|
TQ0026 |
MDR-1339
|
DWK-1339 |
Beta Amyloid
,
Gamma-secretase
|
|
|
|
T22360 |
MDR-652
|
|
TRP/TRPV Channel
|
|
MDR-652 is a highly specific and efficacious agonist of nonpungent transient receptor potential vanilloid 1 (TRPV1) with Ki value of 11.4 nM and 23.8 nM for hTRPV1 and rTRPV1 respectively and EC50s for hTRPV1 and rTRPV1 ... |
|
T41248 |
Thiocolchicine
|
|
Microtubule Associated
|
|
Thiocolchicine is an effective inhibitor of tubulin polymerization with an IC50 of 2.5 µM and a Ki of 0.7 µM. Thiocolchicine induces cell apoptosis. Thiocolchicine can be used as an ADC cytotoxin in ADC technology. |
|
T11888 |
LtaS-IN-1
|
|
Others
,
Antibacterial
|
|
|
|
T22269 |
Benzyldodecyldimethylammonium Chloride Dihydrate
|
|
Antibacterial
|
|
Benzyldodecyldimethylammonium chloride dihydrate can be used as an insecticide reagent. It can target drug-resistant bacteria, such as methicillin-resistant Staphylococcus aureus, multidrug-resistant Pseudomonas aerugino... |
|
T6685 |
Sulbactam sodium
|
CP-45899-2 |
Antibacterial
,
Antibiotic
|
|
Sulbactam sodium (CP-45899-2) (Unasyn) is an irreversible β-lactamase inhibitor. |
|
T4989 |
Fosfomycin Tromethamine
|
|
Antibacterial
,
Antibiotic
|
|
An antibiotic produced by Streptomyces fradiae. |
|
T1631 |
Sulbactam
|
CP45899 |
Antibacterial
,
Antibiotic
|
|
Sulbactam (CP45899) is a semi-synthetic beta-lactamase inhibitor. The beta-lactam ring of sulbactam irreversibly binds to beta-lactamase at or near its active site, thereby blocking enzyme activity and preventing metabol... |
|
T3131 |
Fosfomycin calcium
|
Phosphomycin calcium salt,Fosmicin |
Antibacterial
,
Antibiotic
|
|
Fosfomycin calcium (Phosphomycin calcium salt) is a blood-brain barrier penetrating, broad-spectrum antibiotic by irreversibly inhibiting an early stage in cell wall synthesis. |
|
T11983 |
MDRTB-IN-1
|
|
Others
|
|
MDRTB-IN-1 (5aα) is an antibiotic which is against Mycobacterium tuberculosis H37Rv(MIC90 :10.5 μM). |
|
T17216 |
Valspodar
|
PSC 833 |
P-gp
|
|
Valspodar (PSC 833) is a specific P-glycoprotein inhibitor and MDR regulator often used as a chemical sensitizer to study advanced epithelial ovarian cancer. |
|
T16098 |
Islatravir
|
MK-8591 |
HIV Protease
,
Reverse Transcriptase
|
|
Islatravir (MK-8591) is an effective anti-HIV-1 agent. It acts as a nucleoside reverse transcriptase inhibitor (EC50s: 0.068 nM, 3.1 nM, and 0.15 nM for HIV-1 (WT), HIV-1 (M184V), HIV-1 (MDR), respectively). |
|
T11071 |
Dofequidar fumarate
|
MS-209 |
P-gp
|
|
Dofequidar fumarate (MS-209)(MS-209 fumarate), a quinoline-based compound administered orally, is known for counteracting multidrug resistance (MDR) through the inhibition of ABCB1/P-glycoprotein (P-gp) and ABCC1/MDR-ass... |
|
T9587 |
CCTA-1523
|
|
Others
,
ABC
|
|
CCTA-1523 is an efflux function of ABCG2 inhibitor. CCTA-1523 selectively reverses ABCG2-mediated MDR in cancer cells. |
|
T67790 |
Biricodar dicitrate
|
VX 710,VX 710-3 |
NF-κB
,
AChR
|
|
Biricodar dicitrate (VX-710) is a potent MDR inhibitor with no anticancer activity and can be used to study prostate cancer. |
|
T67912 |
PA3552-IN-1
|
|
|
|
PA3552-IN-1 is an antibiotic adjuvant that can reduce the expression of PA3552 and restore the sensitivity of MDR Pseudomonas aeruginosa DK2 strain to Polymyxin B. |
|
T15168 |
DRF-1042
|
|
Others
|
|
DRF-1042 acts to inhibit DNA topoisomerase I. DRF-1042 displays perfect anticancer activity against a panel of human cancer cell lines including multi-drug resistance (MDR) phenotype. |
|
T9830 |
GSK2556286
|
GSK286 |
Antibacterial
|
|
GSK2556286 (GSK286) is an orally active inhibitor of Mycobacterium tuberculosis (M. tuberculosis).GSK2556286 inhibits the growth of human macrophages with an IC50 value of 0.07 μM.GSK2556286 is effective against both mul... |
|
T2657 |
Elacridar
|
GW0918,GW120918,GF120918,GG918 |
