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Search Results for " 3T3-L1 "

ターゲット

阻害剤

天然化合物

リコンビナントタンパク質

カタログ番号	製品名	別名	ターゲット
T62656	GPR81 agonist 1		GPR
	GPR81 agonist 1 is a potent and selective GPR81 agonist with high affinity for human and mouse GPR81.GPR81 agonist 1 inhibits lipolysis of differentiated 3T3-L1 adipocytes, improves insulin sensitivity and glycaemic cont...		GPR
T10877	CPDA		Phosphatase
	CPDA is a new potent inhibitor of SH2 domain-containing inositol phosphatase 2 (SHIP2).		Phosphatase
T8760	NNMTi	5-Amino-1-methylquinolinium	Others
	NNMTi (5-Amino-1-methylquinolinium) is a substrate site-targeting, selective nicotinamide N-methyltransferase (NNMT) inhibitor (IC50 = 1.2 μM; 50 μM SAM, 100 μM NCA) that reduces 3T3-L1 lipogenesis (EC50 = 30μM) and adip...		Others
T9491	Pyraclostrobin		Antibacterial , Antifungal
	Pyraclostrobin is one of the most heavily used fungicides that inhibits mitochondrial complex III of fungal and mammalian cells.		Antibacterial , Antifungal
T9568	SGC-SMARCA-BRDVIII		Epigenetic Reader Domain
	SGC-SMARCA-BRDVIII is a potent and selective inhibitor of SMARCA2, SMARCA4, PB1(2), PB1(3) and PB1(5) with Kds of 35 nM, 36 nM, 3.7 μM, 2.0 μM and 13 nM, respectively.		Epigenetic Reader Domain
T40058	IQZ23	IQZ23
	IQZ23 is a chemical compound that effectively inhibits adipocyte differentiation by activating the AMPK pathway. It demonstrates high efficacy in reducing triglyceride levels (EC50=0.033 μM) in 3T3-L1 adipocytes. Given i...
T83127	AMPK activator 13		AMPK
	AMPK Activator 13 is a potent activator of the AMPK pathway, effectively inhibiting mitotic clonal expansion in 3T3-L1 cells and enhancing mitochondrial oxygen consumption rates. This compound is utilized in the study of...		AMPK
T79678	PPARγ-IN-2		PPAR
	"PPARγ-IN-2 (Compound 5a), a PPARγ inhibitor, exhibits an EC50 of 0.106 μM in inhibiting TG accumulation in 3T3-L1 preadipocytes. Furthermore, PPARγ-IN-2 counteracts obesity and associated metabolic syndrome induced by a...		PPAR
T62052	AMPK activator 6
	AMPK activator 6 (Compound GC) activates the AMPK pathway and reduces lipid content in HepG2 and 3T3-L1 cells. AMPK activator 6 significantly suppresses the increase of total cholesterol (TC), low-density lipoprotein-C (...
T36471	Ternatin
	Ternatin is a cyclic heptapeptide first isolated from the mushroom C. versicolor that has been shown to have cytotoxic and anti-adipogenic effects in vitro. It inhibits adipogenesis with an IC50 value of 27 nM and become...
T71328	Theobromine-d6
	Theobromine-d6 is intended for use as an internal standard for the quantification of theobromine by GC- or LC-MS. Theobromine is a methylxanthine alkaloid and derivative of caffeine that has been found in cocoa beans and...
T36830	9-Nitrooleate
	Nitrated unsaturated fatty acids, such as 10- and 12-nitrolinoleate , cholesteryl nitrolinoleate, and nitrohydroxylinoleate, represent a new class of endogenous lipid-derived signalling molecules. LNO2 isomers serve as p...
T35854	9(Z),11(E)-Conjugated Linoleic Acid (sodium salt)
	9(Z),11(E)-Conjugated linoleic acid is an isomer of linoleic acid that has been found in beef and milk fat.1It binds to peroxisome proliferator-activated receptor α (PPARα; IC50= 140 nM) and activates the receptor in a r...
T35800	MD001
	MD001 is a dual agonist of peroxisome proliferator-activated receptor α (PPARα) and PPARγ.1 It binds to PPARα and PPARγ (Kds = 9.55 and 0.14 μM, respectively) but does not bind to PPARβ/δ at concentrations up to 500 μM. ...
T37579	GW 1929 hydrochloride
	Highly selective orally active peroxisome proliferator-activated receptor (PPAR)γ agonist (pEC50 values are 8.05, < 4 and < 4 for human PPARγ, PPARα and PPARδ receptors respectively). Decreases glucose, fatty acid and tr...

