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Search Results for " thyroid "

ターゲット

97

阻害剤

11

天然化合物

58

リコンビナントタンパク質

2

ライブラリー

カタログ番号 製品名 別名 ターゲット
T9111 8-Azaadenosine Adenosine deaminase
8-Azaadenosine, a powerful ADAR1 (ADAR1) and A-to-I editing inhibitor, effectively blocks RNA editing and suppresses proliferation, 3D growth, invasion, and migration in thyroid cancer cells.
T12073 ML-109 TSH Receptor
ML-109 is a potent agonist of thyroid stimulating hormone receptor (TSHR) (EC50 of 40 nM)
T5360 Eprotirome KB2115 Thyroid hormone receptor(THR)
Eprotirome (KB2115), a synthetic thyroid hormone mimetic, is a thyroid hormone receptor agonist.
T8843 APS6-45 MAPK , Ras
APS6-45 inhibits RAS/MAPK signaling and exhibits anti-tumor activity.
T2282 RPI-1 Others , Phospholipase , c-Met/HGFR , c-RET
RPI-1 is a competitive, potent ATP-dependent Ret kinase inhibitor.
T40548 NH-3 Thyroid hormone receptor(THR)
NH-3 is a potent orally active thyroid hormone receptor (THR) antagonist which exhibits reversible behavior, demonstrated by an IC 50 of 55 nM. Derived from the selective thyromi-metic GC-1, NH-3 effectively inhibits the...
T1604 Tiratricol 3,3',5-Triiodothyroacetic acid Thyroid hormone receptor(THR)
Tiratricol (3,3',5-Triiodothyroacetic acid) is a metabolite of T3 and T4 thyroid hormones; promoted for hyperlipidemia, localized lipodystrophy, and obesity. Tiratricol has been used in trials studying the treatment of A...
T12192 NCGC00229600 Others , TSH Receptor
NCGC00229600 is an allosteric inverse thyrotropin receptor (TSHR) agonist. NCGC00229600 inhibits both TSH and stimulating antibody activation of TSHRs endogenously and can be used in Graves' disease studies.
T15012 Crolibulin EPC2407 Microtubule Associated
Crolibulin (EPC2407) is an inhibitor of small molecule tubulin polymerization.
T13072 Taltirelin acetate TA-0910 acetate Thyroid hormone receptor(THR)
Taltirelin acetate (TA-0910 acetate) is a superagonist at thyrotropin-releasing hormone receptor (TRH-R)(IC50 of 910 nM and EC50 of 36 nM for stimulating an increase in cytosolic Ca2+ concentration (Ca2+ release)).
T3595 Resmetirom VIA-3196,MGL3196 Thyroid hormone receptor(THR)
Resmetirom (VIA-3196) is a highly selective thyroid hormone receptor β (THR-β) agonist.
T5383 D3-βArr NCGC00379308 TSH Receptor
D3-βArr (NCGC00379308) is a positive allosteric modulator for thyrotropin receptor (TSHR), which initiates translocation of β-Arr 1 (EC50: 11.6 μM) by direct TSHR activation.
T1669 Liothyronine sodium 3,3',5-Triiodo-L-thyronine sodium,Triostat,T3 Sodium salt,Sodium L-3,3',5-triiodothyronine,Cytomel Thyroid hormone receptor(THR)
Liothyronine Sodium is the sodium salt form of liothyronine, a synthetic form of the levorotatory isomer of the naturally occurring thyroid hormone triiodothyronine (T3). Liothyronine sodium (3,3',5-Triiodo-L-thyronine s...
T13492 3,5-Diiodothyropropionic acid C082182,Ditpa cpd Thyroid hormone receptor(THR)
3,5-Diiodothyropropionic acid (C082182) is a thyroid hormone analog. It induces α-myosin heavy chain mRNA expression, binds to thyroid hormone receptor (Ka: 2.40/M and 4.06/M for TRα1 and TRβ1).
T5313 Sobetirome IACS-010759,QRX-431 Thyroid hormone receptor(THR)
Sobetirome (IACS-010759) is a selective agonist of thyroid hormone receptor β (TRβ) and binds selectively to TRβ-1 (EC50: 0.16 μM).
T7578 REVERSE T3 3,3',5'-triiodo-L-thyronine Thyroid hormone receptor(THR)
Reverse T3 (3,3',5'-triiodo-L-thyronine) inhibits the increase of sodium current generated by other thyroid hormone analogs in neonatal rat myocytes.
TP1022 Protirelin Acetate TSH-RF Acetate,TRH Acetate,TRF Acetate Thyroid hormone receptor(THR) , Endogenous Metabolite
Protirelin Acetate (TRH Acetate) is a thyrotropin-releasing hormone, stimulating the release of thyrotropin and prolactin from the anterior pituitary.
T21505 Suberoyl bis-hydroxamic acid SBHA,Suberohydroxamic acid Apoptosis , HDAC
Suberoyl bis-hydroxamic acid (SBHA) is a Histone deacetylase (HDAC) inhibitor. HDAC is required for transcriptional modulation, cell cycle regulation and development. It is an enzyme that deacetylates lysine residues on ...
T22355 L-Thyroxine sodium LT4 sodium,Levothyroxine sodium,L-T4 sodium Thyroid hormone receptor(THR)
L-Thyroxine sodium (LT4 sodium), the major hormone derived from the thyroid gland, is the agonist of Thyroid hormone receptor alpha and beta.
T1826 PI3K-IN-1 Voxtalisib Analogue,Voxtalisib (SAR245409, XL765) Analogue,XL765,SAR245409 DNA-PK , PI3K
PI3K-IN-1 (Voxtalisib Analogue) is a dual inhibitor of mTOR/PI3K, mostly for p110γ , also inhibits DNA-PK and mTOR.
T7590 Taltirelin TA-0910 Thyroid hormone receptor(THR)
Taltirelin (TA-0910) is at thyrotropin-releasing hormone receptor (TRH-R) superagonist (IC50 of 910 nM and EC50 of 36 nM for stimulating an increase in cytosolic Ca2+ concentration (Ca2+ release))[1].
T15699 L-Thyroxine sodium salt pentahydrate Sodium levothyroxine pentahydrate,Levothyroxine Thyroid hormone receptor(THR)
L-Thyroxine sodium salt pentahydrate, also known as Levothyroxine, is a synthetic hormone utilized in the study of hypothyroidism. It is biologically activated into Triiodothyronine (T3) from its original form, L-Thyroxi...
T21535 Parathyroid Hormone (1-34), bovine Thyroid hormone receptor(THR)
Parathyroid Hormone (1-34), bovine is a parathyroid hormone (PTH) receptor agonist that is part of the parathyroid hormone family. Parathyroid Hormone (1-34), bovine is used to study osteoporosis and hypoparathyroidism.
T36767 Parathyroid Hormone (1-13) (trifluoroacetate salt)
Parathyroid hormone (PTH) (1-13) is an N-terminal fragment of PTH (1-34) . In vivo, PTH (1-13) (0.003-1 μmol/kg) increases mean arterial pressure (MAP) in anesthetized rats.
TP2283 Parathyroid hormone (7-34) [Homo sapiens]/[Macaca fascicularis] Others
