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天然化合物

リコンビナントタンパク質

カタログ番号	製品名	別名	ターゲット
T12019	Methylproamine		Others
	Methylproamine is a DNA-binding radioprotector , acts by repair of transient radiation-induced oxidative species on DNA.		Others
T9168	NSC 617145	NSC617145,NSC-617145	DNA/RNA Synthesis
	NSC 617145 (NSC617145) is an inhibitor of WRN helicase that inhibits the ATPase, but not exonuclease, activity of WRN helicase in a concentration-dependent manner.		DNA/RNA Synthesis
T5363	Tempo	2,2,6,6-Tetramethylpiperidinooxy	Free radical scavengers , Reactive Oxygen Species , DNA/RNA Synthesis , Mitochondrial Metabolism
	Tempo (2,2,6,6-Tetramethylpiperidinooxy) has a wide range of applications including use as a free radical scavenger, a reagent in organic synthesis and as a structural probe in electron spin resonance spectroscopy.
T24925	UNC-2170	UNC2170 Maleate,UNC-2170 Maleate,UNC 2170 Maleate	Others
	UNC-2170 (UNC2170 Maleate) is the methyl-lysine binding protein, 53BP1 ligand.		Others
T14858	Calicheamicin	Calicheamicin γ1	Others
			Others
T1798	RITA	NSC 652287,RITA (NSC 652287)	Mdm2 , DNA Alkylator/Crosslinker , p53 , Autophagy
	RITA (NSC-652287)(NSC-652287) induced cross-links of both DNA-DNA and DNA-protein with no detectable DNA single-strand breaks. RITA, like nutlin-3, can disrupt the p53/Mdm2 interaction.		Mdm2 , DNA Alkylator/Crosslinker , p53 , Autophagy
T3353	Niraparib hydrochloride	MK-4827 hydrochloride,MK-4827 (hydrochloride)	Apoptosis , Others , PARP
	Niraparib hydrochloride (MK-4827 hydrochloride) is an inhibitor of poly (ADP-ribose) polymerase (PARP) with potential antineoplastic activity. Niraparib hydrochloride inhibits PARP activity, enhancing the accumulation of...		Apoptosis , Others , PARP
T9497	Niraparib tosylate monohyrate		PARP
	Niraparib, also know as MK-4827, is an inhibitor of poly (ADP-ribose) polymerase (PARP) with potential antineoplastic activity. MK4827 inhibits PARP activity, enhancing the accumulation of DNA strand breaks and promoting...		PARP
T6336	Amonafide	NSC308847,AS1413,Nafidimide,AS1413,Quinamed	Topoisomerase
	Amonafide (NSC-308847,AS1413)(AS1413) produces protein-associated DNA-strand breaks through a topoisomerase II-mediated reaction, but does not produce topoisomerase I-mediated DNA cleavage.		Topoisomerase
T6588	Mitoxantrone	mitozantrone	Topoisomerase , PKC
	Mitoxantrone (mitozantrone) is an anthracenedione antibiotic with antineoplastic activity. Mitoxantrone intercalates into and crosslinks DNA, thereby disrupting DNA and RNA replication. This agent also binds to topoisome...		Topoisomerase , PKC
T11332	FUBP1-IN-1	FUBP1–IN-1	Others
	FUBP1 - in-1, with an IC50 value of 11.0 M, is an effective FUSE binding protein 1 (FUBP1) inhibitor that can interfere with the binding of FUBP1 to its SINGLE-strand target DNA FUSE sequence.		Others
T1055	Ifosfamide	NSC109724,Isophosphamide	DNA Alkylator/Crosslinker , DNA/RNA Synthesis
	Ifosfamide (NSC-109724) alkylates and forms DNA crosslinks, thereby preventing DNA strand separation and DNA replication. Ifosfamide is a synthetic analog of the nitrogen mustard cyclophosphamide with antineoplastic acti...		DNA Alkylator/Crosslinker , DNA/RNA Synthesis
T9760	IC 86621		DNA-PK