BCRP
,
P-gp
|
|
Elacridar (GG918) (GF120918) is an effective BCRP and P-gp (MDR-1) inhibitor. |
|
T23801 |
WCK-4234 sodium
|
WCK-4234,WCK4234,WCK 4234 |
Antibacterial
|
|
WCK-4234 sodium (WCK 4234) is an inhibitor of β-lactamase can be used in studies targeting MDR infections. WCK-4234 sodium inhibits class A, C, and D β-lactamases and OXA carbapenemases. |
|
T6287 |
Tariquidar
|
XR9576 |
P-gp
|
|
Tariquidar (XR9576)(Kd=5.1 nM) is a specific and effective non-competitive inhibitor of P-glycoprotein. It can reverse drug resistance in MDR cell Lines. |
|
T14492 |
BAL-30072
|
|
Others
|
|
BAL30072 shows MIC90 values of 4 μg/mL for MDR Acinetobacter spp. and 8 μg/mL for MDR P. aeruginosa, respectively[1][2]. BAL-30072, a siderophore sulfactam, is a monocyclic beta-lactam antibiotic, with activity against m... |
|
T33754 |
NSC-57969
|
NSC57969 |
|
|
NSC-57969 is a MDR-selective agent, exhibiting a robust Pgp-dependent toxic activity across diverse cancer cell lines. |
|
T68404 |
Azidopine
|
|
|
|
Azidopine is a photoactive dihydropyridine channel blocker which may also act as a multidrug resistant (MDR) modulator. |
|
TQ0043 |
Dofequidar
|
MS-209 |
P-gp
|
|
Dofequidar (MS-209) is a quinoline compound that can reverse P-glycoprotein (P-gp)-mediated MDR. |
|
T69317 |
Dexverapamil
|
|
|
|
Dexverapamil is the R-enantiomer of the calcium channel blocker verapamil. Dexverapamil competitively inhibits the multidrug resistance efflux pump P-glycoprotein (MDR-1), thereby potentially increasing the effectiveness... |
|
T29169 |
XR9051 Hydrochloride
|
|
|
|
XR9051 Hydrochloride, a potent modulator of P-glycoprotein-mediated multidrug resistance (MDR), inhibits the binding of cytotoxics to P-glycoprotein. |
|
T68737 |
XR9051
|
|
|
|
XR9051 is as a potent modulator of P-glycoprotein (P-gp)-mediated multidrug resistance (MDR) following a synthetic chemistry programme based on a natural product lead compound. XR9051 was shown to be a potent inhibitor o... |
|
T28120 |
MTC420
|
MTC-420,MTC 420 |
|
|
MTC420 is a anti-tuberculosis agent with acceptable anti-tuberculosis activity (Mtb IC50 =525 nM, Mtb Wayne IC50 = 76 nM and MDR Mtb patient isolates IC50 = 140 nM). |
|
T15383 |
Glesatinib hydrochloride
|
MGCD265 hydrochloride |
c-Met/HGFR
|
|
Glesatinib hydrochloride is an orally active and potent dual inhibitor of MET/SMO. Glesatinib hydrochloride is also a tyrosine kinase inhibitor. It antagonizes P-glycoprotein mediated multidrug resistance (MDR) in NSCLC. |
|
T33683 |
NITD-304
|
NITD304 |
|
|
NITD-304 is an anti-tuberculosis drug candidate for the treatment of multidrug-resistant tuberculosis (MDR-TB), showing effective activity against both MTB drug-sensitive and multidrug-resistant clinical isolates. |
|
T15384 |
Glesatinib
|
MGCD265 |
c-Met/HGFR
|
|
Glesatinib is an orally active and potent dual inhibitor of MET/SMO. Glesatinib is also a tyrosine kinase inhibitor. It antagonizes P-glycoprotein mediated multidrug resistance (MDR) in NSCLC. |
|
T70695 |
CP 100356
|
|
|
|
CP 100356 is a specific inhibitor of MDR1 (P-Gp), the protypical ABC transporter. The compound has low uM to nM potency for inhibiting several MDR-1 substrates (calcein-AM, digoxin) in transfected MDCKII cells. |
|
T79514 |
ABCG2-IN-2
|
|
BCRP
|
|
ABCG2-IN-2 is a potent inhibitor of ABCG2, exhibiting favorable oral pharmacokinetic profiles in mice, and is applicable for investigating tumor multidrug resistance (MDR) and erythropoietic protoporphyria (EPP) [1]. |
|
T61471 |
Antitubercular agent-13
|
|
|
|
Antitubercular agent-13 (Compound 3d) is an antitubercular agent with MIC values of 0.007 μg/mL and 1.851 μg/mL against MTB H37Rv and MDR-MTB 16833, respectively. Antitubercular agent-13 shows metabolic instability [1]. |
|
T13222 |
TTT-28
|
|
Others
|
|
