|
T4980 |
Betrixaban maleate
|
|
Factor Xa
|
|
Betrixaban maleate is a non-vitamin K oral anticoagulant whose action is driven by the competitive and reversible inhibition of the factor Xa. |
|
T3536 |
AZD1283
|
|
P2Y Receptor
|
|
AZD1283 is an effective P2Y12 receptor antagonist (EC50: 3.0 ug/kg/min, binding IC50: 11 nM). AZD1283 dose-dependently induced increases in blood flow and inhibition of ADP-induced platelet aggregation with antithromboti... |
|
T4132 |
BPTU
|
BMS-646786 |
P2Y Receptor
|
|
BPTU (BMS-646786) is an allosteric antagonist of P2Y1 (EC50 = 0.06-0.3 μM). Non-nucleotide ligand. Binds receptor outside of the helical bundle. Blocks inhibition of spontaneous contraction of rat and mouse colon induced... |
|
T0435 |
Sulfinpyrazone
|
(+/-)-Sulfinpyrazone,G-28315,NSC 75925 |
COX
|
|
Sulfinpyrazone (NSC-75925) is a uricosuric drug that is used to reduce the serum urate levels in gout therapy. It lacks anti-inflammatory, analgesic, and diuretic properties. |
|
T0389 |
Dabigatran etexilate
|
BIBR 1048 |
Thrombin
|
|
Dabigatran etexilate (BIBR 1048) is a thrombin inhibitor, which acts by binding and blocking thrombogenic activity and the prevention of thrombus formation. |
|
T4190 |
Ticlopidine
|
PCR 5332,Ticlid |
ATPase
,
Adiponectin receptor
|
|
Ticlopidine (PCR 5332) is an antiplatelet drug in the thienopyridine family which is an adenosine diphosphate (ADP) receptor inhibitor. |
|
T31206 |
Darexaban
|
YM 150,Darexaban, Tanexaban,YM150 |
Factor Xa
|
|
Darexaban (Tanexaban, YM-150) is a direct inhibitor of Factor Xa.Darexaban and Darexaban glucuronide selectively and competitively inhibit FXA and inhibit prothrombin activity at the site of blood clot (thrombus) formati... |
|
T6182 |
Tirofiban
|
L700462,Aggrastat,MK383 |
Integrin
|
|
Tirofiban (L700462) (MK-383) is a selective palate GPIIb/IIIa antagonist which inhibits platelet aggregation with IC50 of 9 nM. |
|
T5133 |
Dabigatran Etexilate Mesylate
|
BIBR 1048MS,Dabigatran etexilate methanesulfonate |
Thrombin
|
|
Dabigatran Etexilate Mesylate (BIBR 1048MS) is the orally active prodrug of dabigatran. Dabigatran is a reversible and selective, direct thrombin inhibitor (DTI, Ki: 4.5 nM). |
|
T2537 |
Tirofiban hydrochloride monohydrate
|
Tirofiban Hydrochloride,MK-383 Hydrochloride |
ATPase
,
Integrin
|
|
Tirofiban hydrochloride monohydrate (MK-383 Hydrochloride) is a potent non-peptide, glycoprotein IIb/IIIa (integrins alphaIIbbetaIII) antagonist. |
|
T0182L |
Clopidogrel hydrogen sulfate
|
(S)-(+)-Clopidogrel hydrogen sulfate,(S)-(+)-Clopidogrel bisulfate,SR-25990C,Clopidogrel |
P450
,
P2Y Receptor
|
|
Clopidogrel hydrogen sulfate ((S)-(+)-Clopidogrel bisulfate) , a selective, high-affinity P2Y12 receptor antagonist, suppressess fibrinogen binding to platelets and platelet adhesion and aggregation. |
|
T2368 |
Edoxaban Tosylate Monohydrate
|
DU-176b,DU-176b tosylate Monohydrate,Lixiana,Edoxaban |
Factor Xa
,
Thrombin
|
|
Edoxaban(DU-176) is an oral factor Xa (FXa) inhibitor in clinical development for stroke prevention. |
|
T25741 |
Linotroban
|
HN 11500,CL-871502 |
PPAR
|
|
Linotroban（CL-871502） is a potent selective thromboxane (TXA2) receptor antagonist with antithrombotic activity. |
|
T67991 |
Iliparcil
|
|
Others
|
|
Iliparcil is an antithrombotic compound with oral activity. |
|
T13210 |
Trombodipine
|
PCA-4230 |
Antibiotic
