|
T35878 |
N-(3-Aminopropyl)cyclohexylamine
|
|
Others
|
|
N-(3-Aminopropyl)cyclohexylamine, a derivative of cyclohexylamine, functions as a selective and competitive inhibitor of spermine synthase, making it suitable for research on neurological diseases[1]. |
|
T9989 |
AChE-IN-27
|
|
Others
|
|
AChE-IN-27 is a small molecule used for high-throughput assays. |
|
TP1856 |
Colivelin
|
|
Beta Amyloid
,
STAT
|
|
Colivelin is a neuroprotective peptide and activator of STAT3. Colivelin is a hybrid peptide synthesized to enhance the neuroprotective effects of humanin (HN). |
|
T1476 |
Pramipexole
|
SND 919 |
Dopamine Receptor
|
|
Pramipexole (SND 919) is a selective dopamine receptor agonist used in the therapy of Parkinson disease. Pramipexole therapy is associated with a low rate of transient serum enzyme elevations during treatment but has not... |
|
T1594 |
Vecuronium bromide
|
ORG NC 45 |
AChR
|
|
Vecuronium bromide (ORG NC 45) is a synthetic, intermediate-acting mono-quaternary steroid and non-depolarizing neuromuscular blocking agent, with muscle relaxant activity. |
|
T7805 |
GW791343 dihydrochloride
|
GW791343 (HCl) |
P2X Receptor
|
|
GW791343 dihydrochloride (GW791343 (HCl)) is a P2X7 allosteric modulator. |
|
T3198L |
PRE-084 hydrochloride
|
|
Sigma receptor
|
|
PRE-084 hydrochloride is a selective agonist of σ1(IC50:44 nM, in the sigma receptor assay). |
|
T3217 |
PF-CBP1 hydrochloride
|
PF-CBP1 HCl |
Epigenetic Reader Domain
,
Histone Acetyltransferase
|
|
PF-CBP1 hydrochloride (PF-CBP1 HCl) is a highly selective inhibitor of the bromodomain of CREB-binding protein(CREBBP).It inhibits CREBBP and p300 bromodomains with IC50 of 125 and 363 nM respectively. |
|
T4497 |
Amifampridine
|
3,4-Pyridinediamine,Pyridine-3,4-Diamine,3,4-Diaminopyridine |
Others
|
|
Amifampridine (3,4-Diaminopyridine) is predominantly in the treatment of a number of rare muscle diseases. Amifampridine works by blocking potassium channel efflux in nerve terminals so that action potential duration is ... |
|
T6951 |
Pramipexole dihydrochloride hydrate
|
Pramipexole 2HCl Monohydrate,Mirapex |
Dopamine Receptor
|
|
Pramipexole dihydrochloride hydrate (Mirapex) is the hydrochloride salt of pramipexole, a benzothiazole derivative. As a nonergot dopamine agonist, pramipexole binds to D2 and D3 dopamine receptors in the striatum and su... |
|
T6526 |
GW791343 trihydrochloride
|
GW791343 3HCl |
P2X Receptor
|
|
GW791343 trihydrochloride (GW791343 3HCl) is aHCl salt form of GW791343, which is a non-competitive allosteric modulator of human P2X7 receptor inhibitor with pIC50 of 7. |
|
T27143 |
Delucemine Hydrochloride
|
NPS 1506,Delucemine,Delucemine HCl,NPS1506,NPS-1506 |
NMDAR
|
|
Delucemine Hydrochloride (Delucemine) is a polyamine NMDA receptor antagonist used in the study of neurological disorders such as depression and Alzheimer's disease. |
|
T28441 |
PPI-1019
|
PPI1019,Apan |
Beta Amyloid
|
|
PPI-1019 is an APP (β-amyloid A4) inhibitor for the treatment of neurological disorders and the study of Alzheimer's disease (AD). |
|
TP1195 |
Cibinetide
|
ARA290 |
Others
|
|
Cibinetide (ARA290) is a nonerythropoietic peptide engineered from erythropoietin,, and used for neurological disease treatment. |
|
T13047 |
Synta66
|
|
Calcium Channel
|
|
Synta66 is a store-operated calcium entry channel Orai inhibitor, and used for the research of neurological disease. |
|
T64344 |
N-Methyl-DL-aspartic acid
|
|
NMDAR
|
|
N-Methyl-DL-aspartic acid, a glutamate analogue and NMDA receptor agonist, is utilized in neurological disease research. |
|
T31079 |
CP-810123
|
CP 810123,UNII-E6G4550EC4,CP810123 |
AChR
|
|
CP-810123 is a new alpha 7 nAChR agonist for the treatment of cognitive impairment associated with psychiatric or neurological disorders such as schizophrenia and Alzheimer's disease. |
|
T23649 |
AF-710B
|
ANAVEX 3-71,AF 710B,AF710B |
Sigma receptor
,
AChR
|
|
AF-710B is a specific variant of M1 muscarinic and Sigma-1 receptor agonist used in the study of neurological disorders such as Alzheimer's disease dementia and schizophrenia. |
|
TP1866L |
β-amyloid 1-11 acetate(190436-05-6 free base)
