|
T6065 |
Triciribine
|
VD-0002,Tricyclic nucleoside,NSC 154020,API-2,TCN |
Akt
,
HIV Protease
,
DNA/RNA Synthesis
|
|
Triciribine (NSC-154020) is a DNA synthesis inhibitor, and it also inhibits Akt and HIV-1/2. |
|
T83937 |
Tricyclic cytosine tC
|
|
|
|
Tricyclic cytosine (tC) is a fluorescent analog of cytosine designed for RNA imaging within live cells, facilitating the study of RNA synthesis, degradation, and trafficking with single-cell precision through confocal im... |
|
T3086 |
Mesoridazine Besylate
|
Mesoridazine benzenesulfonate,Serentil |
Dopamine Receptor
,
5-HT Receptor
|
|
Mesoridazine Besylate (Serentil) is a piperidine neuroleptic drug belonging to the class of drugs called phenothiazines, used in the treatment of schizophrenia. It is a metabolite of thioridazine. |
|
T4274 |
Melitracen hydrochloride
|
Thymeol hydrochloride,Melixeran |
Dopamine Receptor
,
5-HT Receptor
|
|
Melitracen hydrochloride (Thymeol hydrochloride) , an antidepressant, is used as potential dopamine D1/2 receptor antagonist to treat depression. |
|
T1327 |
Nortriptyline hydrochloride
|
Desitriptyline HCl,EN-7048 hydrochloride,Desmethylamitriptyline hydrochloride,ELF-101 hydrochloride |
Apoptosis
,
Dopamine Receptor
,
5-HT Receptor
,
Adrenergic Receptor
,
AChR
,
Norepinephrine
,
Autophagy
,
Histamine Receptor
,
Drug Metabolite
|
|
Nortriptyline hydrochloride (ELF-101 hydrochloride) is a metabolite of AMITRIPTYLINE that is also used as an antidepressive agent. Nortriptyline is used in major depression, dysthymia, and atypical depressions. |
|
T20025 |
Imipramine
|
Melipramine,HSDB3100,HSDB 3100,Dimipressin,HSDB-3100 |
|
|
Imipramine is an agent of tricyclic antidepressants. |
|
T37015 |
Iprindole
|
|
5-HT Receptor
|
|
Iprindole, a tricyclic indole antidepressant, is a dual weak inhibitor of noradrenaline and 5-HT uptake [1]. |
|
T22240 |
Amitriptyline
|
|
Sigma receptor
,
5-HT Receptor
,
Norepinephrine
,
Histamine Receptor
|
|
Amitriptyline (MK-230, N-750, Ro41575) is a tricyclic antidepressant (TCA) with analgesic properties. Amitriptyline is widely used to treat depression and neuropathic pain. |
|
T0172 |
Maprotiline hydrochloride
|
Maprotiline HCl,Psymion,Deprilept,Ludiomil |
5-HT Receptor
,
Adrenergic Receptor
,
AChR
,
Norepinephrine
,
Autophagy
,
Histamine Receptor
|
|
Maprotiline hydrochloride (Psymion) is a bridged-ring tetracyclic antidepressant that is both mechanistically and functionally similar to the tricyclic antidepressants, including side effects associated with its use. |
|
T0943 |
Carbamazepine
|
NSC 169864 |
Mitophagy
,
Sodium Channel
,
Autophagy
|
|
Carbamazepine (NSC-169864) is a tricyclic compound chemically related to tricyclic antidepressants (TCA) with anticonvulsant and analgesic properties. Carbamazepine exerts its anticonvulsant activity by reducing polysyna... |
|
T12232 |
Nitroxazepine
|
CIBA 2330Go |
Serotonin Transporter
|
|
Nitroxazepine (CIBA 2330Go) is a serotonin-norepinephrine reuptake inhibitor, and treatment depression. Nitroxazepine is a tricyclic antidepressant (TCA) for the research of depression |
|
T0255 |
Clomipramine hydrochloride
|
Clomipramine HCl,Anafranil |
Dopamine Receptor
,
5-HT Receptor
,
Serotonin Transporter
,
Norepinephrine
,
GST
|
|
Clomipramine hydrochloride (Anafranil) is a tricyclic antidepressant similar to IMIPRAMINE that selectively inhibits the uptake of serotonin in the brain. It is readily absorbed from the gastrointestinal tract and demeth... |
|
T7941 |
Imipramine hydrochloride
|
Imipramine (hydrochloride),Tofranil,G 22355,Imipramine HCl,Melipramine |
Serotonin Transporter
|
|
Imipramine hydrochloride (Imipramine HCl) is a first generation tricyclic antidepressant that acts primarily as an inhibitor of serotonin and norepinephrine transporters (Kds = 1.4 and 37 nM, respectively).Imipramine hyd... |
|
T0074L |
Chlorprothixene hydrochloride
