|
T12010 |
Aurora B inhibitor 1
|
|
Aurora Kinase
|
|
|
|
T9040 |
Aurora kinase inhibitor-2
|
IUN-70219,Aurora Kinase Inhibitor II |
Aurora Kinase
|
|
Aurora kinase inhibitor-2 (IUN-70219) is a cell-permeable anilinoquinazoline that inhibit the activity of Aurora A (IC50 = 0.39 M). |
|
T35570 |
Chiauranib
|
CS2164 |
c-Fms
,
VEGFR
,
FLT
,
PDGFR
,
c-Kit
,
Aurora Kinase
|
|
Chiauranib is a multi-target inhibitor against tumor angiogenesis and exhibits potent anticancer effects. Chiauranib potently inhibits the angiogenesis-related kinases (VEGFR1, VEGFR2, VEGFR3, PDGFRα and c-Kit), mitosis-... |
|
T6435 |
CCT129202
|
|
Aurora Kinase
|
|
CCT129202 is an ATP-competitive pan-Aurora inhibitor for Aurora A, Aurora B and Aurora C with IC50 of 0.042 μM, 0.198 μM and 0.227 μM, respectively. It is less potent to FGFR3, GSK3β, PDGFRβ, etc. |
|
T1825 |
Reversine
|
|
Aurora Kinase
,
Adenosine Receptor
,
Autophagy
|
|
Reversine, a small synthetic purine analogue (2, 6-disubstituted purine), is a potent inhibitior of Aurora A/B/C(IC50s=150-500 nM). |
|
T2509 |
Tozasertib
|
MK-0457,VX 680 |
Aurora Kinase
,
Autophagy
|
|
Tozasertib (MK-0457) is a pan-Aurora kinase inhibitor (Kis: 0.6/18/4.6 nM for Aurora A/Aurora B/Aurora C). It shows selectivity against more than 190 different kinases. |
|
T6077 |
ZM-447439
|
|
Apoptosis
,
MEK
,
Src
,
Aurora Kinase
|
|
ZM 447439 is a selective and ATP-competitive inhibitor for Aurora A and Aurora B with IC50 of 110 nM and 130 nM, respectively. It is more than 8-fold selective for Aurora A/B than MEK1, Src, Lck and has little effect aga... |
|
T6338 |
PHA-680632
|
PHA 680632,PHA680632 |
FGFR
,
PLK
,
Aurora Kinase
|
|
PHA-680632 is potent inhibitor of Aurora A, Aurora B and Aurora C with IC50 of 27 nM, 135 nM and 120 nM, respectively. It has 10- to 200-fold higher IC50 for FGFR1, FLT3, LCK, PLK1, STLK2, and VEGFR2/3. |
|
T8685 |
SP-146
|
|
Aurora Kinase
|
|
SP-146 is a selective, potent and non-ATP-competitive Aurora B inhibitor(IC50 : 0.316 nM). |
|
T2611 |
CCT 137690
|
CCT137690 |
Apoptosis
,
Aurora Kinase
|
|
CCT 137690 is a highly specific and oral-available aurora kinase inhibitor, for aurora A(IC50=15 nM ), B(IC50=25 nM) and C(IC50=19 nM). |
|
T14371 |
Barasertib
|
AZD1152 |
Apoptosis
,
Aurora Kinase
|
|
|
|
T11638 |
Ilorasertib hydrochloride
|
ABT-348 hydrochloride |
Aurora Kinase
|
|
Ilorasertib hydrochloride (ABT-348 hydrochloride) is an ATP-competitive multitargeted kinase inhibitor, which inhibits Aurora C, Aurora B, and Aurora A (IC50s: 1 nM, 7 nM, 120 nM). It also suppresses RET tyrosine kinase,... |
|
T6380 |
AMG 900
|
AMG900,AMG-900 |
p38 MAPK
,
Tyrosine Kinases
,
Aurora Kinase
|
|
