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T65554 |
Cholesterol-absorption inhibitor Intermediate 2
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|
Others
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|
cholesterol-absorption inhibitor Intermediate 2 is a potent and orally active cholesterol absorption inhibitor that reduces blood cholesterol levels. |
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T8926 |
Salcaprozate sodium
|
SNAC |
Others
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Salcaprozate sodium (SNAC), an oral absorption promoter, serves as a potent delivery agent for oral heparin and insulin by enhancing passive transcellular permeation through small intestinal epithelia. This is achieved t... |
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T3279 |
Silver sulfadiazine
|
Silvadene,Dermazin,Flamazine |
DNA/RNA Synthesis
,
Antibacterial
,
Antibiotic
|
|
Silver sulfadiazine (Dermazin) is a sulfonamide-based topical agent with antibacterial and antifungal activity. |
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T7587 |
Tenapanor
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RDX-5791,RDX 5791,AZD 1722,Tenapanor free base,RDX5791,AZD-1722,AZD1722 |
Sodium Channel
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|
Tenapanor (RDX 5791) is an inhibitor of the sodium-proton (Na(+)/H(+)) exchanger NHE3, which plays a prominent role in sodium handling in the gastrointestinal tract and kidney. Tenapanor possesses an excellent preclinica... |
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T20362 |
Glutamyl-glutamic acid
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Glu-glu,Dipotassium glutamyl-glutamate,N-L-alpha-Glutamyl-L-glutamic acid |
Amino Acids and Derivatives
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|
Glutamyl-glutamic acid (Glu-glu) is an Interpeptide Bridge in the Murein of Some Micrococci and Arthrobacter sp.. |
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T1593 |
Ezetimibe
|
SCH 58235 |
Others
,
Nrf2
,
NPC1L1
,
Autophagy
|
|
Ezetimibe (SCH 58235) is a Dietary Cholesterol Absorption Inhibitor. The physiologic effect of ezetimibe is by means of Decreased Cholesterol Absorption. |
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T6675 |
Sodium Picosulfate
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Evacuol,Picolax,Sodium Picosulphate,Laxoberal |
Others
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|
Sodium Picosulfate (Laxoberal) inhibits absorption of water and electrolytes, and increases their secretion. |
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T3286 |
Sodium picosulfate monohydrate
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Sodium picosulfate hydrate,Laxoberal |
Others
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|
Sodium picosulfate monohydrate (Sodium picosulfate hydrate) increases secretion of water and electrolytes and inhibits their absorption. |
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T11205 |
Ent-Ezetimibe
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ent-SCH 58235 |
Others
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|
Ezetimibe is a Niemann-Pick C1-like1 (NPC1L1) inhibitor, and is a potent Nrf2 activator.ent-Ezetimibe (ent-SCH 58235) (ent-SCH 58235) is the RRS-enantiomer of Ezetimibe. Ezetimibe is a potent cholesterol absorption inhib... |
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T6344 |
Sevelamer hydrochloride
|
Sevelamer HCl |
FXR
,
Autophagy
|
|
Sevelamer hydrochloride (Sevelamer HCl) is a phosphate binding drug used to treat hyperphosphatemia via binding to dietary phosphate and prevents its absorption. |
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T18987 |
Py-BODIPY-NHS ester
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|
Autophagy
|
|
Py-BODIPY-NHS ester is a small molecular dye with strong UV absorption that can be used to label living cells and immobilise cells. |
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T77556 |
2-(4-Hydroxyphenylazo)benzoicacid
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|
|
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2-(4-Hydroxyphenylazo)benzoicacid is a spectrophotometric probe that shows changes in absorption spectra upon binding to proteins and binds to bovine serum proteins. |
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T31750 |
Faxeladol
|
EM906,GCR 9905,EM 906,GCR-9905,EM-906,GCR9905 |
5-HT Receptor
,
Opioid Receptor
,
Adrenergic Receptor
|
|
Faxeladol, a potent adrenergic absorption inhibitor and serotonin reuptake inhibitor, is a small-molecule Opioid receptor agonist that can be used to study neurological disorders. |
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T14057 |
6-CFDA
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6-Carboxyfluorescein diacetate |
Others
|
|
6-CFDA (6-Carboxyfluorescein diacetate) is fluorescent polyanionic probe that used to measure changes in intracellular pH (pHi) and processes such as dendrimer aggregation and absorption. |
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T7614 |
Eniluracil
|
GW776C85,5-Ethynyluracil |
Others
|
|
Eniluracil (GW776C85) is an orally activedihydropyrimidine dehydrogenase (DPD) inhibitor,increases the oral bioavailability of 5-FU to 100%, facilitating uniform absorption and predictable toxicity. |
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T0790 |
Carbaryl
|
1-naphthyl methylcarbamate,Sevin |
AChR
|
|
