|
T23101 |
O-3M3FBS
|
|
Others
|
|
Inactive analog of m-3M3FBS (PLC activator) |
|
T3630 |
Relugolix
|
RVT-601,TAK-385 |
GNRH Receptor
|
|
Relugolix (RVT-601) is an orally available, non-peptide gonadotropin-releasing hormone (GnRH or luteinizing hormone-releasing hormone (LHRH)) antagonist, with potential antineoplastic activity. Relugolix competitively bi... |
|
T2623 |
PD98059
|
PD 98059 |
ERK
,
Aryl Hydrocarbon Receptor
,
MEK
,
Autophagy
|
|
PD98059 is an MEK inhibitor that inhibits MEK1 and MEK2 (IC50=2/50 μM) and is non-ATP-competitive. PD98059 is also antagonistic as a ligand for AHR. PD98059 inhibits autophagy. |
|
T0147 |
Clemastine fumarate
|
HS-592 (fumarate),Meclastine fumarate,Meclastine (fumarate) |
Autophagy
,
Histamine Receptor
|
|
Clemastine fumarate (Meclastine (fumarate)) is a synthetic ethanolamine with anticholinergic, sedative, and histamine H1 antagonistic properties. |
|
T67957 |
Pipoxizine
|
|
|
|
Pipoxizine has an antagonistic effect on histamine-induced bronchoconstriction and may be used in the study of asthma disease. |
|
T67811 |
Tefludazine
|
|
|
|
Tefludazine, a novel neuroleptic with a benzindone structure, is a compound with good oral activity and antagonistic effects on dopamine and 5-hydroxytryptamine receptors. Tefludazine has shown potent dopamine (DA) antag... |
|
T11851 |
Lin28-let-7a antagonist 1
|
|
Others
|
|
Lin28-let-7a antagonist 1, with an IC50 of 4.03 μM for Lin28A-let-7a-1 interaction,and shows a clear antagonistic effect against the Lin28-let-7a interaction. |
|
T23283 |
2-Methoxyidazoxan monohydrochloride
|
RX 821002 hydrochloride |
Adrenergic Receptor
|
|
L-Albizziin (2-Methoxyidazoxan monohydrochloride) is a highly potent selective antagonist of the alpha 2r adrenergic receptor, with little or no antagonistic effect on imidazoline. It has a significantly higher affinity ... |
|
T67894 |
Butyzamide
|
|
Thrombopoietin Receptor
,
JAK
|
|
Butyzamide is an effective and oral Mpl activator. It is a novel non-peptide-based molecule with antagonistic effects on thrombopoietin (TPO) receptors, which promotes proliferation of human Mpl (hMpl) expression and mou... |
|
T23380 |
Sonepiprazole
|
|
Dopamine Receptor
|
|
Sonepiprazole (PNU-101387G) is a chemical compound known for its selective antagonistic properties toward D4 dopamine receptors, exhibiting dissociation constants (Kis) of 3.6 nM and 10.1 nM for rat D4 (rD4) and human D4... |
|
T31195 |
Dalcotidine
|
KU 1257,KU-1257 |
Histamine Receptor
|
|
Dalcotidine (KU 1257) is a novel histamine H2 receptor antagonist with histamine H9 receptor antagonistic activity and antisecretory effects.The Ki value for binding to guinea pig cerebral cortex was 0.040 The KB value f... |
|
T9833 |
Opiranserin hydrochloride
|
|
P2X Receptor
,
GlyT
,
5-HT Receptor
|
|
Opiranserin (VVZ-149) hydrochloride is a dual antagonist of glycine transporter type 2 (GlyT2) and serotonin receptor 2A (5HT2A), with IC50s of 0.86 and 1.3 μM, respectively. It shows antagonistic activity on rP2X3 (IC50... |
|
T9524 |
Lanthanum trichloride
|
|
Others
|
|
Lanthanum trichloride can be used as an analytical reagent and can be used as a raw material for extracting metal lanthanum and as a petroleum cracking catalyst. Lanthanum chloride also has a certain role in the field of... |
|
T67959 |
Pirodomast
|
|
Thrombin
,
Serine Protease
|
|
Pirodomast is a thromboxane A (TXA2) synthase inhibitor. Pirodomast inhibits leukotriene (LT) D4, C4, E4 formation and thromboxane B2 (TXB2) activity, but is weakly or ineffectively antagonistic to guinea pig bronchospas... |
|
T23580 |
20681-S
|
20681 S |
|
|
20681-S has narcotic antagonistic properties and antinociceptive. |
|
T71159 |
F-0401
|
|
|
|
F-0401 is a novel calcium antagonist with platelet-activating factor-antagonistic action. |
|
T68838 |
Medroxalol hydrochloride
|
|
|
|
Medroxalol hydrochloride is an antihypertensive agent that possesses both alpha and beta-adrenergic antagonistic properties. |
|
T70634 |
Psycholeine
|
|
|
