|
T11696 |
Ivachtin
|
Caspase-3 Inhibitor VII |
Caspase
|
|
Ivachtin (Caspase-3 Inhibitor VII) is a nonpeptide, noncompetitive and reversibl caspase-3 inhibitor(IC50 = 23 nM) and is a modest inhibitor of the remaining caspases. |
|
TQ0101 |
MKC3946
|
|
IRE1
|
|
MKC3946 is an effective and soluble IRE1α inhibitor which triggered modest growth inhibition in multiple myeloma cell lines. |
|
T6139 |
A-674563
|
A674563 |
ERK
,
GSK-3
,
Akt
,
PKA
,
CDK
|
|
A-674563 is an Akt1 inhibitor with Ki of 11 nM, modest potent to PKA and >30-fold selective for Akt1 over PKC. |
|
T12338 |
OXFBD04
|
|
Epigenetic Reader Domain
|
|
|
|
T6139L |
A-674563 2HCl(552325-73-2(fb-2hcl))
|
|
ERK
,
Akt
,
PKA
,
CDK
,
PKC
|
|
A-674563 2HCl is an Akt1 inhibitor with Ki of 11 nM, modest potent to PKA and >30-fold selective for Akt1 over PKC. |
|
T11381 |
Pictilisib dimethanesulfonate
|
GDC-0941 dimethanesulfonate,GDC-0941 2 MeSO3H salt |
Apoptosis
,
DNA-PK
,
PI3K
,
mTOR
,
Autophagy
|
|
Pictilisib dimethanesulfonate (GDC-0941 2 MeSO3H salt) is a potent inhibitor of PI3Kα/δ with IC50 of 3 nM, with modest selectivity against p110β (11-fold) and p110γ (25-fold). |
|
T68095 |
Losulazine
|
|
Dopamine Receptor
,
Norepinephrine
|
|
Losulazine is a peripheral sympathetic antihypertensive compound that can be taken orally. Losulazine causes relatively modest, transient depletion of dopamine and norepinephrine in brain regions protected by the blood-b... |
|
T6419 |
BMS-536924
|
HY-10262,BMS 536924,CS-0117 |
Apoptosis
,
FAK
,
MEK
,
IGF-1R
,
Src
|
|
BMS-536924 (BMS 536924) is an ATP-competitive IGF-1R/IR inhibitor with IC50 of 100 nM/73 nM, modest activity for Mek, Fak, and Lck with very little activity for Akt1, MAPK1/2. |
|
T6865 |
Quisinostat dihydrochloride
|
Quisinostat 2HCl,Quisinostat (JNJ-26481585) 2HCl,JNJ26854165(Quisinostat) 2HCl,JNJ-26481585 2HCl |
Apoptosis
,
HDAC
,
Autophagy
|
|
Quisinostat dihydrochloride (JNJ26854165(Quisinostat) 2HCl) is a novel second-generation HDAC inhibitor with highest potency for HDAC1 with IC50 of 0.11 nM in a cell-free assay, modest potent to HDACs 2, 4, 10, and 11; g... |
|
T3465 |
Vesnarinone
|
OPC-8212,Arkin,Piteranometozine |
HIV Protease
,
PDE
|
|
Vesnarinone (Arkin) (INN) is a mixed phosphodiesterase 3 inhibitor and ion-channel modifier that has modest, dose-dependent, positive inotropic activity, but minimal negative chronotropic activity. It also suppresses cel... |
|
T2329 |
Dolutegravir sodium
|
GSK1349572,GSK-1349572A |
HIV Protease
|
|
Dolutegravir sodium (GSK-1349572A) salt(DTG; GSK1349572) is an HIV integrase inhibitor(IC50: 2.7 nM), modest activity against raltegravir-resistant signature mutants Y143R, Q148K, N155H, and G140S/Q148H. |
|
T11143 |
EB-47
|
|
PARP
|
|
EB-47 mimics the substrate NAD+ and extends from the nicotinamide to the adenosine subsite.EB-47, a potent and selective PARP-1/ARTD-1 inhibitor with an IC50 value of 45 nM, shows modest potency against ARTD5 with an IC... |
|
T6055 |
Quisinostat
|
JNJ-26481585 |
Apoptosis
,
HDAC
,
Autophagy
|
|
Quisinostat (JNJ-26481585) (JNJ-26481585) is a novel second-generation HDAC inhibitor with highest potency for HDAC1 with IC50 of 0.11 nM, modest potent to HDACs 2, 4, 10, and 11; greater than 30-fold selectivity against... |
|
T15781 |
LP-935509
|
|
Serine/threonin kinase
,
AAK1 (AP2 associated kinase 1)
|
|
LP-935509 is highly brain-penetrant and reverses fully established pain behavior following the SNL procedure. LP-935509 is also an effective inhibitor of BIKE (IC50=14 nM) and a modest inhibitor of GAK (IC50=320 nM). LP-... |
|
TQ0291 |
Firategrast
|
SB 683699 |
Integrin
|
|
Firategrast (SB 683699) is an orally active and specific α4β1/α4β7 integrin antagonist.Firategrast reduces the transport of lymphocytes into the central nervous system (CNS) and decreases multiple sclerosis (MS) activity... |
