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ターゲット

阻害剤

天然化合物

リコンビナントタンパク質

カタログ番号	製品名	別名	ターゲット
T8773	MID-1		Others , IGF-1R
	MID-1 is an inhibitor of MG53-IRS-1 (Mitsugumin 53-Insulin Receptor Substrate-1) interaction. It disrupts molecular association of MG53 with IRS-1 and abolishes MG53-induced IRS-1 ubiquitination and degradation in skelet...		Others , IGF-1R
T7184	Firsocostat	ND-630,NDI-010976,GS-0976	Acetyl-CoA Carboxylase
	Firsocostat (GS-0976) is an inhibitor of acetyl-CoA carboxylase (ACC) dimerization that inhibits human ACC1 and ACC2 activity (IC50s of 2.1 and 6.1 nM, respectively)		Acetyl-CoA Carboxylase
T77100	Nirsevimab	MEDI8897	RSV
	Nirsevimab (MEDI8897) is a recombinant human respiratory syncytial virus (RSV) monoclonal antibody with a modified Fc region. Nirsevimab efficiently targets RSV-B with a Kd value of 1.5 nM. Nirsevimab can be used to prev...		RSV
T50031	Virstatin		Others
	Virstatin is a novel antiviral drug that is a potent inhibitor of viral replication . It has been shown to be effective against a wide range of viruses, including herpes simplex virus (HSV), human immunodeficiency virus ...		Others
T6548	Irsogladine	Dicloguamine	PDE , AChR
	Irsogladine (Dicloguamine) is an anti-gastric ulcer agent that facilitates gap-junctional intercellular communication through M1 muscarininc acetylcholine receptor binding.		PDE , AChR
T75151	Aganirsen
	Aganirsen, a 25-mer DNA antisense oligonucleotide, silences the expression of insulin receptor substrate-1 (IRS-1).
T38464	Miravirsen	SPC-3649,Miravirsen
	Miravirsen (SPC-3649), a β-d-oxy-locked nucleic acid-modified phosphorothioate antisense oligonucleotide, inhibit the biogenesis of miR-122 . Miravirsen (SPC-3649) is used in the study for HCV infections.
T38860	Golodirsen	Golodirsen,SRP-4053
	Golodirsen (SRP-4053) is a phosphorodiamidate morpholino oligomer (PMO) designed to selectively bind and target exon 53 of dystrophin pre-mRNA, with applications in the investigation of Duchenne muscular dystrophy (DMD).
T38554	Eteplirsen	AVI 4658
	Eteplirsen (AVI 4658) is a synthetic antisense oligonucleotide utilized in research for Duchenne muscular dystrophy.
T74842	Trecovirsen
	Trecovirsen (GEM91) is a 25-mer antisense phosphorothioate oligonucleotide that targets the gag site of the HIV gene.
T74569	Bepirovirsen
	Bepirovirsen, an antisense oligonucleotide, targets all HBV messenger RNAs, resulting in decreased levels of HBV-derived RNAs, HBV DNA, and viral proteins. It is utilized in researching chronic HBV infection. The binding...
T61770	(R)-Irsenontrine
	(R)-Irsenontrine ((R)-E2027), the R-enantiomer of Irsenontrine, serves as a potent inhibitor of phosphodiesterase 9 (PDE9) with an inhibition concentration (IC50) of 0.041 μM, primarily utilized in the research of neurol...
T75157	Cimdelirsen
	Cimdelirsen, a novel ligand-conjugated, hepatic-targeted antisense oligonucleotide under investigation, aims to diminish growth hormone receptor (GHr) synthesis. This inhibits the harmful effects of growth hormone (GH) h...
T39517	Suvodirsen	WVE-210201
	Suvodirsen (WVE-210201) is an oligonucleotide compound with potential applications in the study of Duchenne muscular dystrophy (DMD).
T38829	Lademirsen	RG-012,SAR339375
	Lademirsen (SAR339375; RG-012) is a highly specific antisense oligonucleotide (ASO) targeting miR-21 . Lademirsen has the potential for Alport nephropathy research.
T73749	Fomivirsen
	Fomivirsen (ISIS-2922 free base), a 21-mer phosphorothioate antisense oligonucleotide, serves as an antiviral agent, particularly in CMV research, including AIDS studies. It functions by binding to and degrading the mRNA...
T74250	Custirsen
	Custirsen, a highly specific antisense oligonucleotide, inhibits the production of clusterin—an antiapoptotic protein upregulated in response to chemotherapy, thereby conferring treatment resistance.
T12200	Firsocostat S enantiomer	ND-630 S enantiomer,NDI-010976 S enantiomer,GS-0976 S enantiomer	Others
	Firsocostat S enantiomer is the less active S enantiomer of Firsocostat.		Others
T75251	Firsocostat (S enantiomer)
	Firsocostat S enantiomer (ND-630 S enantiomer) is the less active S enantiomer of Firsocostat. Firsocostat is an acetyl-CoA carboxylase ( ACC ) inhibitor.
T39068	Fomivirsen sodium
	Fomivirsen sodium is an antisense 21 mer phosphorothioate oligonucleotide. Fomivirsen is an antiviral agent that is used cytomegalovirus retinitis (CMV) research, incluiding in AIDs. Fomivirsen sodium binds to and degrad...
T38899	Irsenontrine	E2027,Irsenontrine
	Irsenontrine (E2027) is a selective and orally active inhibitor of phosphodiesterase 9 (PDE9), primarily used for researching neurological diseases.
T39108	Irsenontrine maleate	E2027 maleate
	Irsenontrine (E2027) maleate is a selective and orally active inhibitor of phosphodiesterase 9 (PDE9). It can be utilized in the study of neurological diseases.
T74436	Danvatirsen
	Danvatirsen, an antisense oligonucleotide targeting STAT3, demonstrates potential antitumor activity by binding to STAT3 mRNA. This interaction inhibits the translation of the transcript, resulting in the suppression of ...
T73993	Fazirsiran
	Fazirsiran (ARO-AAT), a second-generation RNAi agent, comprises a cholesterol-conjugated RNAi trigger (chol-RNAi) that selectively degrades AAT mRNA via RNAi, and a melittin-derived peptide conjugated to N-acetylgalactos...
T75157L	Cimdelirsen sodium
	Cimdelirsen is a novel, ligand-conjugated, hepatic-targeted investigative antisense oligonucleotide designed to reduce growth hormone receptor (GHr) synthesis, thereby inhibiting deleterious effects of growth hormone (GH...
T4605	NT157		IGF-1R , STAT
	NT157 is a small molecule tyrphostin targeting IRS protein and has the potential to inhibit IGF-1R and STAT3 signaling pathways in TME cancer cells and stromal cells, resulting in decreased cancer cell survival.		IGF-1R , STAT

