|
T6546 |
IPA-3
|
IPA3,IPA 3 |
PAK
|
|
|
|
TP1026 |
Tos-Gly-Pro-Arg-ANBA-IPA
|
tos-GPR-ANBA-IPA |
|
|
Tos-Gly-Pro-Arg-ANBA-IPA is a chromogenic peptide substrate. Tos-Gly-Pro-Arg-ANBA-IPA is used for the rapid and specific photometric assay of recombinant hirudin (r-hirudin). |
|
TP1025 |
Tos-Gly-Pro-Arg-ANBA-IPA acetate
|
tos-GPR-ANBA-IPA acetate |
|
|
Tos-Gly-Pro-Arg-ANBA-IPA (acetate) is a peptide substrate for luminescence measurement. |
|
T32099 |
Homocysteinylpropachlor
|
Homo-cys-ipa |
|
|
Homocysteinylpropachlor is a bioactive chemical. |
|
T17266 |
Xipamide
|
Diurexan,Aquaphor |
Others
|
|
Xipamide (Diurexan) is a sulfonamide-based diuretic with antihypertensive properties. Xipamide selectively inhibits anion exchanger. |
|
T23477 |
Tris(dibenzylideneacetone)dipalladium
|
Tris DBA |
Others
|
|
tris(dibenzylideneacetone)dipalladium (Tris DBA) is a N-myristoyltransferase-1 (NMT-1) inhibitor |
|
T26637 |
Antipain dihydrochloride
|
Antipain 2HCl,BDBM-32804,BDBM 32804, Antipain,BDBM32804 |
Protease
|
|
Antipain dihydrochloride (Antipain 2HCl) is a protease inhibitor derived from Actinomycetes that exhibits analgesic activity and inhibits X-ray-induced chromosomal aberrations in human lymphocytes. |
|
T23212 |
Quipazine dimaleate
|
|
5-HT Receptor
|
|
Quipazine dimaleate is a selective 5-HT3 agonist. |
|
T0271 |
Iodipamide
|
Iodipamic acid,Adipiodone |
Others
|
|
Iodipamide (Iodipamic acid) is a water-soluble radiographic contrast media for intravenous cholangiography and cholecystography. |
|
T63228 |
Simmiparib
|
SMOCL-9112 |
Apoptosis
,
PARP
|
|
Simmiparib (SMOCL-9112) is a novel and potent PARP1 and PARP2 inhibitor, a derivative of Olaparib.Simmiparib induces DNA double-strand breaks (DSBs) and cell cycle arrest in homologous recombination repair (HR)-deficient... |
|
T2105 |
Veliparib dihydrochloride
|
ABT-888 dihydrochloride |
PARP
,
Autophagy
|
|
Veliparib dihydrochloride (ABT-888 dihydrochloride) is a potent inhibitor of PARP1 and PARP2 with Ki of 5.2 nM and 2.9 nM in cell-free assays, respectively. It is inactive to SIRT2. |
|
T3216 |
Selexipag
|
NS-304,ACT-293987,Uptravi |
Others
,
Prostaglandin Receptor
|
|
Selexipag (ACT-293987)(NS-304) is prostacyclin receptor agonist that causes vasodilation in pulmonary vasculature and is used in the therapy of pulmonary arterial hypertension (PAH). |
|
T6200 |
Ledipasvir
|
GS-5885 |
HCV Protease
,
SARS-CoV
|
|
|
|
TQ0319 |
Ripasudil
|
K-115,Ripasudil hydrochloride dihydrate |
ROCK
|
|
Ripasudil (Ripasudil hydrochloride dihydrate) (K-115) hydrochloride dihydrate is a specific ROCK inhibitor (IC50s: 51/19 nM for ROCK1/ROCK2). |
|
T16326 |
Cipargamin
|
KAE609,NITD609 |
Parasite
|
|
Cipargamin (NITD609) is an effective antimalarial compound. It has an IC50 of appr 1 nM against P. falciparum. |
|
T67991 |
Iliparcil
|
|
Others
|
|
Iliparcil is an antithrombotic compound with oral activity. |
|
T1861 |
Omipalisib
|
GSK458,GSK2126458 |
PI3K
,
mTOR
,
Autophagy
|
|
Omipalisib (GSK2126458) is a small-molecule pyridylsulfonamide inhibitor of phosphatidylinositol 3-kinase (PI3K) with potential antineoplastic activity. |
|
T4203 |
Ledipasvir (acetone)
|
Ledipasvir acetone,GS-5885 acetone |
HCV Protease
|
|
Ledipasvir (acetone) (GS-5885 acetone) is an HCV NS5A polymerase inhibitor, used for the treatment of hepatitis C virus infection. |
|
T7809L |
Ipamorelin 2 Pivalic acid