parathyroid hormone (7-34) [Homo sapiens] [Macaca fascicularis] is a peptide with the sequence H2N-LMHNLGKHLNSMERVEWLRKKLQDVHNF-OH, MW= 3474.03. Parathyroid hormone (PTH) is secreted by the chief cells of the parathyroid...
T75867 Parathyroid Hormone (1-34), bovine TFA
Parathyroid Hormone (1-34), bovine TFA, a potent agonist of the parathyroid hormone (PTH) receptor, elevates calcium and inorganic phosphate levels in vivo. This compound is employed in osteoporosis research [1].
T76061 Parathyroid hormone (1-34) (rat) acetate
Parathyroid hormone (1-34) (rat) (acetate) is a parathyroid hormone variant that enhances the structure of both cortical and cancellous bones. It is utilized in osteoporosis research [1] [2].
TP1964 Parathyroid hormone (1-34) (rat)
Parathyroid hormone (PTH) receptor agonist. Increases serum PTH levels and bone mass in rats.
T76084 Parathyroid Hormone (1-34), human, biotinylated
Parathyroid Hormone (1-34), human, biotinylated serves as a probe targeting the parathyroid hormone receptor. It is utilized in the analysis of interactions between parathyroid hormone and its receptors within living cel...
T73692 Parathyroid hormone
Parathyroid hormone (PTH), an 84-amino acid circulating hormone synthesized in the parathyroid glands, primarily regulates bone and kidney functions to maintain extracellular calcium levels within normal ranges. It is al...
T2588 Ivacaftor Ivacaftor (VX-770),VX-770 CFTR , Autophagy
Ivacaftor (VX-770) (VX-770) is a potentiator of CFTR targeting G551D-CFTR (EC50: 100 nM) and F508del-CFTR (EC50: 25 nM) in Fisher rat thyroid cells, respectively.
T16756 Risarestat CT 112 Reductase
Risarestat (CT-112) is a potent aldose reductase inhibitor and thyroid hormone receptor (TR) antagonist for the treatment of hypoglycemia.
T8672 2,2-BIS(2-HYDROXY-5-BIPHENYLYL)PROPANE BisOPP-A Thyroid hormone receptor(THR)
2,2-BIS(2-HYDROXY-5-BIPHENYLYL)PROPANE is targets the thyroid stimulating hormone receptor (human)
T23673 AH-3960 AH3960 Thyroid hormone receptor(THR)
AH-3960 is an thyroid hormone receptor-1 (PTHR1) agonist.
T27454 GSK2008607 Raf
GSK2008607 is a potent B-RafV600E inhibitor with anticancer activity and can be used to study breast, colorectal, melanoma, thyroid, and ovarian cancers.
T1309 Propylthiouracil Pseudocapsaicin,NSC 6498,NSC 70461,6-n-Propylthiouracil,6-Propyl-2-thiouracil Thyroid hormone receptor(THR)
Propylthiouracil (6-n-Propylthiouracil) is a thyroid peroxidase inhibitor and also a 5' -deiodinase inhibitor.
T0357 Potassium iodide Tyrosinase
Potassium iodide is used as the treatment of overactive thyroid and as protection of the thyroid gland from the influences of radiation from swallowed or inhaled radioactive iodine. It may be used after accidental exposu...
TP1028L Calcitonin eel acetate Calcitonin eel acetate (57014-02-5 Free base),Thyrocalcitonin eel Others
Calcitonin eel acetate (Calcitonin eel acetate (57014-02-5 Free base)) is the regulation of calcium homeostasis thyroid hormone peptide.
T7407 Thyrotropin-Releasing Hormone (TRH), Free Acid TRH-OH Others
Thyrotropin-Releasing Hormone (TRH), Free Acid (TRH-OH) (TRH-OH) causes a variety of thyroidal and non-thyroidal effects, the best known being the feedback regulation of thyroid hormone levels.
T19561 Simetryn Others
Simetryn is a rice paddy herbicide and acts as a chemical stressor retarding tadpole growth and development without disrupting thyroid functions, even at 1/100 of the 96-h LC50 value.
T0495 Aminothiazole 2-Aminothiazole,2-Thiazolylamine Virus Protease , Antibacterial , Antibiotic , Antifungal
Aminothiazole (2-Aminothiazole), a thyroid inhibitor, displays antibacterial activity.
T0304 Methylthiouracil NSC-193526,NSC-9378,MTU ERK , Antiviral , TNF , NF-κB , Interleukin
Methylthiouracil (NSC-193526) is a thiourea antithyroid agent that inhibits the synthesis of thyroid hormone, and it is used to treat hyperthyroidism.
T9901A-004 Labetuzumab IMMU-14,hMN-14,IMMU-100
Labetuzumab is a humanized anti-carcinoembryonic antigen (CEA) monoclonal antibody with anticancer activity that inhibits tumor growth and is used in the study of thyroid and colorectal cancer (CRC).
T8628 2,4,6-Triiodophenol Others
2,4,6-Triiodophenol is used as an iodinated disinfection by product formed during chlorination of sewage effluents. It is also used as a potent thyroid disrupting chemical and to investigate deiodinase
T0952 Carbimazole Athyromazole,Carbimazol,Neomercazole Thyroid hormone receptor(THR)
Carbimazole (Athyromazole) is an Imidazolium thyroid antagonist, which is rapidly transformed into MMI in vivo and can be converted into methidazole in vitro, and can be used in the study of Graves' disease.
T0312 Toluidine Blue Blutene chloride Others
Toluidine Blue (Blutene chloride), a phenothiazine, is used as a biological stain, a hemostatic, and a dye for silk and wool. Blutene chloride is also used as a diagnostic aid for gastric neoplasms and oral, and used in ...
T77075 Spartalizumab PDR001 PD-1/PD-L1
Spartalizumab (PDR001) is a humanized immunoglobulin 4 monoclonal antibody that selectively binds to PD-1 at low concentrations and shows high activity. Spartalizumab blocks the interaction with PD-L1 and PD-L2, and can ...
T76727 Teprotumumab R 1507,HZN 001 TSH Receptor , IGF-1R
Teprotumumab is a human monoclonal antibody that blocks the IGF-1 receptor (IGF-1R). Teprotumumab binds to the extracellular α-subunit domain ligand of IGF-1R. Teprotumumab inhibits TSH and IGF-1 action in fibrocytes. Te...
T2595 Lumacaftor VX-809,VRT 826809 CFTR , Autophagy
Lumacaftor (VRT 826809) is a CFTR modulator that corrects the folding and trafficking of CFTR protein. It enhances F508del-CFTR protein maturation in FRT cells (EC50: 100 nM).
T36493 CMLD-2 Apoptosis , HuR
CMLD-2 is an inhibitor of HuR-ARE interaction (Ki: 350 nM) that competitively binds HuR protein and disrupts its interaction with adenine element-rich (ARE) mRNA targets.CMLD-2 induces apoptosis and exhibits antitumor ef...