Carbaryl (1-naphthyl methylcarbamate) is a carbamate insecticide and parasiticide. It is a potent anticholinesterase agent belonging to the carbamate group of reversible cholinesterase inhibitors. It has a particularly l... |
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T11063 |
DMT1 blocker 1
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|
Others
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|
DMT1 blocker 1 is a blocker of divalent metal transporter 1 (DMT1) with IC50 of 0.64 μM, which is expected to block the absorption of iron by intestinal cells in vivo. |
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T38851 |
SiR-COOH
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|
|
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SiR-COOH enables tracking of the model therapeutic drug's intracellular location in GFP cells, characterized by absorption (Abs) at 645 nm and emission (Em) at 676 nm. |
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T35337L |
Teduglutide acetate
|
|
Glucagon Receptor
|
|
Teduglutide acetate, a GLP-2 analogue, maximizes small intestinal mucosal hypertrophy. Teduglutide acetate partially restores small intestinal epithelial function through an altered distribution of claudin-10, facilitati... |
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T4949 |
1,2-Didecanoyl-sn-glycero-3-phosphocholi
|
1,2-Didecanoyl Phosphatidylcholine,1,2-Didecanoyl PC |
Others
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|
1,2-Didecanoyl-sn-glycero-3-phosphocholi (1,2-Didecanoyl PC) is a synthetic, less hydrophobic phospholipid that has been found to be useful for enhancing the absorption of peptide drugs and hormones such as insulin. |
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T19310 |
Ensulizole
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2-PHENYLBENZIMIDAZOLE-5-SULFONIC ACID,2-Phenyl-1H-benzo[d]imidazole-5-sulfonic acid,Phenylbenzimidazole sulfonic acid |
Others
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|
Ensulizole (2-PHENYLBENZIMIDAZOLE-5-SULFONIC ACID) can damage the DNA through the generation of reactive oxygen species (ROS) upon UV or sunlight irradiation. Ensulizole is a water soluble sunscreen ingredient.Ensulizole... |
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T72054 |
SLC26A3-IN-1
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|
transporter
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SLC26A3-IN-1 is an inhibitor of the anion-exchange protein SLC26A3 with an IC50 value of 340 nM.SLC26A3 is a solute carrier (SLC) protein and a member of the SLC26 family, which has a wide range of anionic specificities ... |
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T62893 |
SM-2470
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Adrenergic Receptor
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SM-2470 is an α1-adrenoceptor antagonist with antihypertensive activity that decreases anterior ganglionic adrenal nerve activity and aortic descending nerve activity.SM-2470 has hypocholesterolemic activity and inhibits... |
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T2400 |
Candesartan Cilexetil
|
TCV-116 |
Apoptosis
,
RAAS
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|
Candesartan Cilexetil (TCV-116) is an angiotensin II receptor antagonist (IC50: 0.26 nM). After hydrolysis of candesartan cilexetil to candesartan during gastrointestinal absorption, candesartan selectively competes with... |
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T0195 |
Secnidazole
|
RP-14539,PM-185184 |
Antibiotic
,
Parasite
|
|
Secnidazole (PM-185184) is a second-generation 5-nitroimidazole antimicrobial that is structurally related to other 5-nitroimidazoles including [DB00916] and [DB00911], but displays improved oral absorption and longer te... |
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T21302 |
UNC569
|
UNC 569 |
TAM Receptor
|
|
UNC569 (UNC 569) is a selective inhibitor of URAT1, a transporter in the kidney that regulates uric acid excretion from the body. It is also a selective uric acid re-absorption inhibitor. UNC569 could normalize the amoun... |
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T0923 |
Busulfan
|
Myleran,Sulphabutin,Busulphan |
Apoptosis
,
DNA Alkylator/Crosslinker
,
DNA Alkylation
|
|
Busulfan (Busulphan) is a synthetic derivative of dimethane-sulfonate with antineoplastic and cytotoxic properties. Although its mechanism of action is not fully understood, busulfan appears to act through the alkylation... |
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T71012 |
Nemazoline Free Base
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|
|
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Nemazoline Free Base is a nasal decongestant. It has alpha 1-agonist/alpha 2-antagonist activity and was more effective and long-acting than oxymetazoline on canine nasal mucosa, in-vitro and in-vivo. Upon intranasal adm... |
|
T1101 |
Minocycline hydrochloride
|
Minocycline HCl |
HIF/HIF Prolyl-Hydroxylase
,
Antibacterial
,
Antibiotic
|
|
Minocycline hydrochloride (Minocycline HCl) is a tetracycline antibiotic with excellent absorption and tissue penetration that is used for several bacterial infections as well as treatment of acne. Minocycline hydrochlor... |
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T20029 |
Buformin hydrochloride
|
NSC528218,NSC-528218,NSC 528218 |
AMPK
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|
