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カタログ番号	製品名	別名	ターゲット
T14152	Akt1 and Akt2-IN-1		Akt
	Akt1 and Akt2-IN-1 is an allosteric inhibitor of Akt1 (IC50=3.5 nM) and Akt2 (IC50=42 nM). It has potent and balanced activity.		Akt
T73255	Akt1-IN-1
	Akt1-IN-1 is a potent and selective inhibitor of Akt1, demonstrating an IC50 of 18.79 nM in MIA PaCa-2 cells, indicating its high efficacy in inhibiting this specific kinase. Notably, it shows no significant teratogenici...
T79214	Tubulin/AKT1-IN-1		Akt
	Tubulin/AKT1-IN-1 (Compound D1-1) serves as an inhibitor of both tubulin polymerization and AKT pathway activation, effectively suppressing proliferation and metastasis of H1975 cells while modestly inducing apoptosis. T...		Akt
T72886	Akt1&PKA-IN-2
	Akt1&PKA-IN-2 ((R)-29), a compound with specificity towards PKB/AKT and notable selectivity for cyclin-dependent kinase 2 (CDK2), effectively inhibits AKT1, PKAa, and CDK2a with IC50 values of 0.007 µM, 0.01 µM, and 0.69...
T72885	Akt1&PKA-IN-1
	Akt1&PKA-IN-1 is a potent dual inhibitor targeting Akt and PKA, exhibiting IC50 values of 0.11 μM for Akt, 0.03 μM for PKAα, and 9.8 μM for CDK2. Notably, it demonstrates selectivity for cyclin-dependent kinase 2 (CDK2).
T3467	Miransertib	ARQ-092,AKT inhibitor 2	Akt , Parasite
	Miransertib (ARQ-092) is an orally bioavailable, selective, and potent allosteric Akt inhibitor.		Akt , Parasite
T38846	Vevorisertib trihydrochloride	ARQ 751 trihydrochloride	Akt
	Vevorisertib trihydrochloride (ARQ 751 trihydrochloride) is a selective and potent inhibitor of pan-AKT and AKT1-E17K mutations, inhibiting AKT1, AKT2 and AKT3. Vevorisertib trihydrochloride is used in the study of hepat...		Akt
T6139	A-674563	A674563	ERK , GSK-3 , Akt , PKA , CDK
	A-674563 is an Akt1 inhibitor with Ki of 11 nM, modest potent to PKA and >30-fold selective for Akt1 over PKC.		ERK , GSK-3 , Akt , PKA , CDK
T3346	AKT inhibitor VIII	AKTi-1/2	Apoptosis , Akt
	AKT inhibitor VIII (AKTi-1/2) is a highly specific Akt1/2 inhibitor (IC50: 58/210 nM). The selectivity for Akt1 is higher about 36-fold than Akt3.		Apoptosis , Akt
T6139L	A-674563 2HCl(552325-73-2(fb-2hcl))		ERK , Akt , PKA , CDK , PKC
	A-674563 2HCl is an Akt1 inhibitor with Ki of 11 nM, modest potent to PKA and >30-fold selective for Akt1 over PKC.		ERK , Akt , PKA , CDK , PKC
T7315	BAY1125976		Akt
	BAY1125976 is an allosteric inhibitor of Akt1 and Akt2 (IC50s of 5.2 and 18 nM, respectively, in a time-resolved FRET assay)		Akt
T11928	M2698	MSC2363318A	Akt , mTOR
	M2698 (MSC2363318A) is an inhibitor of p70S6K, Akt1 and Akt3 with IC50s of 1 nM. M2698 shows anti-cancer activity.		Akt , mTOR
T15374	Ipatasertib dihydrochloride	GDC-0068 dihydrochloride,RG-7440 dihydrochloride	Akt , PKA
	Ipatasertib dihydrochloride (GDC-0068 dihydrochloride) is a highly selective and ATP-competitive inhibitor of pan-Akt (IC50s: 5, 18 and 8 nM for Akt1, Akt2 and Akt3, respectively).		Akt , PKA
T4444	A-674563 HCl (552325-73-2(free base))		ERK , Akt , PKA , CDK , PKC
	A-674563 is an orally available, ATP-competitive, and reversible inhibitor of Akt (Ki: 11 nM for Akt1) [1]. It exhibits inhibitory activity against PKA and Cdk2 (IC50: 16/46 nM) but is 10- to >1, 800-fold selective for A...		ERK , Akt , PKA , CDK , PKC
T6252	Ipatasertib	GDC-0068,RG7440	Akt
	Ipatasertib (GDC-0068) (GDC-0068), a highly specific pan-Akt inhibitor, targets Akt1/2/3 with IC50 of 5 nM/18 nM/8 nM, respectively.		Akt
T7885	Afuresertib hydrochloride		ROCK , Akt , PKC
	Afuresertib hydrochloride is an inhibitor of Akt kinase (Kis of 0.08/2/2.6 nM for Akt1/Akt2/Akt3 respectively)		ROCK , Akt , PKC
T2482	AT13148		ROCK , SGK , Akt , PKA , S6 Kinase
