|
T7545 |
6-Aminonicotinamide
|
|
Others
|
|
6-Aminonicotinamide (6-AN) is a well-established inhibitor of the NADP+-dependent enzyme. |
|
T9919 |
Alemtuzumab
|
|
Others
|
|
Alemtuzumab is a humanized monoclonal antibody against CD52 an antigen found on the surface of normal and malignant lymphocytes. |
|
T38369 |
CAY10678
|
|
Prostaglandin Receptor
,
PD-1/PD-L1
|
|
CAY10678 is an mPGES-1 inhibitor that inhibits PD-1.CAY10678 reduces collagen deposition and T-cell depletion, and may be used to study melanoma.CASHIPS |
|
T38709 |
PFM39
|
|
Others
|
|
PFM39 is a selective MRE11 nucleic acid exonuclease inhibitor and Mirin analog that prolongs mitosis.PFM39 inhibits HR and alleviates repair defects caused by EXO1/BLM depletion. |
|
T13810 |
Palmitoylcarnitine chloride
|
Palmitoyl DL-carnitine chloride |
PKC
|
|
Palmitoylcarnitine chloride (Palmitoyl DL-carnitine chloride) is a mitochondrial fatty acid oxidation intermediate that mediates intralipid cardioprotection.Palmitoylcarnitine chloride eliminates colorectal cancer cell s... |
|
T14283 |
Amyloid P-IN-1
|
|
Beta Amyloid
|
|
amyloid P-IN-1 can be used in studies about diseases with depletion of serum amyloid P components such as Alzheimer's disease, amyloidosis, osteoarthritis, and type 2 diabetes mellitus. |
|
T7295 |
Miridesap
|
Ro63-8695,CPHPC,GSK2315698 |
Others
|
|
Miridesap (GSK2315698) is a divalent crosslinker of SAP that causes rapid depletion of circulating SAP via hepatic clearance. It also produces significant reduction of SAP from cerebrospinal fluid and visceral amyloid de... |
|
T5523 |
Imidazole ketone erastin
|
IKE |
Ferroptosis
|
|
Imidazole ketone erastin (IKE) is an iron death inducer with inhibitory effects on system Xc-cystine/glutamate transporter proteins. Imidazole ketone erastin has antitumor activity and induces glutathione depletion and l... |
|
T16680 |
PTC-028
|
|
Apoptosis
,
BMI-1
|
|
PTC-028 selectively suppresses cancer cells whereas normal cells remain unaffected. PTC-028 is an orally bioavailable inhibitor of stem cell factor BMI-1 in ovarian cancer. The depletion of BMI-1 by PTC-028 causes caspas... |
|
T68095 |
Losulazine
|
|
Dopamine Receptor
,
Norepinephrine
|
|
Losulazine is a peripheral sympathetic antihypertensive compound that can be taken orally. Losulazine causes relatively modest, transient depletion of dopamine and norepinephrine in brain regions protected by the blood-b... |
|
T6543 |
Indoximod
|
NLG-8189,Indoximod (NLG-8189）,1-Methyl-D-tryptophan |
Indoleamine 2,3-Dioxygenase (IDO)
|
|
Indoximod (Indoximod (NLG-8189)) is a methylated tryptophan with immune checkpoint inhibitory activity. Indoximod inhibits the enzyme indoleamine 2, 3-dioxygenase (IDO), which degrades the essential amino acid tryptophan... |
|
T10497 |
Benralizumab
|
BIW-8405,MEDI-563 |
Apoptosis
,
IL Receptor
,
Interleukin
|
|
|
|
T76830 |
Teneliximab
|
Chi220,Anti-Human CD40 Recombinant Antibody,BMS 224819 |
TNF
|
|
Teneliximab (Chi220) is a chimeric monoclonal antibody and a tumor necrosis factor receptor superfamily member 5 (CD40) inhibitor that blocks CD40-CD40L interactions.Teneliximab exerts partial agonist activity through CD... |
|
T0893 |
Tinidazole
|
CP12574 |
Antibacterial
,
Antibiotic
|
|
Tinidazole (CP12574)a is a 5-nitroimidazole derivative with the antiprotozoal property. Although the mechanism of action has not been fully elucidated, it has been suggested that tinidazole is metabolized and yields nitr... |
|
T38034 |
MAO-IN-M30 dihydrochloride
|
M 30 dihydrochloride |
Monoamine Oxidase
|
|
MAO-IN-M30 dihydrochloride (M 30 dihydrochloride) is a potent and brain selective monoamine oxidase (MAO) inhibitor (EC50 values are 37 and 57 nM for MAO-A and MAO-B, respectively). Also an iron chelator with antioxidant... |
|
T4013 |
SGC2085 HCl
|
|
Histone Methyltransferase
|
|
SGC2085 is a potent and selective coactivator associated arginine methyltransferase 1 (CARM1) Inhibitor with an IC50 of 50 nM and more than undred-fold selectivity over other PRMTs. CARM1 is an important positive modulat... |
|
T5371 |
L-BUTHIONINE-(S,R)-SULFOXIMINE
|
L-Butionine sulfoximine |
Others
,
Ferroptosis
|
|
L-Buthionine-(S,R)-sulfoximine is a cell-permeable and irreversible inhibitor of γ-glutamylcysteine synthetase (Ki <100 μM) that induces oxidative stress in cells by depleting GSH. |
|
T35689 |
MTP 131 acetate
|
|
Others
|
|
MTP 131 is a mitochondria-targeted peptide antioxidant.1,2It localizes to the mitochondria and reducestert-butyl hydroperoxide-induced lipid peroxidation and apoptosis in SH-SY5Y cells when used at concentrations ranging... |
|
T36949 |
Niaprazine
|
|
5-HT Receptor
,
Adrenergic Receptor
,
Histamine Receptor
|
|
Niaprazine is a histamine H1-receptor antagonist with marked sedative properties. Niaprazine has antihistamine and antiserotonin activities and can be used for sleep disorder research[1][2].