Compounds

MID-1

T8773

Synonym:

Target: Others, IGF-1R

Firsocostat

T7184

Synonym: ND-630,NDI-010976,GS-0976

Target: Acetyl-CoA Carboxylase

Synonym: Dicloguamine

Synonym: SPC-3649,Miravirsen

Target:

Golodirsen

T38860

Synonym: Golodirsen,SRP-4053

Synonym: RG-012,SAR339375

Firsocostat S enantiomer

T12200

Synonym: ND-630 S enantiomer,NDI-010976 S enantiomer,GS-0976 S enantiomer

Target: Others

Firsocostat (S enantiomer)

Synonym: E2027,Irsenontrine

Target:

Irsenontrine maleate

T39108

Synonym: E2027 maleate

カタログ番号	製品名	別名	ターゲット
TN1911	Marein		transporter , Akt , HDAC , AMPK
	Marein shows neuroprotective effect on PC12 cell damage induced by methylglyoxal, which is due to a reduction of damage to mitochondria function and activation of the AMPK signal pathway, it may be a potent compound for ...		transporter , Akt , HDAC , AMPK
T0760	Cholesterol	Cholesterin,Cholesteryl alcohol	Estrogen Receptor/ERR , MRP , Endogenous Metabolite , ROR
	Cholesterol (cholesteryl alcohol) is a natural product that is the major sterol in mammals and an agonist of estrogen-related receptor α (ERRα). Cholesterol is widely found in the cell membranes of animals and is also us...		Estrogen Receptor/ERR , MRP , Endogenous Metabolite , ROR
TN1065	Hirsutine		Apoptosis
	Hirsutine induces apoptosis and is a potent Dengue virus inhibitor exhibiting low cytotoxicity.Hirsutine has anticancer, cardioprotective, anti-hypertensive and anti-arrhythmic activities, it also has vasodilatation acti...		Apoptosis
TN6975	Cirsiumaldehyde	5,5’-oxydimethylenebis(2-furfural)	Platelet aggregation
	Cirsiumaldehyde is a compound isolated from the mature fruits of Lobelia chinensis, Cornus officinalis, and the fruits of Hippophae rhamnoides.Cirsiumaldehyde in the presence of collagen inhibited U46619-induced (1~5 uM)...		Platelet aggregation
TQ0119	Cirsimaritin		GABA Receptor
			GABA Receptor
TN1081	Hirsuteine		Dopamine Receptor
	Hirsuteine is a natural product. It non-competitively antagonizes nicotine-mediated dopamine release by blocking ion permeation through nicotinic receptor channel complexes.		Dopamine Receptor
T10822	Cirsimarin	Cirsitakaoside	Adenosine Receptor
	Cirsimarin (Cirsitakaoside) is a flavonoid isolated from Microtea debilis. It shows a potent antilipogenic effect and decreases adipose tissue deposition in mice. Cirsimarin has antagonist activity on the adenosine A1 re...		Adenosine Receptor
TN3295	8alpha-(2-Methylacryloyloxy)hirsutinolide		Others
	8alpha-(2-Methylacryloyloxy)hirsutinolide is a natural product for research related to life sciences. The catalog number is TN3295 and the CAS number is 188293-70-1.		Others
TN3298	8alpha-Hydroxyhirsutinolide		TNF , NF-κB
	8alpha-Hydroxyhirsutinolide shows anti-inflammatory activity, it inhibits TNF-α-induced NF-ÎºB activity with the IC(50) value of 1.9 uM.		TNF , NF-κB
T75532	Cirsiliol 4′-glucoside