AMG 900 is a potent and highly selective pan-Aurora kinases inhibitor for Aurora A/B/C with IC50 of 5 nM/4 nM /1 nM. It is >10-fold selective for Aurora kinases than p38α, Tyk2, JNK2, Met and Tie2. Phase 1. |
|
T34787 |
TAS-119
|
TAS119,TAS2104,TAS 2104,TAS-2104,TAS 119 |
Aurora Kinase
|
|
|
|
TQ0059 |
Ilorasertib
|
ABT-348 |
VEGFR
,
FLT
,
c-RET
,
PDGFR
,
Aurora Kinase
|
|
Ilorasertib (ABT-348) (ABT-348) is an ATP-competitive multitargeted kinase inhibitor, which inhibits Aurora A/Aurora B/Aurora C (IC50s: 120 nM/7 nM/1 nM). It also suppresses RET tyrosine kinase, PDGFRβ, and Flt1 (IC50s: ... |
|
T6129 |
GSK-1070916
|
GSK-1070916A,GSK1070916 |
Apoptosis
,
Tie-2
,
FLT
,
AMPK
,
Aurora Kinase
|
|
GSK-1070916 (GSK-1070916A) is a reversible and ATP-competitive inhibitor of Aurora B/C with IC50 of 3.5 nM/6.5 nM. It displays >100-fold selectivity against the closely related Aurora A-TPX2 complex. Phase 1. |
|
T2602 |
Barasertib-HQPA
|
1H-Pyrazole-3-acetamide,Barasertib,AZD1152-HQPA,AZD2811,AZD1152-HQPA|AZD2811 |
Apoptosis
,
Aurora Kinase
|
|
Barasertib-HQPA (AZD2811) is a highly selective Aurora B inhibitor (IC50: 0.37 nM) and demonstrates ~3,700-fold greater selectivity than Aurora A. |
|
T6532 |
Hesperadin
|
|
Influenza Virus
,
Parasite
,
Aurora Kinase
,
Autophagy
|
|
Hesperadin(IC50=250 nM) effectively inhibits Aurora B. It potently reduces the activity of AMPK, MAPKAP-K1, MKK1, Lck, CHK1 and PHK, but it could not inhibit MKK1 activity in vivo. |
|
T6126 |
JNJ-7706621
|
JNJ 7706621 |
Apoptosis
,
CDK
,
Aurora Kinase
|
|
JNJ-7706621 is a potent aurora kinase inhibitor, and also inhibits CDK1 and CDK2. |
|
T41256 |
SP-96
|
|
Aurora Kinase
|
|
SP-96 is a highly effective and selective inhibitor of Aurora B with an IC50 of 0.316 nM. SP-96 shows selective growth inhibition in NCI60 screening, including MDA-MD-468 (GI50=107 nM). SP-96 can be used in triple negati... |
|
T2617 |
SNS-314 Mesylate
|
SNS-314 |
Aurora Kinase
|
|
SNS-314 Mesylate (SNS-314) is an effective and specific Aurora A/B/C inhibitor (IC50: 9/31/3 nM). It is less inhibition of Trk A/B, Fms, Flt4, c-Raf, Axl, and DDR2. |
|
T6458 |
CYC-116
|
|
VEGFR
,
FLT
,
CDK
,
S6 Kinase
,
Aurora Kinase
|
|
CYC116 is a potent inhibitor of Aurora A/B with Ki of 8.0 nM/9.2 nM, is less potent to VEGFR2 (Ki of 44 nM), with 50-fold greater potency than CDKs, not active against PKA, Akt/PKB, PKC, no effect on GSK-3α/β, CK2, Plk1 ... |
|
T10215 |
AAPK-25
|
|
Apoptosis
,
PLK
,
Aurora Kinase
|
|
|
|
T15815 |
LY3295668
|
AK-01 |
Aurora Kinase
|
|
LY3295668 (AK-01) is a selective inhibitor of Aurora A with Kis of 0.8 nM and 1038 nM for Aurora A and B, respectively. |
|
T16359 |
NU6140
|
|
CDK
,
Aurora Kinase
|
|