	IC 86621 is a selective and reversible ATP-competitive inhibitor of DNA-PK with an IC50 of 120 nM. IC 86621 increases DNA double-strand break(DSB)-induced antitumor activity with an EC50 of 68 µM for DNA-PK mediated cell...		DNA-PK
T4047	Bisantrene	CL216942	Topoisomerase
	Bisantrene (CL216942) is an anthracenyl bishydrazone with antineoplastic activity. Bisantrene intercalates with and disrupts the configuration of DNA, resulting in DNA single-strand breaks, DNA-protein crosslinking, and ...		Topoisomerase
T11600	IBR2	Isoquinoline	DNA/RNA Synthesis
	IBR2 (Isoquinoline) is a potent and specific RAD51 inhibitor known for its ability to suppress RAD51-mediated DNA double-strand break repair. By interfering with RAD51 multimerization, accelerating proteasome-mediated RA...		DNA/RNA Synthesis
T9430	Venadaparib	NOV140101,IDX-1197	PARP
	Venadaparib (NOV140101) (IDX-1197) is a potent, selective and orally active PARP inhibitor with IC50s of 1.4 nM and 1.0 nM for PARP1 and PARP2, respectively. Venadaparib is insensitive to PARP-5. Venadaparib prevents the...		PARP
T50098	TIQ-A		PARP
	TIQ-A is a PARP1 inhibitor which involved in DNA single-strand break repair via the base excision repair pathway. PARP1 is triggered by DNA damage and its excessive activation has been proposed as a causative factor in m...		PARP
T11067	VX-984	M9831	DNA-PK
	VX-984 (M9831) is an oral, selective DNA-PK inhibitor that can cross the blood-brain barrier. VX-984 inhibited the conjugation of non-homologous terminal NHEJ and acted on DSBs to break DNA double strand. VX-984 is commo...		DNA-PK
T21320	Methoxyamine HCl	TRC102,TRC 102,Methoxyamine,TRC-102	Others
	Methoxyamine HCl (Methoxyamine) covalently binds to apurinic/apyrimidinic (AP) DNA damage sites and inhibits base excision repair (BER), which may result in an increase in DNA strand breaks and apoptosis. Methoxyamine is...		Others
T3615	Evofosfamide	TH-302	Apoptosis , Others
	Evofosfamide (TH-302) is a hypoxia-activated prodrug of the cytotoxin bromo-isophosphoramide mustard (Br-IPM) conjugated with 2-nitroimidazole, with potential antineoplastic activity. When exposed to hypoxic conditions, ...		Apoptosis , Others
T63228	Simmiparib	SMOCL-9112	Apoptosis , PARP
	Simmiparib (SMOCL-9112) is a novel and potent PARP1 and PARP2 inhibitor, a derivative of Olaparib.Simmiparib induces DNA double-strand breaks (DSBs) and cell cycle arrest in homologous recombination repair (HR)-deficient...		Apoptosis , PARP
T3157	COH29	RNR Inhibitor COH29	DNA/RNA Synthesis
	COH29 (RNR Inhibitor COH29) is an orally available, aromatically substituted thiazole and inhibitor of the human ribonucleotide reductase (RNR), with potential antineoplastic activity. Upon oral administration, the RNR i...		DNA/RNA Synthesis
T15826	Lometrexol	LY 264618,DDATHF	DHFR
	Lometrexol (LY 264618), an antipurine Antifolate, can inhibit the activity of glycinamide ribonucleotide formyltransferase (GARFT) but do not induce detectable levels of DNA strand breaks. Lometrexol can further inhibit ...		DHFR
T1600	Doxifluridine	Ro 21-9738,AMC 0101,5'-DFUR,5-Fluoro-5'-deoxyuridine	Nucleoside Antimetabolite/Analog , DNA/RNA Synthesis
