|
T19438 |
Myristyl nicotinate
|
Tetradecyl nicotinate |
GPR
|
|
Myristyl nicotinate (Tetradecyl nicotinate) is an ester prodrug being developed for delivery of nicotinic acid (NIC) into the skin for prevention of actinic keratosis and its progression to skin cancer. |
|
T22012 |
7BIO
|
|
FLT
,
DYRK
,
Aurora Kinase
|
|
7-bromoindirubin-3'-oxime (7BIO) is a caspase independent nonapoptotic cell death inducer. 7BIO is an inhibitor of FLT3, DYRK1A, DYRK2, Aurora B and Aurora C kinases. |
|
T19659 |
Annaosanchun
|
YC6,YC-6,YC 6 |
Others
,
AMPK
|
|
Annaosanchun (YC-6) is potentially for the treatment of acute ischemic stroke (AIS). |
|
T7530 |
PD146176
|
NSC168807 |
Ferroptosis
,
Lipoxygenase
,
Autophagy
|
|
PD146176 (NSC-168807) is an inhibitor of 15-Lipoxygenase (15-LO) , it inhibits rabbit reticulocyte 15-LO with Ki of 197 nM and IC50 of 0.54 μM. PD146176 reverses cognitive impairment, brain amyloidosis, and tau pathology... |
|
T28368 |
PF-04859989 HCl
|
PF 04859989,PF04859989,PF-04859989HCl,PF-04859989 |
Others
|
|
PF-04859989 HCl is a brain-penetrable irreversible inhibitor of kynurenine amino transferase II (KAT II), the enzyme responsible for most of the brain synthesis of kynurenic acid. PF-04859989 HCl has been implicated in s... |
|
T1406 |
Amantadine hydrochloride
|
1-adamantanamine HCl,1-Adamantanamine hydrochloride,Symmetrel,CI-719,Amantadine HCl,1-Adamantylamine hydrochloride |
Dopamine Receptor
,
Influenza Virus
|
|
Amantadine hydrochloride (CI-719) is an antiviral that is used in the prophylactic or symptomatic treatment of influenza A and Parkinson disease. |
|
T34435 |
RU 47213
|
RU-47213,Itameline,RU47213 |
Others
|
|
RU 47213 can be used to inhibit scopolamine-induced working memory impairment in rats. |
|
T16881 |
SIB-1553A hydrochloride
|
|
AChR
|
|
SIB-1553A hydrochloride is an orally available, selective nicotinic acetylcholine receptor agonist and a selective neuronal nAChR ligand.SIB-1553A hydrochloride enhances cognition and may be useful in the study of Alzhei... |
|
T37184 |
CX08005
|
2-[(2-tetradecoxyphenyl)carbamoyl]benzoic acid |
Phosphatase
|
|
CX08005 is a protein tyrosine phosphatase 1B inhibitor. CX08005 reduces hepatic lipid accumulation and microcirculatory impairment associated with non-alcoholic fatty liver disease. |
|
T7193 |
Encenicline
|
EVP-6124 |
AChR
|
|
Encenicline (EVP-6124) is a selective α7 nicotinic acetylcholine receptor (nAChRs) agonist in development for treating cognitive impairment in schizophrenia and Alzheimer's disease. |
|
T31079 |
CP-810123
|
CP 810123,UNII-E6G4550EC4,CP810123 |
AChR
|
|
CP-810123 is a new alpha 7 nAChR agonist for the treatment of cognitive impairment associated with psychiatric or neurological disorders such as schizophrenia and Alzheimer's disease. |
|
T1884 |
CX516
|
Ampakine CX516,BDP 12,Ampalex |
GluR
,
iGluR
|
|
CX516 (Ampalex), an ampakine and nootropic, acts as an AMPA receptor positive allosteric modulator as a therapy for Alzheimer's disease, schizophrenia and mild cognitive impairment (MCI). |
|
T77678 |
TZ3O
|
|
AChR
|
|
TZ3O is an anticholinergic compound with neuroprotective activity.TZ3O ameliorates memory impairment and cognitive decay in Scopolamine-induced Alzheimer's type model in rats, and can be used in the study of Alzheimer's ... |