	AT13148 is an oral-active and ATP-competitive, multi-AGC kinase inhibitor for Akt1/2/3, p70S6K, PKA, and ROCKI/II.		ROCK , SGK , Akt , PKA , S6 Kinase
T6304	AT7867		Akt , PKA , S6 Kinase
	AT7867 is a potent ATP-competitive inhibitor of Akt1/2/3 and p70S6K/PKA with IC50 of 32 nM/17 nM/47 nM and 85 nM/20 nM, respectively; little activity outside the AGC kinase family.		Akt , PKA , S6 Kinase
T23695	Akt-I-1,2		Akt
	Akt-I-1,2 is a selective inhibitor of Akt1 and Akt2.		Akt
T25017	AKT-I-1		Akt
	AKT-I-1 is a selective reversible Akt1 inhibitor.		Akt
T14072	A-443654		ERK , VEGFR , GSK-3 , FLT , Casein Kinase , MAPK , Akt , PKA , Chk , CDK , Src , PKC , S6 Kinase
	A-443654 is a pan-Akt inhibitor. A-443654 has equal potency against Akt1, Akt2, or Akt3 within cells (Ki=160 pM).
T6285	GSK-690693	GSK690693	Serine Protease , Akt , PKC , AMPK , Autophagy
	GSK-690693 is a pan-Akt inhibitor targeting Akt1/2/3 with IC50 of 2 nM/13 nM/9 nM, also sensitive to the AGC kinase family: PKA, PrkX and PKC isozymes. Phase 1.		Serine Protease , Akt , PKC , AMPK , Autophagy
T1952	MK-2206 dihydrochloride	MK-2206 2HCl	Apoptosis , Akt , Autophagy
	MK-2206 dihydrochloride (MK-2206 2HCl) is a variant Akt inhibitor that inhibits Akt1, Akt2, and Akt3 (IC50=8/12/65 nM) with orally active, highly potent and selective potency. MK-2206 dihydrochloride exhibits antitumor a...		Apoptosis , Akt , Autophagy
T1920	Capivasertib	AZD5363	Akt , PKA , mTOR , Autophagy
	Capivasertib (AZD5363) is a broad-spectrum AKT inhibitor with inhibitory activity against Akt1, Akt2, and Akt3 (IC50=3/7/7 nM) with oral activity. Capivasertib has antitumor activity for the treatment of breast cancer.		Akt , PKA , mTOR , Autophagy
T39733	Hu7691 free base		Akt
	Hu7691 free base is an orally active, potent and selective Akt inhibitor with anti-proliferative and neurogenic effects on a variety of neuroblastoma cell lines.Hu7691 free base inhibits Akt1, Akt2, and Akt3 and induces ...		Akt
T14860	CaMKII-IN-1		CaMK , Autophagy
	CaMKII-IN-1 is a potent and highly selective CaMKII inhibitor (IC50: 63 nM). It has significantly high selectivity against CaMKIV, p38a, MLCK, Akt1, and PKC.		CaMK , Autophagy
T9545	Compound 1T-0219 (SC)		FAK
	Compound 1T-0219 (SC) is a blocker of AKT1-FAK interaction reducing the stimulation of FAK phosphorylation in response to extracellular pressure in human SW620 colon cancer cells without affecting basal FAK phosphorylati...		FAK
T14034	3CAI		Akt
			Akt
T9544	Compound 1T-0216		Others
	Compound 1T-0216 is a blocker of AKT1-FAK interactions and reduces stimulation of FAK phosphorylation by extracellular stress in human SW620 colon cancer cells without affecting basal FAK phosphorylation.		Others
T1911	Afuresertib	GSK2110183C,GSK2110183	ROCK , Akt , PKC
	Afuresertib (GSK2110183) is an orally bioavailable inhibitor of the serine/threonine protein kinase Akt (protein kinase B) with potential antineoplastic activity.		ROCK , Akt , PKC
T6849	Uprosertib	GSK2141795,GSK795	Akt
	Uprosertib (GSK2141795) (GSK2141795) is a selective, ATP-competitive, and orally bioavailable Akt inhibitor with IC50 of 180 nM, 328 nM, and 38 nM for Akt 1, 2 and 3, respectively. Phase 2.		Akt
T6419	BMS-536924	HY-10262,BMS 536924,CS-0117	Apoptosis , FAK , MEK , IGF-1R , Src
	BMS-536924 (BMS 536924) is an ATP-competitive IGF-1R/IR inhibitor with IC50 of 100 nM/73 nM, modest activity for Mek, Fak, and Lck with very little activity for Akt1, MAPK1/2.		Apoptosis , FAK , MEK , IGF-1R , Src
T15056	DB07107		Akt
	DB07107 is a potent inhibitor of drug resistant T315I mutant Bcr-Abl tyrosine kinase and a potent Akt1 inhibitor (IC50: 360 nM).		Akt