	Doxifluridine (AMC 0101) is a fluoropyrimidine derivative and oral prodrug of the antineoplastic agent 5-fluorouracil (5-FU) with antitumor activity. Doxifluridine, designed to circumvent the rapid degradation of 5-FU by...		Nucleoside Antimetabolite/Analog , DNA/RNA Synthesis
T0893	Tinidazole	CP12574	Antibacterial , Antibiotic
	Tinidazole (CP12574)a is a 5-nitroimidazole derivative with the antiprotozoal property. Although the mechanism of action has not been fully elucidated, it has been suggested that tinidazole is metabolized and yields nitr...		Antibacterial , Antibiotic
T1408	Capecitabine	Xeloda,Capecitibine,Capiibine,RO 09-1978	Apoptosis , Nucleoside Antimetabolite/Analog , DNA/RNA Synthesis
	Capecitabine (Capecitibine) is a fluoropyrimidine carbamate belonging to the class of antineoplastic agents called antimetabolites. As a prodrug, capecitabine is selectively activated by tumor cells to its cytotoxic moie...
T24555	NSC666715	NSC 666715,NSC-666715
	NSC666715 is the strand-displacement activity of DNA polymerase inhibitor.
T21303	Etoposide Phosphate	Eposin Etopophos Vepesid VP16
	Etoposide phosphate is a phosphate salt of Etoposide, which binds to the enzyme topoisomerase II, then induces double-strand DNA breaks and inhibits DNA repair, leading to decreased DNA synthesis and tumor cell prolifera...
T20907	DBC	3,4,5,6-Dibenzocarbazole
	DBC, a ubiquitous environmental pollutant, induces significant DNA strand break levels and micronuclei in HepG2 cells.
T28293	Pamiparib maleate	BGB290,BGB 290,BGB-29 maleat 0
	Pamiparib is a highly potent and selective PARP inhibitor. BGB-290 selectively binds to PARP and prevents PARP-mediated repair of single-strand DNA breaks via the base-excision repair (BER) pathway. This enhances the acc...
T71482	Penclomedine
	Penclomedine is an antineoplastic agent which alkylates and crosslinks DNA, resulting in DNA strand breaks and inhibition of DNA and RNA synthesis.
T15200	Edotecarin	PF 804950,J 107088	Topoisomerase
			Topoisomerase
T23654	Afeletecan free base	BAY 56-3722,BAY56-3722,BAY-563722,Afeletecan
	Afeletecan is a water-soluble camptothecin derivative. Afeletecan stabilizes the topoisomerase I-DNA covalent complex and forms an enzyme-drug-DNA ternary complex. Both the initial cleavage reaction and religation steps ...
T16283	Neocarzinostatin		5-HT Receptor
	Neocarzinostatin is an effective DNA-damaging, anti-tumor antibiotic. It recognizes double-stranded DNA bulge and induces DNA double strand breaks (DSBs). Neocarzinostatin leads to apoptosis. Neocarzinostatin has potenti...		5-HT Receptor
T21323	Picoplatin	NX 473,AMD-473,AMD473,NX-473,NX473,AMD 473
	Picoplatin has a broad spectrum of antineoplastic activity and is designed to overcome platinum drug resistance. Picoplatin alkylates DNA, forming both intra- and inter-strand cross-linkages, resulting in the inhibition ...
T79330	PARP-1-IN-13		PARP
	PARP-1-IN-13 (Compound 19c) is a potent PARP-1 inhibitor with an IC50 of 26 nM, hindering DNA single-strand break repair and exacerbating DNA double-strand breaks. It induces apoptosis in cancer cells via the mitochondri...		PARP
T70533	Amonafide dihydrochloride
	Amonafide dihydrochloride is the dihydrochloride salt of amonafide, an imide derivative of naphthalic acid. Amonafide intercalates into DNA and inhibits topoisomerase II, resulting in protein-associated strand breaks and...
