| T12651 |
Rabdosiin
|
(+)-Rabdosiin |
Others
|
|
Rabdosiin ((+)-Rabdosiin) is a natural product, and has anti-allergic activity, anti-HIV activity and inhibition on DNA topoisomerase. |
| T2982 |
Xanthone
|
Genicide,Xanthenone,Benzophenone oxide |
Apoptosis
,
Others
,
Influenza Virus
,
Antibacterial
,
Antifungal
|
|
Xanthone (Xanthenone) is currently used as ovicide for codling moth eggs and as a larvicide. |
| T2902 |
Costunolide
|
Costus lactone,NSC 106404,Costunolid,(+)-Costunolide |
Apoptosis
,
Endogenous Metabolite
,
Telomerase
|
|
Costunolide (Costus lactone) has anti-inflammatory and anti-oxidant properties and mediates apoptosis. |
| T2S0504 |
Ilexoside D
|
|
Others
|
|
Ilexoside D has ant-allergic, and anti-coagulant activities, it shows anti-tissue factor activity as well as the antithrombotic activity. |
| T4S2164 |
Narirutin
|
Naringenin-7-O-rutinoside,Isonaringin |
Others
,
Antibacterial
|
|
1. Narirutin (Naringenin-7-O-rutinoside) has antiproliferative property. 2. Narirutin has anti-oxidant property. 3. Narirutin has anti-allergic and anti-inflammatory properties , can reduce airway inflammation in ovalbum... |
| T5666 |
Dipotassium glycyrrhizinate
|
|
Virus Protease
|
|
Dipotassium glycyrrhizinate is an anionic surfactant having anti-allergic and anti-inflammatory activities. |
| T3872 |
Nodakenin
|
(+)-Marmesinin |
AChE
|
|
Nodakenin ((+)-Marmesinin) is a compound with anti-allergic and anti-inflammatory activities. |
| TMA1570 |
Sappanone A
|
|
NF-κB
,
Nrf2
|
|
Sappanone A is a high isoflavanone that exhibits anti-inflammatory effects by modulating Nrf2.Sappanone A attenuates allergic airway inflammation in ovalbumin-induced asthma. |
| T2S2362 |
Dehydrocorydaline nitrate
|
|
BCL
,
Others
,
PARP
,
p38 MAPK
,
Caspase
,
Parasite
,
Autophagy
|
|
1. Dehydrocorydaline(DHC) not only inhibits antibody-mediated allergic reactions but also influences cell-mediated allergic reactions, and the inhibitory effect of Corydalis Tuber on allergic reactions may be partially a... |
| TN1088 |
3,5,6,7,8,3',4'-Heptemthoxyflavone
|
3,3',4',5,6,7,8-heptamethoxyflavone |
Others
|
|
3,5,6,7,8,3',4'-Heptemthoxyflavone has neuroprotective, chemopreventive, anti-allergic, anti-inflammatory, immunomodulatory, anti-aging and photoprotective effects; it inhibits collagenase activity and induces type I pro... |
| TN1516 |
Cnidicin
|
|
NOS
,
NO Synthase
|
|
Cnidicin has anti-allergic and anti-inflammatory activity, it inhibits the degranulation of mast cell and the NO generation in RAW 264.7 cells(IC50 value, 7.5 microM). Cnidicin exhibits a significant inhibition on the pr... |
| T6S0117 |
Avicularin
|
Fenicularin |
ERK
|
|
Avicularin (Fenicularin) has anti-allergic, anti-inflammatory, hepatoprotective, antioxidant, anti-tumor and other activities. It ameliorates human hepatocellular carcinoma by modulating the activities of NF-κB(p65), COX... |
| T4S1943 |
Kirenol
|
Kirel |
Wnt/beta-catenin
|
|
1. Kirenol (Kirel) has anti-oxidant, anti-inflammatory, anti-allergic, and anti-arthritic activities. 2. Kirenol is effective against gram-positive bacteria. 3. Kirenol possesses antitumor action on human chronic myeloid... |
| T17214 |
Valencene
|
NSC 148969,NSC-148969,NSC148969 |
Others
,
Antioxidant
,
NF-κB
|
|
Valencene (NSC-148969) is a sesquiterpenoid isolated from Cyperus rotundus and is an aroma component of citrus fruits and citrus-derived odors.ValenceneValencene has anti-allergic, anti-inflammatory, anti-melanogenic, an... |
| TN1712 |
Gossypin
|
|
NF-κB
,
S6 Kinase
|
|
Gossypin has antidiabetic, antioxdiant, anticonvulsant, anti-allergic, antiinflammatory, antinociceptive, cytotoxic and antibacterial activities; it inhibits the NF-kappaB activation pathway, which may explain its role i... |
| T5S1285 |
(+)-(3R,8S)-Falcarindiol
|
Falcarindiol |
Others
|
|
1. (+)-(3R,8S)-Falcarindiol is a potential new anticancer agent that exerts its activity through inducing ER stress and apoptosis. 2. Falcarindiol induces immunosuppressive effects in vitro and in vivo and might be a nov... |
| TN1040 |
Skullcapflavone II
|
|
COX
,
Antibacterial
,
TGF-beta/Smad
|
|
Skullcapflavone II is a flavonoid derived from Scutellaria baicalensis, a widely used herbal medicine in anti-inflammatory and anticancer therapy. Skullcapflavone II may have therapeutic potential for the treatment of al... |
| TN1470 |
Cassiaside B2
|
|
Phosphatase
,
MAO
,
5-HT Receptor
|
|
Cassiaside B2 is an inhibitor of protein tyrosine phosphatase 1B (PTP1B) and human monoamine oxidase A (hMAO-A).Cassiaside B2 is an agonist of the 5-HT2C receptor with anti-allergic activity.Cassiaside B2 is one of the a... |
| T5S1286 |
(+)-Columbianetin
