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T12831 |
SAR405 R enantiomer
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Others
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SAR405 R enantiomer is the less active enantiomer of SAR405. SAR405 is an inhibitor of PIK3C3/Vps34. |
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T12064 |
Niraparib (R-enantiomer)
|
MK 4827 (R-enantiomer),Niraparib R-enantiomer |
PARP
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Niraparib R-enantiomer (MK 4827 R-enantiomer) is an inhibitor of PARP1(IC50 of 2.4 nM). |
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T15263 |
Selisistat R-enantiomer
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EX-527 (R-enantiomer) |
Sirtuin
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Selisistat R-enantiomer (EX-527 (R-enantiomer)) is a SIRT1 inhibitor with much less activity than the R-enantiomer of Selisistat (IC50 of SIRT1 > 100 μM). |
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T12697 |
Refametinib R enantiomer
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RDEA119 R enantiomer,Refametinib R enantiomer,BAY 869766 R enantiomer |
MEK
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|
|
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T13140 |
Umbralisib R-enantiomer
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TGR-1202 R-enantiomer,RP5264 R-enantiomer |
PI3K
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Umbralisib R-enantiomer (RP5264 R-enantiomer) is a delta inhibitor of PI3K and a less active enantiomer of TGR-1202. The IC50 of Umbralisib R-enantiomers against δPI3 kinase is at least 20 times lower than that of the in... |
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T19618 |
(R)-(-)-JQ1 Enantiomer
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Epigenetic Reader Domain
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(R)-(-)-JQ1 Enantiomer is the stereoisomer of (+)-JQ1. (+)-JQ1 is a BET bromodomain inhibitor, acting on BRD4(1/2)(IC50 of 77 nM/33 nM in a cell-free assay) |
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T11129L |
Duvelisib (R enantiomer) hydrochloride
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IPI-145 R enantiomer HCl,Duvelisib (R enantiomer) hydrochloride(1261590-48-0 Free base),INK1197 R enantiomer HCl |
PI3K
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Duvelisib (R enantiomer) hydrochloride (INK1197 R enantiomer HCl) is a PI3K inhibitor. Duvelisib (R enantiomer) hydrochloride is the less active enantiomer of Duvelisib. |
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T39541 |
THK5351 (R enantiomer)
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|
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THK5351 R enantiomer is an R enantiomer of THK5351. |
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T10552 |
Bitopertin (R enantiomer)
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RO4917838 (R enantiomer),RG1678 (R enantiomer),Bitopertin R enantiomer |
GlyT
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Bitopertin R enantiomer (RG1678 R enantiomer) is the R-enantiomer of Bitopertin. Bitopertin is a noncompetitive glycine reuptake inhibitor and inhibits glycine uptake at human GlyT1 (IC50: 25 nM). |
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T12274 |
Siremadlin (R Enantiomer)
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Siremadlin R Enantiomer,HDM201 R Enantiomer,NVP-HDM201 R Enantiomer |
Others
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Siremadlin R Enantiomer is the R enantiomer of Siremadlin. Siremadlin is a potent and highly specific inhibitor of MDM-2/p53. |
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T13422L |
Talarozole (R enantiomer)
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(R)-Talarozole,Talarozole R enantiomer |
Others
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Talarozole R enantiomer is a potent and selective inhibitor of cytochrome P450 26-mediated breakdown of endogenous all-trans retinoic acid. |
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T11334 |
Fulvestrant (R enantiomer)
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ICI 182780 R enantiomer,ZD 9238 R enantiomer,ZM 182780 R enantiomer,Fulvestrant R enantiomer |
Others
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Fulvestrant R enantiomer is the less active R enantiomer of Fulvestrant. Fulvestrant is a potent estrogen receptor antagonist with an IC50 of 9.4 nM. |
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T13120 |
Tenalisib R Enantiomer
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RP6530 R Enantiomer |
Others
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Tenalisib R Enantiomer is an R enantiomer of Tenalisib . |
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T13312 |
Seviteronel R enantiomer
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VT-464 (R enantiomer) |
Others
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Seviteronel R enantiomer is the R enantiomer of Seviteronel and is a potent inhibitor of CYP17 lyase (IC50: 69 nM for h-Lyase). |
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T10856 |
Cobimetinib (R-enantiomer)
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XL-518 R-enantiomer,Cobimetinib R-enantiomer,GDC-0973 R-enantiomer |
Others
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Cobimetinib R-enantiomer is the less active R-enantiomer of Cobimetinib which is a selective MEK inhibitor. |
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T11410 |
GLPG0492 (R enantiomer)
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GLPG0492 R enantiomer |
Others
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GLPG0492 R enantiomer is the R enantiomer of GLPG-0492, a novel selective androgen receptor modulator. |
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T12775 |
RSV604 (R enantiomer)
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RSV604 R enantiomer |
Others