T68985	Amonafide L-malate
	Amonafide L-malate is the malate salt of amonafide, an imide derivative of naphthalic acid, with potential antineoplastic activity. Amonafide intercalates into DNA and inhibits topoisomerase II, resulting in DNA double-s...
T70115	Pamiparib hydrate
	Pamiparib, also known as BGB-290, is a highly potent and selective PARP inhibitor with favorable drug metabolism and pharmacokinetic properties. BGB-290 selectively binds to PARP and prevents PARP-mediated repair of sin...
T76109	Nuclease S1
	Nuclease S1, a specific endonuclease, degrades single-stranded DNA (ssDNA) and RNA, and can remove protruding single-strand ends from double-stranded DNA [1] [2].
T68671	Amsacrine Isothionate
	Amsacrine Isothionate is an aminoacridine derivative with potential antineoplastic activity. Although its mechanism of action is incompletely defined, amsacrine may intercalate into DNA and inhibit topoisomerase II, resu...
T68673	Amsacrine gluconate
	Amsacrine gluconate is an aminoacridine derivative with potential antineoplastic activity. Although its mechanism of action is incompletely defined, amsacrine may intercalate into DNA and inhibit topoisomerase II, result...
T68672	Amsacrine lactate
	Amsacrine lactate is an aminoacridine derivative with potential antineoplastic activity. Although its mechanism of action is incompletely defined, amsacrine may intercalate into DNA and inhibit topoisomerase II, resultin...
T69862	Afeletecan HCl
	Afeletecan, also known as BAY 56-3722, is a water-soluble camptothecin derivative conjugated to a carbohydrate moiety exhibiting antineoplastic activity. BAY 56-3722 stabilizes the topoisomerase I-DNA covalent complex a...
T68971	Ormaplatin
	Ormaplatin is a platinum(IV) analogue with antineoplastic activity. Ormaplatin alkylates DNA, forming both inter- and intra-strand platinum-DNA crosslinks, which result in inhibition of DNA replication and transcription ...
T40345	AV-153
	AV-153 is a 1,4-dihydropyridine derivative with antimutagenic properties. It intercalates into DNA at single strand breaks, resulting in reduced DNA damage and stimulation of DNA repair in human cells in vitro. AV-153 al...
T19149	5-BrdUTP sodium salt	5-Bromo-2'-deoxyuridine 5'-triphosphate sodium salt	Others
	5-BrdUTP sodium salt is a TdT substrate that can be used to label the DNA double-strand breaks.		Others
T40933	Bromochloroacetonitrile
	Bromochloroacetonitrile is a chemical compound that is formed as a by-product during the chlorine disinfection process of water that contains natural organic material. This compound exhibits direct mutagenic activity and...
T68675	Porfiromycin
	Porfiromycin is a n N-methyl derivative of the antineoplastic antibiotic mitomycin C isolated from the bacterium Streptomyces ardus and other Streptomyces bacterial species. Bioreduced porfiromycin generates oxygen radic...
T38962	MC-SN38	MC-SN38
	MC-SN38 is a drug-linker conjugate that pairs the potent microtubule-disrupting agent SN38 with a non-cleavable MC linker, designed for use in antibody drug conjugates (ADCs). SN38, the active metabolite of the Topoisome...

