|
T26889 |
Borofalan(10B)
|
L-4-Boronophenylalanine |
Others
|
|
Borofalan(10B) (L-4-Boronophenylalanine) echibits antineoplastic effects. Borofalan can be used in studies on recurrent or locally advanced head and neck cancer. |
|
T12695 |
RBN-2397
|
|
PARP
|
|
RBN-2397 is a potent, selective and orally active accross species NAD+ competitive PARP7 inhibitor with IC50 less than 3 nM. |
|
T15771 |
Lobaplatin
|
D-19466 |
DNA Alkylation
|
|
Lobaplatin (D-19466) (D-19466) is a diastereometric mixture of platinum(II) complexe. Lobaplatin (D-19466) is a third-generation platinum anti-neoplastic agent which shows activity for a variety of tumour types and is a ... |
|
T2455 |
PFK-015
|
PFK15,PFK 015 |
Glucokinase
,
Autophagy
|
|
PFK-015 (PFK15) is an effective inhibitor of PFKFB3 (IC50: 110 nM) and inhibits PFKFB3 activity in Y cells (IC50: 20 nM). |
|
T4570 |
Pipobroman
|
Vercyte,A-8103,Amedel |
Others
,
DNA Alkylator/Crosslinker
|
|
Pipobroman (Vercyte) is an anti-cancer drug that probably acts as an alkylating agent. Pipobroman has well documented clinical activity in polycythemia vera (PV) and essential thrombocythemia (ET). Pipobroman allows, wit... |
|
T0314 |
Hexylresorcinol
|
4-Hexylresorcinol |
Apoptosis
,
Tyrosinase
,
Antibacterial
,
Parasite
|
|
Hexylresorcinol (4-Hexylresorcinol) is a substituted dihydroxybenzene used topically as an antiseptic for the treatment of minor skin infections. |
|
T0134 |
Imiquimod
|
R 837,S-26308 |
SARS-CoV
,
TLR
,
Autophagy
,
HSV
|
|
Imiquimod (R 837) is an immune response modifier that acts as a toll-like receptor 7 agonist. |
|
T17035 |
Temoporfin
|
|
Others
|
|
Temoporfin used in photodynamic therapy for the treatment of squamous cell carcinoma of the head and neck. |
|
T76717 |
Serplulimab
|
HLX 10 |
COX
|
|
Serplulimab (HLX 10) is a humanized monoclonal anti-antibody to PD-1. Serplulimab has antitumor activity and can be used in small cell lung cancer and esophageal squamous cell carcinoma. |
|
T14903 |
CCT129957
|
|
Calcium Channel
,
Phospholipase
|
|
CCT129957 is a novel and potent phospholipase C-γ (PLC-γ) inhibitor with an IC50 of about 3 μM and a GC50 of 15 μM.CCT129957 exhibits anticancer activity and inhibits Ca2+ release in squamous cells. |
|
T2618 |
LGK974
|
LGK 974,LGK-974,NVP-LGK974,WNT974 |
Porcupine
|
|
LGK974 (NVP-LGK974) is an effective and selective PORCN inhibitor and inhibits Wnt signaling (IC50: 0.4 nM) in TM3 cells. It has been used in trials studying the treatment of Metastatic Colorectal Cancer and Squamous Cel... |
|
T38387 |
Compound C108
|
|
GTPase
|
|
Compound C108 is an inhibitor of GTPase-activating protein SH3 domain-binding protein 2 (G3BP2). Compound C108 can be used in studies about breast tumors and esophageal squamous cell carcinoma. |
|
T6136 |
Canertinib
|
PD-183805,CI-1033 |
EGFR
|
|
Canertinib (CI-1033) is a pan-erbB tyrosine kinase inhibitor which work against esophageal squamous cell carcinoma in vitro and in vivo. Canertinib treatment significantly affects tumour metabolism, proliferation and hyp... |
|
T67786 |
ABI-1968 PM
|
|
|
|
ABI-1968 PM is a derivative of ABI-1968, an apoptosis-stimulating agent and an inhibitor of viral replication.ABI-1968 can be used to study cervical intraepithelial neoplasia, papillomavirus infection, and squamous intra... |