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RSV604 R enantiomer is the R-enantiomer of RSV604. RSV604 is a respiratory syncytial virus (RSV) replication inhibitor. |
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T11129 |
Duvelisib (R enantiomer)
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Duvelisib R enantiomer,IPI-145 R enantiomer,INK1197 R enantiomer |
PI3K
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Duvelisib R enantiomer (IPI-145 R enantiomer) is an enantiomer of Duvelisib with lower activity. Duvelisib is a PI3K inhibitor. |
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T11841 |
Leu-AMS R enantiomer
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Others
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Leu-AMS R enantiomer is the R enatiomer of Leu-AMS. Leu-AMS is a potent leucyl-tRNA synthetase (LRS) inhibitor that inhibits the bacteria growth. |
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T11662 |
INT-777 R-enantiomer
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S-EMCA R enantiomer |
Others
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INT-777 is the R-enantiomer of INT-777, less potent than INT-777,EC50 of 4.79 μM for TGR5. |
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T12723 |
Ribocil-C R enantiomer
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Others
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Ribocil-C R enantiomer is the R enantiomer of Ribocil-C. Ribocil-C is a highly selective bacterial riboflavin riboswitches inhibitor. |
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T17102 |
Tipifarnib (S enantiomer)
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Tipifarnib S enantiomer,(S)-(-)-R-115777,(S)-Tipifarnib,IND-58359 S enantiomer |
Transferase
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Tipifarnib S enantiomer ((S)-(-)-R-115777) is the S-enantiomer of Tipifarnib. Tipifarnib is a potent and specific farnesyltransferase inhibitor (IC50: 0.6 nM). |
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T11627 |
IACS-8968 R-enantiomer
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IDO/TDO Inhibitor (R-enantiomer) |
IDO
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IACS-8968 R-enantiomer is the R-enantiomer of IACS-8968. IACS-8968 is a dual IDO and TDO inhibitor (pIC50s: 6.43 for IDO and <5 for TDO). |
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T67881 |
Acalabrutinib enantiomer
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R-Acalabrutinib |
BTK
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Acalabrutinib enantiomer (R-Acalabrutinib) is a chemical compound that belongs to the class of Bruton’s tyrosine kinase (BTK) inhibitors. Acarabitinib enantiomers can be used in the study of cancer, autoimmune diseases a... |
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T12096 |
Morinidazole (R enantiomer)
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R-Morinidazole |
Others
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Morinidazole (R enantiomer) is the R-enantiomer of Morinidazole. |
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T12612 |
(R)-Apremilast
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(R)-CC-10004 |
Others
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(R)-Apremilast ((R)-CC-10004) is the enantiomer of Apremilast and one of the isoindoline derivatives. |
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T20898 |
(R)-Propranolol hydrochloride
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Dexpropranolol hydrochloride,(R)-(+)-Propranolol |
Adrenergic Receptor
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(R)-Propranolol hydrochloride (Dexpropranolol hydrochloride) is the less active enantiomer of the anti-adrenoceptor (β-adrenoceptor) antagonist propranolol. Propranolol is a nonselective β-adrenergic receptor (βAR) antag... |
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T10608 |
BRD5648
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(R)-BRD0705 |
GSK-3
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T27210 |
DRX-065
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DRX 065,DRX065,deuterated R-enantiomer of pioglitazone |
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DRX-065 is a stabilized and deuterated R-enantiomer of pioglitazone. DRX-065 has pharmacological properties desirable for the treatment of NASH (mitochondrial function modulation, non-steroidal anti-inflammatory effects,... |
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T13448 |
(R)-(-)-Rolipram
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(R)-Rolipram,(-)-Rolipram |
DNA-PK
,
Others
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(R)-(-)-Rolipram ((-)-Rolipram) is an R-enantiomer of Rolipram which is a PDE4 inhibitor. |
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T36839 |
(R)-Mephenytoin
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R-Mephenytoin,(R)-Mephenytoin,(–)-Mephenytoin |
Others
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(R)-Mephenytoin ((–)-Mephenytoin) is the the R-enantiomer of Mephenytoin which is an anticonvulsant agent. |
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T12624 |
(R)-Ketorolac
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(+)-Ketorolac |
Others
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(R)-Ketorolac ((+)-Ketorolac) is the R-enantiomer of Ketorolac, with potent analgesic activity. |
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T70388L |
(R)-Enitociclib
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CDK
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(R)-Enitociclib, an enantiomer of BAY-1251152, is a CDK9 inhibitor with anticancer activity. |
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T17309 |
(R)-(-)-Ibuprofen
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levibuprofen,(R)-Ibuprofen |
NF-κB
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(R)-(-)-Ibuprofen ((R)-Ibuprofen) is the R enantiomer of Ibuprofen and inhibits NF-κB activation. (R)-(-)-Ibuprofen has anti-inflammatory and antinociceptive effects. |