Compounds

Synonym: NSC617145,NSC-617145

Target: DNA/RNA Synthesis

Tempo

T5363

Synonym: 2,2,6,6-Tetramethylpiperidinooxy

Target: Free radical scavengers, Reactive Oxygen Species, DNA/RNA Synthesis, Mitochondrial Metabolism

UNC-2170

T24925

Synonym: UNC2170 Maleate,UNC-2170 Maleate,UNC 2170 Maleate

Target: Others

Calicheamicin

T14858

Synonym: Calicheamicin γ1

Target: Others

RITA

T1798

Synonym: NSC 652287,RITA (NSC 652287)

Target: Mdm2, DNA Alkylator/Crosslinker, p53, Autophagy

Niraparib hydrochloride

T3353

Synonym: MK-4827 hydrochloride,MK-4827 (hydrochloride)

Target: Apoptosis, Others, PARP

Niraparib tosylate monohyrate

Synonym: NSC308847,AS1413,Nafidimide,AS1413,Quinamed

Target: Topoisomerase

Mitoxantrone

T6588

Synonym: mitozantrone

Target: Topoisomerase, PKC

Synonym: NSC109724,Isophosphamide

Target: DNA Alkylator/Crosslinker, DNA/RNA Synthesis

Target: Topoisomerase

IBR2

T11600

Synonym: Isoquinoline

Target: DNA/RNA Synthesis

Venadaparib

T9430

Synonym: NOV140101,IDX-1197

Synonym: TRC102,TRC 102,Methoxyamine,TRC-102

Target: Apoptosis, Others

Simmiparib

T63228

Synonym: SMOCL-9112

Target: Apoptosis, PARP

COH29

T3157

Synonym: RNR Inhibitor COH29

Target: DNA/RNA Synthesis

Lometrexol

T15826

Synonym: LY 264618,DDATHF

Target: DHFR

Doxifluridine

T1600

Synonym: Ro 21-9738,AMC 0101,5'-DFUR,5-Fluoro-5'-deoxyuridine

Target: Nucleoside Antimetabolite/Analog, DNA/RNA Synthesis

Tinidazole

T0893

Synonym: CP12574

Target: Antibacterial, Antibiotic

Capecitabine

T1408

Synonym: Xeloda,Capecitibine,Capiibine,RO 09-1978

Target: Apoptosis, Nucleoside Antimetabolite/Analog, DNA/RNA Synthesis

NSC666715

T24555

Synonym: NSC 666715,NSC-666715

Target:

Etoposide Phosphate

T21303

Synonym: Eposin Etopophos Vepesid VP16

Target:

DBC

T20907

Synonym: 3,4,5,6-Dibenzocarbazole

Target:

Pamiparib maleate

T28293

Synonym: BGB290,BGB 290,BGB-29 maleat 0

Synonym: PF 804950,J 107088

Target: Topoisomerase

Afeletecan free base

T23654

Synonym: BAY 56-3722,BAY56-3722,BAY-563722,Afeletecan

Target: 5-HT Receptor

Picoplatin

T21323

Synonym: NX 473,AMD-473,AMD473,NX-473,NX473,AMD 473

Amonafide dihydrochloride

Amsacrine Isothionate

Synonym: 5-Bromo-2'-deoxyuridine 5'-triphosphate sodium salt

Target: Others

Bromochloroacetonitrile

カタログ番号	製品名	別名	ターゲット
TN1637	Eurycomalactone		Anti-infection , NF-κB
	Eurycomalactone is a natural product isolated from Eurycoma longifolia Jack., acts as a potent NF-κB inhibitor( IC50 of 0.5 μM). Eurycomalactone inhibits protein synthesis, depletes cyclin D1, but does not affect TNFα-in...		Anti-infection , NF-κB
T6116	Bleomycin Sulfate	Blenoxane,NSC125066	DNA/RNA Synthesis , Antibiotic
	Bleomycin Sulfate (Blenoxane) is a glycopeptide antibiotic, an inhibitor of DNA synthesis. Bleomycin Sulfate causes DNA strand breaks but not RNA strand breaks. Bleomycin Sulfate has antitumor activity.		DNA/RNA Synthesis , Antibiotic
T6228	Irinotecan	CPT-11,Topotecin,(+)-Irinotecan	Topoisomerase , Autophagy
	Irinotecan (CPT-11), a derivative of camptothecin, is an inhibitor of DNA topoisomerase I (Topo I). Irinotecan has antitumor activity by preventing DNA strand reattachment through binding to the Topo I complex, resulting...		Topoisomerase , Autophagy
TN1170	1-Cinnamoylpyrrolidine		Platelet aggregation
	1-Cinnamoylpyrrolidine, a natural product prepared from Piper caninum, can be used as a DNA strand breaking agent, inducing the relaxation of the plasmid pBR322 DNA superhelix in the presence of Cu2+. 1-Cinnamoylpyrrolid...		Platelet aggregation
T5780	HYPOCRELLIN B		Apoptosis , Parasite , Antifungal
	HYPOCRELLIN B are photosensitive pigments isolated from Hypocrella bambusae Sacc. Hypocrellin B causes DNA strand breakage, induces apoptosis in ovarian cancer cells, and inhibits proliferation of Staphylococcus by incre...		Apoptosis , Parasite , Antifungal
T2S2172	Nerolidol	(±)-Nerolidol,Peruviol	Others , Endogenous Metabolite , Antibacterial , Parasite , Antifungal
	Nerolidol (Peruviol) shows sedative effects in animals, oxidative process plays a crucial role on neuronal pathological consequence. Nerolidol is mainly related to ROS and DNA single strand breaks generated by the presen...
T82046	Irisquinone
	Irisquinone, a natural anticancer agent, also acts as a radiation sensitizer for cancer therapies. It diminishes glutathione (GSH) levels and hampers the repair of single-strand DNA breaks [1] [2] [3].
T35770	Cylindrospermopsin
	Cylindrospermopsin, a tricyclic uracil derivative, is a cyanobacterial toxin that was first discovered in an algal bloom contaminating a local drinking supply on Palm Island in Queensland, Australia after an outbreak of ...

