||
AMPA-IN-1 is a potent inhibitor of AMPA receptors, a widely expressed receptor in the brain with a central role in the regulation of rapid excitatory synaptic transmission and synaptic plasticity. 14). | |||
T26879 | BNC-1 | BNC 1 | |
BNC-1 is a modulator of amyloid pathology. BNC-1 significantly decreases amyloid burden and improves markers of synaptic integrity in well-established mouse models of amyloid deposition by promoting phosphorylation and a... | |||
T41088 | Diadenosine pentaphosphate pentalithium | ||
Diadenosine pentaphosphate pentalithium is an endogenous vasoactive purine dinucleotide, isolated from thrombocytes. It is a member of the diadenosine polyphosphates (ApnA, n=2–7) and is found in secretory vesicles of pl... | |||
T68289 | Nicotine hemicitrate | ||
Nicotine hemicitrate is highly toxic alkaloid. It is the prototypical agonist at nicotinic cholinergic receptors where it dramatically stimulates neurons and ultimately blocks synaptic transmission. Nicotine is also impo... | |||
T68439 | Nicotine dicitrate | ||
Nicotine dicitrate is highly toxic alkaloid. It is the prototypical agonist at nicotinic cholinergic receptors where it dramatically stimulates neurons and ultimately blocks synaptic transmission. Nicotine is also import... | |||
T69804 | Nicotine monomethiodide | ||
Nicotine monomethiodide is highly toxic alkaloid. It is the prototypical agonist at nicotinic cholinergic receptors where it dramatically stimulates neurons and ultimately blocks synaptic transmission. Nicotine is also i... | |||
T68960 | F-15599 Fumarate | ||
F-15599 Fumarate is a highly selective post-synaptic 5-HT(1A) receptor agonist: in-vivo profile in behavioural models of antidepressant and serotonergic activity. | |||
T74759 | 18:0,18:1 PS sodium | ||
18:0,18:1 PS sodium, a lipid found in synaptic vesicles and cholesterol, serves a role in metabolic research [1]. | |||
TP1471 | Ziconotide TFA (107452-89-1 free base) | Ziconotide TFA | |
Ziconotide TEA acts by binding to N-type calcium channels situated on the terminal part of primary afferent neurons of the nociceptive pathway therefore reducing synaptic transmission with potent antinociceptive effects. | |||
T71854 | AA43279 | ||
AA43279 is a novel selective Nav1.1 activator, increasing the firing activity of parvalbumin-expressing, fast-spiking GABAergic interneurons and increasing the spontaneous inhibitory post-synaptic currents (sIPSCs) recor... | |||
T37310 | Diadenosine pentaphosphate pentasodium | ||
Diadenosine pentaphosphate pentasodium, an endogenous vasoactive purine dinucleotide isolated from thrombocytes, serves as a key component of secretory vesicles in platelets, chromaffin cells, Torpedo synaptic terminals,... |
カタログ番号 | 製品名 | 別名 | ターゲット |
---|---|---|---|
T9299 | D-Leucine | (R)-Leucine | Endogenous Metabolite |
D-Leucine ((R)-Leucine) potently terminates seizures even after the onset of seizure activity. D-leucine reduces long-term potentiation but had no effect on basal synaptic transmission in vitro. | |||
TN1202 | (-)-α-Pinene | (1S)-(-)-Alpha-Pinene | Virus Protease , GABA Receptor , Endogenous Metabolite , Antibacterial |
(-)-α-Pinene ((1S)-(-)-Alpha-Pinene) enhances the quantity of NREMS without affecting the intensity of NREMS by prolonging GABAergic synaptic transmission, acting as a partial modulator of GABAA-BZD receptors and directl... | |||
T0958 | Penicillin G sodium salt | Penicillin G Sodium,Benzylpenicillin sodium salt,Benzylpenicillin Sodium | GABA Receptor , Antibacterial , Antibiotic |
Penicillin G sodium(Benzylpenicillin sodium) salt is a penicillin derivative commonly used in the form of its sodium or potassium salts in the treatment of a variety of infections. It is effective against most gram-posit... | |||
T10191L | 7-Chlorokynurenic acid | 7-chloro-4-hydroxy-2-carboxyquinoline,7-CKA | GluR , NMDAR |
7-Chlorokynurenic acid (7-chloro-4-hydroxy-2-carboxyquinoline) is an effecitve and selective antagonist of NMDA receptor with IC50 of 0.56 μM for the glycine B coagonist site. 7-Chlorokynurenic acid inhibits the reuptake... | |||