|
NSC 78193,Minithixen,Truxal hydrochloride,NSC 56379,NSC 169899,Minithixen hydrochloride |
Dopamine Receptor
,
5-HT Receptor
,
Antibacterial
,
AChR
,
Histamine Receptor
|
|
Chlorprothixene hydrochloride (Truxal hydrochloride) brings strong blocking effects by blocking the 5-HT2 D1, D2, D3, histamine H1, muscarinic and alpha1 adrenergic receptors. Chlorprothixene hydrochloride s a typical an... |
|
T0204 |
Protriptyline hydrochloride
|
Protriptyline HCl |
5-HT Receptor
,
AChE
|
|
Protriptyline Hydrochloride is the hydrochloride salt form of protriptyline, a tricyclic secondary amine with an antidepressant property. Protriptyline hydrochloride (Protriptyline HCl) blocks the re-uptake of norepineph... |
|
T60330 |
Metapramine
|
|
|
|
Metapramine (19560 RP) is a tricyclic antidepressant[1]. Metapramine inhibits norepinephrine reuptake without affecting the reuptake of serotonin or dopamine [1] [2] [3]. Metapramine is a low-affinity antagonist of the N... |
|
T21013 |
Clomipramine
|
Chlorimipramine,Anafranil,Clomicalm,Anafranil (free base),Clomipramina |
5-HT Receptor
|
|
Clomipramine (Clomicalm) is a tricyclic antidepressant (TCA). It is used for the treatment of the panic disorder, obsessive-compulsive disorder, major depressive disorder, and chronic pain. It may decrease the risk of su... |
|
T0678 |
Amitriptyline hydrochloride
|
Amitriptyline HCl,Tryptizol,Domical,Annoyltin |
Trk receptor
,
Sigma receptor
,
5-HT Receptor
,
Serotonin Transporter
,
Sodium Channel
,
Adrenergic Receptor
,
AChR
,
Norepinephrine
,
Histamine Receptor
|
|
Amitriptyline hydrochloride (Annoyltin) is the hydrochloride salt of the tricyclic dibenzocycloheptadiene amitriptyline with antidepressant and antinociceptive activities. |
|
T1540 |
Doxepin hydrochloride
|
Toruan,Doxepin HCl,Aponal,Novoxapin |
P450
,
Dopamine Receptor
,
5-HT Receptor
,
Adrenergic Receptor
,
AChR
,
Norepinephrine
,
Histamine Receptor
|
|
Doxepin hydrochloride (Aponal) is a dibenzoxepin tricyclic compound. It displays a range of pharmacological actions including maintaining adrenergic innervation. Its mechanism of action is not fully understood, but it ap... |
|
T1568 |
Amoxapine
|
CL-67772 |
GlyT
|
|
Amoxapine (CL-67772) exerts its antidepressant effect by inhibiting the re-uptake of norepinephrine and, to a lesser degree, of serotonin, at adrenergic nerve endings and blocks the response of dopamine receptors to dopa... |
|
T15773 |
Lofepramine
|
Gamanil,Amplit,Leo 640,Lopramine |
5-HT Receptor
,
Norepinephrine
|
|
Lofepramine (Leo 640) is a potent tricyclic antidepressant that is extensively metabolized to desipramine. It inhibits the serotonin and norepinephrine transporters by inhibiting neurons with Kd values of 70 and 5.4 nM, ... |
|
T0991 |
Desipramine hydrochloride
|
NSC-114901,Desmethylimipramine,JB-8181,EX-4355,Norimipramine,G-35020 |
Dopamine Receptor
,
5-HT Receptor
,
Serotonin Transporter
,
Adrenergic Receptor
|
|
Desipramine hydrochloride (Norimipramine) ,a secondary amine tricyclic antidepressant (TCA), is the hydrochloride salt form of desipramine. In the central nervous system (CNS), Desipramine hydrochloride blocks the re-upt... |
|
T68070 |
Fezolamine
|
|
Norepinephrine
|
|
Fezolamine is a novel orally available non-tricyclic compound with antidepressant activity. It is three to two times more selective in blocking synaptosomal uptake of [3H]norepinephrine than uptake of [4H]3-hydroxytrypta... |
|
T28557 |
Ro 14-9578
|
Ro-14-9578,Ro 149578 |
|
|
Ro 14-9578 is anantibacterial agent in the class of tricyclic quinolone. |
|
T20017 |
Melitracen
|
Melitracene |
|
|
Melitracen is a tricyclic antidepressant. |
|
T32805 |
LK 157
|
LK-157,LK157 |
|
|
LK 157 is a tricyclic carbapenem with potent activity against class A and class C beta-lactamases. |
|
T71355 |
MDL-27788
|
|
|
|
MDL-27788 is a tricyclic inhibitor. |
|
T33675 |
Nimbosone
