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カタログ番号 | 製品名 | 別名 | ターゲット |
---|---|---|---|
T9023 | Atuliflapon | AZD5718 | FLAP |
Atuliflapon (AZD5718) is a novel 5-Lipoxygenase Activating Protein(FLAP) inhibitor for Treatment of Coronary Artery Disease. | |||
T6792 | BQ-123 | BQ123 | Endothelin Receptor |
BQ-123 is a selective endothelin A receptor (ETA) antagonist with IC50 of 7.3 nM. Phase 2. | |||
T4330 | CaCCinh-A01 | Chloride channel | |
CaCCinh-A01 is an inhibitor of the calcium-activated chloride channel (CaCC, 10 μM) and TMEM16A (IC50: 2.1 μM). | |||
T1476 | Pramipexole | SND 919 | Dopamine Receptor |
Pramipexole (SND 919) is a selective dopamine receptor agonist used in the therapy of Parkinson disease. Pramipexole therapy is associated with a low rate of transient serum enzyme elevations during treatment but has not... | |||
T19659 | Annaosanchun | YC6,YC-6,YC 6 | Others , AMPK |
Annaosanchun (YC-6) is potentially for the treatment of acute ischemic stroke (AIS). | |||
T6033 | Zotarolimus | ABT-578,A 179578 | mTOR |
Zotarolimus (ABT-578), an analogue of rapamycin, inhibits FKBP-12 (IC50= 2.8 nM). | |||
T23146 | PHA 568487 free base | PHA 568487 | AChR |
The quinuclidine PHA 568487 free base is an agonist of the alpha 7 nicotinic acetylcholine receptor that was designed to mitigate the bioactivation associated with the core scaffold and subsequently remove associated lia... | |||
T0005 | Aspirin | Acetylsalicylate,Acetylsalicylic Acid,ASA | Mitophagy , Virus Protease , COX , Autophagy |
Aspirin (Acetylsalicylic Acid) is a potent and selective inhibitor of COX with various pharmacological activities, such as anti-inflammation and pain relief. Aspirin is a histone deacetylase inhibitors to up-regulate cel... | |||
T6951 | Pramipexole dihydrochloride hydrate | Pramipexole 2HCl Monohydrate,Mirapex | Dopamine Receptor |
Pramipexole dihydrochloride hydrate (Mirapex) is the hydrochloride salt of pramipexole, a benzothiazole derivative. As a nonergot dopamine agonist, pramipexole binds to D2 and D3 dopamine receptors in the striatum and su... | |||
T0154 | Nebivolol hydrochloride | R 065824 hydrochloride,Nebivolol HCl,R-65824 | Apoptosis , Adrenergic Receptor |
Nebivolol hydrochloride (R 065824 hydrochloride) is a cardioselective ADRENERGIC BETA-1 RECEPTOR ANTAGONIST (beta-blocker) that functions as a VASODILATOR through the endothelial L-arginine/ NITRIC OXIDE system. It is us... | |||
T19345 | GP2-114 | Others | |
GP2-114 is a catecholamine exercise mimetic that can be used to study coronary artery disease (CAD). | |||
T2480 | Apabetalone | RVX-208,RVX000222 | Epigenetic Reader Domain , HIV Protease |
Apabetalone (RVX000222) , an effective BET bromodomain inhibitor, has been investigated for the treatment of diabetes, atherosclerosis, and coronary artery disease. | |||
T1986 | Atopaxar | E5555,ER-172594-00 | Protease-activated Receptor |
Atopaxar (E5555), a reversible PAR-1 thrombin receptor antagonist, interferes with platelet signaling. Atopaxar has been investigated for the treatment of Coronary Artery Disease and Acute Coronary Syndrome. | |||
T1986L | Atopaxar Hydrobromide | Protease-activated Receptor | |
Atopaxar, a reversible PAR-1 thrombin receptor antagonist, interferes with platelet signaling. Atopaxar has been investigated for the treatment of Coronary Artery Disease and Acute Coronary Syndrome. | |||
T24873 | TGX-115 | TGX 115 | PI3K |
TGX-115 is a cell-permeable and potent inhibitor of the PI 3-K isoform p110β/p110δ (IC50 values of 0.13 μM for p110β and 0.63 μM for p110δ), an enzyme that regulates platelet adhesion and inhibits phosphoinositide (PI) 3... | |||
T22787 | FPL 55712 | LTR | |