|
|
Trombodipine (PCA-4230) is a platelet aggregation inhibitor with antithrombotic activity and protection against Listeria monocytogenes. |
|
T4076 |
Fondaparinux sodium
|
Natural heparin pentasaccharide Sodium,Fondaparin sodium,SR-90107A,Arixtra |
Factor Xa
|
|
Fondaparinux sodium (SR-90107A) is an antithrombin-dependent factor Xa inhibitor with antithrombotic activity. |
|
T27920 |
LY 517717
|
LY-517717,LY517717 |
Factor Xa
|
|
LY 517717 is an orally active inhibitor of coagulation factor Xa with antithrombotic activity for the study of venous thromboembolism (VTE). |
|
T27318 |
Fidexaban
|
CI-1031,BX-807834,PD-200022,CI1031,BX807834,ZK-807834 |
Factor Xa
|
|
Fidexaban (CI1031) is a novel, potent, selective and orally active factor Xa inhibitor that has demonstrated antithrombotic activity in a variety of assays |
|
T80792 |
WAY-639228
|
|
Others
|
|
WAY-639228-A has potential antithrombotic and anticoagulant activity for the study of cerebral thrombosis. |
|
T3757 |
NQ301
|
|
Thrombin
,
Platelet aggregation
|
|
NQ301, an antithrombotic agent, inhibits collagen-challenged rabbit platelet aggregation (IC50: 10 mg/mL). |
|
T9620 |
Sodium Tetradecyl Sulfate
|
|
Others
|
|
Sodium Tetradecyl Sulfate is a detergent sclerosant with antithrombotic effects and commonly used for the treatment of varicose veins. |
|
T24542 |
NP-313
|
NP 313,NSC 4264,NSC-4264,NSC4264 |
|
|
NP-313 (NSC-4264) is a potent antithrombotic agent that inhibits platelet aggregation and activation by inhibiting thromboxane A 2 synthesis and selectively inhibiting SOCC-mediated Ca2+ efflux. |
|
T8580 |
Bupranolol
|
|
Adrenergic Receptor
|
|
Bupranolol is an antagonist of β2-adrenergic receptor and has been used for angina pectoris, hypertension, glaucoma, cardiac arrhythmia and as an antithrombotic. |
|
T3469 |
PCI-27483
|
PCI27483 |
Others
|
|
PCI-27483 is an activated coagulation factor VIIa inhibitor with antithrombotic effects in a baboon model of arterial thrombosis. It also inhibits the growth of BxPC3 xenografts by 42% and 85% at doses of 60 and 90 mg/kg... |
|
T11825 |
LCB-2853
|
|
PPAR
|
|
|
|
T17025 |
Tecarfarin
|
ATI-5000,ATI-5923 |
Others
|
|
Tecarfarin (ATI-5923) is an orally active and potent vitamin K epoxide reductase (VKOR) antagonist and cannabinoid-1 receptor inverse agonist with antithrombotic activity that attenuates abdominal pain and increases inte... |
|
T63966 |
BMS-986141
|
UDM-003183 |
Protease-activated Receptor
|
|
BMS-986141(UDM-003183) is a selective and potent protease-activated receptor-4 (PAR-4) antagonist with oral activity and an IC50 value of 0.4 nM.BMS-98614 exhibits significant antithrombotic effects. |
|
T68002 |
Naroparcil
|
|
Thrombin
|
|
Naroparcil, an orally available thioglycoside analog of 4-methylumbelliferyl β-D-xyloside, showed antithrombotic effects in the Wessler sludge model of venous thrombosis (jugular vein).Naroparcil enhanced the formation o... |
|
T16328 |
Nitroaspirin
|
NCX 4016 |
Apoptosis
,
COX
|
|
Nitroaspirin (NCX 4016) is a nitric oxide donor and a nitro-derivative of Aspirin, which combines with Nitroaspirin to inhibit cyclooxygenase. Nitroaspirin induces significant induction of cell cycle arrest and apoptosis... |
|
T2368L |
Edoxaban
|
Lixiana |
Factor Xa
,
Thrombin
|
|