Buformin hydrochloride (NSC-528218) is a potent AMPK activator,an oral antidiabetic drug of the biguanide class. Buformin delays the absorption of glucose from the gastrointestinal tract increases insulin sensitivity and... |
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T14835 |
BTRX-335140
|
CYM-53093 |
Opioid Receptor
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|
BTRX-335140 (CYM-53093) is a potent and selective, orally active κ opioid receptor (KOR) antagonist, has antagonist activity for κOR, μOR and δOR with IC50 values of 0.8 nM, 110 nM, and 6500 nM, respectively. BTRX-335140... |
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T36126 |
TMP-153
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|
|
|
Acyl-CoA:cholesterol acyltransferase (ACAT) catalyses the esterification of excess cellular cholesterol with fatty acids and is important for intestinal cholesterol absorption, hepatic lipoprotein secretion, and choleste... |
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T8947 |
Dasiglucagon acetate
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dasiglucagon acetate(1544300-84-6 free base) |
Others
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|
Dasiglucagon acetate is a novel glucagon analog for diabetic hypoglycemia therapy. Dasiglucagon acetate has demonstrated established solubility and stability in an aqueous formulation. Pharmacokinetics studies have shown... |
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T68724 |
Canosimibe
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|
|
|
Canosimibe is a cholesterol absorption inhibitor |
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T71562 |
Boxidine
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|
|
|
Boxidine inhibits the transformation of 7-dehydrocholesterol to cholesterol & also inhibits sterol absorption. |
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T27565 |
Hyzetimibe
|
HS25,HS 25,HS-25 |
|
|
Hyzetimibe, a cholesterol absorption blocker, is used potentially for the treatment of hypercholesterolemia. |
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T30297 |
Bay-02752
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|
|
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BAY-02752 is a lipid lowering agent that has been shown in rats to inhibit the absorption of intestinal cholesterol. |
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T70849 |
AZD-4121
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|
|
|
AZD-4121 is an oral cholesterol absorption inhibitor targeting NPC1L1 for the treatment of dyslipidaemia. |
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T29359 |
2-n-Nonyl-1,3-dioxolane
|
AI3-22560,Decanal ethylene acetal,2-Nonyldioxolane |
|
|
2-n-Nonyl-1,3-dioxolane is a biochemical. It is used as an absorption and penetration enhanceron transdermal. |
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T17174 |
Troriluzole
|
BHV-4157 |
Others
|
|
Troriluzole is an orally active glutamate modulator. Troriluzole reduces the synaptic glutamate level and increases synaptic glutamate absorption. |
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TP1013 |
N-CBZ-Phe-Arg-AMC
|
Z-FR-AMC |
|
|
N-CBZ-Phe-Arg-AMC (Z-FR-AMC) is a substrate for serine proteases, including cathepsins, kallikrein and plasmin.
Absorption/emission of substrate = 330/390 nm (weak fluorescence); absorption/emission of end product (AMC) ... |
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T32144 |
Imazapyr
|
|
|
|
Imazapyr is a non-selective herbicide. It is highly water soluble. Thus, it has a low absorption into the soil and may leak into groundwater. |
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T70848 |
AZD-4121 tert-butylammonium
|
|
|
|
AZD-4121 tert-butylammonium is an oral cholesterol absorption inhibitor targeting NPC1L1 for the treatment of dyslipidaemia. |
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TNU0598 |
Dodecyl 2-(N,N-dimethylamino)propionate Hydrochloride
|
|
|
|
Formulation product; absorption enhancer |
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T31522 |
Dipropyl sulfone
|
|
|
|
Dipropyl sulfone may function as an enhancer of heparin absorption in the intestine. |
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T71340 |
Mizagliflozin sebacate
|
|
|
|
Mizagliflozin sebacate is a sodium-glucose transporter inhibitor. It is expected to improve postprandial hyperglycemia by suppressing glucose absorption from the intestine with a novel mechanism of action different from... |
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T16036 |
Melinamide
|
AC 223,DL-N-(α-Methylbenzyl)linoleamide |
Others
|
|
|
|
T24622 |
PF-06679142
|
PF06679142,PF-6679142,PF6679142,PF 6679142 |
|
|
PF-06679142 is an effective AMPK activator. PF-06679142 exhibited robust activation of AMPK in rat kidneys as well as desirable oral absorption. |
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T21417 |
Dihydrotachysterol
|
Hytakerol,HSDB-3314,HSDB3314,Parterol,HSDB 3314 |
|
|
Dihydrotachysterol (DHT) is a biologically active synthetic analog of vitamin D. It promotes intestinal absorption of active calcium and phosphate . It is also beneficial in the treatment of hypoparathyroidism. |
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T68534 |
FK-448 methanesulfonate
|
|
|
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FK-448 methanesulfonate is a chymotrypsin inhibitor that has been shown to affect intestinal absorption of insulin in rats and dogs . |