Niaprazine exhibits a low aff... |
|
T26993 |
CGP 56999A
|
CGP56999A,CGP-56999A |
Others
|
|
CGP 56999A is an antagonist of GABA(B) receptor, it enhances expression of brain-derived neurotrophic factor and attenuates dopamine depletion in the rat corpus striatum. |
|
T71413 |
U 26384
|
|
Others
|
|
U 26384 is a phospholipase A2 inhibitor reduces the severity of cell injury, but does not maintain cell viability in cultured human astroglial cell line UC-11MG during ATP depletion. |
|
T30807 |
CG0009
|
CG-0009,CG 0009 |
Others
|
|
CG0009 is a potent and highly selective glycogen synthase kinase 3 (GSK3) inhibitor that inhibitions proliferation, induces apoptosis, and activates the p53-Bax pathway in breast cancer cells through cyclin D1 depletion.... |
|
T15412 |
GPP78
|
CAY10618 |
Autophagy
|
|
GPP78 is a potent inhibitor of Nampt (IC50: 3.0 nM for nicotinamide adenine dinucleotide (NAD) depletion). GPP78 is cytotoxic to neuroblastoma cell line SH-SY5Y cells (IC50: 3.8 nM by inducing autophagy). GPP78 has anti-... |
|
T21315 |
Folitixorin
|
ANX-510 |
Others
|
|
ANX-510 is a folate-based biomodulator. It stabilizes the covalent binding of the fluorouracil metabolite FdUMP to thymidylate synthase, which results in inhibition of thymidylate synthase, depletion of thymidine triphos... |
|
T28488 |
Quinuronium Sulfate
|
Pirevan,Zothelone,Acaprin |
Others
|
|
Quinuronium sulfate is a drug used to treat Babesia divergens infections in calves. It did not prevent treated animals from being disease carriers. It may also cause hepatic centrilobular fatty degeneration, but no deple... |
|
T39243 |
Janelia Fluor® 585, SE
|
JF585, SE,JF585,NHS |
|
|
Janelia Fluor 585, SE (JF585, SE) is an orange fluorescent dye containing an NHS ester that can be conjugated with primary amine groups. Janelia Fluor 585, SE can be used immediately for structured illumination (SIM) and... |
|
T61097 |
Anticancer agent 70
|
|
Others
|
|
Anticancer agent 70 (Compound 21) is a potent anticancer compound that demonstrates remarkable cytotoxicity against multiple human cancer cell lines. It induces G0/G1-cell cycle arrest and concurrently elevates the level... |
|
T60667 |
NAT
|
|
Others
|
|
NAT, an initial NAMPT activator, targets NAMPT, a crucial enzyme in the NAD salvage pathway and a key focal point for researching a variety of diseases linked to NAD depletion, including neurodegenerative diseases[1]. |
|
T25374 |
Emofolin sodium
|
NSC139490,MeTHHF disodium,NSC-139490,NSC 139490 |
Others
|
|
Emofolin sodium is the sodium salt of a synthetic antimetabolite analogue of folate with antineoplastic activity，which competes for the folate binding site of the enzyme dihydrofolate reductase, resulting in inhibition o... |
|
T36194 |
CAY10726
|
CAY10726 |
Others
|
|
CAY10726 is an arylurea fatty acid. It decreases ATP production by 28% in MDA-MB-231 breast cancer cells when used at a concentration of 10 μM. CAY10726 decreases proliferation and initiates apoptosis in MDA-MB-231 cells... |
|
T35652 |
2'-Deoxyguanosine 5'-monophosphate (sodium salt hydrate)
|
|
Others
|
|
2'-Deoxyguanosine 5'-monophosphate (dGMP) is used as a substrate of guanylate kinases to generate dGDP, which in turn is phosphorylated to dGTP, a nucleotide precursor used in DNA synthesis. In addition, dGMP can be effi... |
|
T36570 |
KUS121
|
|
Others
|
|
KUS121 is a valosin-containing protein (VCP) modulator that inhibits VCP ATPase activity (IC50= 330 nM).1It inhibits cell death, ATP depletion, and upregulation of C/EBP-homologous protein (CHOP) induced by tunicamycin, ... |