|
|
Beta Amyloid
|
|
β-amyloid 1-11 acetate is a fragment of Amyloid-β peptide, maybe used in the research of neurological disease. |
|
T11949 |
Masupirdine mesylate
|
SUVN-502 mesylate,SVN-502 mesylate |
5-HT Receptor
|
|
Masupirdine mesylate (SUVN-502 mesylate) is a selective 5-HT6 receptor antagonist that crosses the blood-brain barrier.Masupirdine mesylate is used in the study of neurological disorders such as Alzheimer's disease and d... |
|
T32368 |
KB-74935
|
KB 74935 |
Others
|
|
KB-74935 is an enzyme inhibitor and a mineralocorticoid receptor antagonist used to treat cholesterol, hypolipidemia, neurological disorders, and Alzheimer's disease. |
|
TQ0238 |
Lanabecestat
|
LY3314814,AZD3293 |
BACE
|
|
Lanabecestat (AZD3293) is a highly potent and highly permeable, orally active BACE1 inhibitor (Ki: 0.4 nM) that crosses the blood-brain barrier.Lanabecestat can be used for the study of neurological diseases such as Alzh... |
|
T68084 |
Icopezil
|
|
AChE
|
|
Icopezil is a small molecule acetylcholinesterase in (AChE) inhibitor for the treatment of neurological disorders and can be used in the study of Alzheimer's disease. |
|
TP1214L |
β-Amyloid 15-21 acetate
|
Beta-Amyloid (15-21) acetate |
Beta Amyloid
|
|
β-Amyloid 15-21 acetate (Beta-Amyloid (15-21) acetate) is a fragment of Amyloid-β peptide, maybe used in the research of neurological disease. This fragment is involved in beta sheet formation. |
|
T26551 |
Acetyl-L-carnitine
|
RO 447190,L-Acetylcarnitine,LAC,L-O-Acetylcarnitine,ALCAR,Acetyl L carnitine |
Endogenous Metabolite
|
|
Acetyl-L-carnitine(RO 447190) is an amino acid that crosses the blood-brain barrier and is often used as a dietary supplement for neuroinflammation.Acetyl-L-carnitine is neuroprotective and can be used in the study of ne... |
|
T76726 |
Zagotenemab
|
LY33003560 |
Microtubule Associated
|
|
Zagotenemab is a humanized antibody against the microtubule-associated protein tau that selectively regulates tau deposits in the brain. Zagotenemab can be used to study neurological disorders such as Alzheimer's disease... |
|
T69726 |
Oditrasertib
|
DNL-788 |
RIP kinase
|
|
Oditrasertib (DNL-788) is a potent RIPKl inhibitor with an IC50 value of less than 100 nM.Oditrasertib can be used for the study of immune and neurological disorders such as multiple sclerosis and Alzheimer's disease. |
|
T27795L |
(Iso)-Landipirdine
|
(Iso)-SYN120,(Iso)-RO5025181,(Iso)-Landipirdine(Iso-1000308-25-7) |
5-HT Receptor
|
|
(Iso)-Landipirdine((Iso)-RO5025181) is a selective and potent 5-HT6R antagonist. (Iso)-Landipirdine has a significant effect on the hERG pharmacophore and can be used to study neurological disorders in the Alzheimer's di... |
|
T68492 |
AM 374
|
HDSF,Hexadecanesulfonyl fluoride |
FAAH
|
|
AM 374 (HDSF), a fatty acid amide hydrolase (FAAH) inhibitor, demonstrates the capacity to inhibit amidase activity, boasting an IC50 value of 13 nM. This compound is potentially applicable in neurological disease resear... |
|
T80622 |
Trontinemab
|
RO-7126209,RG6102 |
Beta Amyloid
|
|
Trontinemab (RG6102) is a human IgG1-κ antibody selectively targeting Aβ precursor protein (APP) with transferrin receptor p90, CD71 (TFRC), inhibits amyloid production, and can be used to study neurological disorders su... |
|
T50046 |
L-Valyl-L-phenylalanine HCl
|
Valylphenylalanine HCl; H-VAL-PHE-OH HCl |
Others
|
|
2-(2-amino-3-methylbutanamido)-3-phenylpropanoic acid hydrochloride is an amino acid compound that is a synthetic analog of glutamate, an important neurotransmitter in the central nervous system. It has been investigated... |
|
T9340 |
1-phenyl-3,4-dihydroisochinoline
|
3,4-Dihydro-1-phenylisoquinoline |
Others
|
|
1-phenyl-3,4-dihydroisochinoline (3,4-Dihydro-1-phenylisoquinoline) is a structural analog of the neurotransmitter dopamine that interacts with dopamine receptors in the central nervous system. It has been studied as a p... |
|
T50090 |
3-(2-phenylethynyl)pyridine
|
|
Others
|
|
3-(2-phenylethynyl)pyridine is a pyridine derivative that is a ligand for a variety of receptors in the human body, including dopamine D2 receptors, sigma-1 receptors, and 5-HT6 receptors. It has been studied for the tre... |