FPL 55712 is a leukotriene receptor and SRS-A antagonist that inhibits bronchoconstriction and can be used in studies of asthma and coronary artery thrombosis. | |||
T10595 | BQ-788 | BQ788 | Endothelin Receptor |
BQ-788 is a selective and potent ETB receptor antagonist with potential hypertensive activity.BQ-788 inhibits ET-1 binding to ETB receptors and inhibits exogenous ET-1-induced elevation of coronary artery perfusion press... | |||
T10364 | Arbutamine | GP 21213 | Adrenergic Receptor |
Arbutamine (GP 21213) is a novel potent non-selective beta-adrenoceptor agonist with alpha-1-sympathomimetic activity.Arbutamine promotes cardiac stress and increases heart rate, cardiac contractility.Arbutamine can be u... | |||
T4179 | Probucol disuccinate | LDL | |
Probucol is an anti-hyperlipidemic drug initially developed in the treatment of coronary artery disease by lowering the level of cholesterol in the bloodstream by increasing the rate of LDL catabolism. | |||
T23557 | Talibegron hydrochloride | ZD2079 hydrochloride,ZD 2079 | Adrenergic Receptor |
Talibegron hydrochloride (ZD2079 hydrochloride) is an β3 adrenergic receptor agonist with a pD2 of 3.72 on phenylephrine-preconstricted rat mesenteric artery. Relaxes rat mesenteric artery and isolated aorta in vitro. In... | |||
T32155 | Indecainide | Ricainide,Ricainid,Decabid,Indecainidum,Indecainida | Others |
Indecainide (Ricainid) is a novel antiarrhythmic compound that is carcinogenic and can be used to study chronic stable ventricular arrhythmias secondary to coronary artery disease or cardiomyopathy. | |||
T27627 | Iroxanadine | BRX005,BRX-235,BRX-005,BRX235,BRX 005,BRX 235 | p38 MAPK |
Iroxanadine (BRX-005) is a Novel small molecule MAPK p38 inhibitor that induces phosphorylation of p38 SAPK and induces concentration-dependent relaxation in guinea pig pulmonary artery preparations precontracted with ph... | |||
T61028 | Mitiperstat | AZD4831 | Glutathione Peroxidase |
Mitiperstat is a potent myeloperoxidase (MPO) inhibitor that is effective in preventing cardiovascular diseases such as heart failure and coronary artery disease. | |||
T4287 | Succinobucol | Probucol monosuccinate,AGI-1067 | Antioxidant , Reactive Oxygen Species |
Succinobucol (Probucol monosuccinate) is a novel phenolic antioxidant small molecule with anti-oxidant and anti-inflammatory properties. It designed to treat atherosclerosis of the blood vessels of the heart or coronary ... | |||
T8687 | Diaminohydroxypropanetetraacetic acid | Others | |
Diaminohydroxypropanetetraacetic acid has been investigated for the treatment of Vascular Disease, Coronary Disease, Myocardial Ischemia, Coronary Restenosis, and Coronary Artery Disease, among others | |||
T31992 | Granotapide | CETP | |
Granotapide is a microsomal triglyceride transfer protein (MTP) inhibitor that treats and rather prevents atherosclerosis, coronary artery disease, metabolic syndrome, obesity, diabetes mellitus, prediabetes mellitus, an... | |||
T5856 | Barnidipine hydrochloride | YM-09730-5 hydrochloride,Mepirodipine (hydrochloride) | Calcium Channel |
Barnidipine hydrochloride (YM-09730-5 hydrochloride) is a dihydropyridine calcium channel blocker that has an IC50 value of 0.35 nM in potassium-induced tonic contraction of pig coronary artery | |||
T0182L2 | (±) Clopidogrel hydrogen sulfate | Plavix,Clopidogrel hydrogen sulfate,Iscover | P2Y Receptor |
(±) Clopidogrel hydrogen sulfate (Iscover) , an antiplatelet agent pharmacologically and structurally analogous to ticlopidine, is used to inhibit blood clots in various conditions such as cerebrovascular disease, periph... | |||
TP1886L1 | NoxA1ds acetate(1435893-78-9 free base) | NADPH-oxidase | |
NoxA1ds acetate is a potent and selective NADPH oxidase 1 (NOX1) inhibitor (IC50 : 20 nM). Exhibits selectivity for NOX1 over NOX2, NOX4, NOX5 and xanthine oxidase. Inhibits NOX1-derived O2- production in HT-29 human col... | |||