天然物製品

Eurycomalactone

TN1637

Synonym:

Target: Anti-infection, NF-κB

Bleomycin Sulfate

T6116

Synonym: Blenoxane,NSC125066

Target: DNA/RNA Synthesis, Antibiotic

Irinotecan

T6228

Synonym: CPT-11,Topotecin,(+)-Irinotecan

Target: Topoisomerase, Autophagy

1-Cinnamoylpyrrolidine

TN1170

Synonym:

Target: Platelet aggregation

HYPOCRELLIN B

T5780

Synonym:

Target: Apoptosis, Parasite, Antifungal

nerolidol

T2S2172

Synonym: (±)-Nerolidol,Peruviol

Target: Others, Endogenous Metabolite, Antibacterial, Parasite, Antifungal

Recombinant Proteins

Species：

Expression System：

Tag：

カタログ番号	製品名	Species	Expression System
TMPH-00039	Single-strand DNA-binding protein Protein, Agrobacterium fabrum, Recombinant (His & Myc)	Agrobacterium fabrum	E. coli
	Involved in DNA transformation; mediates the nuclear uptake of single-stranded DNA copies of the transferred DNA (T-DNA) element. Binds single-stranded but not double-stranded DNA regardless of nucleotide sequence compos...
TMPH-01241	TOP1 Protein, Human, Recombinant (His & Myc)	Human	Baculovirus Insect Cells
	Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via tran...
TMPH-00530	SSB Protein, Enterobacteria phage T4, Recombinant (His & Myc)	Enterobacteria phage T4	E. coli
	Single-stranded DNA-binding protein that participates in viral DNA replication, recombination, and repair (Probable). Coats the lagging-strand ssDNA as the replication fork advances. Stimulates the activities of viral DN...
TMPH-00532	SSB Protein, Enterobacteria phage T7, Recombinant	Enterobacteria phage T7	P. pastoris (Yeast)
	Single-stranded DNA-binding protein that participates in viral DNA replication, formation of concatemers, recombination and repair of double-stranded breaks. Coats the lagging-strand ssDNA as the replication fork advance...
TMPH-00528	Recombination and repair protein Protein, Enterobacteria phage T4, Recombinant (His)	Enterobacteria phage T4	E. coli
	Important in genetic recombination, DNA repair, and replication. Possesses pairing and strand-transfer activity. Interacts with dda and gene 32 proteins.
TMPH-00531	SSB Protein, Enterobacteria phage T7, Recombinant (His & SUMO)	Enterobacteria phage T7	E. coli
	Single-stranded DNA-binding protein that participates in viral DNA replication, formation of concatemers, recombination and repair of double-stranded breaks. Coats the lagging-strand ssDNA as the replication fork advance...
TMPH-03440	RAD52 Protein, S. cerevisiae, Recombinant (His & SUMO)	Saccharomyces cerevisiae	E. coli
	Involved in DNA double-strand break (DSB) repair and recombination. Promotes the annealing of complementary single-stranded DNA and by stimulation of the RAD51 recombinase. RAD52 Protein, S. cerevisiae, Recombinant (His ...
TMPH-01237	POLQ Protein, Human, Recombinant (E. coli, His)	Human	E. coli
	DNA polymerase that promotes microhomology-mediated end-joining (MMEJ), an alternative non-homologous end-joining (NHEJ) machinery triggered in response to double-strand breaks in DNA. MMEJ is an error-prone repair pathw...
TMPH-01238	POLQ Protein, Human, Recombinant (His)	Human	Baculovirus Insect Cells
	DNA polymerase that promotes microhomology-mediated end-joining (MMEJ), an alternative non-homologous end-joining (NHEJ) machinery triggered in response to double-strand breaks in DNA. MMEJ is an error-prone repair pathw...
