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T19777 |
ODQ
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Apoptosis
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Others
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Guanylate cyclase
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ODQ is an effective and selective soluble guanylyl cyclase (sGC) inhibitor. |
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T12783 |
RWJ 50271
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Integrin
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RWJ 50271 is a selective lymphocyte function-associated antigen-1/intercellular adhesion molecule-1(LFA-1/ICAM-1) interaction inhibitor( IC50 of 5.0 μM in HL60 cells). |
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T20812 |
Azamethiphos
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AChE
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Azamethiphos, an organothiophosphate insecticide, is used in Atlantic salmon fish farming to control parasites. |
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T76173 |
Inorganic pyrophosphatase
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Inorganic pyrophosphatase (PPase), key for RNA preparation in in vitro transcription reactions and critical in biochemical studies for nucleic acid and protein synthesis [1], hydrolyzes pyrophosphate (PPi) into phosphate... |
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T10009 |
JAK3-IN-7
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JAK
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JAK3-IN-7 is a potent and selective JAK3 inhibitor (IC50<0.01 μM) for the treatment of rejection in organ transplantation, graft-versus-host reaction after organ transplantation, autoimmune disorders, allergic diseases, ... |
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T11318 |
Dopexamine hydrochloride
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FPL60278AR |
Adrenergic Receptor
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Dopexamine hydrochloride (FPL60278AR) is a β2-adrenergic receptor agonist. Dopexamine can attenuate the inflammatory response and protect against organ injury in the absence of significant effects on hemodynamics or regi... |
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T6459 |
Cyclosporine
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Phosphatase
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Cyclosporine is a calcineurin phosphatase pathway inhibitor, used as an immunosuppressant drug to prevent rejection in organ transplantation. |
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T17105 |
TM6089
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HIF/HIF Prolyl-Hydroxylase
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TM6089 is an inhibitor of Prolyl Hydroxylase that stimulates HIF activity without iron chelation, induces angiogenesis, and protects organ against ischemia. |
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T13187 |
Topterone
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Win 17665 |
Androgen Receptor
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T21334 |
Bucillamine
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DE-019,Thiobutarit,Tiobutarit,SA96,DE 019,DE019 |
VEGFR
,
Antioxidant
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Bucillamine (DE019) protects against Ischemia/reperfusion injury in high-risk organ transplants and inhibits the production of VEGF. Bucillamine is an orally active sulfhydryl donor and antioxidant with antirheumatic and... |
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T60144 |
TDI-011536
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Others
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TDI-011536, a potent Lats kinase inhibitor, disrupts Hippo-Yap signaling and promotes the proliferation of lesioned heart muscle cells. This compound is valuable for research in organ conservation and regeneration. |
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T31615 |
Elsibucol
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AGI-1096,UNII-O7T92N1Y8T,AGI 1096 |
Antioxidant
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Elsibucol (AGI 1096) is a VCAM1 inhibitor for the study of organ transplant rejection.Elsibucol is a metabolically stable propanol derivative with antioxidant, anti-inflammatory and anti-proliferative properties. It lowe... |
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T76830 |
Teneliximab
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Chi220,Anti-Human CD40 Recombinant Antibody,BMS 224819 |
TNF
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Teneliximab (Chi220) is a chimeric monoclonal antibody and a tumor necrosis factor receptor superfamily member 5 (CD40) inhibitor that blocks CD40-CD40L interactions.Teneliximab exerts partial agonist activity through CD... |
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T74485 |
STC314
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Others
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STC314 is an anti-infective agent that reverses organ damage caused by excessive immune response by neutralizing extracellular histones and neutrophil trapping networks, and can be used in the study of sepsis and acute r... |
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T19722 |
Benazeprilat
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CGS14831,CGS-14831,CGS 14831 |
RAAS
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Endogenous Metabolite
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Benazeprilat(CGS 14831) is an orally active active metabolite of Benazepril.Benazeprilat has potent antihypertensive activity and can be used in combination with other classes of compounds, including thiazide diuretics a... |
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T9543 |
Syk Inhibitor II hydrochloride
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Others
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The impact of spleen tyrosine kinase (Syk) signaling might be prominent in lupus because (i) Syk is a shared downstream signaling molecule among circulating immune complex, LPS, and (1→3)-β-D-glucan (BG), and (ii) all of... |
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T69431 |
A-420983
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A-420983 is a novel potent Lck inhibitor, exhibiting oral efficacy in animal models of delayed-type hypersensitivity and organ transplant rejection. |
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T38672 |
VTP-27999 Hydrochloride
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VTP-27999 Hcl is an alkyl amine Renin inhibitor; VTP-27999 is useful for Hypertension and End-Organ Diseases.