|
T50003 |
Debrisoquin hydriodide
|
1,2,3,4-tetrahydroisoquinoline-2-carboximidamide hydroiodide |
Others
|
|
Debrisoquin hydriodide (1,2,3,4-tetrahydroisoquinoline-2-carboximidamide hydroiodide) has antioxidant, anti-inflammatory and neuroprotective properties. It has also been found to modulate the activity of certain neurotra... |
|
T111959 |
IFB-088 acetate
|
|
|
|
IFB-088 acetate, a benzyl guanidine derivative, is used to treat diseases and cancers associated with the PPP1R15A pathway and associated with protein misfolding stress, Examples include tau disease, synaptic riboprotein... |
|
T11948 |
Masupirdine free base
|
Masupirdine,SUVN-502 free base |
5-HT Receptor
|
|
Masupirdine free base (SUVN-502 free base) is an orally available 5-HT6 receptor antagonist that crosses the blood-brain barrier and has a Ki value of 2.04 nM for the human 5-HT6 receptor.Masupirdine free base is potent ... |
|
T77342 |
GSK-3 inhibitor 3
|
|
GSK-3
,
Microtubule Associated
|
|
GSK-3 inhibitor 3 is a selective, orally active, brain-permeable GSK-3 inhibitor that inhibits GSK-3α and GSK-3β with IC50s of 0.35 nM and 0.25 nM, respectively.GSK-3 inhibitor 3 reduces the phosphorylation level of tau ... |
|
T39218 |
(S)-CVN424
|
(S)-CVN424 |
|
|
(S)-CVN424 is a powerful modulator of G-Protein-Coupled Receptor 6 (GPR6), known for its involvement in neurological and psychiatric disorders research, such as Parkinson's disease. |
|
T7352L |
Pridopidine hydrochloride
|
ASP2314 HCl,Pridopidine HCl,FR310826,ASP-2314 hydrochloride |
|
|
Pridopidine Hydrochloride is a dopaminergic stabilizer that has been shown to improve a variety of neurological and psychiatric disorders, including Huntington's disease. Pridopidine Hydrochloride stabilizes psychomotor ... |
|
T79191 |
AMPA receptor modulator-5
|
|
iGluR
|
|
AMPA Receptor Modulator-5 (Example 217) serves as an AMPA receptor modulator, utilized in neurological disease research [1]. |
|
T81520 |
Penta-alanine
|
Penta-L-alanine |
|
|
Penta-alanine (Penta-L-alanine) is a peptide with potential applications in neurological disease research [1] [2]. |
|
T74031 |
Cardiolipin (Heart, Bovine) (sodium)
|
|
|
|
Cardiolipin (Heart, Bovine) Sodium, a phospholipid exclusive to mitochondria, shows potential for neurological disease research [1]. |
|
T75969 |
β-Amyloid (15-21)
|
|
|
|
β-amyloid (15-21) is a fragment of Amyloid-β peptide, maybe used in the research of neurological disease . |
|
TP1214 |
β-Amyloid 15-21
|
Beta-Amyloid (15-21) |
|
|
β-amyloid (15-21) is a fragment of Amyloid-β peptide, maybe used in the research of neurological disease. This fragment is involved in beta sheet formation. |
|
T40701 |
Ezeprogind
|
AZP-2006 |
|
|
Ezeprogind (AZP-2006) is an orally active neurotrophic inducer that effectively addresses the underlying factors contributing to neurodegeneration, with a broad scope extending beyond the conventional targets like Abeta ... |
|
T80468 |
δ-Dendrotoxin
|
|
Potassium Channel
|
|
δ-Dendrotoxin is a potassium (K+) channel blocker derived from black mamba snake venom and is utilized in neurological disease research [1]. |
|
T78111 |
NCS-382 sodium
|
|
GABA Receptor
|
|
NCS-382 (sodium) is a potent antagonist of the GABA receptor, exhibiting anti-sedative and anti-hypnotic properties, with applications in neurological disease research [1]. |
|
T80484 |
Aa1 toxin
|
|
Potassium Channel
|
|
Aa1 toxin, sourced from Androctonus australis Garzoni venom, is a neurotoxic peptide that specifically blocks potassium channels and has applications in neurological disease research [1]. |
|
T81817 |
Met-Arg-Phe-Ala
|
|
|
|
Met-Arg-Phe-Ala, a peptide, serves as a potent competitive inhibitor of enkephalin-generating endopeptidase (EGE) and is utilized in neurological disease research [1]. |
|
T75257 |
4-Butyl-alpha-agarofuran
|
|
|
|
4-Butyl-alpha-agarofuran (AF 5), an α-agarofuran derivative isolated from Gharu-wood, functions as an anxiolytic and antidepressant agent. It is utilized in neurological disease research [1]. |