Compounds

8-Azaadenosine
T9111
Synonym:
Target: Adenosine deaminase
ML-109
T12073
Synonym:
Target: TSH Receptor
Eprotirome
T5360
Synonym: KB2115
Target: Thyroid hormone receptor(THR)
APS6-45
T8843
Synonym:
Target: MAPK, Ras
RPI-1
T2282
Synonym:
Target: Others, Phospholipase, c-Met/HGFR, c-RET
NH-3
T40548
Synonym:
Target: Thyroid hormone receptor(THR)
Tiratricol
T1604
Synonym: 3,3',5-Triiodothyroacetic acid
Target: Thyroid hormone receptor(THR)
NCGC00229600
T12192
Synonym:
Target: Others, TSH Receptor
Crolibulin
T15012
Synonym: EPC2407
Target: Microtubule Associated
Taltirelin acetate
T13072
Synonym: TA-0910 acetate
Target: Thyroid hormone receptor(THR)
Resmetirom
T3595
Synonym: VIA-3196,MGL3196
Target: Thyroid hormone receptor(THR)
D3-βArr
T5383
Synonym: NCGC00379308
Target: TSH Receptor
Liothyronine sodium
T1669
Synonym: 3,3',5-Triiodo-L-thyronine sodium,Triostat,T3 Sodium salt,Sodium L-3,3',5-triiodothyronine,Cytomel
Target: Thyroid hormone receptor(THR)
3,5-Diiodothyropropionic acid
T13492
Synonym: C082182,Ditpa cpd
Target: Thyroid hormone receptor(THR)
Sobetirome
T5313
Synonym: IACS-010759,QRX-431
Target: Thyroid hormone receptor(THR)
REVERSE T3
T7578
Synonym: 3,3',5'-triiodo-L-thyronine
Target: Thyroid hormone receptor(THR)
Protirelin Acetate
TP1022
Synonym: TSH-RF Acetate,TRH Acetate,TRF Acetate
Target: Thyroid hormone receptor(THR), Endogenous Metabolite
Suberoyl bis-hydroxamic acid
T21505
Synonym: SBHA,Suberohydroxamic acid
Target: Apoptosis, HDAC
L-Thyroxine sodium
T22355
Synonym: LT4 sodium,Levothyroxine sodium,L-T4 sodium
Target: Thyroid hormone receptor(THR)
PI3K-IN-1
T1826
Synonym: Voxtalisib Analogue,Voxtalisib (SAR245409, XL765) Analogue,XL765,SAR245409
Target: DNA-PK, PI3K
Taltirelin
T7590
Synonym: TA-0910
Target: Thyroid hormone receptor(THR)
L-Thyroxine sodium salt pentahydrate
T15699
Synonym: Sodium levothyroxine pentahydrate,Levothyroxine
Target: Thyroid hormone receptor(THR)
Parathyroid Hormone (1-34), bovine
T21535
Synonym:
Target: Thyroid hormone receptor(THR)
Parathyroid Hormone (1-13) (trifluoroacetate salt)
T36767
Synonym:
Target:
parathyroid hormone (7-34) [Homo sapiens]/[Macaca fascicularis]
TP2283
Synonym:
Target: Others
Parathyroid Hormone (1-34), bovine TFA
T75867
Synonym:
Target:
Parathyroid hormone (1-34) (rat) acetate
T76061
Synonym:
Target:
Parathyroid hormone (1-34) (rat)
TP1964
Synonym:
Target:
Parathyroid Hormone (1-34), human, biotinylated
T76084
Synonym:
Target:
Parathyroid hormone
T73692
Synonym:
Target:
Ivacaftor
T2588
Synonym: Ivacaftor (VX-770),VX-770
Target: CFTR, Autophagy
Risarestat
T16756
Synonym: CT 112
Target: Reductase
2,2-BIS(2-HYDROXY-5-BIPHENYLYL)PROPANE
T8672
Synonym: BisOPP-A
Target: Thyroid hormone receptor(THR)
AH-3960
T23673
Synonym: AH3960
Target: Thyroid hormone receptor(THR)
GSK2008607
T27454
Synonym:
Target: Raf
Propylthiouracil
T1309
Synonym: Pseudocapsaicin,NSC 6498,NSC 70461,6-n-Propylthiouracil,6-Propyl-2-thiouracil
Target: Thyroid hormone receptor(THR)
Potassium iodide
T0357
Synonym:
Target: Tyrosinase
Calcitonin eel acetate
TP1028L
Synonym: Calcitonin eel acetate (57014-02-5 Free base),Thyrocalcitonin eel
Target: Others
Thyrotropin-Releasing Hormone (TRH), Free Acid
T7407
Synonym: TRH-OH
Target: Others
Simetryn
T19561
Synonym:
Target: Others
Aminothiazole
T0495
Synonym: 2-Aminothiazole,2-Thiazolylamine
Target: Virus Protease, Antibacterial, Antibiotic, Antifungal
Methylthiouracil
T0304
Synonym: NSC-193526,NSC-9378,MTU
Target: ERK, Antiviral, TNF, NF-κB, Interleukin
Labetuzumab
T9901A-004
Synonym: IMMU-14,hMN-14,IMMU-100
Target:
2,4,6-Triiodophenol
T8628
Synonym:
Target: Others
Carbimazole
T0952
Synonym: Athyromazole,Carbimazol,Neomercazole
Target: Thyroid hormone receptor(THR)
Toluidine Blue
T0312