TMPH-02649	FAN1 Protein, Mouse, Recombinant (His & Myc)	Mouse	E. coli
	Nuclease required for the repair of DNA interstrand cross-links (ICL) recruited at sites of DNA damage by monoubiquitinated FANCD2. Specifically involved in repair of ICL-induced DNA breaks by being required for efficien...
TMPH-03614	DNA photolyase Protein, Synechococcus sp., Recombinant (His & Myc & SUMO)	Synechococcus	E. coli
	Involved in repair of UV radiation-induced DNA damage. Catalyzes the light-dependent monomerization (300-600 nm) of cyclobutyl pyrimidine dimers (in cis-syn configuration), which are formed between adjacent bases on the ...
TMPH-00611	DNA helicase II Protein, E. coli, Recombinant	E. coli	E. coli
	A helicase with DNA-dependent ATPase activity. Unwinds DNA duplexes with 3' to 5' polarity with respect to the bound strand. Initiates unwinding more efficiently from a nicked substrate than ds duplex DNA. Involved in th...
TMPH-01431	HELQ Protein, Human, Recombinant (His & Myc)	Human	E. coli
	Single-stranded DNA-dependent ATPase and 5' to 3' DNA helicase. Involved in the repair of DNA cross-links and double-strand break (DSB) resistance. Participates in FANCD2-mediated repair. Forms a complex with POLN polyme...
TMPY-02798	NEIL1 Protein, Human, Recombinant (His)	Human	E. coli
	NEIL1 is a member of DNA glycosylases. DNA glycosylases are a family homologous to the bacterial Fpg/Nei family. They play a role in base excision repair which is the mechanism by which damaged bases in DNA are removed a...
TMPH-01245	POLM Protein, Human, Recombinant (His & Myc)	Human	Baculovirus Insect Cells
	Gap-filling polymerase involved in repair of DNA double-strand breaks by non-homologous end joining (NHEJ). Participates in immunoglobulin (Ig) light chain gene rearrangement in V(D)J recombination. POLM Protein, Human, ...
TMPH-01244	POLM Protein, Human, Recombinant (His)	Human	E. coli
	Gap-filling polymerase involved in repair of DNA double-strand breaks by non-homologous end joining (NHEJ). Participates in immunoglobulin (Ig) light chain gene rearrangement in V(D)J recombination. POLM Protein, Human, ...
TMPJ-00918	HMGB2 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	High Mobility Group Protein B2 (HMGB2) belongs to the non-histone chromosomal high-mobility group protein family. Members of this family are chromatin-associated and widely spread in the nucleus of higher eukaryotic cell...
TMPH-02681	GPX7 Protein, Mouse, Recombinant (His & Myc)	Mouse	E. coli
	It protects esophageal epithelia from hydrogen peroxide-induced oxidative stress. It suppresses acidic bile acid-induced reactive oxigen species (ROS) and protects against oxidative DNA damage and double-strand breaks. G...
TMPH-02314	XRCC5 Protein, Human, Recombinant (His & MBP)	Human	Baculovirus Insect Cells
	Single-stranded DNA-dependent ATP-dependent helicase that plays a key role in DNA non-homologous end joining (NHEJ) by recruiting DNA-PK to DNA. Required for double-strand break repair and V(D)J recombination. Also has a...
TMPH-00533	T7 RNA polymerase Protein, Enterobacteria phage T7, Recombinant (His & Myc)	Escherichia phage T7	E. coli