T4567 | Sulfaphenazole | Plisulfan,Raziosulfa,Depocid,Depotsulfonamide | P450 , Antibacterial |
Sulfaphenazole (Plisulfan) is an inhibitor of CYP2C9 (Ki: 0.3 μM) that demonstrates at least 100-fold selectivity over other CYP450 isoforms (Ki: 63/29 μM for CYP2C8/CYP2C18, respectively, and no activity at CYP1A1, CYP1... | |||
T27753 | KT-362 fumarate | KT 362,KT362,KT-362 | Potassium Channel , Calcium Channel , Sodium Channel |
KT-362 fumarate is a novel compound that acts as an antagonist of calcium channels, potassium channels and sodium channels.KT-362 fumarate causes vasodilation by affecting intracellular calcium mobilization in atrial mus... | |||
T14021 | 20-HETE | 20-hydroxy Arachidonic Acid | Others |
20-HETE (20-hydroxy Arachidonic Acid) is a CYP450 metabolite and a potent vasoconstrictor and it is an endogenous inhibitor of the large-conductance Ca2+-activated K+ channel in renal arterioles. 20-HETE increases NADPH ... | |||
T14390L | (2R,3S)-Azelaprag | Apelin receptor | |
(2R,3S)-N-(4-(2,6-dimethoxyphenyl)-5-(5-methylpyridin-3-yl)-4H-1,2,4-triazol-3-yl)-3-(5-methylpyrimidin-2-yl)butane-2-sulfonamide is an Apelin receptor agonist with an EC50 for Apelin receptors of 0.012 µM.(2R,3S)-N-(4-(... | |||
T73695 | Canakinumab | ACZ 885,Ilaris | IL Receptor |
Canakinumab (ACZ885) is a recombinant human IL-1β-targeting monoclonal antibody.Canakinumab has been shown to inhibit human and chorioallantoic monkey IL-1β, with IC50 values of 43.6 and 40.8 pM, respectively.Canakinumab... | |||
T70540 | Pinokalant | LOE-908 | SARS-CoV , TRP/TRPV Channel |
Pinokalant (LOE-908) is a novel non-selective cation channel inhibitor.Pinokalant significantly reduces cortical infarct volume in in vivo experiments, improves the metabolic and electrophysiological status of the ischem... | |||
T35689 | MTP 131 acetate | Others | |
MTP 131 is a mitochondria-targeted peptide antioxidant.1,2It localizes to the mitochondria and reducestert-butyl hydroperoxide-induced lipid peroxidation and apoptosis in SH-SY5Y cells when used at concentrations ranging... | |||
T2531L | Eprosartan | KF-108566J free base,Teveten | RAAS |
Eprosartan (SKF-108566J free base) is a selective and competitive nonpeptide angiotensin II receptor antagonist with high affinity for AT1 receptor subtypes and can be used as an antihypertensive agent.Eprosartan has an ... | |||
T27351 | Fostedil | KB-944,KB944,A 53986,KB 944,A-53986,BRN 3626546 | |
Fostedil is a calcium channel antagonist. KB-944 increased regional segment function in normal and ischemic regions and maintained distal coronary artery perfusion pressure, coronary flow and transmural regional myocardi... | |||
T26739 | Batifiban | ||
Batifiban, a glycoprotein IIb/IIIa antagonist, is used potentially for the treatment of coronary artery disease. | |||
T19478 | Nicotinoyl cyclandelate | RV 12128 | Others |
Nicotinoyl cyclandelate can effectively reduce blood pressure in the femoral artery and perfusion pressure in cerebral blood vessels. | |||
T16902 | SMND-309 | Others | |
SMND-309 is a metabolite of salvianolic acid B. It also shows neuroprotective effects in cultured neurons and in permanent middle cerebral artery occlusion rats. | |||
T69970 | AZD5718 | ||
AZD5718 is a potent and selective FLAP inhibitor (IC50 = 2.0 nM) for Treatment of Coronary Artery Disease. AZD5718 demonstrated a dose dependent and greater than 90% suppression of leukotriene production over 24 h. Precl... | |||
T30255 | AZD2716 | AZD 2716,AZD-2716 | |
AZD2716 is an effective selective phospholipase A2 inhibitor for the treatment of coronary artery and cardiovascular disease. | |||