Synonym: Blutene chloride
Target: Others
Spartalizumab
T77075
Synonym: PDR001
Target: PD-1/PD-L1
Teprotumumab
T76727
Synonym: R 1507,HZN 001
Target: TSH Receptor, IGF-1R
Lumacaftor
T2595
Synonym: VX-809,VRT 826809
Target: CFTR, Autophagy
CMLD-2
T36493
Synonym:
Target: Apoptosis, HuR
1 2
カタログ番号 製品名 別名 ターゲット
T1653 Liothyronine Tresitope,O-(4-Hydroxy-3-iodophenyl)-3,5-diiodo-L-tyrosine,Triiodothyronine,L-3,3',5-Triiodothyronine,3,3',5-Triiodo-L-thyronine,Lyothyronine Thyroid hormone receptor(THR) , Endogenous Metabolite
Liothyronine (Tresitope) is an active form of thyroid hormone, binding to β1 thyroid hormone receptor (TRβ1), and activates its activity.
T5568 H-Tyr(3-I)-OH 3-Iodo-L-tyrosine Endogenous Metabolite
H-Tyr(3-I)-OH (3-Iodo-L-tyrosine) is an inhibitor of tyrosine hydroxylase (Ki = 0.39 M) and an intermediate in the synthesis of thyroid hormones
T0864 L-Thyroxine Levothyroxine,NSC 36397,T4 Thyroid hormone receptor(THR) , Endogenous Metabolite
L-Thyroxine (NSC 36397) is the major hormone derived from the thyroid gland. L-Thyroxine (NSC 36397) is synthesized via the iodination of tyrosines (MONOIODOTYROSINE) and the coupling of iodotyrosines (DIIODOTYROSINE) in...
T2988 (-)-Epigallocatechin Gallate Epigallocatechol Gallate,EGCG Ferroptosis , Reactive Oxygen Species , HIV Protease , Mitochondrial Metabolism , Endogenous Metabolite , Autophagy
(-)-Epigallocatechin Gallate (EGCG) is an antioxidant polyphenol flavonoid that inhibits telomerase and DNA methyltransferase. (-)-Epigallocatechin Gallate (EGCG) blocks the activation of EGF receptors and HER-2 receptor...
T6956 Protirelin Lopremone,pGlu-His-Pro-NH2,Synthetic thyrotropin-releasing hormone,Thyroliberin,TRH,TRF Thyroid hormone receptor(THR) , Endogenous Metabolite
Protirelin (Thyroliberin) is a tripeptide that stimulates the release of thyrotropin and prolactin.
T16442 PCO371 2,4-Imidazolidinedione, 1-(3,5-dimethyl-4-(2-((4-oxo-2-(4-(trifluoromethoxy)phenyl)-1,3,8-triazaspiro(4.5)dec-1-en-8-yl)sulfonyl)ethyl)phenyl)-5,5-dimethyl- Thyroid hormone receptor(THR)
PCO371 (2,4-Imidazolidinedione, 1-(3,5-dimethyl-4-(2-((4-oxo-2-(4-(trifluoromethoxy)phenyl)-1,3,8-triazaspiro(4.5)dec-1-en-8-yl)sulfonyl)ethyl)phenyl)-5,5-dimethyl-) is an orally active full agonist of parathyroid hormon...
T2760 (S)-2-Amino-3-(4-hydroxy-3,5-diiodophenyl)propanoic acid dihydrate Iodogorgoic acid,apothyrin,jodgorgon,3,5-Diiodotyrosine Dihydrate Others , Endogenous Metabolite
(S)-2-Amino-3-(4-hydroxy-3,5-diiodophenyl)propanoic acid dihydrate (jodgorgon) is a product from the iodination of MONOIODOTYROSINE. In the biosynthesis of thyroid hormones, diiodotyrosine residues are coupled with other...
T3665 Tectoridin Shekanin Estrogen Receptor/ERR , Reductase
Tectoridin (Shekanin) possesses an estrogenic and thyroid hormone-like agent by activating estrogen and thyroid hormone receptors. Tectoridin has anti-oxidant, anti-inflammatory and hypoglycemic activities; Tectoridin an...
TN6798 Progoitrin Others
Progoitrin is a biochemical from the glucosinolate family that is found in some food, which is inactive but after ingestion is converted to goitrin. Goitrin decreases the thyroid hormone production. Apart from goitrin, p...
T39836 Monoethyl phthalate
Monoethyl phthalate is a metabolite of diethyl phthalate, serving as a urinary biomarker for phthalate exposure, and indicating potential risks of thyroid cancer and benign nodules.
T73465 Goitrin L-5-Vinyl-2-thiooxazolidone,(S)-Goitrin,(S)-Goitrin ; L-5-Vinyl-2-thiooxazolidone
Goitrin ((S)-Goitrin), formed through glucosinolate-myrosinase reactions, serves as a potent inhibitor of thyroid peroxidase, thereby hindering the thyroid's utilization of iodine. Additionally, it demonstrates anti-infl...

