| T7177 |
Capsazepine
|
|
Apoptosis
,
TRP/TRPV Channel
|
|
Capsazepine is an antagonist of TRPV1 receptor ( IC50 : 562 nM). Capsazepine blocks the painful sensation of heat caused by capsaicin (the active ingredient of chilli pepper) which activates the TRPV1 ion channel. It is ... |
| T12514 |
Podocarpic acid
|
|
Others
,
TRP/TRPV Channel
|
|
Podocarpic acid is a natural product and a novel TRPA1 activator. |
| T6S1684 |
8-Gingerol
|
|
Antioxidant
,
Antibacterial
,
TRP/TRPV Channel
|
|
1. 8-Gingerol has antioxidant activity. 2. 8-Gingerol has antimycobacterial activity. 3. 8-Gingerol could be used as an effective skin-whitening agent. 4. 8-Gingerol shows antipyretic and anti-inflammation characteristic... |
| T2807 |
Caffeic Acid
|
|
Lipoxygenase
,
Endogenous Metabolite
,
TRP/TRPV Channel
|
|
Caffeic Acid is an orally bioavailable, hydroxycinnamic acid derivative and polyphenol, with potential anti-oxidant, anti-inflammatory, and antineoplastic activities. |
| TN4417 |
Larixyl acetate
|
|
Others
|
|
Larixyl acetate is a bioactive chemical. |
| TQ0001 |
1,4-Cineole
|
Isocineole |
Endogenous Metabolite
,
TRP/TRPV Channel
|
|
1,4-Cineole (Isocineole) is a natural, oxygenated monoterpene. 1,4-Cineole can activate both human TRPM8 and human TRPA1. |
| T2952 |
Camphor
|
(±)-Camphor,Bornan-2-one,2-Camphanone,2-Bornanone,Formosa |
Influenza Virus
,
TRP/TRPV Channel
|
|
Camphor (2-Camphanone) is a bicyclic monoterpene ketone found widely in plants, especially CINNAMOMUM CAMPHORA. It is used topically as a skin antipruritic and as an anti-infective agent. |
| T3727 |
Methyl syringate
|
Syringic Acid Methyl Ester |
TRP/TRPV Channel
|
|
Methyl syringate (Syringic Acid Methyl Ester) has a unique inhibitory activity toward aflatoxin production with a different mode of action from that of gallic acid. Methyl syringate from K. pictus is a specific and selec... |
| TCS0102 |
Pulegone
|
(+)-Pulegone |
Calcium Channel
,
Endogenous Metabolite
,
TRP/TRPV Channel
|
|
1. Pulegone ((+)-Pulegone) has cytotoxicity followed by regenerative cell proliferation is the MOA for Pulegone-induced urothelial tumors in female rats. 2. Pulegone induces a verapamil-sensitive psychostimulant effect t... |
| T1407 |
(-)-Menthol
|
L-Menthol,Levomenthol,Menthomenthol,Menthacamphor |
Opioid Receptor
,
Endogenous Metabolite
,
TRP/TRPV Channel
|
|
(-)-Menthol (Levomenthol) is a levo isomer of menthol, an organic compound made synthetically or obtained from peppermint or mint oils with flavoring and local anesthetic properties. When added to pharmaceuticals and foo... |
| TN1465 |
Cannabigerol
|
|
NOS
,
5-HT Receptor
,
ROS
|
|
Cannabigerol is a high affinity α±2-adrenergic receptor agonist, moderate affinity 5-HT1A receptor antagonist, and low affinity CB1 receptor antagonist ; also binds to the CB2 receptor; it can relieve interocular pressur... |
| TN1377 |
α-Spinasterol
|
alpha-Spinasterol |
COX
,
Antibacterial
,
TRP/TRPV Channel
|
|
α-Spinasterol is a transient receptor potential vanilloid 1 (TRPV1) antagonist, has anti-inflammatory, antidepressant, antioxidant and antinociceptive effects. α-Spinasterol inhibits COX-1 andCOX-2 activities with IC50 v... |
| T8307 |
Hydroxy-α-sanshool
|
Hydroxy-α-sanshool |
Endogenous Metabolite
,
TRP/TRPV Channel
|
|
Hydroxy-α-sanshool is an alkyl amide isolated from the pepper. It acts as a TRPA1 covalent and TRPV1 non-covalent agonist (EC50s: 69 and 1.1 μM). |
| T3865 |
Beta-Eudesmol
|
Beta-Selinenol |
TRP/TRPV Channel
,
AChR
|
|
beta-Eudesmol (Beta-Selinenol) is a noncompetitive antagonist of nicotinic acetylcholine receptors (nAChRs). It is a sesquiterpene that has been found in a variety of plants, including Cannabis, and has diverse biologica... |
| T2845 |
Imperatorin
|
Ammidin,8-Isoamylenoxypsoralen,8-Isopentenyloxypsoralene,Marmelosin,Pentosalen |
TRP/TRPV Channel
,
AChR
,
AChE
,
NOD
|
|
Imperatorin (8-Isopentenyloxypsoralene) is a modulator of p38, ERK pathway. Imperatorin increases BMP-2 expression (mRNA) and increases bone density/volume and mineralization in vivo. |
| T23107 |
Ononetin
|
2',4'-Dihydroxy-2-(4-methoxyphenyl)acetophenone |
TRP/TRPV Channel
|
|