|
T19812 |
Propentofylline
|
HWA-285,Karsivan,Propentophylline,Hextol,HWA 285,HWA285 |
PDE
|
|
Propentofylline (Hextol) is a methylxanthine derivative with neuroprotective, antiproliferative, and anti-inflammatory activity and enhanced synaptic adenosine signaling, which may be useful in the study of Alzheimer's d... |
|
T26834 |
BL-1020 Mesylate
|
CYP-1020 Mesylate |
Dopamine Receptor
,
GABA Receptor
|
|
BL-1020 Mesylate (CYP-1020 Mesylate) is an orally available GABA A receptor agonist and D2 antagonist that decreases dopamine activity and enhances GABAA activity.BL-1020 Mesylate has been used in the study of schizophre... |
|
T77054 |
Lecanemab
|
BAN-2401 |
Beta Amyloid
|
|
Lecanemab (BAN-2401) is an IgG1 monoclonal antibody targeting soluble aggregated β-amyloid (Abeta) with activity against oligomers, protofibrils, and insoluble protofibrils, and may be useful in the study of Alzheimer's ... |
|
TP1570 |
Cortistatin-14
|
|
Somatostatin
|
|
Cortistatin-14, a neuropeptide structurally similar to growth inhibitor-14, has anticonvulsant and neuroprotective effects and impairs recognition memory consolidation in mice through activation of sst(2), growth hormone... |
|
T6552 |
Istradefylline
|
KW-6002 |
Adenosine Receptor
|
|
Istradefylline (KW-6002)(Ki of 2.2 nM) is a selective adenosine A2A receptor (A2AR) antagonist, which is under development in Phase 3 trails. It has been used in trials studying the treatment and basic science of Drug Ab... |
|
T8532 |
IM156
|
|
OXPHOS
|
|
IM156 (HL156A; HL271 acetate) is a chemical derivative of Metformin. IM156 is a potent and orally active AMPK activator that increases AMPK phosphorylation. IM156 attenuates aging-associated cognitive impairment in anima... |
|
T67729 |
UCM-1306
|
|
Dopamine Receptor
|
|
UCM-1306 is a potent and orally active allosteric modulator (PAM) of human dopamine D1 receptor. UCM-1306 could increase the maximal effect of endogenous dopamine (DA) both in human and mouse D1 receptors. UCM-1306 could... |
|
T21792 |
CGP 3466B maleate
|
Omigapil (Maleate),Omigapil maleate |
Apoptosis
|
|
CGP 3466B maleate (Omigapil maleate) is an orally bioavailable GAPDH nitrosylation inhibitor. Omigapil maleate abrogates Aβ1-42-induced tau acetylation, memory impairment, and locomotor dysfunction in mice. Omigapil male... |
|
T62899 |
Tau-aggregation and neuroinflammation-IN-1
|
|
Microtubule Associated
,
NO Synthase
|
|
Tau-aggregation and neuroinflammation-IN-1 is a potent inhibitor of tau protein aggregates, showing significant inhibitory activity against AcPHF6 and full-length tau protein aggregates. Tau-aggregation and neuroinflamma... |
|
T32191 |
Irdabisant
|
CEP-26401,CEP 26401,CEP26401 |
Histamine Receptor
|
|
Irdabisant (CEP-26401) (CEP-26401) is a selective, orally active and blood-brain barrier (BBB) penetrant antagonist/inverse agonist of histamine H3 receptor (H3R) (rat H3R Ki= 7.2 nM, human H3R Ki= 2.0 nM). Irdabisant ex... |
|
T33424 |
MK-0952
|
MK 0952 |
|
|
MK-0952 is a selective PDE4 inhibitor used to treat long-term memory loss and mild cognitive impairment. It is an intrinsically potent inhibitor and has shown limited whole blood activity. |