Recombinant Proteins

カタログ番号 製品名 Species Expression System
TMPY-02779 Thyroid peroxidase Protein, Human, Recombinant (S257A & P725T, His) Human Baculovirus Insect Cells
Thyroid peroxidase is a membrane-bound glycoprotein which belongs to the peroxidase family, XPO subfamily. It contains 1 EGF-like domain and 1 Sushi (CCP/SCR) domain. Thyroid Peroxidase represents one of the main autoant...
TMPK-00874 Thyroid Peroxidase Protein, Mouse, Recombinant (His) Mouse HEK293 Cells
Thyroid peroxidase, also called thyroperoxidase (TPO) or iodide peroxidase that encodes a 933 amino-acid residue (aa) molecule with a single membrane-spanning region. Thyroid peroxidase plays a key role in thyroid hormon...
TMPY-04127 CIp4 Protein, Human, Recombinant (His) Human Baculovirus Insect Cells
CIp4 Protein, Human, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 64 kDa and the accession number is Q15642-2.
TMPY-06821 THRB Protein, Human, Recombinant (His) Human E. coli
Thyroid hormone receptor beta (THRB), also known as TRbeta and NR1A2, belongs to the nuclear hormone receptor family. Featuring an N-terminal transactivation domain, a central DNA-binding domain, and a hormone/ligand-bin...
TMPY-04853 TSHR Protein, Human, Recombinant (His) Human Baculovirus Insect Cells
Thyroid-stimulating hormone (TSH) is secreted by the pituitary gland and promotes thyroid growth and function, with increased TSH levels typically associated with hypothyroidism. Immunohistochemical analysis revealed pre...
TMPY-02287 Ku70 & Ku80 Heterodimer Protein, Human, Recombinant (His) Human Baculovirus Insect Cells
X-ray repair cross-complementing protein 5, also known as 86 kDa subunit of Ku antigen, ATP-dependent DNA helicase 2 subunit 2, ATP-dependent DNA helicase II 8 kDa subunit, CTC box-binding factor 85 kDa subunit, DNA repa...
TMPH-02203 THRA Protein, Human, Recombinant (His) Human E. coli
Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine.; Does not bind thyroid hormone and functions as a...
TMPY-03502 PAX8 Protein, Human, Recombinant (His) Human E. coli
PAX8 gene is a member of the paired box (PAX) family of transcription factors. Members of this gene family typically encode proteins that contain a paired box domain, an octapeptide, and a paired-type homeodomain. PAX8 i...
TMPH-02685 GPHB5 Protein, Mouse, Recombinant (His & Myc) Mouse E. coli
Functions as a heterodimeric glycoprotein hormone with GPHA2 able to bind and activate the thyroid-stimulating hormone receptor (TSHR), leading to increased cAMP production. Plays a central role in controlling thyroid ce...
TMPH-02242 Transthyretin Protein, Human, Recombinant (hFc & Myc) Human HEK293 Cells
Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain.
TMPH-03262 Cathepsin K Protein, Rat, Recombinant (His) Rat E. coli
Thiol protease involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in...
TMPH-02684 GPHB5 Protein, Mouse, Recombinant (His) Mouse P. pastoris (Yeast)
Functions as a heterodimeric glycoprotein hormone with GPHA2 able to bind and activate the thyroid-stimulating hormone receptor (TSHR), leading to increased cAMP production. Plays a central role in controlling thyroid ce...
TMPH-02565 Cathepsin K Protein, Mouse, Recombinant (His) Mouse E. coli
Thiol protease involved in osteoclastic bone resorption. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation. Involved in the release of thy...
TMPH-02204 THRB Protein, Human, Recombinant (His & SUMO) Human E. coli
Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine.
TMPH-02947 Transthyretin Protein, Mouse, Recombinant Mouse E. coli
Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain. Transthyretin Protein, Mouse, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 13....
TMPH-02120 SLC5A5 Protein, Human, Recombinant (His) Human E. coli
Mediates iodide uptake in the thyroid gland. SLC5A5 Protein, Human, Recombinant (His) is expressed in E. coli expression system with C-6xHis tag. The predicted molecular weight is 17.4 kDa and the accession number is Q92...
TMPH-03385 Thyroglobulin Protein, Rat, Recombinant (His & SUMO) Rat E. coli
Acts as a substrate for the production of iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3). The synthesis of T3 and T4 involves iodination of selected tyrosine residues of TG/thyroglobulin followed by ...
TMPH-03387 TSHB Protein, Rat, Recombinant (His & Myc) Rat P. pastoris (Yeast)
Indispensable for the control of thyroid structure and metabolism. TSHB Protein, Rat, Recombinant (His & Myc) is expressed in yeast with N-6xHis and C-Myc tag. The predicted molecular weight is 16.4 kDa and the accession...
TMPY-01584 PR-Set7 Protein, Human, Recombinant Human E. coli