T4S1962 | Beta-Asarone | Cis-Isoasarone,Cis-Asarone,Cis-Isoelemicin | NF-κB , JNK |
1. beta-Asarone (Cis-Isoelemicin) may be a potential preventive drug for Alzheimer's disease. 2. Beta-Asarone prevents autophagy and synaptic loss by reducing ROCK expression in SAMP8 mice. 3. The co-administration of be... | |||
T4881 | Phosphorylethanolamine | O-Phosphorylethanolamine | Others , Endogenous Metabolite |
Phosphorylethanolamine (O-Phosphorylethanolamine) is a phosphomonoester metabolite of the phospholipid metabolism. Phosphorylethanolamine is a precursor of phospholipid synthesis and a product of phospholipid breakdown. ... |
カタログ番号 | 製品名 | Species | Expression System |
---|---|---|---|
TMPJ-00281 | CADM1 Protein, Mouse, Recombinant (hFc) | Mouse | HEK293 Cells |
Cell adhesion molecule 1(CADM1) is a single-pass type I membrane protein and belongs to the nectin family. It contains 2 Ig-like C2-type (immunoglobulin-like) domains and 1 Ig-like V-type (immunoglobulin-like) domain. C... | |||
TMPY-05510 | BDNF Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells |
BDNF is a member of thenerve growth factorfamily. It is highly expressed in hippocampus, amygdala, cerebral cortex and cerebellum. It also can be detected in heart, lung, skeletal muscle, testis, prostate and placenta. B... | |||
TMPJ-00135 | BDNF Protein, Human/Murine/Rat, Recombinant | Human,Mouse,Rat | E. coli |
Brain-Derived Neurotrophic Factor (BDNF) is a member of the neurotrophin family. Along with other structurally related neurotrophic factors NGF, NT-3 and NT-4, BDNF binds with high affinity to the TrkB kinase receptor. I... | |||
TMPY-02245 | SNAP-25 Protein, Human, Recombinant (His) | Human | E. coli |
Synaptosomal-associated protein 25, also known as Super protein, Synaptosomal-associated 25 kDa protein, SNAP25 and SNAP, is a cytoplasm and cell membrane protein that belongs to the SNAP-25 family. SNAP25 / SUP contains... | |||
TMPH-02807 | NPTXR Protein, Mouse, Recombinant (His & Myc) | Mouse | Baculovirus Insect Cells |
May be involved in mediating uptake of synaptic material during synapse remodeling or in mediating the synaptic clustering of AMPA glutamate receptors at a subset of excitatory synapses. | |||
TMPH-02808 | NPTX1 Protein, Mouse, Recombinant (His) | Mouse | E. coli |
May be involved in mediating uptake of synaptic material during synapse remodeling or in mediating the synaptic clustering of AMPA glutamate receptors at a subset of excitatory synapses. | |||
TMPH-03379 | Synaptogyrin-1/SYNGR1 Protein, Rat, Recombinant (His) | Rat | E. coli |
May play a role in regulated exocytosis. Modulates the localization of synaptophysin/SYP into synaptic-like microvesicles and may therefore play a role in synaptic-like microvesicle formation and/or maturation. Involved ... | |||
TMPH-00929 | APBA2 Protein, Human, Recombinant (His & Myc) | Human | HEK293 Cells |
Putative function in synaptic vesicle exocytosis by binding to STXBP1, an essential component of the synaptic vesicle exocytotic machinery. May modulate processing of the amyloid-beta precursor protein (APP) and hence fo... | |||
TMPH-03399 | VAMP2 Protein, Rat, Recombinant (His) | Rat | E. coli |
Involved in the targeting and/or fusion of transport vesicles to their target membrane. Major SNARE protein of synaptic vesicles which mediates fusion of synaptic vesicles to release neurotransmitters. Essential for fast... | |||
TMPH-02166 | STXBP1 Protein, Human, Recombinant | Human | E. coli |
Participates in the regulation of synaptic vesicle docking and fusion through interaction with GTP-binding proteins. Essential for neurotransmission and binds syntaxin, a component of the synaptic vesicle fusion machiner... | |||
TMPK-01233 | LAMP5 Protein, Human, Recombinant (hFc) | Human | HEK293 Cells |
Lysosome-associated membrane protein 5 (LAMP5) is a mammalian ortholog of the Caenorhabditis elegans protein, UNC-46, which functions as a sorting factor to localize the vesicular GABA transporter UNC-47 to synaptic vesi... | |||