|
T76750 |
Cemiplimab
|
REGN-2810,SAR-439684 |
Others
|
|
Cemiplimab (Anti-Human PD-1) is a human monoclonal antibody against programmed cell death receptor 1 (PD-1) and a checkpoint inhibitor that blocks PD-1/PD-L1 mediated T-cell inhibition and can be used in metastatic cance... |
|
T77423 |
Lirilumab
|
ONO-4483,IPH2102 |
Virus Protease
|
|
Lirilumab (IPH2102) is an antibody against the lethal immunoglobulin-like receptor antibody KIR2D with antitumor activity that enhances the anti-HPV + cervical cancer activity of natural killer cells through VAV1-depende... |
|
T76691 |
Monalizumab
|
|
IFNAR
,
Chk
|
|
Monalizumab is a novel immune checkpoint inhibitor targeting natural killer cell population 2A (NKG2A). Monalizumab is a humanized monoclonal antibody against NKG2A that induces IFN-γ production, thereby activating natur... |
|
T9636 |
Dalpiciclib
|
SHR-6390 |
CDK
|
|
Dalpiciclib (SHR-6390) is a highly selective, orally bioavailable, and comparable potency inhibitor of CDK4 and CKD6 with IC50s of 12.4 nM and 9.9 nM, respectively. Dalpiciclib exerts potent antitumor activity in esophag... |
|
T27242 |
EF24
|
EF 24,EF-24,3,5-Bis[(2-fluorophenyl)Methylene]-4-piperidinone |
ERK
,
MEK
,
Caspase
|
|
EF24 (3,5-Bis[(2-fluorophenyl)Methylene]-4-piperidinone) treatment increases the levels of activated caspase 3 and 9, and decreases the phosphorylated forms of MEK1 and ERK. EF24 shows potent anti-tumor activity in oral ... |
|
T76890 |
Petosemtamab
|
MCLA 158 |
EGFR
|
|
Petosemtamab (MCLA 158) is a highly potent monoclonal antibody against EGFR (Kd: 0.22 nM) and LGR5 (Kd: 0.86 nM). Petosemtamab promotes EGFR signaling disruption and receptor breakdown in LGR5+ cancer cells. Petosemtamab... |
|
T74794 |
USP28-IN-4
|
|
DUB
|
|
USP28-IN-4 is a potent USP28 inhibitor with an IC50 value of 0.04 μM against USP28. USP28-IN-4 exhibits anticancer activity and inhibits USP2, USP7, USP8, USP9x, UCHL3 and UCHL5. USP28-IN-4 is cytotoxic to human colorect... |
|
T74793 |
USP28-IN-3
|
|
DUB
|
|
USP28-IN-3 is a highly selective USP28 inhibitor with an IC50 value of 0.1 μM against USP28.USP28-IN-3 exhibits anticancer activity and inhibits USP2, USP7, USP8, USP9x, UCHL3, and UCHL5.USP28-IN-3 is cytotoxic to human ... |
|
T36466 |
Chlorin E6
|
Ce6,Chlorin e6,CE6 |
Parasite
|
|
Chlorin E6 (CE6) is a second-generation photosensitizer with antitumor activity when used in combination with irradiation. In a mouse model of implanted fibrosarcoma, Chlorin E6 (2.5-10 mg/kg, i.v., 50-200 J/cm2 irradiat... |
|
T35821 |
CAY10721
|
|
|
|
CAY10721 is an inhibitor of sirtuin 3 (SIRT3), a class III HDAC (39% SIRT3 inhibition at 200 μM). Upregulation of SIRT3 transcription is associated with oral squamous cell carcinoma (OSCC) and breast cancer with lymph no... |
|
T11691 |
IV-23
|
|
Others
|
|
IV-23, a potent inhibitor of cell growth both in vitro and in vivo, effectively reduces colony formation, arrests the cell cycle at the M phase, and induces apoptosis in esophageal squamous cell carcinoma through Noxa-me... |
|
T76918 |
Barecetamab
|
|
|
|