IC50 value:
Target: Renin |
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T34173 |
P-SCN-Bn-HOPO
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p-SCN-Bn-HOPO is an excellent bifunctional chelating agent for (89)Zr ImmunoPET, with low background, good tumor-organ contrast, and importantly, very low bone uptake for BT474 breast cancer imaging. |
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T27743 |
KRH-594 free acid
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WK14922K,WK-1492,WK-14922K,WK1492 |
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KRH-594 is a potent, specific and insurmountable AT1 receptor antagonist. KRH-594 ameliorates hyperlipidaemia and nephropathy in diabetic spontaneously hypertensive rats. KRH-594 prevents end-organ damage in stroke-pron... |
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T60483 |
Fasedienol
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Fasedienol is a neurochemical stimulator of the vomeronasal organ (VON ) to alleviate the symptoms of premenstrual dysphoric disorder(PMS) and anxiety [1]. |
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T19848 |
Cyclosporin B
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7-L-Alanine-cyclosporin A,Antibiotic S 7481F2 |
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Cyclosporin B is an immunosuppressant that has revolutionized organ transplantation through its use in the prevention of graft rejection. Cyclosporin B displays antiviral properties, inhibiting the entry of hepatitis B i... |
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T70838 |
RO27-3225 TFA
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RO27-3225, also known as RO273225 is a melanocortin type 4 receptor agonist with EC50 = 1 nM. It may alleviate intestinal dysfuntion and brain damage. It has been investigated for an anti-obesity medication. Ro 27-3225... |
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T76719 |
Muromonab
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Muromonab, a monoclonal antibody that targets the CD3 receptor, blocks cytotoxic T cell function and serves as an immunosuppressant agent. It is administered to mitigate acute rejection of solid organ transplants [1]. |
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T82858 |
Bleselumab
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ASKP 1240,Anti-Human CD40 Recombinant Antibody |
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Bleselumab (ASKP 1240), a human anti-CD40 monoclonal antibody (mAb), exhibits high-affinity binding to CD40 (Kd: 0.24 nM) and hinders immune responses by impeding the CD40-CD40L interaction, thereby preventing organ tran... |
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T64239 |
Belatacept
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Belatacept (BMS 224818) is a selective blocker of T-cell costimulation. Belatacept binds CD 80/86 ligands and thus exhibits an inhibitory effect on CD-28-mediated T-cell costimulation. Belatacept can be used to study org... |
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T60238 |
Acloproxalap
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Acloproxalap is a quinoline-based aldehyde scavenger that can be used in studies of diseases with toxic aldehyde accumulation, such as inflammatory diseases of the eye and skin, respiratory diseases such as pneumonia, or... |
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T76958 |
Vilobelimab
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Vilobelimab (CaCP-29, IFX-1), a monoclonal antibody targeting C5a, inhibits this pro-inflammatory complement component which is pivotal in causing organ dysfunction. By preventing the activation and chemotaxis of neutrop... |
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T75847 |
PG-931 TFA
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PG-931 TFA, a potent and selective agonist of the melanocortin 4 (MC4) receptor (IC50=0.58 nM) compared to the hMC3R (IC50=55 nM) and hMC5R (IC50=2.4 nM), is an analog of SHU 9119. This compound has demonstrated efficacy... |
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T37953 |
Sphingomyelins (buttermilk)
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Sphingomyelins (SMs) are bioactive sphingolipids found in mammalian cell membranes.1SMs make up 2-15% of the total organ phospholipid population but are found at higher concentrations in the brain and myelin sheaths surr... |
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T37679 |
3-hydroxy Palmitic Acid
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3-hydroxy Palmitic acid is a form of the 16:0 lipid palmitic acid . The lipid A part of lipopolysaccharides contain various 3-hydroxy fatty acids, making oxylipins such as 3-hydroxy palmitic acid useful as chemical marke... |
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T67921 |
Retinoic acid-d5
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all-trans-Retinoic acid-d5,Isotretinoin-d5,Vitamin A acid-d5,Accutane-d5,ATRA-d5 |
Retinoid Receptor
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Retinoic acid-d5 (Vitamin A acid-d5) is the deuterium-labeled form of Retinoic acid. Retinoic acid is a natural RAR receptor agonist with an IC50 of 14 nM for RARα/β/γ and a Kd of 17 nM for PPARβ/δ. Retinoic acid, a meta... |
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T81182 |
Secretin (swine)
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Secretin (swine), a neuroendocrine hormone first identified as secreted by S cells in the duodenal mucosa, is a 27-amino acid peptide targeting secretin receptors. Present in all mature enteroendocrine cell subsets, it i... |
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T82474 |
Empasiprubart
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ARGX-117 |
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Empasiprubart (ARGX-117) is a humanized inhibitory monoclonal antibody targeting complement C2. It inhibits the formation of C3 proconvertase, obstructing classical and lectin pathway activation by binding to the Sushi-2... |
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T37383 |
1,2,3-Trilinoelaidoyl-rac-glycerol
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1,2,3-Trilinoelaidoyl-rac-glycerol is a triacylglycerol that contains linoelaidic acid at the sn-1, sn-2, and sn-3 positions. Dietary administration of 1,2,3-trilinoelaidoyl-rac-glycerol (0.6-6.3% w/w) lowers serum level... |