KMT5A (known as PR-Set7/9, SETD8 and SET8), a member of the SET domain containing methyltransferase family specifically targeting H4K20 for methylation, has been implicated in multiple biological processes. Inhibition of...
TMPH-01061 Cathepsin K Protein, Human, Recombinant (His) Human E. coli
Thiol protease involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in...
TMPH-02946 Transthyretin Protein, Mouse, Recombinant (His & SUMO) Mouse E. coli
Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain. Transthyretin Protein, Mouse, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. Th...
TMPH-03386 TSHB Protein, Rat, Recombinant (E. coli, His & Myc) Rat E. coli
Indispensable for the control of thyroid structure and metabolism. TSHB Protein, Rat, Recombinant (E. coli, His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight...
TMPJ-01319 TINAGL1 Protein, Human, Recombinant (His) Human HEK293 Cells
TINAGL1 is a secreted protein and contains one SMB (somatomedin-B) domain. TINAGL1 is expressed in aorta, lymph nodes, heart, bone marrow, placenta, lung, kidney, skeletal muscle, pancreas, thyroid, adrenal gland and so ...
TMPY-00483 Parvalbumin/PVALB Protein, Human, Recombinant (His) Human E. coli
Parvalbumins (PVALBs) are particularly abundant in the fast-contracting muscles and correlate positively with muscle relaxation speed in amphibians and fishes. The loss of PVALB plays a role in the pathogenesis of thyroi...
TMPH-01059 Cathepsin B Protein, Human, Recombinant (GST) Human E. coli
Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Cleaves matrix extracellular phosphoglycoprotein MEPE. Involved in the solubilization of cross-linked TG/thyroglobuli...
TMPH-01251 DUSP26 Protein, Human, Recombinant (His & SUMO) Human E. coli
Inactivates MAPK1 and MAPK3 which leads to dephosphorylation of heat shock factor protein 4 and a reduction in its DNA-binding activity. Inhibits MAP kinase p38 by dephosphorylating it and inhibits p38-mediated apoptosis...
TMPY-01617 SULT1B1 Protein, Human, Recombinant (His) Human E. coli
Sulfotransferase family cytosolic 1B member 1, also known as Sulfotransferase 1B1, Sulfotransferase 1B2, Thyroid hormone sulfotransferase, SULT1B1 and ST1B2, is a cytoplasm protein that belongs to the sulfotransferase 1 ...
TMPH-03377 SULT1B1 Protein, Rat, Recombinant (His & Myc & SUMO) Rat E. coli
Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of dopamine, small phenols such as 1-naphthol and p-nitrophenol and thyroid hormones, including ...
TMPJ-00656 SULT1C2 Protein, Human, Recombinant (His) Human E. coli
Sulfotransferase 1C2 (SULT1C2) is a cytosolic enzyme member of the Sulfotransferase 1 family. Human SULT1C2 is primarily expressed in the adult stomach, kidney and thyroid gland, and in the fetal kidney and liver. SULT1C...
TMPJ-00793 TPM3 Protein, Human, Recombinant Human E. coli
Tropomyosin Alpha-3 Chain (TPM3) is a member of the Tropomyosin family. TPM3 exists as a heterodimer consisting of an alpha and a beta chain. TPM3 plays a central role in association with the Troponin complex and in the ...
TMPJ-00705 BCAS2 Protein, Human, Recombinant (His, T7) Human E. coli
Breast Carcinoma-Amplified Sequence 2 (BCAS2) is a member of the SPF27 family. BCAS2 is a nuclear protein and widely expressed in many rtissues. BCAS2 is identified as being overexpressed in various breast cancer cell li...
TMPJ-01260 WBP2 Protein, Human, Recombinant (His) Human E. coli
WW Domain-Binding Protein 2 (WBP2) is a ubiquitous protein that contains one GRAM domain. The WW domain is composed of 38 to 40 semi-conserved AA shared by proteins of diverse functions including structural, regulatory, ...
TMPJ-00701 Carbonic Anhydrase 11 Protein, Human, Recombinant (His) Human HEK293 Cells
Carbonic Anhydrase-Related Protein 11 (CA11) is a secreted protein member of the α-carbonic anhydrase family. Carbonic Anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of ...
TMPY-04445 PDK4 Protein, Mouse, Recombinant (His & GST) Mouse Baculovirus Insect Cells
Pyruvate dehydrogenase kinase 4 (PDK4) is a mitochondrial protein that regulates the TCA cycle.PDK4, a vital mitochondrial protein, controls the switch between glycolysis and oxidative phosphorylation based upon nutrient...
TMPY-03613 COMMD8 Protein, Human, Recombinant (His) Human E. coli
COMMD8 is a member of the COMMD family. Members of this family are a group of evolutionary conserved proteins that share a common COMM domain at the extreme C-terminus, which provides an interface for protein-protein int...
TMPY-03811 KCT2 Protein, Human, Recombinant (His) Human HEK293 Cells
C5orf15 (Chromosome 5 Open Reading Frame 15, also known as KCT2) is a Protein Coding gene. KCT2 gene maps to human chromosome 5q31.1 and is conserved in human, chimpanzee, cow, rat, and chicken. KCT2 is a 265 amino acid ...