|
T28163 |
NEU-730
|
|
Others
|
|
NEU-730, a novel inhibitor of TbrPDEB1, shows modest inhibition of T. brucei proliferation. |
|
T32458 |
L 653328
|
L 653,328,L653328,L653,328,L-653,328,L-653328 |
Others
|
|
L 653328 is an ocular hypotensive agent that has modest beta-receptor blocking activity. |
|
T68409 |
SHP244
|
|
Others
|
|
SHP244 is an allosteric inhibitor of SHP2 with modest thermal stabilization of the enzyme. |
|
T32341 |
JWH-251
|
|
Others
|
|
JWH 251, a cannabimimetic indole, has a high affinity tothe central cannabinoid (CB1) receptor (Ki = 29 nM) and a comparatively modest affinity for the peripheral cannabinoid (CB2) receptor (Ki = 146 nM). JWH 251 can st... |
|
T26580 |
AI-4-57 Hydrochloride
|
AI457 HCl,AI-4-57 HCl,AI 4 57 HCl |
Others
|
|
AI-4-57 Hydrochloride is a ligand to the CBFß. AI-4-57 Hydrochloride is a modest potency inhibitor of the binding of wildtype CBFß to the RUNX1 Runt domain. |
|
T26710 |
Azapropazone
|
DuP-141,NSC-102824,AHR-3018,AHR 3018,MI-85 |
Others
|
|
Azapropazone is anti-inflammatory agent. Azapropazone has uricosuric properties used to treat rheumatoid arthritis and ankylosing spondylitis. Azapropazone lowered plasma uric acid but exerted only a modest and variable ... |
|
T41065 |
Atrial natriuretic factor (1-28) (human, porcine)
|
Atrial natriuretic factor (1-28) (human, porcine),Atrial natriuretic peptide (1-28) |
|
|
Atrial natriuretic factor (1-28) from both human and porcine sources is a powerful suppressor of pro-opiomelanocortin (POMC) mRNA, while it only has a modest inhibition effect on βEP-LI release. |
|
T71231 |
VMY-1-101
|
|
Others
|
|
VMY-1-101 is a synthesized fluorescent CDK inhibitor. VMY-1-101 demonstrates potent CDK inhibitory activity, enhanced induction of G2/M arrest and modest apoptosis as compared to purvalanol B. |
|
T84739 |
Topoisomerase IIα-IN-8
|
|
Others
|
|
Topoisomerase IIα-IN-8 (compound 15) serves as a modest inhibitor of human DNA topoisomerase IIα (htIIα), exhibiting an inhibitory concentration (IC50) of 462 ± 38.0 μM [1]. |
|
T61335 |
Rucaparib hydrochloride
|
|
Others
|
|
Rucaparib hydrochloride, also known as AG014699, is a powerful and orally active compound that inhibits PARP proteins including PARP-1, PARP-2, and PARP-3 with a Ki value of 1.4 nM for PARP1. Additionally, Rucaparib hydr... |
|
T79606 |
CAF-382
|
|
CDK
|
|
CAF-382 (compound B1), an analog of SNS-032, functions as a CDKL5 and pan-CDK inhibitor, exhibiting modest inhibitory activity against GSK3α/β with an affinity greater than 1.8 μM. It effectively inhibits CDKL5 and imped... |
|
T60354 |
KDM4-IN-4
|
|
Others
|
|
KDM4-IN-4 (compound 47) is a potent inhibitor of histone lysine demethylase 4 (KDM4), demonstrating modest affinity with a binding constant of approximately 80 μM for the KDM4A-Tudor domain. It effectively inhibits the b... |
|
T78135 |
Nicotelline
|
Nicotellin |
Others
|
|
Nicotelline, also known as Nicotellin, is an alkaloid associated with nicotine and acts as a modest inhibitor of the enzyme human cDNA-expressed cytochrome P-450 2A6 (CYP2A6), which is responsible for coumarin 7-hydroxyl... |
|
T73842 |
Leriglitazone hydrochloride
|
|
Others
|
|
Leriglitazone (Hydroxypioglitazone) hydrochloride, a pioglitazone metabolite, acts as a PPARγ agonist, effectively stabilizing the PPARγ activation function-2 (AF-2) co-activator binding surface to enhance co-activator b... |
|
T81772 |
MOG (92–106), mouse, rat
|
|
|
|
MOG (92–106), mouse, rat, is a biologically active peptide corresponding to the fragment of amino acids 92 to 106 in myelin oligodendrocyte glycoprotein (MOG) from mice and rats. It is noteworthy that mice subjected to M... |