|
Psycholeine is isolated from the tropical plant Psychotria oleoides; exhibits somatostatin antagonistic activity on growth hormone secretion. |
|
T68690 |
Temiverine hydrochloride monohydrate
|
|
|
|
Temiverine hydrochloride monohydrate is an anticholinergic drug with calcium antagonistic activity. |
|
T80183 |
Muscarinic toxin 7
|
|
|
|
Muscarinic toxin 7 (MT7) is a peptide exhibiting selective, noncompetitive antagonistic activity at the muscarinic M1 receptor [1]. |
|
T68871 |
Pipradimadol
|
|
|
|
Pipradimadol is a 4,4-disubstituted piperidine derivative with antidepressive and serotonin antagonistic activity. |
|
T25911 |
Oxycinchophen
|
Magnophenyl,Sintofene,Reumartril,Chinoxone |
|
|
Oxycinchophen is a quinoline-like organic, anti-rheumatic compound. It has been used to study P- selectin antagonistic activity, DHOD inhibitory activity, and the effects of anti-inflammatory drugs on vascular smooth mus... |
|
T69021 |
Nifedipine HCl
|
|
|
|
Nifedipine HCl is a potent vasodilator agent with calcium antagonistic action. It is a useful anti-anginal agent that also lowers blood pressure. |
|
T36597 |
ISPA-28
|
|
|
|
ISPA-28 is a specific antagonist of the plasmodial surface anion channel (PSAC). It exerts its antagonistic effects by direct and reversible binding to CLAG3[1][2]. |
|
T71466 |
Sdz 210-096
|
|
|
|
Sdz 210-096 is a novel opiate antagonist. It is a novel 14 beta-benzyl morphinan derivative with antagonistic actions at mu and kappa opiate receptors. This compound has been characterized for luteinizing hormone (LH) se... |
|
T38139 |
Orexin receptor antagonist 2
|
|
|
|
Orexin Receptor Antagonist 2 (compound 30), characterized by its potent antagonistic activity with pKis of 7.69 and 9.78, holds promise for insomnia research[1]. |
|
T71029 |
RCC-36 HCl
|
|
|
|
Rcc 36 is an active metabolite of temiverine that has inhibitory actions toward the atropine-resistant part of contractions, which may be related to the calcium antagonistic actions of these compounds. |
|
T78778 |
D3R/MOR antagonist 1
|
|
Dopamine Receptor
|
|
Compound 114 (D3R/MOR antagonist 1) exhibits dual antagonistic activity at dopamine D3 receptors (D3R) and mu-opioid receptors (MOR), with K i values of 46.5 nM and 691 nM, respectively. It offers analgesic benefits thro... |
|
T28795 |
SKI2496
|
SKI 2496,SKI-2496 |
|
|
SKI2496 is a potent and orally bioavailableantagonist of Gonadotropin-Releasing Hormone Receptor (hGnRHR IC50 = 0.46 nM; max. LH inh. inh. (%, h)= 84%, 12h; LH inh. (24h) = 76%.). SKI2496 exhibits more selective antagoni... |
|
T61347 |
D4R antagonist-1
|
|
|
|
D4R Antagonist-1, characterized by its potent and selective antagonistic action against D4 receptors with an IC50 value of 6.87 μM, holds potential for Parkinson’s disease research [1]. |
|
T78013 |
Pep2-8 TFA
|
|
|
|
Pep2-8 is a peptide that has demonstrated enhanced antagonistic activity against proprotein convertase subtilin/kexin type 9 (PCSK9) [1]. |
|
T83487 |
[Pmp1,Tyr(OEt)2] AVP
|
|
|
|
[Pmp1,Tyr(OEt)2] AVP, a linear analog of the cyclic arginine vasopressin (AVP) antagonist, retains the antagonistic properties of its parent compound while featuring modified phenylalanine (Pmp) and diethyltyrosine (Tyr(... |
|
T82901 |
Belrestotug
|
GSK4428859A,EOS884448,EOS-448 |
|
|
Belrestotug (EOS-448), an antagonistic anti-TIGIT (VSIG9, VSTM3) antibody of the human immunoglobulin G1 kappa (hIgG1 kappa) class, exhibits antineoplastic activity [1]. |
|
T61145 |
Topiramate lithium
|
|
|
|
Topiramate lithium (McN 4853) is a wide-ranging antiepileptic compound with GluR5 receptor antagonistic properties. Its mechanism of action involves enhancing GABAergic activity, inhibiting kainate/AMPA receptors, voltag... |
|
T79266 |
Antihypertensive agent 2
|
|
|
|
Antihypertensive agent 2 (Compound 4g) exhibits effective antagonistic activities against angiotensin II receptor 1 and reduces blood pressure with equal or greater potency than Losartan [1]. |
|
TP1075 |
AUNP-12 TFA (1353563-85-5 free base)