TMPJ-00456 APRIL/TNFSF13 Protein, Mouse, Recombinant (hFc) Mouse HEK293 Cells
Tumor necrosis factor ligand superfamily member 13 belongs to the tumor necrosis factor family. It is also known as APRIL, TALL2, TRDL1, and CD256. It is synthesized as a 32 kDa proprotein which is cleaved by furin in th...
TMPY-02394 IMPA1 Protein, Human, Recombinant (His) Human E. coli
IMPA1 (Inositol Monophosphatase 1) is a Protein Coding gene. This gene encodes an enzyme that dephosphorylates Myo-inositol monophosphate to generate free Myo-inositol, a precursor of phosphatidylinositol, and is, theref...
TMPJ-01320 BSSP-4 Protein, Human, Recombinant (His) Human HEK293 Cells
Brain-Specific Serine Protease 4 (BSSP-4) is a serine protease that preferentially cleaves the synthetic substrate H-D-Leu-Thr-Arg-pNA compared to tosyl-Gly-Pro-Arg-pNA. BSSP-4 is expressed abundantly in the epithelial c...
TMPY-01451 MESDC2 Protein, Human, Recombinant (His) Human HEK293 Cells
MESD (Mesoderm Development LRP Chaperone) is a Protein Coding gene. LDLR chaperone MESD, also known as Mesoderm development protein, Mesoderm development candidate 2, Renal carcinoma antigen NY-REN-61, and MESDC2, is a m...
TMPY-03857 MMGT1 Protein, Human, Recombinant (His) Human HEK293 Cells
MMGT1 (Membrane Magnesium Transporter 1, also known as EMC5 and TMEM32) is a Protein Coding gene. 2 alternatively spliced human isoforms have been reported. The encoded protein belongs to the membrane magnesium transport...
TMPY-03615 CSEN Protein, Human, Recombinant (His) Human E. coli
KCNIP3 (Potassium Voltage-Gated Channel Interacting Protein 3, also known as CSEN) is a Protein Coding gene. CSEN is a member of the family of voltage-gated potassium (Kv) channel-interacting proteins, which belong to th...
TMPJ-01283 UGRP1 Protein, Human, Recombinant Human E. coli
Uteroglobin-Related Protein 1 (UGRP1) belongs to the secretoglobin family which has been suggested to play a role in lung inflammation and allergic diseases. UGRP1 is a 17 kDa secreted homodimeric protein that shows amin...
TMPH-02221 TRIM24 Protein, Human, Recombinant (His & SUMO) Human E. coli
Transcriptional coactivator that interacts with numerous nuclear receptors and coactivators and modulates the transcription of target genes. Interacts with chromatin depending on histone H3 modifications, having the high...
TMPY-03616 NAPG Protein, Human, Recombinant (His) Human E. coli
NAPG (NSF Attachment Protein Gamma, also known as gamma SNAP) is a Protein Coding gene. This gene encodes soluble NSF attachment protein gamma. The encoded protein mediates platelet exocytosis and controls the membrane f...
TMPY-02883 C1D Protein, Human, Recombinant (GST) Human E. coli
C1D nuclear receptor corepressor belongs to the C1D family. It is a DNA binding and apoptosis-inducing protein.C1D nuclear receptor corepressorinteracts with TSNAX and DNA-PKcs. It acts as a corepressor for the thyroid h...
TMPY-03280 RAMP3 Protein, Human, Recombinant (hFc) Human HEK293 Cells
RAMP3 belongs to the RAMP family. Members of this family are single-transmembrane-domain proteins, called receptor (calcitonin) activity modifying proteins (RAMPs). RAMPs have a wide biological distribution; high concent...
TMPY-04930 Notch 2 Protein, Human, Recombinant (His) Human Baculovirus Insect Cells
NOTCH2 (Notch Receptor 2) is a Protein Coding gene. This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics and play a role in a variety of dev...
TMPY-02979 HMGN3 Protein, Human, Recombinant (His) Human E. coli
HMGN3 belongs to the HMGN family and is expressed in the kidney, lung, pancreas, testis, skeletal muscle, heart, thyroid gland, pituitary gland, prostate, and uterus. Members of the HMGN family bind to nucleosomes withou...
TMPY-01551 Serpin B8 Protein, Mouse, Recombinant (His) Mouse Baculovirus Insect Cells
Serpins are the largest and most diverse family of serine protease inhibitors which are involved in a number of fundamental biological processes such as blood coagulation, complement activation, fibrinolysis, angiogenesi...
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Thyroid peroxidase Protein, Human, Recombinant (S257A & P725T, His)
TMPY-02779
Species: Human
Expression System: Baculovirus Insect Cells
Thyroid Peroxidase Protein, Mouse, Recombinant (His)
TMPK-00874
Species: Mouse
Expression System: HEK293 Cells
CIp4 Protein, Human, Recombinant (His)
TMPY-04127
Species: Human
Expression System: Baculovirus Insect Cells
THRB Protein, Human, Recombinant (His)
TMPY-06821
Species: Human
Expression System: E. coli
TSHR Protein, Human, Recombinant (His)
TMPY-04853
Species: Human
Expression System: Baculovirus Insect Cells
Ku70 & Ku80 Heterodimer Protein, Human, Recombinant (His)
TMPY-02287
Species: Human
Expression System: Baculovirus Insect Cells