T10274	AKT-IN-2		Akt
	AKT-IN-2 is a selective, and orally bioavailable AKT inhibitor (IC50: 5 nM for AKT1).		Akt
T15428	Uprosertib hydrochloride	GSK2141795 (hydrochloride)	Others
	Uprosertib hydrochloride is a potent and selective inhibitor of pan-Akt (IC50: 180/328/38 nM for Akt1/Akt2/Akt3, respectively).		Others
T25791	Merck-22-6	Merck 22 6,Merck226
	Merck-22-6 is an allosteric dual inhibitor of Akt1, Akt2.
T61680	AKT-IN-5
	AKT-IN-5 (Example 8) is a chemical compound known as an Akt inhibitor, specifically targeting Akt1 and Akt2. Its potency is reflected in IC50 values of 450 nM and 400 nM for Akt1 and Akt2, respectively [1].
T11664	INY-03-041		Others
	INY-03-041, a potent and highly selective PROTAC-based pan-AKT degrader, inhibits AKT1, AKT2, and AKT3 with IC50s of 2.0 nM, 6.8 nM, and 3.5 nM, respectively. This compound consists of the ATP-competitive AKT inhibitor G...		Others
T39930	MS98
	MS98 is a highly effective and specific PROTAC AKT degrader compound that effectively targets and depletes total AKT (T-AKT) within cells, exhibiting a DC 50 value of 78 nM. This compound readily binds to AKT1, AKT2, and...
T28203	NSC156529	NSC-156529,NSC 156529
	NSC156529 downregulates AKT1 signaling. NSC156529 efficiently decreases the proliferation of human cancer cells in vitro, and substantially inhibits the growth of prostate tumor xenografts in vivo.
T39899	Hu7691		Akt
	Hu7691 is an orally active, selective and potent Akt inhibitor that inhibits Akt1, Akt2 and Akt3, inhibits proliferation of neuroblastoma cells and induces differentiation of neuroblastoma cells.		Akt
T74983	MS15
	MS15 is a potent, selective degrader of AKT PROTAC, effectively inhibiting activities of AKT1, AKT2, and AKT3. It exhibits IC50 values of 798 nM for AKT1, 90 nM for AKT2, and 544 nM for AKT3, respectively [1].
T10275	AKT-IN-3		Akt
	AKT-IN-3 is a potent, orally active low hERG blocking Akt inhibitor (IC50: 1.4 nM, 1.2 nM, and 1.7 nM for Akt1, Akt2, and Akt3). AKT-IN-3 (compound E22) also exhibits good inhibitory activity against other AGC family kin...		Akt
T62842	AKT-IN-8
	AKT-IN-8 is a potent inhibitor of AKT, acting on AKT1 (IC50: 4.46 nM), AKT2 (IC50: 2.44 nM) and AKT3 (IC50: 9.47 nM).
T22247	Miransertib (ARQ 092) HCl
	Miransertib hydrochloride (ARQ-092 hydrochloride) is a powerful, orally bioavailable, selective, and allosteric inhibitor of Akt. It exhibits an inhibitory concentration (IC50) of 2.7 nM, 14 nM, and 8.1 nM against Akt1, ...
T39928	MS170
	MS170 is a highly effective and specific PROTAC AKT degrader compound that exhibits potent activity. It efficiently reduces the levels of total AKT (T-AKT) within cells, with a DC 50 value of 32 nM. Furthermore, MS170 de...
T63039	AKT-IN-13
	AKT-IN-13 (compound 4b) is a potent inhibitor of Akt, acting on Akt1 (IC50: 1.6 nM), Akt2 (IC50: 2.4 nM) and Akt3 (IC50: 0.3 nM). AKT-IN-13 can be used in anticancer research.
T25394	ETB067	ETB-067,ETB 067
	ETB067, an H-89 analog, acts as a PKA and AKT1 inhibitor with specificity on no longer inhibiting CAMK2B and neither affecting viability of mice nor causing any detectable tissue damage at the dose given.
T38847	Vevorisertib	Vevorisertib,ARQ 751
	Vevorisertib (ARQ 751) is a highly effective oral compound that selectively inhibits pan-AKT serine/threonine kinases such as AKT1 (with an IC50 value of 0.55 nM), AKT2 (with an IC50 value of 0.81 nM), and AKT3 (with an ...
T39958	(32-Carbonyl)-RMC-5552
	(32-Carbonyl)-RMC-5552 is a highly effective mTOR inhibitor, exhibiting inhibitory effects on both mTORC1 and mTORC2 substrate phosphorylation. Specifically, it significantly suppresses the phosphorylation of p-P70S6K-(T...