|
T14334 |
ASP2535
|
|
GlyT
|
|
ASP2535 is a potent, selective, orally bioavailable, brain permeable and centrally-active glycine transporter-1 (GlyT1) inhibitor.ASP2535 can improve cognitive impairment in animal models of schizophrenia and Alzheimer's... |
|
T38192 |
Unifiram
|
|
Others
|
|
Unifiram is a nootropic agent.1It increases acetylcholine (ACh) release in the rat cerebral cortexin vivoand induces a long-lasting increase in the amplitude of field excitatory postsynaptic potentials (fEPSPs) in the ra... |
|
T39384 |
Exendin (5-39)
|
|
|
|
Exendin (5-39) is a powerful antagonist of the glucagon-like peptide 1 (GLP-1) receptor with the ability to ameliorate memory impairment in rats treated with β-amyloid protein. |
|
T11570 |
HL271
|
|
AMPK
|
|
HL271, a derivative of metformin, is a potent AMPK activator that increases AMPK phosphorylation. HL271 attenuates aging-associated cognitive impairment. |
|
T26691 |
AVN-322
|
AVN 322 |
|
|
AVN-322 is a 5-HT6 receptor antagonist. 5-HT6R antagonists improves cognition in animal models of cognitive impairment. |
|
T25757 |
Lorcainide hydrochloride
|
Ro 13-1042,EINECS 261-504-6,Lorcainide HCl,Lopantrol,R 15889 |
|
|
Lorcainide hydrochloride is an antiarrhythmic drug with local anesthetic activity. The antiarrhythmic actions of lorcainide are mediated by an impairment of fast sodium conductance. Lorcainide appears effective in suppre... |
|
T69314 |
T-82
|
|
|
|
T-82 is an acetylcholinesterase inhibitor that may ameliorate the impairment of memory induced by acetylcholinergic dysfunction. |
|
T33918 |
Pentanochlor
|
Hortox,Niagara 4512,Solane,Dutom,FMC 4512 |
|
|
Pentanochlor can be used in agricultural use and biological study of herbicide composition containing a pyrazolyl pyrazole derivative. The impairment of mobility and development in freshwater snails (Physa fontinalis and... |
|
T28313 |
PD 117302
|
PD-117302,PD117302 |
|
|
PD 117302 is a nonpeptide opioid compound. It is a selective kappa-opioid agonist. PD 117302 causes naloxone-reversible locomotor impairment and diuresis. It is an Anti-Arrhythmia Agent, an Anticonvulsants, a Cardiovascu... |
|
T13151L |
THK5351
|
|
Others
|
|
THK5351 is a tracer involved in PET imaging for electron emission tomography imaging of Alzheimer's disease and cognitive impairment. |
|
T34752 |
Samelisant dihydrochloride
|
SUVN-G3031,SUVN-G 3031,SUVN G3031,SUVN-G3031 HCl |
|
|
Samelisant dihydrochloride (SUVN-G3031) is a antagonist of histamine H3 receptor with potential for the treatment of cognitive impairment, dementia, attention deficit hyperactivity disorder, epilepsy, sleep disorders, ob... |
|
T75884 |
ZIP TFA
|
|
|
|
ZIP TFA, a selective peptide inhibitor of PKMζ, is capable of blocking the impairment in morphine-conditioned place preference as induced by injections [1]. |
|
T61540 |
F15845
|
|
|
|
F 15845 is a potent and persistent blocker of the sodium current. It possesses cardioprotective properties and exhibits both anti-ischemic activity and short- and long-term cardioprotection following myocardial infarctio... |
|
T68881 |
OL-135
|
|
|
|