|
T76824 |
Quilizumab
|
|
|
|
Quilizumab, a humanized IgG1κ monoclonal antibody also known as Anti-Human NGcGM3 Recombinant Antibody, specifically targets the M1-prime segment of membrane-expressed IgE. This action leads to the depletion of IgE-switc... |
|
T64293 |
SLN124
|
|
Others
|
|
SLN124 is a GalNac-siRNA that targets transmembrane serine protease 6 (Tmprss6) and consists of a trimeric GalNAc ligand bound to TMPRSS6-siRNA. SLN124 has the potential to be used as an siRNA agent to restore ferroregul... |
|
T37578 |
GPP 78 hydrochloride
|
|
Others
|
|
GPP 78 hydrochloride is a potent inhibitor of nicotinamide phosphoribosyltransferase (Nampt) with an IC50 of 3 nM for NAD depletion. GPP 78 hydrochloride is toxic to neuroblastoma cells SH-SY5Y via induction of autophagy... |
|
T73697 |
Denileukin diftitox
|
|
Others
|
|
Denileukin diftitox (DAB 389IL-2), a fusion protein toxin combining diphtheria toxin (DT) and interleukin 2 (IL-2), selectively depletes cells with the high-affinity IL-2 receptor (IL-2R), specifically CD25. By binding t... |
|
T13907 |
Sulfo-ara-F-NMN
|
CZ-48 |
Others
|
|
Sulfo-ara-F-NMN is an analogue of nicotinamide mononucleotide (NMN) with cellular permeability. Sulfo-ara-F-NMN was selective to activate SARM1 and inhibited CD38 with an IC50 of about 10 μM. Activation by Sulfo-ara-F-NM... |
|
T82609 |
Dargistotug
|
M-6223 |
|
|
Dargistotug (M-6223) is a fully human IgG1 monoclonal antibody that targets TIGIT (T cell immune receptor with Ig domain and ITIM), an inhibitory immune checkpoint responsible for NK cell depletion and diminished cytokin... |
|
T37922 |
7(Z),11(Z)-Pentacosadiene
|
|
Others
|
|
Unsaturated, long-chain hydrocarbons are found on the cuticles of insects and can act as pheromones. In mature Drosophila melanogaster, certain cuticular hydrocarbons are sexually dimorphic: males synthesize 23- and 25-C... |
|
T74174 |
JB170
|
|
PROTACs
|
|
JB170, a potent and highly specific PROTAC-mediated AURORA-A (Aurora Kinase) degrader (DC50=28 nM), achieves its selectivity by linking Alisertib to the Cereblon-binding molecule Thalidomide. It demonstrates a strong pre... |
|
T14553 |
BHPI
|
|
Others
|
|
BHPI is a potent ERα inhibitor that blocks nuclear estrogen–ERα-regulated gene expression effectively. It triggers sustained ERα-dependent activation of the endoplasmic reticulum (EnR) stress sensor, notably the unfolded... |
|
T37295 |
Ganglioside GM1 Asialo Mixture
|
|
Others
|
|
Ganglioside GM1 asialo is a component of cellular lipid rafts and can be formed by the cleavage of the sialic acid residue from ganglioside GM1 by neuraminidase. Ganglioside GM1 asialo is a glycolipid receptor for P. aer... |
|
T36507 |
Tetrachlorohydroquinone
|
|
Others
|
|
Tetrachlorohydroquinone (TCHQ) is a metabolite of the organochlorine biocide pentachlorophenol. It is cytotoxic to RTL-W1 rainbow trout liver cells (EC50 = 1.55 μM in a neutral red assay). TCHQ increases production of re... |
|
T36521 |
Alaproclate (hydrochloride)
|
|
Others
|
|
Alaproclate is a selective serotonin reuptake inhibitor (SSRI).1,2 It inhibits depletion of serotonin (5-HT) induced by 4-methyl-α-ethyl-m-tyramine in rat cerebral cortex, hippocampus, hypothalamus, and striatum (EC50s =... |
|
T37248 |
Pantothenate Kinase Inhibitor
|
|
Others
|
|
Pantothenate Kinase Inhibitor (PANKi) is a reversible inhibitor of pantothenate kinase (PanK; IC50s = 70, 92, and 25 nM for PanK1β, PanK2, and PanK3, respectively), the rate-limiting enzyme in the synthesis of coenzyme A... |