Compounds

Akt1 and Akt2-IN-1

Synonym: ARQ-092,AKT inhibitor 2

Target: Akt, Parasite

Vevorisertib trihydrochloride

T38846

Synonym: ARQ 751 trihydrochloride

Target: ERK, GSK-3, Akt, PKA, CDK

AKT inhibitor VIII

T3346

Synonym: AKTi-1/2

Target: Apoptosis, Akt

A-674563 2HCl(552325-73-2(fb-2hcl))

T6139L

Synonym:

Target: ERK, Akt, PKA, CDK, PKC

Ipatasertib dihydrochloride

T15374

Synonym: GDC-0068 dihydrochloride,RG-7440 dihydrochloride

Target: Akt, PKA

A-674563 HCl (552325-73-2(free base))

T4444

Synonym:

Target: ERK, Akt, PKA, CDK, PKC

Ipatasertib

T6252

Synonym: GDC-0068,RG7440

Target: Akt

Afuresertib hydrochloride

T7885

Synonym:

Target: ROCK, Akt, PKC

AT13148

T2482

Synonym:

Target: ROCK, SGK, Akt, PKA, S6 Kinase

AT7867

T6304

Synonym:

Target: Akt, PKA, S6 Kinase

Target: ERK, VEGFR, GSK-3, FLT, Casein Kinase, MAPK, Akt, PKA, Chk, CDK, Src, PKC, S6 Kinase

GSK-690693

T6285

Synonym: GSK690693

Target: Serine Protease, Akt, PKC, AMPK, Autophagy

MK-2206 dihydrochloride

T1952

Synonym: MK-2206 2HCl

Target: Apoptosis, Akt, Autophagy

Capivasertib

T1920

Synonym: AZD5363

Target: Akt, PKA, mTOR, Autophagy

Target: CaMK, Autophagy

Compound 1T-0219 (SC)

Synonym: GSK2110183C,GSK2110183

Target: ROCK, Akt, PKC

Uprosertib

T6849

Synonym: GSK2141795,GSK795

Target: Akt

BMS-536924

T6419

Synonym: HY-10262,BMS 536924,CS-0117

Target: Apoptosis, FAK, MEK, IGF-1R, Src

Uprosertib hydrochloride

T15428

Synonym: GSK2141795 (hydrochloride)

Target: Others

Merck-22-6

T25791

Synonym: Merck 22 6,Merck226

Synonym: NSC-156529,NSC 156529

Miransertib (ARQ 092) HCl

Synonym: ETB-067,ETB 067

Target:

Vevorisertib

T38847

Synonym: Vevorisertib,ARQ 751

Target:

(32-Carbonyl)-RMC-5552

T39958

Synonym:

Target:

カタログ番号	製品名	別名	ターゲット
T2790	Oridonin	NSC-250682,Rubescenin,Isodonol,Rubescensin A	Akt , Antibacterial
	Oridonin (NSC-250682) is a diterpenoid isolated from Rabdosia rubescens with anti-tumor, anti-bacterial and anti-inflammatory effects. It acts as an inhibitor of AKT, with IC50s of 8.4 and 8.9 μM for AKT1 and AKT2.		Akt , Antibacterial
T40562	24-Methylenecycloartanyl ferulate
	24-Methylenecycloartanyl ferulate, a compound belonging to the γ-oryzanol family, demonstrates the ability to enhance parvin-beta expression within human breast cancer cells. Furthermore, it exhibits potential as an ATP-...