Edoxaban (Lixiana) (DU-176) is a selective, potent and orally active factor Xa (FXa) inhibitor with K i s of 0.561 nM and 2.98 nM for free FXa and prothrombinase, respectively. Edoxaban is an anticoagulant agent and is a... |
|
T29070 |
Uproleselan
|
|
|
|
Uproleselan has antithrombotic and antineoplastic properties. |
|
T26874 |
BN 50341
|
BN50341,BN-50341 |
|
|
BN 50341 is an inhibitor of antithrombotic platelet activating factor. |
|
T30186 |
AT-1459
|
UNII-JWP323ABVS |
|
|
AT-1459 is a novel direct thrombin inhibitor with antithrombotic efficacy. |
|
T17091 |
Thrombin Inhibitor 2
|
|
Others
|
|
Thrombin Inhibitor 2 is a small molecule direct thrombin inhibitor. Thrombin Inhibitor 2 has antithrombotic activity. |
|
T17024 |
Tecarfarin sodium
|
ATI-5923 sodium |
Others
|
|
Tecarfarin sodium is a novel orally active non-competitive vitamin K epoxide reductase antagonist. Tecarfarin sodium has the antithrombotic activity. |
|
T21471 |
Dazoxiben free base
|
Dazoxiben hydrochloride,Dazoxiben hydrochloride, Dazoxiben HCl,Dazoxiben hydrochloride, UK-37,248-01 |
|
|
Dazoxiben is an antithrombotic agent used to reduce the formation of blood clots. |
|
T28909 |
TA-993 maleate
|
TA 993,TA993,TA-993 |
|
|
TA-993 is a calcium channel antagonist. TA-993 has an antithrombotic effect. |
|
T12741 |
Ro-15-2041
|
|
Others
|
|
Ro 15-2041 is a selective inhibitor of platelet phosphodiesterase, with antithrombotic properties. |
|
T70909 |
AY 31390
|
|
|
|
AY 31390 is a phosphodiesterase (PDE) inhibitor with antithrombotic activity. |
|
T70737 |
HN 11500
|
|
|
|
HN 11500 is an antithrombotic agent and thromboxane A2 receptor antagonist. |
|
T70536 |
Idraparinux Na
|
|
|
|
Idraparinux Na is an Antithrombotic, Indirect, Selective, Synthetic Factor Xa Inhibitor |
|
T68719 |
Ro 15-2041
|
|
|
|
Ro 15-2041 is a selective platelet camp phosphodiesterase inhibitor with antithrombotic properties. |
|
T24898 |
Trifenagrel
|
BW-325U,BW 325U,BW325U |
|
|
Trifenagrel is an antithrombotic. It has been found to produce less gastric irritation and fecal blood loss in humans. |
|
T70458 |
FXIa-6f
|
|
|
|
FXIa-6f is a high affinity, orally bioavailable macrocyclic FXIa inhibitor with antithrombotic activity in preclinical species |
|
T12694 |
Razaxaban hydrochloride
|
BMS 561389 hydrochloride,DPC 906 hydrochloride |
Others
|
|
Razaxaban hydrochloride is a highly potent, selective and orally active inhibitor of factor Xa(Ki of 0.19 nM),has strongly antithrombotic activity. |
|
T12782 |
RWJ-445167
|
3DP-10017 |
Factor Xa
,
Thrombin
|
|
RWJ-445167 is a thrombin and factor Xa dual inhibitor(Ki of 4.0 nM and 230 nM, respectively), with potent antithrombotic activity. |
|
T15256 |
Etofylline clofibrate
|
|
Others
|
|
|
|
T80512 |
Thrombin receptor peptide ligand
|
|
Thrombin
|
|
Thrombin receptor peptide ligand, a thrombin receptor antagonist, serves as an antithrombotic agent [1]. |
|
T16377 |
Odiparcil
|
SB-424323 |
Thrombin
|
|
Odiparcil is an orally active beta-d-thioxyloside analog. Odiparcil is an indirect thrombin inhibitor that exerts its anticoagulant effect through activation of antithrombin II (heparin cofactor II). It also has an antit... |
|
T33579 |
Nafazatrom
|
Nafazatromum |
|
|
Nafazatrom is a pyrazolinone derivative and lipoxygenase inhibitor that increases endogenous prostacyclin (PGI2) and has experimental anticancer activity. Nafazatrom is also an antithrombotic drug that increases prostacy... |