TMPH-03381 | Synaptoporin/SYNPR Protein, Rat, Recombinant (His) | Rat | E. coli |
Intrinsic membrane protein of small synaptic vesicles. Probable vesicular channel protein. Synaptoporin/SYNPR Protein, Rat, Recombinant (His) is expressed in E. coli expression system with N-10xHis tag. The predicted mol... | |||
TMPH-02165 | STXBP1 Protein, Human, Recombinant (His) | Human | HEK293 Cells |
Participates in the regulation of synaptic vesicle docking and fusion through interaction with GTP-binding proteins. Essential for neurotransmission and binds syntaxin, a component of the synaptic vesicle fusion machiner... | |||
TMPY-01820 | Munc18-1/STXBP1 Protein, Human, Recombinant (His & GST) | Human | Baculovirus Insect Cells |
Syntaxin-binding protein 1, also known as N-Sec1, Protein unc-18 homolog 1, MUNC18-1 and STXBP1, is a peripheral membrane protein that belongs to the STXBP / unc-18 / SEC1 family. STXBP1 is an evolutionally conserved neu... | |||
TMPH-03146 | LAMP5 Protein, Pongo abelii, Recombinant (His & Myc) | Pongo abelii | E. coli |
Plays a role in short-term synaptic plasticity in a subset of GABAergic neurons in the brain. LAMP5 Protein, Pongo abelii, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. Th... | |||
TMPK-00659 | LAMP5 Protein, Cynomolgus, Recombinant (His) | Cynomolgus | HEK293 Cells |
Lysosome-associated membrane protein 5 (LAMP5) is a mammalian ortholog of the Caenorhabditis elegans protein, UNC-46, which functions as a sorting factor to localize the vesicular GABA transporter UNC-47 to synaptic vesi... | |||
TMPH-03741 | BoNT/F Protein, Clostridium botulinum, Recombinant (His) | Clostridium botulinum | E. coli |
Botulinum toxin causes flaccid paralysis by inhibiting neurotransmitter (acetylcholine) release from the presynaptic membranes of nerve terminals of the eukaryotic host skeletal and autonomic nervous system, with frequen... | |||
TMPH-03234 | Acetylcholinesterase Protein, Rat, Recombinant (His) | Rat | E. coli |
Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft. Acetylcholinesterase Protein, Rat, Recombinant (His) is expressed in E. coli express... | |||
TMPH-02161 | Synapsin-1 Protein, Human, Recombinant (GST) | Human | E. coli |
Neuronal phosphoprotein that coats synaptic vesicles, binds to the cytoskeleton, and is believed to function in the regulation of neurotransmitter release. The complex formed with NOS1 and CAPON proteins is necessary for... | |||
TMPY-01842 | Neuroligin-3/NLGN3 Protein, Human, Recombinant (His) | Human | HEK293 Cells |
Neuroligin 3 (NLGN3) is a member of the type-B carboxylesterase/lipase family. Neuroligins (NLGNs) are a family of presumptive postsynaptic cell adhesion molecules. Neuroligins (NLs) constitute a family of cell-surface p... | |||
TMPH-02278 | PTPN5 Protein, Human, Recombinant (His & SUMO) | Human | E. coli |
May regulate the activity of several effector molecules involved in synaptic plasticity and neuronal cell survival, including MAPKs, Src family kinases and NMDA receptors. PTPN5 Protein, Human, Recombinant (His & SUMO) i... | |||
TMPJ-01130 | NPTX1 Protein, Human, Recombinant (His) | Human | HEK293 Cells |
Neuronal Pentraxin (NPTX1, NP1) is a secreted glycoprotein within the Pentraxin family. NPTX1 is co‑expressed and forms heteromultimers with the related secreted protein, NPTX2/NARP, NPTXR (Neuronal Pentraxin Receptor) a... | |||
TMPY-02025 | CPLX2 Protein, Human, Recombinant (His) | Human | E. coli |
Complexin-2 (CPLX2), a member of the complexin/synaphin family, is a soluble pre-synaptic protein believed to regulate neurotransmitter release from pre-synaptic terminals. Complexins are soluble proteins that regulate t... | |||
TMPK-00612 | CSPG5 Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells |
CALEB also known as chondroitin sulfate proteoglycan (CSPG)5 or neuroglycan C, is a neural chondroitin sulfate-containing and epidermal growth factor (EGF)-domain-containing transmembrane protein that is implicated in sy... | |||