	Cirsiliol 4′-glucoside, a compound extracted from Ruellia tuberosa L., acts as a free radical scavenger and demonstrates potential anti-diabetic activity [1].
T19886	Cirsilineol	Fastigenin,SPM 927,Eupatrin	Apoptosis , COX , STAT
	Cirsilineol (Eupatrin) is isolated from the herb of Artemisia vestita Wall and shows immunosuppressive, anti-proliferative, and anti-tumor properties. Cirsilineol selectively induces apoptosis via the mitochondrial pathw...		Apoptosis , COX , STAT
TN3300	8alpha-Tigloyloxyhirsutinolide 13-O-acetate		NADPH-oxidase , P450 , MAO
	8alpha-Tigloyloxyhirsutinolide 13-O-acetate shows inhibitory activity toward CYP2A6 and MAO-A and MAO-B enzymes. 8alpha-Tigloyloxyhirsutinolide 13-O-acetate has anti-cancer activity, it is active against both cancer cell...		NADPH-oxidase , P450 , MAO
T10821	Cirsiliol		Lipoxygenase
			Lipoxygenase
TN3293	8alpha-(2-Methylacryloyloxy)-1-O-methylhirsutinolide 13-O-acetate		Others
	8alpha-(2-Methylacryloyloxy)-1-O-methylhirsutinolide 13-O-acetate is a natural product for research related to life sciences. The catalog number is TN3293 and the CAS number is 883872-71-7.		Others
T38016	Hirsutide
	Hirsutide is a cyclotetrapeptide fungal metabolite produced by the entomopathogenic fungus Hirsutella. It has antibacterial activity against C. pyogenes, S. aureus, P. aeruginosa, and K. pneumonia (MICs = 25, 13, 6, and ...
TN4213	Hirsutenone		ERK , EGFR , IL Receptor , NF-κB , Akt , PI3K , Antifection , mTOR , p53 , Autophagy
	Hirsutenone has potent antioxidant activity, it shows significant free radical scavenging activity and exhibits inhibition effect on the mitochondrial lipid peroxidation.Hirsutenone exhibits anti-cancer, and anti-filaria...
TN4212	Hirsutanonol		COX , Antifection
	Hirsutanonol is a secondary metabolite from the bark of Alnus glutinosa. Hirsutanonol has potent antioxidant and free radical scavenging activities and exhibits an inhibition effect on mitochondrial lipid peroxidation. H...		COX , Antifection
TN4211	Hirsutanonol 5-O-glucoside		Others
	Hirsutanonol 5-O-glucoside is a natural product for research related to life sciences. The catalog number is TN4211 and the CAS number is 93915-36-7.		Others
TN3294	8alpha-(2-Methylacryloyloxy)hirsutinolide 13-O-acetate		NADPH-oxidase , P450 , MAO
	8alpha-(2-Methylacryloyloxy)hirsutinolide 13-O-acetate shows inhibitory activity toward CYP2A6 and MAO-A and MAO-B enzymes.		NADPH-oxidase , P450 , MAO
T4S1545	Licarin B	(-)-Licarin B,Licarine B	transporter , Antibacterial , PPAR
	1.(-)-Licarin B (Licarine B) has anti-mycobacterial activity.		transporter , Antibacterial , PPAR
TL0014	Pinusolide		ERK , p38 MAPK , Calcium Channel , Lipoxygenase , PAFR , Caspase , JNK , AMPK
	Pinusolide is a platelet activating factor ( PAF) antagonist, it may prove of therapeutic value in the treatment of hypotension, it has antileukemic potential, and could be used to treat neurodegenerative diseases. Pinus...