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T10012 |
P7C3-OMe
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Others
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P7C3-OMe, a pro-neurogenic agent, has therapeutic benefits in neurodegenerative diseases. The R-enantiomer of P7C3-OMe is far more active than the S-enantiomer. |
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T12632L |
(S)-Mirtazapine
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(S)-6-Azamianserin,(S)-Org3770 |
5-HT Receptor
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(S)-Mirtazapine ((S)-Org3770) is the S(+)-enantiomer of Mirtazapine. (S)-Mirtazapine is a selective 5-HT2 receptor antagonist with pro-nociceptive effects and is often used in combination with the R(-)-enantiomer of Mirt... |
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T12632 |
(R)-Mirtazapine
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(R)-Org3770,(R)-6-Azamianserin |
5-HT Receptor
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(R)-Mirtazapine ((R)-Org3770) is the R(-)-enantiomer of Mirtazapine, which has anti-injury sensory properties in an animal model of acute thermal hyperalgesia. (R)-Mirtazapine is an antagonist of 5-HT3 receptors and a po... |
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T10003 |
α1 adrenoceptor-MO-1
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|
Others
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α1 adrenoceptor-MO-1 (S enantiomer) has affinity at alpha 1 adrenergic receptor with alphalytic activity and analgesic action. It has more active than R enantiomer. |
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T10174 |
5-R-Rivaroxaban
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Factor Xa
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5-R-Rivaroxaban is (R)-enantiomer of Rivaroxaban. Rivaroxaban (BAY 59-7939) is a highly potent and selective, direct Factor Xa (FXa) inhibitor (IC50 0.7 nM; Ki 0.4 nM). |
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T5843 |
Tarenflurbil
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MPC7869,(R)-Flurbiprofen,R-flurbiprofen |
Retinoid Receptor
,
Autophagy
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Tarenflurbil ((R)-Flurbiprofen) is the non-cyclooxygenase inhibiting R-enantiomer of the non-steroidal anti-inflammatory drug flurbiprofen, which was assessed as a remedy for Alzheimer's disease. |
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T22148 |
(S)-Lisofylline
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Others
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(S)-Lisofylline is the inactive optical enantiomer of (R)-lisofylline which is an anti-inflammatory agent. (S)-Lisofylline is exclusively converted to pentoxifylline in human liver microsomes. |
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T12643 |
(R)-Terazosin
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Adrenergic Receptor
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(R)-Terazosin is an active R-enantiomer of Terazosin. (R)-Terazosin is a potent antagonist of α1-adrenoceptor (α1a, α1b and α1d-adrenoceptor with Ki values of 6.51 nM, 1.01 nM and 1.97 nM, respectively). |
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T12628 |
(R)-MG-132
|
(S,R,S)-(-)-MG-132,Z-Leu-D-leu-leu-al |
Proteasome
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|
|
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T22354 |
Levocetirizine Dihydrochloride
|
Xyzal Dihydrochloride,(-)-Cetirizine Dihydrochloride |
Histamine Receptor
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Levocetirizine Dihydrochloride (Xyzal Dihydrochloride) is a third-generation peripheral H1-receptor antagonist. Acting as an antihistaminic agent, it specifically targets the histamine H1-receptor. Levocetirizine Dihydro... |
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T4295 |
(R)-GNE-140
|
GNE-140 |
Dehydrogenase
|
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(R)-GNE-140 (GNE-140) is an effective LDHA/LDHB inhibitor (IC50s: 3/5 nM) and is 18-fold more potent than S enantiomer. |
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T6396 |
(R)-(-)-Gossypol acetic acid
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(-)-Gossypol acetic acid,AT-101 (acetic acid),(R)-Gossypol acetic acid,AT101,AT101 acetate |
BCL
,
Autophagy
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|
(R)-(-)-Gossypol acetic acid (AT101 acetate) , the R-(-) enantiomer of Gossypol acetic acid, binds with Bcl-2, Bcl-xL and Mcl-1 with Ki of 0.32 μM, 0.48 μM and 0.18 μM; does not inhibit BIR3 domain and BID. Phase 2. |
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T13428 |
(5R)-BW-4030W92
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|
Sodium Channel
|
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(5R)-BW-4030W92 is the R-type of BW-4030W92, the active enantiomer. (5R)-BW-4030W92 is an orally available, non-selective, voltage-dependent and use-dependent sodium channel antagonist for the study of neurological disor... |
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T10776 |
CFTR corrector 4
|
|
CFTR
|
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CFTR corrector 4 is a potent and orally available transmembrane conductance regulator (CFTR) for cystic fibrosis and is a potent (R,R) type active enantiomer. CFTR corrector 4 increases CFTR levels on the cell surface a... |
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T6649 |
(S)-(+)-Rolipram
|
(S)-Rolipram,(+)-Rolipram,S- (+)-Rolipram |
Apoptosis
,
PDE
|
|
(S)-(+)-Rolipram ((+)-Rolipram) inhibits human monocyte cyclic AMP-specific PDE4 with IC50 of 0.75 μM, has anti-inflammatory and anti-depressant activity in the central nervous system, less potent than its R enantiomer. |
|
T20828 |
Citalopram
|
Cipram,Lu 10-171,Lu-10-171 Lu10-171 |
5-HT Receptor
|
|
Citalopram (Lu 10-171 is an orally active, selective serotonin reuptake inhibitor (SSRI), a selective 5-hydroxytryptamine reuptake inhibitor, and a racemic mixture of the S(+)-enantiomer (Escitalopram) and the R(-)-enant... |