|
(S)-Columbianetin,Columbianetin |
Antifungal
|
|
(+)-Columbianetin ((S)-Columbianetin) is a new phytoalexin associated with celery (Apium graveolens) resistance to pathogens during storage, it also has antifungal activity. (+)-Columbianetin has anti-inflammatory effect... |
| T4518 |
Licochalcone D
|
|
ERK
,
NF-κB
|
|
Licochalcone D may be a potential drug for human melanoma treatment by inhibiting proliferation, inducing apoptosis via the mitochondrial pathway and blocking cell migration and invasion. Licochalcone D has cardioprotect... |
| T3S1612 |
Kuwanon G
|
Moracenin B,Kuwanone G |
Phosphatase
,
Antibacterial
,
Bombesin Receptor
,
AChR
,
AChE
,
Glucosidase
|
|
1. Kuwanon G (Moracenin B) as dual inhibitors of PTP1B and α-glucosidase enzymes, as well as insulin sensitizers, it may potentially be utilized as an effective treatment for Type II diabetes mellitus. 2. Kuwanon G has a... |
| TN5062 |
Stigmast-4-ene-3,6-dione
|
|
|
|
Stigmast-4-ene-3,6-dione has anti-inflammatory and anti-allergic properties. |
| T39570 |
Cycloartenyl ferulate
|
Cycloartenolferulate,Cycloartenolferulicacidester |
|
|
Cycloartenyl ferulate (also known as cycloartenol ferulate) is a representative triterpene alcohol with diverse biological properties, such as antioxidant, anti-allergic, anti-inflammatory, and anticancer activities. |
| TN3513 |
Bis-5,5-nortrachelogenin
|
|
Others
|
|
Bis-5,5-nortrachelogenin has anti-allergic activity, it inhibited NO production with IC50 value of 48.6 microM. |
| TN3483 |
Bakkenolide D
|
|
IL Receptor
,
Histamine Receptor
|
|
Bakkenolide D has anti-allergic effect, it and bakkenolide D demonstrates inhibitory effect on the trachea contraction induced by histamine in vitro, they have obvious anti-histamine activities. |
| TN1845 |
Kushenol N
|
|
Others
|
|
Kushenol N may have anti-allergic activity, it demonstrates significant inhibition of the release of beta-hexosaminidase from cultured RBL-2H3 cells . |
| TN4429 |
Leucodin
|
|
MMP
,
TNF
|
|
Leucodin shows high anti-hypercholesterolemic potential. Leucodin may have anti-allergic activity, it shows a potent inhibitory activity upon the beta-hexosaminidase release from RBL-2H3 cells in a dose-dependent manner ... |
| TN3936 |
Ent-16-Kaurene-3beta,15beta,18-triol
|
|
Others
|
|
ent-16-Kaurene-3beta,15beta,18-triol, ent-16-kaurene-3beta,15beta-diol,abbeokutone,and helioscopinolide A possess appreciable anti-allergic activities in RBL-2H3 cells model with IC50 values ranging from 22.5 to 42.2 mic... |
| TN3836 |
Desacetylmatricarin
|
|
Others
|
|
Desacetylmatricarin has anti-allergic property, it shows a potent inhibitory activity upon the beta-hexosaminidase release from RBL-2H3 cells in a dose-dependent manner and the IC50 of 7.5 microM. |
| TN4392 |
Koaburaside
|
|
IL Receptor
,
TNF
,
Influenza Virus
|
|
Koaburaside exhibits antioxidant activity with an IC50 value of 9.0μM, it shows weak inhibitory activity against influenza A neuraminidase. Koaburaside may have anti-allergic inflammatory activity, it can suppress histam... |
| TN5033 |
Skullcapflavone I
|
|
IL Receptor
,
Caspase
,
Prostaglandin Receptor
|
|
Skullcapflavone I has anti-inflammatory and anti-allergic potential, it can significantly inhibit LPS stimulated NO and PGE(2) release in J774A.1 macrophages and inhibit LPS induced IL-6 production in a concentration dep... |
| TN3870 |
Iriflophenone 2-O-Rhamnoside
|
Dimethylmatairesinol |
Others
|
|
Dimethylmatairesinol can reduce the amount of Immunoglobulin E (IgE) secreted by human myeloma U266 cells, it has potential as an anti-allergic agent. Dimethylmatairesinol also exhibits significant cytotoxicity against t... |
| TN3325 |
9-O-Feruloyl-5,5'-dimethoxylariciresinol
|
|
IL Receptor
,
TNF
|
|
(+)-9'-O-trans-feruloyl-5,5'-dimethoxylariciresinol may have anti-allergic inflammatory effect, it can inhibit release of histamine from mast cells. It shows cytotoxicity against a small panel of human tumor cell lines, ... |
| TN2511 |
Britannilactone diacetate
|
1,6-O,O-Diacetylbritannilactone |
IL Receptor
,
PARP
,
ROS
,
MAPK
,
Caspase
,
JAK
,
JNK
,
STAT
|
|
1,6-O,O-Diacetylbritannilactone(OODBL) has anti-inflammatory activity, it has a potential therapeutic efficacy on inflammatory diseases especially allergic airway disease as a lead compound. OODBL has anti-asthmatic acti... |
| TN4489 |
Manassantin A
|
|
ERK
,
cAMP
,
TNF
,
NF-κB
,
MAPK
,
COX
,
HIF
,
Prostaglandin Receptor
,
JNK
,
STAT
|
|
Manassantin A is a high potent HIF-1 inhibitor, it protects the gastric mucosa from ethanol-induced acute gastric injury, and suggest that these protective effects might be associated with COX/PGE2 stimulation, inhibitio... |