TMPH-01231 | DIP2A Protein, Human, Recombinant (His) | Human | Baculovirus Insect Cells |
Catalyzes the de novo synthesis of acetyl-CoA in vitro. Promotes acetylation of CTTN, possibly by providing the acetyl donor, ensuring correct dendritic spine morphology and synaptic transmission. Binds to follistatin-re... | |||
TMPH-02187 | Tenascin Protein, Human, Recombinant (E. coli, His) | Human | E. coli |
Extracellular matrix protein implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity as well as neuronal regeneration. Promotes neurite outgrowth from cortical neurons grown o... | |||
TMPH-03380 | Synaptophysin/SYP Protein, Rat, Recombinant (His) | Rat | E. coli |
Possibly involved in structural functions as organizing other membrane components or in targeting the vesicles to the plasma membrane. Involved in the regulation of short-term and long-term synaptic plasticity. Synaptoph... | |||
TMPH-01609 | LGI1 Protein, Human, Recombinant (His & Myc) | Human | E. coli |
Regulates voltage-gated potassium channels assembled from KCNA1, KCNA4 and KCNAB1. It slows down channel inactivation by precluding channel closure mediated by the KCNAB1 subunit. Ligand for ADAM22 that positively regula... | |||
TMPH-03400 | SLC17A6 Protein, Rat, Recombinant (His) | Rat | P. pastoris (Yeast) |
Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. May also mediate the transport of inorganic phosphate. Involved in the regulation of retinal hyaloid vess... | |||
TMPH-03383 | Synaptotagmin-12 Protein, Rat, Recombinant (His) | Rat | E. coli |
Synaptic vesicle phosphoprotein that enhances spontaneous neurotransmitter release but does not effect induced neurotransmitter release. Unlike other synaptotagmins, it does not bind Ca(2+) or phospholipids. Essential fo... | |||
TMPH-03280 | Dystrophin Protein, Rat, Recombinant (His) | Rat | P. pastoris (Yeast) |
Anchors the extracellular matrix to the cytoskeleton via F-actin. Ligand for dystroglycan. Component of the dystrophin-associated glycoprotein complex which accumulates at the neuromuscular junction (NMJ) and at a variet... | |||
TMPH-01209 | DENND1A Protein, Human, Recombinant (His & SUMO) | Human | E. coli |
Guanine nucleotide exchange factor (GEF) regulating clathrin-mediated endocytosis through RAB35 activation. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB35 into its active GTP-bound form. Regulat... | |||
TMPH-01230 | DIP2A Protein, Human, Recombinant (hFc) | Human | HEK293 Cells |
Catalyzes the de novo synthesis of acetyl-CoA in vitro. Promotes acetylation of CTTN, possibly by providing the acetyl donor, ensuring correct dendritic spine morphology and synaptic transmission. Binds to follistatin-re... | |||
TMPH-01036 | Caprin-1/CAPRIN1 Protein, Human, Recombinant (His) | Human | Baculovirus Insect Cells |
May regulate the transport and translation of mRNAs of proteins involved in synaptic plasticity in neurons and cell proliferation and migration in multiple cell types. Binds directly and selectively to MYC and CCND2 RNAs... | |||
TMPK-01161 | LAMP5 Protein, Mouse, Recombinant (hFc) | Mouse | HEK293 Cells |
Lysosome-associated membrane protein 5 (LAMP5) is a mammalian ortholog of the Caenorhabditis elegans protein, UNC-46, which functions as a sorting factor to localize the vesicular GABA transporter UNC-47 to synaptic vesi... | |||
TMPY-01992 | Kallikrein 8/KLK8 Protein, Human, Recombinant (His) | Human | HEK293 Cells |
Kallikrein-8, also known as Neuropsin, Serine protease 19, Serine protease TADG-14, Tumor-associated differentially expressed gene 14 protein, and KLK8 is a secreted protein that belongs to the peptidase S1 family and Ka... | |||
TMPH-01663 | GRM5 Protein, Human, Recombinant (His & Myc) | Human | E. coli |
G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Sign... | |||
TMPJ-00652 | PSD-95 Protein, Rat, Recombinant (His) | Rat | E. coli |