OL-135 is a CNS penetrant, highly potent and selective reversible inhibitor of FAAH. OL-135 exhibits analgesic pharmacology in various animal models without the motor impairment associated with direct CB1 agonism. |
|
T38659 |
MGluR5 modulator 1
|
|
|
|
mGluR5 modulator 1 is a compound that acts as a positive allosteric modulator of the metabotropic glutamate receptor subtype 5 (mGluR5). Its primary application lies in the field of schizophrenia and cognitive impairment... |
|
T75689 |
Mumefural
|
|
|
|
Mumefural, a bioactive compound found in the processed fruit of Prunus mume Sieb., inhibits platelet aggregation, exhibits anti-thrombotic properties, and ameliorates cognitive impairment [1] [2]. |
|
T69513 |
(–)-IHCH7041
|
|
|
|
(–)-IHCH7041 is a optical rotation negative isomer of IHCH7041. (–)-IHCH7041 is a DRD2 partial agonist. (–)-IHCH7041 showed EC50 = 1.38 nM in Gαi1–γ9 dissociation and 2.75 nM in β-arrestin2 recruitment. (–)-IHCH7041... |
|
T64672 |
Colivelin TFA
|
|
|
|
Colivelin (sequence SALLRSIPAPAGASRLLLLTGEIDLP) is composed of activity-dependent neurotrophic factor (ADNF) C-terminally fused to AGA-(C8R)HNG17, a potent HN derivative. It works as a neuroprotective peptide and activat... |
|
T61684 |
S 17092
|
|
|
|
S 17092 (S 17092-1) is a highly effective inhibitor of cerebral prolyl-endopeptidase (PEP), displaying an IC50 value of 1.2 nM. It is utilized in research focused on understanding memory impairment and cognitive disorder... |
|
T72859 |
11β-HSD1-IN-10
|
|
|
|
11β-HSD1-IN-10, a potent inhibitor of 11β-HSD1 with an IC50 value of 1.8 µM for humans, is suitable for research into obesity, hyperglycemia, and cognitive impairment. |
|
T21470 |
Davunetide
|
AL-208,AL 208,AL 108,AL-108 |
|
|
Davunetide is an eight amino acid peptide (NAPVSIPQ) with potent neuroprotection in vitro and in vivo. Davunetide has been shown to enhance functional daily behaviors in schizophrenia patients and to increase memory scor... |
|
T70646 |
Deltarasin HCl
|
|
|
|
Deltarasin is a high affinity PDEδ-KRAS interaction inhibitor. Deltarasin can inhibit KRAS-PDEδ interactions by binding to a hydrophobic pocket on PDEδ, resulting in the impairment of cell growth, KRAS activity, and RAS/... |
|
T80071 |
PKCζ/ι pseudosubstrate inhibitor
|
|
|
|
PKCζ/ι pseudosubstrate inhibitor demonstrates comprehensive inhibitory activity across the protein kinase C (PKC) family and is associated with the induction of memory impairment [1]. |
|
T37012 |
(±)-PPCC oxalate
|
|
|
|
(±)-PPCC (oxalate) is a sigma-1 agonist that interacts with sigma-1 receptors (Ki=1.5 nM). (±)-PPCC (oxalate) has anti-amnestic effects in rats with cognitive impairment and can improve cognitive abilities in rats. |
|
T74195 |
4′-Demethylnobiletin
|
|
|
|
4′-Demethylnobiletin, a bioactive metabolite, activates the PKA/ERK/CREB signaling pathway, enhances CRE-mediated transcription in hippocampal neurons, and reverses memory impairment linked to NMDA receptor antagonism th... |
|
T72874 |
SEH/AChE-IN-2
|
|
|
|
sEH/AChE-IN-2 and acetylcholinesterase ( AChE ). sEH/AChE-IN-2 provides cumulative effects against neuroinflammation and memory impairment. sEH/AChE-IN-2 has the potential for the research of Alzheimer's disease (AD) . |