	Highly processive DNA-dependent RNA polymerase that catalyzes the transcription of class II and class III viral genes. Recognizes a specific promoter sequence and enters first into an 'abortive phase' where very short tr...
TMPH-02315	XRCC5 Protein, Human, Recombinant (His & Myc)	Human	E. coli
	Single-stranded DNA-dependent ATP-dependent helicase that plays a key role in DNA non-homologous end joining (NHEJ) by recruiting DNA-PK to DNA. Required for double-strand break repair and V(D)J recombination. Also has a...
TMPH-00638	RuvB Protein, E. coli, Recombinant (His & SUMO)	E. coli	E. coli
	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a he...
TMPH-00610	GyrA Protein, E. coli, Recombinant (His)	E. coli	E. coli
	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to maintain chromosomes in an underwound state. This makes better substrates for topoisomerase IV (Pa...
TMPH-00028	Adeno-associated virus 2 (isolate Srivastava/1982) Rep78 Protein (His & MBP)	AAV-2	E. coli
	Plays an essential role in the initiation of viral DNA synthesis. Binds specifically to an inverted terminal repeat element (ITR) on the 3' and 5' ends of the viral DNA, where it cleaves a site specifically to generate a...
TMPY-02421	PARP3 Protein, Human, Recombinant (His & GST)	Human	Baculovirus Insect Cells
	Poly(ADP-ribose) polymerase 3 (PARP3) is an important member of the PARP family and shares high structural similarities with both PARP1 and PARP2. Poly(ADP-ribose) polymerase 3 (PARP3), a critical player in cellular resp...
TMPY-03395	PC4/SUB1 Protein, Human, Recombinant (His)	Human	E. coli
	SUB1 belongs to the transcriptional coactivator PC4 family. It is a general coactivator that functions cooperatively with TAFs and mediates functional interactions between upstream activators and the general transcriptio...
TMPH-01621	BRCC3 Protein, Human, Recombinant (His & SUMO)	Human	E. coli
	Metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Does not have activity toward 'Lys-48'-linked polyubiquitin chains. Component of the BRCA1-A complex, a complex that specifically recognizes...
TMPY-02543	PCNA Protein, Human, Recombinant (His)	Human	Baculovirus Insect Cells
	Proliferating Cell Nuclear Antigen (PCNA) is a protein only expressed in normal proliferate cells and cancer cells. It is central to both DNA replication and repair. One of the well-established functions for PCNA is its ...
TMPH-01239	XPC Protein, Human, Recombinant (His)	Human	E. coli
	Involved in global genome nucleotide excision repair (GG-NER) by acting as damage sensing and DNA-binding factor component of the XPC complex. Has only a low DNA repair activity by itself which is stimulated by RAD23B an...
TMPH-01246	POLR3A Protein, Human, Recombinant (His)	Human	E. coli
	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic core component of RNA polymerase III which synthesizes small RNAs,...
TMPH-01267	RNF13 Protein, Human, Recombinant (His & Myc)	Human	E. coli
	E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair protein...
TMPH-01689	PLD6 Protein, Human, Recombinant (His)	Human	E. coli
	Presents phospholipase and nuclease activities, depending on the different physiological conditions. Interaction with Mitoguardin (MIGA1 or MIGA2) affects the dimer conformation, facilitating the lipase activity over the...