|
T35554 |
GSK-3β inhibitor 3
|
|
Apoptosis
,
GSK-3
|
|
GSK-3β inhibitor 3 is a covalent inhibitor (IC50: 6.6 μM) of glycogen synthase kinase 3β (GSK-3β) that is potent, selective, and irreversible.GSK-3β inhibitor 3 can be used to study acute promyelocytic leukemia. |
|
T11467 |
GSK-3β inhibitor 1
|
|
GSK-3
|
|
GSK-3β inhibitor 1 is an inhibitor of GSK-3β( IC50 of 4.9 nM) and demonstrates high antidiabetic efficacy. |
|
T11471 |
GSK-3β inhibitor 2
|
5-Thiazolecarboxamide,2-[2-[(cyclopropylcarbonyl)amino]-4-pyridinyl]-4-methoxy- |
GSK-3
|
|
|
|
T9178 |
(E/Z)-GSK-3β inhibitor 1
|
GSK-3β inhibitor 1 |
GSK-3
|
|
(E/Z)-GSK-3β inhibitor 1 is a glycogen synthase kinase 3β (GSK-3β) inhibitor and demonstrates high antidiabetic efficacy. |
|
T9725 |
GSK-3β inhibitor 10
|
|
Others
|
|
GSK-3β inhibitor 10 has skin-whitening, anti-oxidizing and PPAR activities. |
|
T67856 |
GSK-3β inhibitor 14
|
1,5-Benzothiazepin-4(5H)-one, 2,3-dihydro-2-methyl-5-(phenylmethyl)- |
GSK-3
|
|
GSK-3β inhibitor 14 (1,5-Benzothiazepin-4(5H)-one, 2,3-dihydro-2-methyl-5-(phenylmethyl)-) is a weak GSK-3β inhibitor, IC50﹥ 100μM. |
|
T61809 |
GSK-3β inhibitor 11
|
|
GSK-3
|
|
GSK-3β inhibitor 11 (compound 21) is a potent inhibitor of glycogen synthase kinase-3β (GSK-3β) with an inhibitory concentration (IC50) of 10.02 μM. This compound demonstrates potential utility in the field of neurodegen... |
|
T60472 |
GSK-3β inhibitor 12
|
|
GSK-3
|
|
GSK-3β inhibitor 12 is a selective GSK-3β inhibitor.GSK-3β inhibitor 12 inhibits 49.11% of 25 μM GSK-3β activity and 37.11% of 50 μM GSK-3β activity.GSK-3β inhibitor 12 can be used for the study of Parkinson's in the pre... |
|
T35556 |
GSK-3β inhibitor 8
|
GSK3β Inhibitor XVIII |
GSK-3
,
Wnt/beta-catenin
|
|
GSK-3β inhibitor 8 (GSK3β Inhibitor XVIII) is a potent and selective GSK-3β inhibitor with an IC50 value of 64 nM.GSK-3β inhibitor 8 is a thienopyrimidine derivative that negatively regulates the Wnt signaling pathway an... |
|
T6187 |
TDZD-8
|
GSK-3β Inhibitor I,NP 01139 |
GSK-3
|
|
TDZD-8 (NP 01139) is an inhibitor of GSK-3β, with an IC50 of 2 μM; minimal inhibitory effect observed on CDK1, casein kinase II, PKA and PKC. |
|
T1881 |
AR-A014418
|
AR 0133418,GSK-3beta Inhibitor VIII,AR 014418,GSK 3β inhibitor VIII |
GSK-3
|
|
AR-A014418 (GSK 3β inhibitor VIII) is an ATP-competitive, and selective GSK3β inhibitor. |
|
T14066 |
9-ING-41
|
|
Apoptosis
,
GSK-3
,
Autophagy
|
|
9-ING-41 is a glycogen synthase kinase-3 inhibitor. |
|
T63866 |
GSK-3β inhibitor 7
|
|
|
|
GSK-3β inhibitor 7 is a GSK-3β inhibitor (IC50: 5.25 μM). GSK-3β inhibitor 7 acts by inserting into the ATP-binding binding pocket of GSK-3β and forming hydrogen bonds. GSK-3β inhibitor 7 has a high rate of glucose uptak... |
|
T61804 |
GSK-3β inhibitor 6
|
|
|
|
GSK-3β inhibitor 6 is a highly potent inhibitor of GSK-3β, with an IC50 value of 24.4 μM. It demonstrates significant enhancement of hepatocyte glucose uptake (38%). This compound holds great potential for studying vario... |
|
T78874 |
GSK-3β inhibitor 15
|
|
|
|
GSK-3β inhibitor 15 (Compound 54), with an IC50 of 3.4 nM, effectively suppresses Aβ 1-42-induced phosphorylation of GSK-3β and tau protein, as well as LPS-induced iNOS expression. It demonstrates neuroprotective propert... |
|
T64143 |
AChE/GSK-3β-IN-1
|
|
|
|
AChE/GSK-3β-IN-1 is a potent dual AChE/GSK-3β inhibitor that crosses the blood-brain barrier and acts on hAChE (IC50: 1.2 nM), hBChE (IC50: 149.8 nM) and hGSK-3β (IC50: 22.4 nM). AChE/GSK-3β-IN-1 is able to occupy the AT... |
|
T36088 |
GSK3β Inhibitor XI
|
GSK3β Inhibitor XI |
|
|