|
NNC-26-0161 |
Others
|
|
Ipamorelin 2 Pivalic acid (NNC-26-0161) is a growth-hormone-releasing peptide, induces longitudinal bone growth in rats. |
|
T6252 |
Ipatasertib
|
GDC-0068,RG7440 |
Akt
|
|
Ipatasertib (GDC-0068) (GDC-0068), a highly specific pan-Akt inhibitor, targets Akt1/2/3 with IC50 of 5 nM/18 nM/8 nM, respectively. |
|
T15374 |
Ipatasertib dihydrochloride
|
GDC-0068 dihydrochloride,RG-7440 dihydrochloride |
Akt
,
PKA
|
|
Ipatasertib dihydrochloride (GDC-0068 dihydrochloride) is a highly selective and ATP-competitive inhibitor of pan-Akt (IC50s: 5, 18 and 8 nM for Akt1, Akt2 and Akt3, respectively). |
|
T26296 |
Triparanol
|
MER-29,NSC 65345,NSC-65345,NSC65345 |
Apoptosis
,
Hedgehog/Smoothened
|
|
Triparanol (NSC-65345) interferes with posttranslational modification of Hedgehog signaling molecules as well as the sterol sensing domain of its receptor PTCH1, leading to down-regulation of Hedgehog signaling. Triparan... |
|
TQ0157 |
EIPA
|
L593754,MH 12-43 |
Sodium Channel
,
TRP/TRPV Channel
|
|
EIPA (L593754) (L593754, MH 12-43) is a TRPP3 channel inhibitor (IC50: 10.5 μM). It also inhibits Na+/H+-exchanger (NHE) and macropinocytosis. |
|
T21460 |
Teriparatide acetate
|
hPTH 1-34 (acetate salt),Parathar acetate,Forteo |
Others
|
|
Teriparatide acetate (Forteo) is a PHT agonist, with an IC50 of 2 nM in HEK293 cells.Teriparatide acetate is a recombinant form of parathyroid hormone. It is an effective anabolic (i.e., bone growing) agent used to treat... |
|
T12480 |
Pipamperone
|
Floropipamide,McN-JR 3345,R 3345 |
Others
,
Dopamine Receptor
,
5-HT Receptor
|
|
Pipamperone (McN-JR 3345) binds 5-HT2A closely as receptor. |
|
T2373 |
Vipadenant
|
CEB-4520,BIIB-014 |
Adenosine Receptor
|
|
Vipadenant (CEB-4520)(BIIB-014) is an adenosine A2a antagonist with Ki of 1.3 nM; less potent for A1(Ki=69 nM). |
|
T16887 |
Sipatrigine
|
619C89,BW 619C89 |
Calcium Channel
,
Sodium Channel
|
|
Sipatrigine is a glutamate release inhibitor and voltage-dependent sodium channel. |
|
T6224 |
Iniparib
|
NSC-746045,IND-71677,BSI-201 |
PARP
,
Influenza Virus
|
|
Iniparib (BSI-201) (BSI-201) , a PARP1 inhibitor, exhibits potency in triple-negative breast Y (TNBC). |
|
T68047 |
Clopipazan
|
|
Others
|
|
Clopipazan is an antipsychotic and antidepressant compound.Clopipazan has sedative and anxiolytic activity, possibly due to selective GABergic blockade of certain interneurons. |
|
T26091 |
Riparin III
|
|
|
|
Riparin III is an alcamide isolated from Aniba riparia that has exhibited effects of antidepressant and anxiolytic activities in acute stress behavioral models. |
|
T10772 |
Cevipabulin
|
TTI-237 |
Microtubule Associated
|
|
Cevipabulin (TTI-237) is a microtubule-active antitumor compound and inhibits the binding of [3H] vinblastine to tubulin (IC50: 18-40 nM in the human tumor cell line). |
|
T7146 |
Piperazine adipate
|
|
Parasite
|
|
Piperazine adipate is a potent broad spectrum anthelmintic. |
|
T15257 |
Etripamil
|
MSP-2017,(-)-MSP-2017 |
Calcium Channel
|
|
Etripamil (MSP-2017) displays atrioventricular nodal conduction and prolongs atrioventricular nodal refractory periods by inhibiting calcium ion influx through the calcium slow channels in the atrioventricular node cells... |
|
T11199 |
Endothelial lipase inhibitor-1
|
|
Lipase
|
|
Endothelial lipase inhibitor-1 is a potent endothelial lipase inhibitor with an IC50 of 49 nM. |