NU6140 is a selective inhibitor of CDK2-cyclin A (IC50, 0.41 μM). It shows 10- to 36-fold selectivity over other CDKs. NU6140 also effectively inhibits Aurora A and Aurora B (IC50s: 67 and 35 nM, respectively). It also e... |
|
T6767 |
TCS7010
|
Aurora A Inhibitor I |
Apoptosis
,
Aurora Kinase
|
|
TCS7010 (Aurora A Inhibitor I) is a novel, potent, and selective inhibitor of Aurora A with IC50 of 3.4 nM in a cell-free assay. It is 1000-fold more selective for Aurora A than Aurora B. |
|
T3068 |
AT9283
|
J-504568 |
Apoptosis
,
FLT
,
JAK
,
Bcr-Abl
,
Aurora Kinase
,
Autophagy
|
|
AT9283 (J-504568) is an effective multi-targeted inhibitor of JAK2(IC50=1.2 nM) and JAK3(IC50=1.1 nM), Aurora A, Aurora B and Abl(T315I). |
|
T2241 |
Alisertib
|
MLN 8237 |
Apoptosis
,
Aurora Kinase
,
Autophagy
|
|
Alisertib (MLN 8237) is a specific Aurora A inhibitor (IC50: 1.2 nM). The selectivity of Alisertib(MLN 8237) is >200-fold higher for Aurora A than Aurora B. |
|
T6039 |
TAK-285
|
TAK285,TAK 285 |
EGFR
,
MEK
,
HER
,
Aurora Kinase
|
|
TAK-285 is a novel dual HER2 and EGFR(HER1) inhibitor with IC50 of 17 nM and 23 nM, >10-fold selectivity for HER1/2 than HER4, less potent to MEK1/5, c-Met, Aurora B, Lck, CSK etc. Phase 1. |
|
T22012 |
7BIO
|
|
FLT
,
DYRK
,
Aurora Kinase
|
|
7-bromoindirubin-3'-oxime (7BIO) is a caspase independent nonapoptotic cell death inducer. 7BIO is an inhibitor of FLT3, DYRK1A, DYRK2, Aurora B and Aurora C kinases. |
|
T66175 |
Ceftriaxone Sodium
|
|
GSK-3
,
Antibiotic
,
Aurora Kinase
|
|
Ceftriaxone Sodium is a broad-spectrum β-lactam tertiary cephalosporin antibiotic with anti-inflammatory, antitumor, antibacterial, and antioxidant activities.Ceftriaxone Sodium is a covalent GSK3β and Aurora B inhibitor... |
|
T2094 |
Danusertib
|
PHA-739358 |
FGFR
,
Trk receptor
,
c-RET
,
Bcr-Abl
,
Aurora Kinase
,
Autophagy
|
|
Danusertib (PHA-739358) is a small-molecule 3-aminopyrazole derivative with potential antineoplastic activity. Danusertib binds to and inhibits the Aurora kinases, which may result in cell growth arrest and apoptosis in ... |
|
T22288 |
(1E)-CFI-400437 dihydrochloride
|
CFI-400437 dihydrochloride |
PLK
|
|
(1E)-CFI-400437 dihydrochloride (CFI-400437 dihydrochloride) is a selective and potent polo-like kinase 4 (PLK4) inhibitor. |
|
T10412 |
Aurora inhibitor 1
|
|
Aurora Kinase
|
|
Aurora inhibitor 1 is a potent Aurora inhibitor (IC50: ≤ 4 nM and ≤13 nM for Aurora A and Aurora B kinase). |
|
T16862 |
SCH-1473759
|
|
Aurora Kinase
|
|
SCH-1473759 is an inhibitor of the aurora (IC50s: 4 and 13 nM for Aurora A and B, respectively). |
|
T12864 |
SCH-1473759 hydrochloride
|
|
Aurora Kinase
|
|
|
|
T23426 |
TC-A 2317 hydrochloride
|
|
Others
,
Aurora Kinase
|
|