Barecetamab (ISU-104), a fully human anti-ErbB3 monoclonal antibody, is utilized in researching recurrent/metastatic (R/M) head and neck squamous cell carcinoma (HNSCC) [1]. |
|
T68642 |
Kahweol palmitate
|
|
|
|
Kahweol palmitate is a semi-synthetic derivative of kahweol, a natural product found in coffee beans. It exhibits a wide variety of biological activities, including inhibiting RANKL-induced osteoclast generation, inducin... |
|
T71478 |
Kahweol stearate
|
|
|
|
Kahweol stearate is a semi-synthetic derivative of kahweol, a natural product found in coffee beans. It exhibits a wide variety of biological activities, including inhibiting RANKL-induced osteoclast generation, inducing... |
|
T71479 |
Kahweol oleate
|
|
|
|
Kahweol oleate is emi-syntetic derivative of kahweol, a natural product found in coffee beans. It exhibits a wide variety of biological activities, including inhibiting RANKL-induced osteoclast generation, inducing cell ... |
|
T74997 |
ERK-IN-6
|
|
|
|
ERK-IN-6 (compound 6g) serves as a potent anti-proliferative agent against esophageal squamous cell carcinoma (ESCC), inducing apoptosis through the ERK pathway. This compound has potential applications in ESCC research ... |
|
T68641 |
Kahweol Acetate
|
|
|
|
Kahweol Acetate is a semi-synthetic derivative of kahweol, a natural product found in coffee beans. It exhibits a wide variety of biological activities, including inhibiting RANKL-induced osteoclast generation, inducing ... |
|
T71480 |
Kahweol linoleate
|
|
|
|
Kahweol linoleate is a semi-syntetic derivative of kahweol, a natural product found in coffee beans. It exhibits a wide variety of biological activities, including inhibiting RANKL-induced osteoclast generation, inducing... |
|
T21964 |
KP372-1
|
|
|
|
KP372-1 is an Akt inhibitor which block signalling through the PI3K pathway. KP372-1 inhibit cell proliferation while inducing apoptosis and anoikis in squamous cell carcinoma of the head and neck. |
|
T16354 |
NSC745885
|
|
Others
|
|
NSC745885 is an effective down-regulator of EZH2 via proteasome-mediated degradation. NSC745885 is also an effective anti-tumor agent that displays selective toxicity against multiple cancer cell lines but not normal cel... |
|
T82188 |
HN-1
|
|
|
|
HN-1, a 12-mer peptide with specificity for head and neck squamous cell carcinoma (HNSCC), penetrates tumor tissue and facilitates the translocation of agents across cell membranes [1]. |
|
T79602 |
MTP
|
|
Autophagy
|
|
MTP, a PKM2 inhibitor, promotes apoptosis in cancer cells via caspase-3 activation while also inducing autophagy and enhancing ROS generation. Further, it inhibits JAK2 signaling, rendering it useful for the study of ora... |
|
T73662 |
Peplomycin
|
|
|
|
Peplomycin (Bleomycin PEP; Pepleomycin), an analogue of Bleomycin, exhibits significant antitumor activity with reduced pulmonary toxicity. It induces apoptosis in the oral squamous carcinoma cell line SSCKN and causes p... |
|
T63199 |
Dalpiciclib hydrochloride
|
|
|
|
Dalpiciclib (SHR-6390) hydrochloride is a highly selective, orally active CDK4/6 inhibitor with IC50 values of 12.4 nM and 9.9 nM, respectively, and is capable of acting as an antitumor agent in breast and esophageal squ... |