|
|
|
|
Nimbosone is a novel tricyclic diterpenoid. |
|
T34214 |
QA 241
|
QA-241,QA241 |
|
|
QA 241 is a tricyclic quinolone. |
|
TNU0289 |
1,N6-Ethenoadenosine
|
|
|
|
Nucleoside Derivatives - Tricyclic nucleosides |
|
T12202 |
Nec-4
|
|
TNF
|
|
Nec-4 is a potent inhibitor of receptor interacting protein 1 (RIP1)(IC50 of 2.6 μM),and is a tricyclic derivative. |
|
T15132L |
Dimetacrine tartrate
|
Linostil,Istonil,Istonyl,Miroistonil,MO 709 |
|
|
Dimetacrine tartrate is a tricyclic antidepressant (TCA) used for the therapy of depression in Europe and formerly in Japan. |
|
T37307 |
Nordoxepin hydrochloride
|
|
|
|
Doxepin is a tricyclic antidepressant. Desmethyldoxepin is the primary metabolite of doxepin, produced by metabolism at the liver. The metabolism of tricyclic antidepressants, including doxepin, is affected by a variety ... |
|
T71643 |
FG-7080
|
|
|
|
FG-7080 is a non-tricyclic serotonin reuptake inhibitor. |
|
T25047 |
Alfetamine
|
alpha-allyl-phenethylamine |
|
|
Alfetamine is a chemical compound of the phenethylamine family. It is similar to imipramine and amitriptyline, two tricyclic antidepressants. |
|
TNU0005 |
6-(2-O-Methyl-beta-D-ribofuranosyl)-3-(2-oxo-propyl)-6H-imidazo[1,2-c]pyrimidin-5-one
|
|
|
|
Nucleoside Derivatives - 2’-Modified nucleosides; Scaffolds and Templates;Bi-Tricyclic nucleosides |
|
T36119 |
3-hydroxy Desloratidine
|
|
|
|
3-hydroxy Desloratidine is a major metabolite of desloratadine , a tricyclic antagonist of the histamine H1 receptor. |
|
T25248 |
Cianopramine
|
Ro 112465,Ro-112465,Ro112465 |
|
|
Cianopramine is a tricyclic antidepressant and a potent neuronal serotonin (5-HT) uptake inhibitor in animals. |
|
T23628 |
AD-2646
|
AD2646 |
|
|
AD-2646 is a new quinoline derivative. It also has similar pharmacological properties to tricyclic antidepressants. |
|
TNU0291 |
1,N6-Etheno-9-(b-D-xylofuranosyl)adenosine
|
|
|
|
Nucleoside Derivatives - Tricyclic nucleosides; Xylo-nucleosides |
|
T69265 |
Pirandamine Free Base
|
|
|
|
Pirandamine Free Base is a tricyclic derivative which acts as a selective serotonin reuptake inhibitor |
|
T13377 |
(Z)-10-Hydroxynortriptyline
|
(Z)-10-Hydroxy Nortriptyline |
IL Receptor
|
|
(Z)-10-Hydroxy Nortriptyline is a Nortriptyline metabolite, and is a tricyclic antidepressant,and is used to relieve the symptoms of depression. |
|
TNU1296 |
6-(β-D-5-O-(4,4’-Dimethoxytrityl)-2-deoxyribofuranosyl)-3,4-dihydro-8H-pyrimido[4,5-c][1,2]oxazin-7-one
|
|
|
|
Nucleoside Derivatives - Bi-/Tricyclic nucleosides; Protected nucleosides w/NH2/OH open |
|
TNU0290 |
1,N6-Etheno-ara-adenosine
|
|
|
|
Nucleoside Derivatives - Tricyclic nucleosides; Arabino-nucleosides |
|
T69620 |
Demexiptiline
|
|
|
|
Demexiptiline is a tricyclic antidepressant used in France for the treatment of depression. It acts primarily as a norepinephrine reuptake inhibitor similarly to desipramine. |
|
T74205 |
Imipramine N-oxide
|
|
|
|
Imipramine N-oxide, a metabolite of Imipramine, is a tertiary amine tricyclic antidepressant [1] [2]. |
|
T82804 |
Butriptyline
|
Butriptylene |
|
|
Butriptyline (Butriptylene), a tricyclic antidepressant, is effective when administered orally [1]. |
|
T13338 |
WEHI-9625
|
|
BCL
|
|
WEHI-9625 is a tricyclic sulfone small molecule apoptosis inhibitor (EC50: 69 nM). |
|
T71773 |
Levomepromazine Maleate
|
|
|
|
Levomepromazine Maleate is a Tricyclic antidepressant (TCA), acting as a serotonin–norepinephrine reuptake inhibitor (SNRI) and also having other activities including antihistamine, antiadrenergic, antiserotonergic, anti... |
|
T11135 |
(E)-10-Hydroxynortriptyline maleate
|
(E)-10-Hydroxy Nortriptyline maleate |
Others
|
|
(E)-10-Hydroxy Nortriptyline maleate, a metabolite of Nortriptyline, serves as a key active metabolite of the tricyclic antidepressant Amitriptyline, primarily utilized in alleviating depression symptoms. |