GSK3β Inhibitor XI has GSK3β inhibitory effect. |
|
T2261 |
IM-12
|
IM 12 |
GSK-3
|
|
IM-12, an effective GSK-3β inhibitor(IC50=53 nM), regulates Wnt signalling. |
|
T22657 |
Laduviglusib trihydrochloride
|
CT99021 trihydrochloride,CHIR 99021 trihydrochloride,CHIR 99021 trihydrochloride (252917-06-9 free base) |
GSK-3
,
Wnt/beta-catenin
|
|
Laduviglusib trihydrochloride (CT99021 trihydrochloride) is a selective glycogen synthase kinase 3 (GSK-3) inhibitor with IC50s of 10 nM and 6.7 nM for GSK-3α and GSK-3β. Laduviglusib trihydrochloride inhibits human GSK-... |
|
T9611 |
PF-04802367
|
|
GSK-3
|
|
PF-04802367 is a highly selective GSK-3 inhibitor with an IC50 of 2.1 nM based on a recombinant human GSK-3β enzyme assay and 1.1 nM based on ADP-Glo assay. It shows desirable central nervous system (CNS) properties and ... |
|
T6659 |
SB 415286
|
SB415286 |
Apoptosis
,
GSK-3
|
|
SB 415286 is a potent GSK3α inhibitor with IC50/Ki of 78 nM/31 nM with equally effective inhibition of GSK-3β. |
|
T2166 |
TWS119
|
|
GSK-3
,
Autophagy
|
|
TWS119 is a GSK-3β inhibitor; capable of inducing neuronal differentiation |
|
T61360 |
ARN25068
|
|
GSK-3
,
DYRK
,
Microtubule Associated
,
Src
|
|
ARN25068 is a potent inhibitor of GSK-3β, FYN, and DYRK1A protein kinases, exerting its activity in the sub-micromolar range. This compound effectively addresses tau hyperphosphorylation [1]. |
|
T10202 |
A 1070722
|
|
GSK-3
|
|
|
|
T14613 |
BIP-135
|
|
GSK-3
|
|
BIP-135 is a potent and selective ATP-competitive GSK-3 inhibitor. With IC50s of 16 nM and 21 nM for GSK-3α and GSK-3β, respectively. BIP 135 exhibits neuroprotective effect[1]. |
|
T6358 |
1-Azakenpaullone
|
azakenpaullone |
GSK-3
|
|
1-Azakenpaullone (azakenpaullone) is a potent and selective GSK-3β inhibitor with IC50 of 18 nM, >100-fold selectivity over CDK1/cyclin B and CDK5/p25. |
|
T77341 |
GSK-3 inhibitor 4
|
|
GSK-3
,
CDK
|
|
GSK-3 inhibitor 4 is an orally active and brain-permeable triple inhibitor of GSK-3, CDK2 and CDK5 with inhibitory effects on GSK-3β, GSK-3α, CDK2 and CDK5, with IC50 values of 0.56 nM, 0.45 nM, 0.47 μM, 0.68 μM, respect... |
|
T64366 |
GSK3-IN-4
|
|
GSK-3
|
|
GSK3-IN-4 is a GSK-3 inhibitor with IC50 of 0.101-1 μM of GSK-3α and GSK-3β in Calipe Assay. |
|
T77342 |
GSK-3 inhibitor 3
|
|
GSK-3
,
Microtubule Associated
|
|
GSK-3 inhibitor 3 is a selective, orally active, brain-permeable GSK-3 inhibitor that inhibits GSK-3α and GSK-3β with IC50s of 0.35 nM and 0.25 nM, respectively.GSK-3 inhibitor 3 reduces the phosphorylation level of tau ... |
|
T21966 |
MeBIO
|
|
GSK-3
,
Aryl Hydrocarbon Receptor
,
CDK
|
|
MeBIO is an agonist of aryl hydrocarbon receptor, with IC50 of 44 and 55 μM for GSK-3 and CDK1/CyclinB, respectively. MeBIO does not affect GSK-3β. |
|
T2608 |
CHIR-98014
|
CHIR 98014,CT98014,CHIR98014 |
FGFR
,
GSK-3
,
Src
,
S6 Kinase
|
|
CHIR-98014 (CT98014) is a selective GSK3 inhibitor; potentiate insulin activation of glucose transport and utilization in vitro and in vivo. |
|
T1755 |
LY2090314
|
|
GSK-3
|
|
LY2090314, an effective GSK-3α/β inhibitor (IC50: 1.5 nM/0.9 nM), may improve the efficacy of platinum-based chemotherapy regimens. LY2090314 has been used in trials studying the treatment of Leukemia, Advanced Cancer, a... |
|
T72048 |
CDK8-IN-12
|
|
GSK-3
,
CDK
|
|
CDK8-IN-12 is a selective, potent and orally active inhibitor of CDK8 (Ki: 14 nM) and is an anti-cancer agent. CDK8-IN-12 inhibits GSK-3α, GSK-3β and PCK-θ with Ki of 13 nM, 4 nM and 109 nM respectively. CDK8-IN-12 showe... |
|
T7280 |
CAY10594
|
|
Phospholipase
|
|