Compounds

Synonym: 5-Amino-1-methylquinolinium

Target: Antibacterial, Antifungal

SGC-SMARCA-BRDVIII

T9568

Synonym:

Target: Epigenetic Reader Domain

9(Z),11(E)-Conjugated Linoleic Acid (sodium salt)

GW 1929 hydrochloride

T37579

Synonym:

Target:

カタログ番号	製品名	別名	ターゲット
TN1836	Kudinoside D		LDL , AMPK , PPAR
	Kudinoside D exerts anti-adipogenic effects through modulation of adipogenic transcription factors via AMPK signaling pathway.		LDL , AMPK , PPAR
T6S0117	Avicularin	Fenicularin	ERK
	Avicularin (Fenicularin) has anti-allergic, anti-inflammatory, hepatoprotective, antioxidant, anti-tumor and other activities. It ameliorates human hepatocellular carcinoma by modulating the activities of NF-κB(p65), COX...		ERK
T13803	N-Oleoyl glycine		Cannabinoid Receptor , Akt , Endogenous Metabolite , PPAR
	N-Oleoyl Glycine, a Lipoamino Acid, Stimulates Adipogenesis Associated With Activation of CB1 Receptor and Akt Signaling Pathway in 3T3-L1 Adipocyte		Cannabinoid Receptor , Akt , Endogenous Metabolite , PPAR
T3220	Euphorbiasteroid	Euphobiasteroid,Euphorbia factor L1	Others , AMPK
	Euphorbiasteroid (Euphobiasteroid) (25-50 μM) decreased differentiation of 3T3-L1 cells via reduction of intracellular triglyceride (TG) accumulation.		Others , AMPK
TN2121	3,5,7,3′,4′-Pentamethoxyflavone	Quercetin 3,5,7,3,4-pentamethyl ether	Others
	3,5,7,3′,4′-Pentamethoxyflavone (Quercetin 3,5,7,3,4-pentamethyl ether) is a natural product. It can induce adipogenesis on 3T3-L1 preadipocytes by regulating transcription factors at an early stage of differentiation.		Others
TN2197	Secoisolariciresinol		TNF
	Secoisolariciresinol is an enterolignan precursor, it has antioxidant, and estrogen-like activities, it can significantly suppress triglyceride (TG) accumulation in 3T3-L1 adipocytes.		TNF
TN1189	13-Methylberberine chloride	13-Methylberberine	Others
	13-Methylberberine chloride shows anti-adipogenic effect on 3T3-L1 adipocytes, it has potential as an anti-obesity drug		Others
T5S2361	Epiberberine		ERK , Beta-Secretase , MEK , BACE , AMPK , AChR , AChE
	1. Epiberberine may be caused drug interactions based on CYP2D6 enzyme. 2. Epiberberine has anti-adipogenic effect is mediated by downregulation of the Raf/MEK1/ERK1/2 and AMPKα/Akt pathways during 3T3-L1 adipocyte diffe...		ERK , Beta-Secretase , MEK , BACE , AMPK , AChR , AChE
TN1206	2,4,6-Trihydroxybenzaldehyde		Others
	2,4,6-Trihydroxybenzaldehyde is a natural product		Others
TN2232	Soyasaponin Ab		NOS , NF-κB , COX
	Soyasaponin Ab may represent a viable candidate for effective vaccine adjuvant, TLR4 receptor dependent pathway may be involved in immune stimulatory effects of soyasaponin Ab.		NOS , NF-κB , COX
T6S2391	L-Chicoric Acid	(-)-Chicoric acid,trans-Caffeoyltartaric acid,Chicoric acid,dicaffeoyltartaric acid	Others , HIV Protease
	L-Chicoric Acid (trans-Caffeoyltartaric acid) has been shown to inhibit hyaluronidase and HIV-1 integrase, and to possess phagoeytosis stimulatory activity in vitro and in vivo and antiviral acitivy. L-Chicoric acid may ...		Others , HIV Protease
T34143	Pronuciferine	(+)-Pronuciferine
	Pronuciferine ameliorate the glucose and lipid metabolism in insulin-resistant 3T3-L1 adipocytes.
T81291	Retrofractamide A
	Retrofractamide A, an amide constituent extracted from Piper chaba fruit, enhances adipogenesis in 3T3-L1 cells [1].
TC0028	Dihydrosamidin		Others
	Dihydrosamidin is a natural product. It inhibiting effect on triacylglycerol accumulation in 3T3-L1 preadipocytes		Others
TN5090	Tachioside		Glucokinase
	Tachioside has antiobesity, antioxidant and α-glucosidase inhibitory activities, it decreases lipid content in 3T3-L1 adipocytes by inhibiting lipogenesis, shows antiobesity activities. Tachioside can inhibit nitric oxid...		Glucokinase
TN4390	Kihadanin B		Akt , PPAR , FOXO1
	Kihadanin B can repress the adipogenesis by decreasing lipid accumulation through the suppression of the Akt-FOXO1-PPARγ axis in 3T3-L1 adipocytes.		Akt , PPAR , FOXO1
TN2228	Soyasaponin Aa		PPAR
	Soyasaponin Aa and soyasaponin Ab dose-dependently markedly inhibit adipocyte differentiation and expression of various adipogenic marker genes, through the downregulation of the adipogenesis-related transcription factor...		PPAR
TN3112	5-Heneicosylresorcinol		NADPH-oxidase , Antifection
	5-Heneicosylresorcinol shows inhibitory effects on the release of β-hexosaminidase from RBL-2H3 cells, it also prevents triglyceride accumulation in 3T3-L1 cells. 5-Heneicosylresorcinol has nematicidal activity against n...		NADPH-oxidase , Antifection
TN4094	Gallocatechin gallate		IL Receptor , NF-κB , ROS , MAPK , PPAR , Fatty Acid Synthase
	Gallocatechin gallate has strong antioxidative, and anti-obesity activities, it inhibits 3T3-L1 differentiation and lipopolysaccharide induced inflammation through MAPK and NF-ÎºB signaling; it also may have anti-diabeti...
T35532	Galegine hydrochloride
	Galegine hydrochloride, a guanidine derivative derived from G. officinalis, plays a role in inducing weight loss in mice and has contributed to the development of biguanides, including metformin and phenformin. This comp...
TN4213	Hirsutenone		ERK , EGFR , IL Receptor , NF-κB , Akt , PI3K , Antifection , mTOR , p53 , Autophagy
	Hirsutenone has potent antioxidant activity, it shows significant free radical scavenging activity and exhibits inhibition effect on the mitochondrial lipid peroxidation.Hirsutenone exhibits anti-cancer, and anti-filaria...
TN5655	Broussonin B
	Broussonins A and B, new phytoalexins from diseased paper mulberry. Broussonin B can induce neurite outgrowth in PC-12 cells at concentration of 50 microg/ml, and show moderate inhibitory activities against a chymotrypsi...
T75611	Tibesaikosaponin V
	Tibesaikosaponin V (TKV), a triterpene diglycoside isolated from the methanol extract of Bupleurum chinense DC roots, effectively inhibits lipid accumulation and triacylglycerol content in adipocytes without inducing cyt...
TN3539	Broussonin A		ERK , IL Receptor , IκB/IKK , NOS , NF-κB , Akt
	Broussonins A and B, new phytoalexins from diseased paper mulberry. Broussonin A shows estrogenic activity with ligand-binding activity of estrogen receptor, transcriptional activity of estrogen-responsive element-lucife...		ERK , IL Receptor , IκB/IKK , NOS , NF-κB , Akt