THRA Protein, Human, Recombinant (His)
TMPH-02203
Species: Human
Expression System: E. coli
PAX8 Protein, Human, Recombinant (His)
TMPY-03502
Species: Human
Expression System: E. coli
GPHB5 Protein, Mouse, Recombinant (His & Myc)
TMPH-02685
Species: Mouse
Expression System: E. coli
Transthyretin Protein, Human, Recombinant (hFc & Myc)
TMPH-02242
Species: Human
Expression System: HEK293 Cells
Cathepsin K Protein, Rat, Recombinant (His)
TMPH-03262
Species: Rat
Expression System: E. coli
GPHB5 Protein, Mouse, Recombinant (His)
TMPH-02684
Species: Mouse
Expression System: P. pastoris (Yeast)
Cathepsin K Protein, Mouse, Recombinant (His)
TMPH-02565
Species: Mouse
Expression System: E. coli
THRB Protein, Human, Recombinant (His & SUMO)
TMPH-02204
Species: Human
Expression System: E. coli
Transthyretin Protein, Mouse, Recombinant
TMPH-02947
Species: Mouse
Expression System: E. coli
SLC5A5 Protein, Human, Recombinant (His)
TMPH-02120
Species: Human
Expression System: E. coli
Thyroglobulin Protein, Rat, Recombinant (His & SUMO)
TMPH-03385
Species: Rat
Expression System: E. coli
TSHB Protein, Rat, Recombinant (His & Myc)
TMPH-03387
Species: Rat
Expression System: P. pastoris (Yeast)
PR-Set7 Protein, Human, Recombinant
TMPY-01584
Species: Human
Expression System: E. coli
Cathepsin K Protein, Human, Recombinant (His)
TMPH-01061
Species: Human
Expression System: E. coli
Transthyretin Protein, Mouse, Recombinant (His & SUMO)
TMPH-02946
Species: Mouse
Expression System: E. coli
TSHB Protein, Rat, Recombinant (E. coli, His & Myc)
TMPH-03386
Species: Rat
Expression System: E. coli
TINAGL1 Protein, Human, Recombinant (His)
TMPJ-01319
Species: Human
Expression System: HEK293 Cells
Parvalbumin/PVALB Protein, Human, Recombinant (His)
TMPY-00483
Species: Human
Expression System: E. coli
Cathepsin B Protein, Human, Recombinant (GST)
TMPH-01059
Species: Human
Expression System: E. coli
DUSP26 Protein, Human, Recombinant (His & SUMO)
TMPH-01251
Species: Human
Expression System: E. coli
SULT1B1 Protein, Human, Recombinant (His)
TMPY-01617
Species: Human
Expression System: E. coli
SULT1B1 Protein, Rat, Recombinant (His & Myc & SUMO)
TMPH-03377
Species: Rat
Expression System: E. coli
SULT1C2 Protein, Human, Recombinant (His)
TMPJ-00656
Species: Human
Expression System: E. coli
TPM3 Protein, Human, Recombinant
TMPJ-00793
Species: Human
Expression System: E. coli
BCAS2 Protein, Human, Recombinant (His, T7)
TMPJ-00705
Species: Human
Expression System: E. coli
WBP2 Protein, Human, Recombinant (His)
TMPJ-01260
Species: Human
Expression System: E. coli
Carbonic Anhydrase 11 Protein, Human, Recombinant (His)
TMPJ-00701
Species: Human
Expression System: HEK293 Cells
PDK4 Protein, Mouse, Recombinant (His & GST)
TMPY-04445
Species: Mouse
Expression System: Baculovirus Insect Cells
COMMD8 Protein, Human, Recombinant (His)
TMPY-03613
Species: Human
Expression System: E. coli
KCT2 Protein, Human, Recombinant (His)
TMPY-03811
Species: Human
Expression System: HEK293 Cells
APRIL/TNFSF13 Protein, Mouse, Recombinant (hFc)
TMPJ-00456
Species: Mouse
Expression System: HEK293 Cells
IMPA1 Protein, Human, Recombinant (His)
TMPY-02394
Species: Human
Expression System: E. coli
BSSP-4 Protein, Human, Recombinant (His)
TMPJ-01320
Species: Human
Expression System: HEK293 Cells
MESDC2 Protein, Human, Recombinant (His)
TMPY-01451
Species: Human
Expression System: HEK293 Cells
MMGT1 Protein, Human, Recombinant (His)
TMPY-03857
Species: Human
Expression System: HEK293 Cells
CSEN Protein, Human, Recombinant (His)
TMPY-03615
Species: Human
Expression System: E. coli
UGRP1 Protein, Human, Recombinant
TMPJ-01283
Species: Human
Expression System: E. coli
TRIM24 Protein, Human, Recombinant (His & SUMO)
TMPH-02221
Species: Human
Expression System: E. coli
NAPG Protein, Human, Recombinant (His)
TMPY-03616
Species: Human
Expression System: E. coli
C1D Protein, Human, Recombinant (GST)
TMPY-02883
Species: Human
Expression System: E. coli
RAMP3 Protein, Human, Recombinant (hFc)
TMPY-03280
Species: Human
Expression System: HEK293 Cells
Notch 2 Protein, Human, Recombinant (His)
TMPY-04930
Species: Human
Expression System: Baculovirus Insect Cells
HMGN3 Protein, Human, Recombinant (His)
TMPY-02979
Species: Human
Expression System: E. coli
Serpin B8 Protein, Mouse, Recombinant (His)
TMPY-01551
Species: Mouse
Expression System: Baculovirus Insect Cells
カタログ番号 製品名
L1510 Nuclear Receptor Compound Library

531 compounds
A unique collection of 531 nuclear receptor signaling targeted compounds for high throughput and high content screening;
L2400 Endocrinology-Hormone Compound Library

784 compounds
A unique collection of 784 compounds targeting endocrine system for high throughput screening (HTS) and high content screening (HCS) for new drugs;