天然物製品

Marein

TN1911

Synonym:

Target: transporter, Akt, HDAC, AMPK

Cholesterol

T0760

Synonym: Cholesterin,Cholesteryl alcohol

Target: Estrogen Receptor/ERR, MRP, Endogenous Metabolite, ROR

Synonym: 5,5’-oxydimethylenebis(2-furfural)

Target: Platelet aggregation

Cirsimaritin

TQ0119

Synonym:

Target: GABA Receptor

Hirsuteine

TN1081

Synonym:

Target: Dopamine Receptor

Cirsimarin

T10822

Synonym: Cirsitakaoside

Target: Adenosine Receptor

8alpha-(2-Methylacryloyloxy)hirsutinolide

TN3295

Synonym:

Target: Others

8alpha-Hydroxyhirsutinolide

TN3298

Synonym:

Target: TNF, NF-κB

Cirsiliol 4′-glucoside

Synonym: Fastigenin,SPM 927,Eupatrin

Target: Apoptosis, COX, STAT

8alpha-Tigloyloxyhirsutinolide 13-O-acetate

TN3300

Synonym:

Target: NADPH-oxidase, P450, MAO

8alpha-(2-Methylacryloyloxy)-1-O-methylhirsutinolide 13-O-acetate

Target: ERK, EGFR, IL Receptor, NF-κB, Akt, PI3K, Antifection, mTOR, p53, Autophagy

Hirsutanonol

TN4212

Synonym:

Target: COX, Antifection

Hirsutanonol 5-O-glucoside

TN4211

Synonym:

Target: Others

8alpha-(2-Methylacryloyloxy)hirsutinolide 13-O-acetate

TN3294

Synonym:

Target: NADPH-oxidase, P450, MAO

Licarin B

T4S1545

Synonym: (-)-Licarin B,Licarine B

Target: transporter, Antibacterial, PPAR

Pinusolide

TL0014

Synonym:

Target: ERK, p38 MAPK, Calcium Channel, Lipoxygenase, PAFR, Caspase, JNK, AMPK

Recombinant Proteins

Species：

Expression System：

Tag：

カタログ番号	製品名	Species	Expression System
TMPH-03191	NirS Protein, Pseudomonas stutzeri, Recombinant (His & Myc)	Pseudomonas stutzeri	E. coli
	N/A. NirS Protein, Pseudomonas stutzeri, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 56.0 kDa and the accession number is P24040.
TMPJ-00109	LMIR2 Protein, Human, Recombinant (hFc)	Human	HEK293 Cells
	CD300C is a single-pass type I membrane protein which belongs to the immunoregulatory signaling (IRS) family. CD300C contains one Ig-like V-type domain and is present on the surface of natural killer cells, granulocytes,...

NirS Protein, Pseudomonas stutzeri, Recombinant (His & Myc)

TMPH-03191

Species: Pseudomonas stutzeri

Expression System: E. coli

LMIR2 Protein, Human, Recombinant (hFc)

TMPJ-00109

Species: Human

Expression System: HEK293 Cells