Ononetin (2',4'-Dihydroxy-2-(4-methoxyphenyl)acetophenone) is a TRPM3 channel blocker(IC50: 0.3 μM). |
| T1321 |
Nonivamide
|
Nonanoic acid vanillylamide,Pelargonic acid vanillylamide,Vanillyl-N-nonylamide,Pseudocapsaicin |
TRP/TRPV Channel
|
|
Nonivamide (Nonanoic acid vanillylamide) is found in herbs and spices. Nonivamide is an alkaloid from Capsicum species Nonivamide is a flavoring ingredient. Nonivamide is an organic compound and a capsaicinoid. It is an ... |
| T2994 |
(E)-Cardamonin
|
Alpinetin chalcone,Cardamomin,Cardamonin,(E)-Cardamoni |
Apoptosis
,
TRP/TRPV Channel
|
|
(E)-Cardamonin (Alpinetin chalcone) is a chalconoid that has been isolated from several plants including Alpinia katsumadai and Alpinia conchigera. It is a novel antagonist of hTRPA1 cation channel with an IC50 of 454 nM... |
| T0851 |
Pregnenolone
|
3β-Hydroxy-5-pregnen-20-one,Arthenolone |
Cannabinoid Receptor
,
Endogenous Metabolite
,
TRP/TRPV Channel
,
AChR
,
Autophagy
|
|
Pregnenolone (Arthenolone) is an endogenous steroid hormone synthesized from cholesterol, used in the treatment of Alzheimer's disease. |
| T2163 |
Dihydrocapsaicin
|
CCRIS1589,6,7-Dihydrocapsaicin,8-Methyl-N-vanillylnonanamide |
Others
,
TRP/TRPV Channel
|
|
Dihydrocapsaicin (CCRIS1589) is isolated from Capsicum fruit. Capsaicin is the primary active component of the heat and pain-eliciting lipid soluble fraction of the Capsicum pepper. Like capsaicin, dihydrocapsaicin is an... |
| T14046 |
Anandamide
|
(5Z,8Z,11Z,14Z)-N-(2-Hydroxyethyl)icosa-5,8,11,14-tetraenamide |
Cannabinoid Receptor
,
Endogenous Metabolite
|
|
Anandamide ((5Z,8Z,11Z,14Z)-N-(2-Hydroxyethyl)icosa-5,8,11,14-tetraenamide), an immune modulator, acts via not only cannabinoid receptors (CB1 and CB2) but also other targets (e.g., GPR18/GPR55) in the central nervous sy... |
| TN3575 |
(±)-Cannabichromene
|
Cannabichromene,Cannabichrome |
Cannabinoid Receptor
|
|
(±)-Cannabichromene is a major non-psychotropic phytocannabinoid that inhibits endocannabinoid inactivation and activates the transient receptor potential ankyrin-1 (TRPA1), it selectively reduces inflammation-induced hy... |
| T5120 |
Rhamnose
|
6-Deoxyhexopyranose,6-Deoxy-L-mannose,alpha-L-Rhamnose |
Calcium Channel
,
Endogenous Metabolite
|
|
Addition of the Rhamnose (6-Deoxy-L-mannose)-rich polysaccharide, RROP-1, to normal human dermal fibroblasts (NHDFs) and human endothelial cells produced a dose-dependent stimulation of the calcium-signaling pathway, ind... |
| T0224 |
Meropenem
|
SM 7338 |
Others
,
Antibacterial
,
Antibiotic
|
|
Meropenem (SM 7338) is a carbapenem antibiotic with broad spectrum of activity that is administered intravenously and used for severe bacterial infections due to sensitive agents. Meropenem is a common cause of mild tran... |
| T4A2458 |
Resibufogenin
|
Bufogenin,Recibufogenin |
Others
|
|
1. Resibufogenin (Bufogenin) is a cytotoxic steroid isolated from the Chinese drug ChanSu. 2. Resibufogenin can inhibit rectifier potassium current ( I K ) and transient potassium current ( I A ), it has pathological eff... |
| T37280 |
PE(18:1(9Z)/0:0)
|
|
Endogenous Metabolite
|
|
PE(18:1(9Z)/0:0) is a naturally-occurring lysophospholipid and an analog of plasmalogen lysophosphatidylethanolamine. PE(18:1(9Z)/0:0) induces transient increases in intracellular calcium in PC12 rat neuronal cells in a ... |
| T15541 |
Hyperforin dicyclohexylammonium salt
|
Hyperforin DCHA |
Others
|
|
Hyperforin dicyclohexylammonium salt is a transient receptor canonical 6 channel activator with antidepressant effect. It modulates Ca2+ levels by activating Ca2+-conducting non-selective canonical TRPC6 channels. |
| T37219 |
N-Palmitoyl Glycine
|
|
|
|
The acyl amides are a family of endogenous lipids that act as potent modulators of pain and inflammation. The best characterized members of this family are the arachidonoyl amides, which includes N-arachidonoyl ethanolam... |
| T36448 |
(E)-Ajoene
|
|
|
|
(E)-Ajoene is a disulfide that has been found inA. sativumand has diverse biological activities.1,2,3,4It is active against Gram-positive and Gram-negative bacteria (MICs = 10-250 and 150->500 μg/ml, respectively) and fu... |