|
AUNP-12 TFA,NP-12 TFA |
|
|
AUNP-12 TFA (NP-12 TFA) is a polypeptide antagonist in the pd-1 signaling pathway, which has the same antagonistic effect on pd-l1 and pd-l2, and can protect the proliferation and effector function of lymphocytes. |
|
T75834 |
Antagonist G TFA
|
|
|
|
Antagonist G TFA is a potent antagonist of vasopressin, with additional, weaker antagonistic effects on GRP and Bradykinin. This compound also promotes AP-1 transcription and enhances cellular sensitivity to chemotherapy... |
|
T80561 |
Atrosab
|
|
|
|
Atrosab, a humanized IgG1 anti-TNFR1 antibody, exhibits antagonistic properties by inhibiting TNF-induced apoptosis and reducing the production of IL-6 and IL-8. It is utilized for research on inflammatory diseases [1]. |
|
T72492 |
GnRH-R antagonist 1
|
|
GNRH Receptor
|
|
GnRH-R antagonist 1 (Compound 21a), is an orally active, membrane-permeable agent with a high binding affinity (IC50=0.57 nM) and potent in vitro antagonistic efficacy (IC50=2.18 nM). It is utilized in research focused o... |
|
T74415 |
Imlunestrant tosylate
|
|
|
|
Imlunestrant tosylate (LY-3484356) is a potent, orally active selective estrogen receptor degrader (SERD) exhibiting purely antagonistic properties. It effectively maintains inhibition of estrogen receptor (ER)-dependent... |
|
T73132 |
DS69910557
|
|
|
|
DS69910557, a potent, selective, and orally active antagonist of the human parathyroid hormone receptor 1 (hPTHR1), exhibits antagonistic activity with an IC50 value of 0.08 μM. It is useful in researching hyperparathyro... |
|
T62918 |
GPR84 antagonist 3
|
|
|
|
GPR84 Antagonist 3 (compound 42), a potent inhibitor of the G-protein-coupled receptor 84 (GPR84), exhibits a pIC50 value of 8.28, indicating strong antagonistic activity by inhibiting GTPγS. Additionally, it possesses a... |
|
T26751 |
BBR 2160
|
BBR-2160,BBR2160 |
|
|
BBR 2160 is a dihydropyridine derivative belonging to the group of the so-called tiampidine. BBR 2160 has calcium-antagonistic properties in cardiac tissue. Intracellular microelectrodes have been used to characterize th... |
|
T80787 |
WAY-649123
|
|
|
|
WAY-649123 is an active molecule that exhibits (in vitro) antagonistic properties against (alpha-1A adrenergic receptors), with a (pKi) of 8.9. It also demonstrates a 70-fold selectivity over (alpha-1B) and 100-fold sele... |
|
T16399 |
Opiranserin
|
|
P2X Receptor
,
GlyT
,
5-HT Receptor
|
|
Opiranserin is a development as an injectable agent for the treatment of postoperative pain. Opiranserin is a non-opioid and non-NSAID analgesic candidate and is a dual antagonist of glycine transporter type 2 (GlyT2) an... |
|
T79547 |
MOR agonist-2
|
|
Opioid Receptor
|
|
Compound 46, designated as MOR agonist-2, serves as a D3R antagonist and a MOR agonist with respective K i values of 7.26 nM and 564 nM. This compound holds potential for analgesic effects attributed to its partial agoni... |
|
T60249 |
RhlR antagonist 1
|
|
|
|
RhlR antagonist 1 is a highly effective antagonist of the RhlR protein, showing an IC50 value of 26 μM. It exhibits selective antagonistic activity against RhlR, with minimal effect on LasR and PqsR. RhlR antagonist 1 st... |
|
T78734 |
Sigma-1 receptor antagonist 5
|
|
Sigma receptor
|
|
Sigma-1 receptor antagonist 5 (compound 12), a 4-pyridylpiperidine derivative, exhibits analgesic properties through its antagonistic action on sigma receptors (Ki=4.5 nM (σ1R), 10 nM (σ2R)) and the histamine H3 receptor... |
|
T70309 |
Dicetrorelix pamoate
|
|
|
|
Dicetrorelix pamoate is a synthetic decapeptide with gonadotropin-releasing hormone (GnRH) antagonistic activity. GnRH induces the production and release of luteinizing hormone (LH) and follicle stimulating hormone (FSH)... |
|
T36593 |
TEI-9648
|
|
|
|
TEI-9648, an analogue of Vitamin D3 Lactone, acts as a potent and specific antagonist to the vitamin D receptor (VDR). This compound effectively blocks the genomic actions mediated by VDR and the Vitamin D responsive ele... |