|
T63050 |
JH-XVII-10
|
|
|
|
JH-XVII-10 is a selective, orally active and potent inhibitor of DYRK1A (IC50: 3 nM) and DYRK1B (IC50: 5 nM).JH-XVII-10 exhibits antitumor effects in squamous cell carcinoma of the neck (HNSCC) cell lines. |
|
T62790 |
JH-XIV-68-3
|
|
|
|
JH-XIV-68-3 is a selective inhibitor of the DYRK1A/B macrocycle.JH-XIV-68-3 selectively acts on DYRK1A and its close relative DYRK1B in biochemical and cellular assays.JH-XIV-68-3 has antitumor effects in head and neck s... |
|
T76997 |
Socazolimab
|
|
|
|
Socazolimab (ZKAB001), an anti-PD-L1 monoclonal antibody, demonstrates enduring safety and efficacy in treating recurrent or metastatic cervical cancer. Additionally, it shows promise for treating small cell lung cancer,... |
|
T76703 |
Tislelizumab
|
|
|
|
Tislelizumab is a monoclonal antibody that exhibits strong binding affinity for the PD-1 receptor and reduces Fcγ receptor engagement on macrophages, preventing antibody-dependent phagocytosis, a pathway for T cell elimi... |
|
T64075 |
Afatinib oxalate
|
|
|
|
Afatinib (BIBW 2992) oxalate is an irreversible, orally active bispecific inhibitor of the ErbB family (EGFR and HER2) that acts on EGFRwt (IC50: 0.5 nM), EGFRL858R (IC50: 0.4 nM), EGFRL858R/T790M ( IC50: 10 nM) and HER2... |
|
T35810 |
C24 dihydro Ceramide (d18:0/24:0)
|
Cer(d18:0/24:0) |
|
|
C24 dihydro Ceramide is a sphingolipid that has been found in the stratum corneum of human skin.[1] It is found in higher concentrations in female sebum compared to male sebum.[2] C24 dihydro Ceramide levels positively c... |
|
T72776 |
NR2F1 agonist 1
|
|
|
|
NR2F1 agonist 1, a specific nuclear receptor NR2F1 activator, initiates dormancy programs in cancer cells by upregulating NR2F1 and its target genes controlling dormancy. This compound promotes neural crest-like features... |
|
T72912 |
(R)-Afatinib
|
(R)-BIBW 2992 |
|
|
(R)-Afatinib ((R)-BIBW 2992), an isomer of Afatinib, is a potent, orally administered, irreversible inhibitor targeting the ErbB family (EGFR and HER2) with IC50 values of 0.5 nM for EGFR wt, 0.4 nM for EGFR L858R, 10 nM... |
|
T35426 |
β-Defensin-1 (human) (trifluoroacetate salt)
|
|
|
|
β-Defensin-1 is a peptide with antimicrobial properties that protects the skin and mucosal membranes of the respiratory, genitourinary, and gastrointestinal tracts.1It inhibits the growth ofB. adolescentis,L. acidophilus... |
|
T36844 |
Inostamycin A
|
|
|
|
Inostamycin A is a bacterial metabolite that has been found inStreptomycesand has anticancer activity.1It is an inhibitor of CDP-diacylglycerol:inositol 3-phosphatidyltransferase (IC50= 0.02 μg/ml in A431 cell membranes)... |
|
T36846 |
Chromomycin A2
|
|
|
|
Chromomycin A2 is an aureolic acid that has been found in several marine actinomycetes and has antibacterial and anticancer activities. Chromomycin A2 inhibits the growth of B. subtilis in an agar diffusion assay. It als... |
|
T83704 |
A20FMDV2 TFA
|
|
|
|
A20FMDV2, a peptide derived from the α-helical RGD cell-interacting domain of the VP1 capsid protein of foot-and-mouth disease virus (FMDV) serotype O, targets and binds αVβ6 integrin. It effectively disrupts αVβ6 integr... |