TC-A 2317 hydrochloride is an Aurora kinase A inhibitor (Ki = 1.2 nM compared to 101 nM for inhibition of Aurora kinase B). It's selective over 60 other kinases (IC50: > 1000 nM). TC-A 2317 hydrochloride is also shown go... |
|
T6936 |
PF-03814735
|
|
FAK
,
VEGFR
,
FLT
,
Trk receptor
,
Aurora Kinase
|
|
PF-03814735 is a novel, potent and reversible inhibitor of Aurora A/B with IC50of 0.8 nM/5 nM, is less potent to Flt3, FAK, TrkA, and minimally active to Met and FGFR1. Phase 1. |
|
T21298 |
SNS-314
|
SNS-314 free base,SNS314,SNS 314 |
|
|
SNS-314, a synthetic small molecule Aurora kinase (AK) inhibitor with potential antineoplastic activity, selectively binds and inhibits AKs A and B, resulting in the inhibition of cell division and proliferation in tumor... |
|
T71112 |
SAR156497
|
|
|
|
SAR156497 is an exquisitely selective Aurora A, B, and C inhibitor with in vitro and in vivo efficacy with IC50 = 0.5 nM (Aurora A); 1 nM (Aurora B / incenp); 3 nM (Aurora C / incenp) respectively SAR156497 combines high... |
|
T62789 |
Aurora kinase inhibitor-9
|
|
|
|
Aurora kinase inhibitor-9 (compound 9d) is a potent AURKA/B bipolar kinase inhibitor, acting on Aurora A (IC50: 0.093 μM), Aurora B (IC50: 0.09 μM). broad-spectrum anti-proliferative activity. |
|
T63905 |
Hesperadin hydrochloride
|
|
|
|
Hesperadin hydrochloride is an ATP-competitive indolone inhibitor of Aurora A and B, with an IC50 value of 250 nM for Aurora B. |
|
T70401 |
HOI-07
|
|
|
|
HOI-07 is a specific Aurora B inhibitor. |
|
T8537 |
Tripolin A
|
|
Aurora Kinase
|
|
Tripolin A is a specific non-ATP competitive inhibitor of Aurora A kinase(Aurora A and Aurora B with IC50 values of 1.5 μM and 7 μM, respectively) |
|
T71169 |
XMD-12
|
|
|
|
XMD-12, also known as DUN57447, Aurora inhibitor (compound 1) or Aurora-IN-1, is an Auroro inhibitor, which targets Aurora A/B/C. (5.6/18.4/24.6 nM). |
|
T70600 |
BRD-7880
|
|
|
|
BRD-7880 is a potent and highly specific inhibitor of aurora kinases B and C. |
|
T63853 |
Aurora kinase inhibitor-10
|
|
|
|
Aurora kinase inhibitor-10 is an orally active Aurora B inhibitor (IC50: 8 nM) that exhibits antitumour effects. |
|
T68234 |
BI-831266
|
|
|
|
BI-831266 is a potent and selective Aurora kinase B inhibitor. |
|
T62484 |
Aurora Kinases-IN-2
|
|
|
|
Aurora Kinases-IN-2 (compound 12Aj) is a potent inhibitor of Aurora kinases, acting on Aurora A (IC50: 90 nM) and Aurora B (IC50: 152 nM). Aurora Kinases-IN-2 can be used in cancer research. |
|
T74174 |
JB170
|
|
|
|
JB170, a potent and highly specific PROTAC-mediated AURORA-A (Aurora Kinase) degrader (DC50=28 nM), achieves its selectivity by linking Alisertib to the Cereblon-binding molecule Thalidomide. It demonstrates a strong pre... |