天然物製品

Kudinoside D

TN1836

Synonym:

Target: LDL, AMPK, PPAR

Target: Cannabinoid Receptor, Akt, Endogenous Metabolite, PPAR

Euphorbiasteroid

T3220

Synonym: Euphobiasteroid,Euphorbia factor L1

Target: Others, AMPK

3,5,7,3′,4′-Pentamethoxyflavone

TN2121

Synonym: Quercetin 3,5,7,3,4-pentamethyl ether

13-Methylberberine chloride

TN1189

Synonym: 13-Methylberberine

Target: ERK, Beta-Secretase, MEK, BACE, AMPK, AChR, AChE

2,4,6-Trihydroxybenzaldehyde

Target: NOS, NF-κB, COX

L-Chicoric Acid

T6S2391

Synonym: (-)-Chicoric acid,trans-Caffeoyltartaric acid,Chicoric acid,dicaffeoyltartaric acid

Target: Others, HIV Protease

Pronuciferine

T34143

Synonym: (+)-Pronuciferine

Target: Akt, PPAR, FOXO1

5-Heneicosylresorcinol

TN3112

Synonym:

Target: NADPH-oxidase, Antifection

Gallocatechin gallate

TN4094

Synonym:

Target: IL Receptor, NF-κB, ROS, MAPK, PPAR, Fatty Acid Synthase

Galegine hydrochloride

Target: ERK, EGFR, IL Receptor, NF-κB, Akt, PI3K, Antifection, mTOR, p53, Autophagy

Target: ERK, IL Receptor, IκB/IKK, NOS, NF-κB, Akt

Recombinant Proteins

Species：

Expression System：

Tag：

カタログ番号	製品名	Species	Expression System
TMPY-01427	AACS Protein, Human, Recombinant (His)	Human	Baculovirus Insect Cells
	Acetoacetyl-CoA Synthetase (AACS) is a novel cytosolic ketone body (acetoacetate)-specific ligase. The AACS in adipose tissue plays an important role in utilizing ketone body for the fatty acid-synthesis during adipose t...
TMPY-02135	S100A16 Protein, Human, Recombinant	Human	E. coli
	S100A16 is a member of S100 protein superfamily that carries calcium-binding EF-hand motifs. S100 proteins are cell- and tissue-specific and are involved in many intra- and extracellular processes through interacting wit...

AACS Protein, Human, Recombinant (His)

TMPY-01427

Species: Human

Expression System: Baculovirus Insect Cells

S100A16 Protein, Human, Recombinant

TMPY-02135

Species: Human

Expression System: E. coli