天然物製品

Oridonin

T2790

Synonym: NSC-250682,Rubescenin,Isodonol,Rubescensin A

Target: Akt, Antibacterial

24-Methylenecycloartanyl ferulate

T40562

Synonym:

Target:

Recombinant Proteins

Species：

Expression System：

Tag：

カタログ番号	製品名	Species	Expression System
TMPY-04552	AKT1 Protein, Human, Recombinant (His)	Human	Baculovirus Insect Cells
	v-akt murine thymoma viral oncogene homolog 1 (AKT1), or protein kinase B-alpha (PKB-ALPHA) is a serine-threonine protein kinase, belonging to the Protein Kinase Superfamily. AKT1 is a major mediator of the responses to ...
TMPJ-00166	SCF Protein, Mouse, Recombinant	Mouse	E. coli
	Mouse stem cell factor (SCF), is the ligand for the receptor-type protein-tyrosine kinase KIT. It plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gameto...
TMPY-04387	AKT2 Protein, Human, Recombinant (His & GST)	Human	Baculovirus Insect Cells
	AKT (AK mouse plus Transforming or Thymoma) is a frequent oncogene expressed in most tissues which includes three isoforms AKT1, AKT2, and AKT3. Hyperactivation of AKT signaling is a central key in many human cancer prog...
TMPH-01539	ILK Protein, Human, Recombinant (His)	Human	Baculovirus Insect Cells
	Receptor-proximal protein kinase regulating integrin-mediated signal transduction. May act as a mediator of inside-out integrin signaling. Focal adhesion protein part of the complex ILK-PINCH. This complex is considered ...
TMPJ-00396	SEMA4D Protein, Human, Recombinant (aa 22-734, His)	Human	HEK293 Cells
	Semaphorin-4D is also known as A8,BB18, GR3, CD100. Semaphorin-4D belongs to the semaphorin family containing 1 Ig-like C2-type domain, 1 PSI domain and 1 Sema domain. It is the cell surface receptor for PLXN1B and PLXNB...
TMPJ-00895	SCF Protein, Rat, Recombinant (HEK293, His)	Rat	HEK293 Cells
	SCF/C-kit ligand is the ligand of the tyrosine-kinase receptor encoded by the KIT locus. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, ...
TMPJ-00894	SCF Protein, Rat, Recombinant (His)	Rat	E. coli
	Stem cell factor (SCF), is the ligand for the receptor-type protein-tyrosine kinase KIT. It plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesi...
TMPH-03266	CHI3L1 Protein, Rat, Recombinant (His)	Rat	E. coli
	Carbohydrate-binding lectin with a preference for chitin. Has no chitinase activity. May play a role in tissue remodeling and in the capacity of cells to respond to and cope with changes in their environment. Plays a rol...
TMPY-06815	SYAP1 Protein, Human, Recombinant (His)	Human	Baculovirus Insect Cells
	Synapse-associated protein 1 (SYAP1), also known as PRO3113 and BSTA, belongs to the synapse-associated BSD domain family, featuring three α-helices and two conserved tryptophan and phenylalanine residues located at the ...
TMPY-04461	TRIB3 Protein, Human, Recombinant (GST)	Human	Baculovirus Insect Cells
	Tribbles homolog 3, also known as Neuronal cell death-inducible putative kinase, p65-interacting inhibitor of NF-kappa-B, SINK and TRIB3, is a Nucleus protein that belongs to the protein kinase superfamily and CAMK Ser/T...
TMPH-02549	FHIT Protein, Mouse, Recombinant (His)	Mouse	E. coli
	Possesses dinucleoside triphosphate hydrolase activity. Cleaves P(1)-P(3)-bis(5'-adenosyl) triphosphate (Ap3A) to yield AMP and ADP. Can also hydrolyze P(1)-P(4)-bis(5'-adenosyl) tetraphosphate (Ap4A), but has extremely ...
TMPJ-00395	SEMA4D Protein, Mouse, Recombinant (hFc)	Mouse	HEK293 Cells
	SEMA4D is a member of the semaphorin family,contains one Ig-like C2-type domain, one PSI domain and one Sema domain. SEMA4D is strongly expressed in lymphoid tissues, especially in the thymus, as well as in the nervous t...