TTT-28 is a thiazole-valine peptidomimetic, and is a selective ABCB1 (P-gp/MDR1) inhibitor with high efficacy and low toxicity, which reverses the ATP-binding cassette sub-family B member 1 (ABCB1)-mediated Multidrug res... |
|
T72665 |
P-gp inhibitor 3
|
|
|
|
P-gp Inhibitor 3, an effective P-glycoprotein (P-gp) inhibitor, activates P-gp ATPase to inhibit P-gp's efflux function. It demonstrates a relatively stronger multidrug resistance (MDR) reversal ability, thereby enhancin... |
|
T61624 |
Antibacterial agent 106
|
|
|
|
Antibacterial agent 106 (compound 8) is a highly effective orally active antibacterial compound with antibiofilm activity. It demonstrates potent antibacterial effects against multi-drug resistant (MDR)-Gram-positive pat... |
|
T80535 |
AMPR-22
|
|
|
|
AMPR-22, an antimicrobial peptide, binds to bacterial membranes to induce permeabilization and has demonstrated efficacy in a murine sepsis model induced by multidrug-resistant (MDR) strains [1]. |
|
T68326 |
Annamycin
|
|
|
|
Annamycin is a semi-synthetic doxorubicin analogue annamycin with antineoplastic activity. Annamycin intercalates into DNA and inhibits topoisomerase II, resulting in the inhibition of DNA replication and repair and RNA ... |
|
T63655 |
Antimalarial agent 9
|
|
|
|
Antimalarial agent 9 is an effective antimalarial agent, a quinoline-imidazole derivative compound. antimalarial agent 9 showed significant in vitro antimalarial effects against CQ-susceptible strains (IC50-0.14 μM) and ... |
|
T80276 |
Lynronne-3
|
|
|
|
Lynronne-3, an antimicrobial peptide, demonstrates activity against Gram-positive bacteria, including multi-drug resistant (MDR) strains, with a minimum inhibitory concentration (MIC) ranging from 32-128 μg/mL for methic... |
|
T76219L |
MDP1 acetate
|
|
|
|
MDP1 acetate, a derivative of Melittin, compromises the membrane integrity of both Gram-positive and Gram-negative bacteria leading to bacterial death through membrane damage. It exhibits potent antibacterial activity ag... |
|
T78883 |
DprE1-IN-9
|
|
|
|
DprE1-IN-9 (compound B18) is an efficient reversible inhibitor of DprE1, interacting with the enzyme's receptor cavity. It exhibits potent antimycobacterial properties, demonstrating activity against both non-pathogenic ... |
|
T28480 |
Q-203 Ditosylate
|
Q203,Q-203,Q 203 |
|
|
Q-203 Ditosylate, also known as Q-203, is a mycobacterium tuberculosis protein potentially for the treatment of tuberculosis. The optimized IPA compound Q203 inhibited the growth of MDR and XDR M. tuberculosis clinical i... |
|
T39296 |
DS86760016
|
|
|
|
DS86760016 is a highly effective inhibitor of leucyl-tRNA synthetase (LeuRS), demonstrating potent activity against multidrug-resistant (MDR) Gram-negative bacteria including Escherichia coli, Klebsiella pneumoniae, and ... |
|
T80385 |
K11
|
|
|
|
K11, an antimicrobial peptide, demonstrates activity against MDR/XDR K. pneumoniae isolates (MIC: 8-512 μg/mL) and inhibits bacterial biofilm formation. It also acts synergistically with various antibiotics (Chlorampheni... |
|
T78950 |
HIV-1 protease-IN-8
|
|
HIV Protease
|
|
HIV-1 protease-IN-8 (compound 34b) is a potent inhibitor of the HIV-1 protease enzyme, exhibiting an IC50 of 0.32 nM. It demonstrates IC50 values of 0.29 μM for the wild-type HIV-1 (HIV-1 NL4-3) and 1.90 μM against a dru... |
|
T80274 |
Lynronne-1
|
|
|
|
Lynronne-1, an antimicrobial peptide, exhibits activity against Gram-positive bacteria, including multi-drug resistant (MDR) strains, with a minimal inhibitory concentration (MIC) of 8-32 μg/mL for methicillin-resistant ... |
|
T39983 |
SPR206 acetate
|
|
|
|
SPR206 acetate is a polymyxin analog that exhibits antibiotic activity against Gram-negative pathogens, including multidrug-resistant (MDR) variants. By interacting with the outer membrane of the bacterium, SPR206 acetat... |