T71393 | (S)-FTY-720 Vinylphosphonate | ||
(S)-FTY-720 Vinylphosphonate inhibits sphingosine kinase 1 and promotes its proteasomal degradation in human pulmonary artery smooth muscle, breast cancer cells, and androgen-independent prostate cancer cells. | |||
T29107 | Vintoperol | RT-3003,RGH2981,RGH 2981,RT3003,RT 3003,RGH-2981 | |
Vintoperol, a calcium channel antagonist, is used potentially for the treatment of arterial occlusive disease and peripheral artery disease. | |||
T41029 | Streptokinase | ||
Streptokinase is a bacterial protein that acts as a plasminogen activator, commonly employed in the investigation of blood-clotting disorders. Its application extends to enhancing reperfusion blood flow after coronary ar... | |||
T61526 | Cicaprost | ||
Cicaprost (ZK 96480) is a prostacyclin receptor (IP) agonist, which induces relaxation of the artery via concentration-dependent mechanisms. Its EC50 value, determined to be 5.8 nM [1], further highlights its potency. | |||
T34762 | T-0201 | T 0201,TA0201,TA-0201,TA 0201 | |
T-0201 (TA 0201) is a highly potent, long-acting, orally active, and selective ETA receptor antagonist. T-0201 also inhibited ET-1-induced pulmonary artery contraction in isolated rabbits. | |||
T79239 | PCSK9-IN-19 | ||
PCSK9-IN-19 (Compound 1), a PCSK9 inhibitor, is utilized in researching the treatment of high LDL-cholesterol levels and the prevention of coronary artery disease [1]. | |||
TP2119 | Sarafotoxin S6a | ||
Endothelin receptor agonist (EC50 values are 7.5 and > 150 nM for contraction of pig coronary artery and guinea pig aorta respectively). Nociceptive in vivo. |
カタログ番号 | 製品名 | 別名 | ターゲット |
---|---|---|---|
TN6715 | 7-Ketocholesterol | Others | |
7-Ketocholesterol is a metabolite of Cholesterol | |||
T2163 | Dihydrocapsaicin | CCRIS1589,6,7-Dihydrocapsaicin,8-Methyl-N-vanillylnonanamide | Others , TRP/TRPV Channel |
Dihydrocapsaicin (CCRIS1589) is isolated from Capsicum fruit. Capsaicin is the primary active component of the heat and pain-eliciting lipid soluble fraction of the Capsicum pepper. Like capsaicin, dihydrocapsaicin is an... | |||
TWA2417 | Sodium taurocholate | Taurocholate Sodium | Others |
Sodium taurocholate (Taurocholate Sodium) hydrate is the main end product of cholesterol catabolism. During enterohepatic circulation, bile taurocholic acid is converted by the microorganisms to taurodeoxycholic acid and... | |||
S00015 | Tea polyphenol | Apoptosis , Others , Autophagy | |
Tea polyphenol, also called green tea extract, are a mixture of chemical compounds, such as flavanoids and tannins, found naturally in tea. Polyphenols are powerful antioxidants, which can reduce the risk of developing c... | |||
T2803 | Monocrotaline | Crotaline | TGF-beta/Smad |
Monocrotaline (Crotaline) is a pyrrolizidine alkaloid and a toxic plant constituent that poisons livestock and humans through the ingestion of contaminated grains and other foods. The alkaloid causes pulmonary artery hyp... | |||
T4S1422 | Praeruptorin E | Others , Calcium Channel | |
1. Praeruptorin C and E can relax swine coronary artery and decrease contractility in guinea-pig left atria, these effects are similar in many respects to those displayed by drugs that have calcium entry blocking activit... | |||
T37709 | 2,2,2-Trichloroethanol | Potassium Channel , Endogenous Metabolite | |
2,2,2-Trichloroethanol, the active form of the sedative hypnotic drug chloral hydrate, is an agonist for the nonclassical K2P channels TREK-1 (KCNK2) and TRAAK (KCNK4)[1]. 2,2,2-trichloroethanol activates a nonclassical ... | |||
T5074 | Cholesteryl palmitate | Others , Endogenous Metabolite | |
Cholesteryl palmitic acid is a cholesteryl ester. A cholesteryl ester is an ester of cholesterol. Fatty acid esters of cholesterol constitute about two-thirds of the cholesterol in the plasma. Cholesterol is a sterol (a ... | |||