|
T4180 |
Adipamidoxime
|
NSC70868 |
Others
|
|
Adipamidoxime (NSC-70868) is an oxime-active compound that inhibits the growth of certain bacteria, fungi, and viruses and has some anti-inflammatory and anti-tumor activities. |
|
T22870 |
IPAG
|
|
Opioid Receptor
|
|
IPAG is a potent σ-receptor antagonist (pKi=4.3). IPAG can induce cell apoptosis. |
|
T7795 |
RIPA-56
|
|
RIP kinase
|
|
RIPA-56 is an inhibitor of RIP1 |
|
T31602 |
Ecopipam
|
Sch-39166,UNII-0X748O646K,Sch 39166 |
Dopamine Receptor
|
|
Ecopipam (UNII-0X748O646K) is a potent, selective and orally active antagonist of dopamine D1/D5 receptor, with Kis of 1.2 nM and 2.0 nM, respectively. Ecopipam shows more than 40-flod selectivity over D2, D4, 5-HT, and ... |
|
T2591 |
Veliparib
|
ABT-888,NSC 737664 |
PARP
,
Autophagy
|
|
Veliparib (ABT-888) (ABT-888) is an orally bioavailable inhibitor of PARP (Kis: 5.2/2.9 nM for PARP1/2). It enhances apoptosis and autophagy. |
|
T24064 |
Fipamezole
|
JP-1730,BVF-025,JP 1730,JP1730 |
Adrenergic Receptor
|
|
Fipamezole is a potent alpha2 adrenergic receptor antagonist that may be useful for studying autonomic dysfunction in Parkinson's disease. |
|
T6765 |
Atipamezole hydrochloride
|
MPV-1248 hydrochloride,Antisedan |
Adrenergic Receptor
|
|
Atipamezole is a synthetic α2 adrenergic receptor antagonist. It has also been researched in humans as a potential anti-Parkinsonian drug. Atipamezole hydrochloride (MPV-1248 hydrochloride) is hydrochloride form of atipa... |
|
T6766 |
Atipamezole
|
Antisedan,MPV 1248 |
Adrenergic Receptor
|
|
Atipamezole (Antisedan) is a synthetic α2 adrenergic receptor antagonist. It has also been researched in humans as a potential anti-Parkinsonian drug. |
|
T5058 |
Pamiparib
|
BGB-290 |
PARP
|
|
Pamiparib (BGB-290) is an orally active, potent, highly selective PARP inhibitor(IC50 of 0.9 nM and 0.5 nM for PARP1 and PARP2, respectively). It has potent PARP trapping, and capability to penetrate the brain, and can b... |
|
T83024 |
Antiparasitic agent-20
|
|
Parasite
|
|
Antiparasitic Agent-20 (Compound 1p) exhibits broad-spectrum activity as a parasitic inhibitor, demonstrating efficacy against T. brucei and T. cruzi with EC50 values of 0.09 µM and 14.1 µM, respectively [1]. |
|
T83025 |
Antiparasitic agent-19
|
|
|
|
Antiparasitic Agent-19 (Compound 40) is a broad-spectrum antiparasitic with minimal toxicity to Trypanosoma brucei, Leishmania infantum, and Trypanosoma cruzi [1]. |
|
T14295 |
Antipain
|
|
Others
|
|
Antipain is a protease inhibitor isolated from Actinomycetes. Antipain inhibits N-methyl-N'-nitro-N-nitrosoguanidine (MNNG)-induced transformation and increases chromosomal aberrations[1][2]. |
|
T31512 |
Dipalmitoyl cystine
|
Palmitoyl cystine |
|
|
Dipalmitoyl cystine is a bioactive chemical. |
|
T29997 |
Amlodipine adipate
|
CJ11828,CJ 11828,CJ-11828 |
|
|
Amlodipine adipate is a medication used to lower blood pressure and prevent chest pain. |
|
T29014 |
Tripartin
|
|
|
|
Tripartin specifically inhibits the histone H3 lysine 9 demethylase KDM4 in HeLa cells. |
|
T79415 |
Antiparasitic agent-18
|
|
Parasite
|
|
Antiparasitic agent-18 (compound 3a) exhibits potent and selective antiprotozoal activity, demonstrating effective inhibition of T. brucei (EC 50 =0.4 µM), T. cruzi (EC 50 =0.21 µM), and L. donovani (EC 50 =0.26 µM) [1]. |