CAY10594 is a potent phospholipase D2(PLD2) inhibitor. CAY10594 ameliorates acetaminophen-induced acute liver injury by regulating the phosphorylated-GSK-3β/JNK axis. |
|
T1260 |
Cromolyn sodium
|
Disodium Cromoglycate,FPL 670 (Cromolyn) Disodium,FPL-670,Sodium cromoglycate |
Others
,
Potassium Channel
,
GSK-3
,
Calcium Channel
|
|
Cromolyn sodium (FPL-670) is a chromone complex that acts by inhibiting the release of chemical mediators from sensitized mast cells. |
|
T22180 |
3F8
|
3F 8,3F-8 |
GSK-3
|
|
3F8 is a selective GSK-3β inhibitor that can be used as a new tool and potential therapeutic candidate compound for GSK3-related diseases, and can be used in the study of neurological disorders and cancer. |
|
T1764 |
Adezmapimod
|
PB 203580,RWJ 64809,SB203580 |
Mitophagy
,
p38 MAPK
,
Autophagy
|
|
Adezmapimod (SB 203580) is a p38 MAPK inhibitor (IC50=0.3-0.5 μM) that is selective and ATP-competitive. Adezmapimod possesses autophagy and mitochondrial autophagy activating activity. Adezmapimod displays more than 100... |
|
T1957 |
AZD2858
|
|
GSK-3
|
|
AZD2858 is a selective GSK-3 inhibitor, inhibiting tau phosphorylation at the S396 site and activating Wnt signaling pathway. |
|
T60485 |
DIF-3
|
|
|
|
DIF-3 is a chemical compound that acts by activating GSK-3β to facilitate the degradation of cyclin D1 and c-Myc, resulting in reduced expression levels of these proteins. In addition, DIF-3 inhibits Wnt/β-catenin signal... |
|
T3684 |
CP21R7
|
CP21 |
GSK-3
,
PKC
|
|
CP21R7 (CP21) is an effective and specific GSK3β inhibitor. It is used as an activator of stem cells prior to the induction of differentiation of stem cells to smooth muscle and endothelial cells. CP21R7 can be combined ... |
|
T2247 |
KenPaullone
|
9-Bromopaullone,NSC-664704 |
GSK-3
,
CDK
|
|
KenPaullone (9-Bromopaullone), a potent CDK1, CDK2 and CDK5 inhibitor, as new enhancer for iTreg cell differentiation. Kenpaullone promotes iTreg cell differentiation through increased and prolonged transcription of foxp... |
|
T2378 |
RGB-286638 free base
|
|
GSK-3
,
MEK
,
JAK
,
CDK
|
|
RGB-286638 free base is a novel CDK inhibitor with IC50s of 1 nM/2 nM/3 nM/4 nM/5 nM for cyclin T1-CDK9/cyclin B1-CDK1/cyclin E-CDK2/cyclin D1-CDK4/cyclin E-CDK3/p35-CDK5 respectively; less potent against cyclin H-CDK7 a... |
|
T22884 |
JW 67
|
|
Wnt/beta-catenin
|
|
JW 67 is an inhibitor of canonical Wnt pathway signaling. JW 67 rapidly reduced active β-catenin with a subsequent downregulation of Wnt target genes, including AXIN2, SP5, and NKD1. |
|
T26894 |
BRD0209
|
BRD-0209,BRD 0209 |
GSK-3
|
|
BRD0209 is a highly selective and potent GSK3 inhibitor. |
|
T23436 |
TC-G 24
|
|
Others
|
|
GSK-3β inhibitor |
|
T3067 |
Tideglusib
|
NP-12,NP031112 |
GSK-3
|
|
Tideglusib (NP031112), a non-ATP competitive inhibitor of glycogen synthase kinase 3 (GSK-3), is with anti-inflammatory and neuroprotective activities. |
|
T3077 |
SB 216763
|
SB216763 |
GSK-3
,
Autophagy
|
|
SB 216763 (SB216763) is an effective and specific GSK-3α/β inhibitor (IC50: 34.3 nM). |
|
T1741 |
AZD1080
|
|
GSK-3
|
|
AZD1080 is a selective, orally active, brain permeable GSK3 inhibitor. |
|
T11652 |
Indirubin-3'-monoxime-5-sulphonic acid
|
|
Others
|
|
Indirubin-3'-monoxime-5-sulphonic acid is a potent and selective inhibitor of GSK-3β, CDK5, and CDK1 with IC50s of 80nM,5 nM, and 7 nM, respectively. |
|
T22157 |
TCS 2002
|
|
|
|
GSK-3β inhibitor 9 (Compound 9b) is a highly selective, orally bioavailable and potent GSK-3β inhibitor with the IC 50 of 35 nM. GSK-3β inhibitor 9 exhibits good pharmacokinetic profiles including favorable BBB penetrati... |