T2S0118 | Daurinoline | Calcium Channel , 5-HT Receptor , Histamine Receptor | |
Daurinoline is a non-competitive antagonist, it exerts marked relaxation effect on basilar artery of rabbits through non-competitive antagonism, it would have a protective function on microcirculation of cerebral pia mat... | |||
TN3323 | Monomethyl lithospermate | Lithospermic acid monomethyl ester | Akt , PI3K |
Monomethyl lithospermate (Lithospermic acid monomethyl ester) has potential antiviral activity, alleviating ischemic stroke injury in vivo in middle cerebral artery occlusion mice by activating PI5K/Akt signaling and pro... | |||
TN2533 | 1-Hydroxy-2,3,4,7-tetramethoxyxanthone | 5-HT Receptor | |
1-Hydroxy-2,3,4,7-tetramethoxy-xanthone has vasodilatory action, it can cause vasodilation in the coronary artery pre-contracted with 1uM 5-hydroxytryptamine (5-HT), with the EC 50 value of 6.6±1.4 uM. 1-Hydroxy-2,3,4,7-... |
カタログ番号 | 製品名 | Species | Expression System |
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TMPJ-00137 | APRIL/TNFSF13 Protein, Human, Recombinant (Flag & His) | Human | HEK293 Cells |
APRIL (a proliferation-inducing ligand), also known as TNFSF13, TALL2, TRDL1, and CD256, is a member of the TNF ligand superfamily. It is synthesized as a 32 kDa proprotein which is cleaved by furin in the Golgi to relea... | |||
TMPY-04124 | LPAL2 Protein, Human, Recombinant (mFc) | Human | HEK293 Cells |
LPAL2 (Lipoprotein(A) Like 2, Pseudogene) is a Pseudogene. This gene is similar to the lipoprotein, Lp(a) gene, but all transcripts produced by this gene contain a truncated open reading frame and are candidates for nons... | |||
TMPK-01229 | IL-19 Protein, Human, Recombinant (hFc) | Human | HEK293 Cells |
Interleukin-19 (IL-19) has been shown to be involved in coronary artery diseases and atherosclerosis, while its expression in myocardial infarction is poorly understood. In this study, the dynamic increase in circulating... | |||
TMPY-04321 | CHRNA5 Protein, Human, Recombinant (His) | Human | HEK293 Cells |
Genetic variation in the cluster on chromosome 15, encoding the nicotinic acetylcholine receptor subunits (CHRNA5-CHRNA3-CHRNB4), has shown strong associations with tobacco consumption and an additional risk increase in ... | |||
TMPJ-01005 | Lumican Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells |
Keratan sulfate proteoglycan lumican, mostly known as lumican, belongs to the SLRP class II subfamily and the small leucine-rich proteoglycan (SLRP) family. Lumican binds to laminin. It has positive regulation of transcr... | |||
TMPJ-00158 | Apolipoprotein A-I/APOA1 Protein, Human, Recombinant | Human | E. coli |
Apolipoprotein A1 (APOA1) is a secreted protein which belongs to the Apolipoprotein A1/A4/E family. APOA1 is the major protein component of high density lipoprotein (HDL) in plasma. APOA1 plays a critical role in various... | |||
TMPJ-00835 | FGF-4 Protein, Mouse, Recombinant | Mouse | E. coli |
Fibroblast growth factor 4(FGF-4) is a heparin binding member of the FGF family. The human FGF4 cDNA encodes 206 amino acids (aa) with a 33 aa signal sequence and a 173 aa mature protein with an FGF homology domain that ... |
カタログ番号 | 製品名 | ||
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L5400 | Anti-Cardiovascular Disease Compound Library | 1408 compounds | |
A unique collection of 1408 cardiovascular diseases related compounds for high throughput screening (HTS) and high content screening (HCS); | |||
L6140 | Saccharide and Glycoside Natural Product Library | 362 compounds | |
A unique collection of 362 saccharides and glycosides compounds can be used for HTS and HCS; |