Disks large homolog 4(DLG4) is a cell membrane protein and it is a member of the membrane-associated guanylate kinase (MAGUK) family. The protein contains 1 guanylate kinase-like domain,3 PDZ (DHR) domains and 1 SH3 dom... | |||
TMPK-01234 | LAMP5 Protein, Human, Recombinant (His) | Human | HEK293 Cells |
Lysosome-associated membrane protein 5 (LAMP5) is a mammalian ortholog of the Caenorhabditis elegans protein, UNC-46, which functions as a sorting factor to localize the vesicular GABA transporter UNC-47 to synaptic vesi... | |||
TMPY-01172 | CDH12 Protein, Human, Recombinant (His) | Human | HEK293 Cells |
Classic Cadherins represent a family of calcium-dependent homophilic cell-cell adhesion molecules. They confer strong adhesiveness to animal cells when they are anchored to the actin cytoskeleton via their cytoplasmic bi... | |||
TMPY-01692 | NETO1 Protein, Human, Recombinant (His) | Human | HEK293 Cells |
Neuropilin tolloid-like 1 (NETO1), a complement C1r/C1s, Uegf, Bmp1 (CUB) domain-containing transmembrane protein, is a novel component of the NMDAR complex critical for maintaining the abundance of NR2A-containing NMDAR... | |||
TMPH-01272 | TRIM9 Protein, Human, Recombinant (His & SUMO) | Human | E. coli |
E3 ubiquitin-protein ligase which ubiquitinates itself in cooperation with an E2 enzyme UBE2D2/UBC4 and serves as a targeting signal for proteasomal degradation. May play a role in regulation of neuronal functions and ma... | |||
TMPK-01048 | Aggrecan Protein, Human, Recombinant (His) | Human | HEK293 Cells |
Aggrecan is a large proteoglycan that forms giant hydrated aggregates with hyaluronan in the extracellular matrix (ECM). The extraordinary resistance of these aggregates to compression explains their abundance in articul... | |||
TMPH-01754 | L1CAM Protein, Human, Recombinant (His & Myc) | Human | HEK293 Cells |
Neural cell adhesion molecule involved in the dynamics of cell adhesion and in the generation of transmembrane signals at tyrosine kinase receptors. During brain development, critical in multiple processes, including neu... | |||
TMPJ-01401 | NTNG1 Protein, Human, Recombinant (hFc) | Human | HEK293 Cells |
Netrin-G1, known as NTNG-1, and is a member of the UNC-6/Netrin family of proteins. The NTNG1 gene is located on chromosome 1p13.3 and encodes a glycosylphosphatidylinositol protein anchored to the presynaptic membrane. ... | |||
TMPH-02637 | Embigin Protein, Mouse, Recombinant (His) | Mouse | E. coli |
Plays a role in targeting the monocarboxylate transporters SLC16A1 and SLC16A7 to the cell membrane. Plays a role in the outgrowth of motoneurons and in the formation of neuromuscular junctions. Following muscle denervat... | |||
TMPH-02162 | Synaptotagmin-1 Protein, Human, Recombinant (His) | Human | E. coli |
Calcium sensor that participates in triggering neurotransmitter release at the synapse. May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. I... | |||
TMPY-03604 | VAMP3 Protein, Human, Recombinant (His) | Human | E. coli |
VAMP3, also known as cellubrevin, is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein are the main components... | |||
TMPY-06815 | SYAP1 Protein, Human, Recombinant (His) | Human | Baculovirus Insect Cells |
Synapse-associated protein 1 (SYAP1), also known as PRO3113 and BSTA, belongs to the synapse-associated BSD domain family, featuring three α-helices and two conserved tryptophan and phenylalanine residues located at the ... | |||
TMPJ-00883 | EGR1 Protein, Human, Recombinant (His) | Human | E. coli |
EGR-1 belongs to the EGR family of C2H2-type zinc finger proteins. It is a nuclear protein and functions as a transcriptional regulator. EGR-1 recognizes and binds to the DNA sequence 5'-CGCCCCCGC-3'(EGR-site).The produc... | |||
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カタログ番号 | 製品名 | ||
---|---|---|---|
L9830 | Anti-Parkinson's Disease Compound Library | 857 compounds | |
A unique collection of 857 compounds with anti-PD activities or acting on main drug targets of PD can be used for HTS and HCS. |